Author results

1AWO
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THE SOLUTION NMR STRUCTURE OF ABL SH3 AND ITS RELATIONSHIP TO SH2 IN THE SH(32) CONSTRUCT, 20 STRUCTURES
Descriptor:ABL TYROSINE KINASE
Authors:Cowburn, D.
Deposit date:1997-10-03
Release date:1998-01-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The solution structure of Abl SH3, and its relationship to SH2 in the SH(32) construct.
Structure, 3, 1995
1AB2
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THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY 2 DOMAIN OF C-ABL
Descriptor:C-ABL TYROSINE KINASE SH2 DOMAIN
Authors:Overduin, M., Rios, C.B., Mayer, B.J., Baltimore, D., Cowburn, D.
Deposit date:1993-07-19
Release date:1994-01-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Three-dimensional solution structure of the src homology 2 domain of c-abl.
Cell(Cambridge,Mass.), 70, 1992
1BAK
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SIGNAL TRANSDUCTION PLECKSTRIN HOMOLOGY DOMAIN OF G-PROTEIN COUPLED RECEPTOR KINASE 2 (BETA-ADRENERGIC RECEPTOR KINASE 1), C-TERMINAL EXTENDED, NMR, 20 STRUCTURES
Descriptor:G-PROTEIN COUPLED RECEPTOR KINASE 2
Authors:Fushman, D., Cowburn, D.
Deposit date:1997-11-21
Release date:1998-02-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The solution structure and dynamics of the pleckstrin homology domain of G protein-coupled receptor kinase 2 (beta-adrenergic receptor kinase 1). A binding partner of Gbetagamma subunits.
J.Biol.Chem., 273, 1998
1A6S
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M-DOMAIN FROM GAG POLYPROTEIN OF ROUS SARCOMA VIRUS, NMR, 20 STRUCTURES
Descriptor:GAG POLYPROTEIN
Authors:Mcdonnell, J.M., Fushman, D., Cahill, S.M., Zhou, W., Wolven, A., Wilson, C.B., Nelle, T.D., Resh, M.D., Wills, J., Cowburn, D.
Deposit date:1998-03-02
Release date:1998-10-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and dynamics of the bioactive retroviral M domain from Rous sarcoma virus
J.Mol.Biol., 279, 1998
1C4B
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A BETA-HAIRPIN MIMIC FROM FCERI-ALPHA-CYCLO(RD-262)
Descriptor:PROTEIN (CYCLO(RD-262))
Authors:Mcdonnell, J.M., Fushman, D., Cahill, S.M., Sutton, B.J., Cowburn, D.
Deposit date:1999-08-02
Release date:1999-08-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structures of FceRI Alpha-Chain Mimics: A Beta-Hairpin Peptide and Its Retroenantiomer
J.Am.Chem.Soc., 119, 1997
1DDB
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STRUCTURE OF MOUSE BID, NMR, 20 STRUCTURES
Descriptor:PROTEIN (BID)
Authors:Mcdonnell, J.M., Fushman, D., Milliman, C., Korsmeyer, S.J., Cowburn, D.
Deposit date:1999-02-19
Release date:1999-08-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists.
Cell(Cambridge,Mass.), 96, 1999
1XBH
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A BETA-HAIRPIN MIMIC FROM FCERI-ALPHA-CYCLO(L-262)
Descriptor:PROTEIN (CYCLO(L-262))
Authors:Mcdonnell, J.M., Fushman, D., Cahill, S.M., Sutton, B.J., Cowburn, D.
Deposit date:1999-02-17
Release date:1999-02-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structures of FceRI Alpha-Chain Mimics: A Beta-Hairpin Peptide and Its Retroenantiomer
J.Am.Chem.Soc., 119, 1997
3EAC
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CRYSTAL STRUCTURE OF SH2 DOMAIN OF HUMAN CSK (CARBOXYL-TERMINAL SRC KINASE), OXIDIZED FORM.
Descriptor:Tyrosine-protein kinase CSK
Authors:Liu, D., Seidel, R.D., Cowburn, D.
Deposit date:2008-08-25
Release date:2009-11-10
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase.
Biophys Rep, 2, 2016
3EAZ
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CRYSTAL STRUCTURE OF SH2 DOMAIN OF HUMAN CSK (CARBOXYL-TERMINAL SRC KINASE), C122S MUTANT.
Descriptor:Tyrosine-protein kinase CSK
Authors:Liu, D., Seidel, R.D., Cowburn, D.
Deposit date:2008-08-26
Release date:2009-11-10
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase.
Biophys Rep, 2, 2016
1AWE
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HUMAN SOS1 PLECKSTRIN HOMOLOGY (PH) DOMAIN, NMR, 20 STRUCTURES
Descriptor:SOS1
Authors:Zheng, J., Cowburn, D.
Deposit date:1997-10-01
Release date:1998-02-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains.
J.Biol.Chem., 272, 1997
1G84
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THE SOLUTION STRUCTURE OF THE C EPSILON2 DOMAIN FROM IGE
Descriptor:IMMUNOGLOBULIN E
Authors:McDonnell, J.M., Cowburn, D., Gould, H.J., Sutton, B.J., Calvert, R., Beavil, R.E., Beavil, A.J., Henry, A.J.
Deposit date:2000-11-16
Release date:2001-05-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalpha.
Nat.Struct.Biol., 8, 2001
1JEG
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SOLUTION STRUCTURE OF THE SH3 DOMAIN FROM C-TERMINAL SRC KINASE COMPLEXED WITH A PEPTIDE FROM THE TYROSINE PHOSPHATASE PEP
Descriptor:TYROSINE-PROTEIN KINASE CSK, HEMATOPOIETIC CELL PROTEIN-TYROSINE PHOSPHATASE 70Z-PEP
Authors:Ghose, R., Shekhtman, A., Goger, M.J., Ji, H., Cowburn, D.
Deposit date:2001-06-17
Release date:2001-10-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A novel, specific interaction involving the Csk SH3 domain and its natural ligand.
Nat.Struct.Biol., 8, 2001
1Z66
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NMR SOLUTION STRUCTURE OF DOMAIN III OF E-PROTEIN OF TICK-BORNE LANGAT FLAVIVIRUS (NO RDC RESTRAINTS)
Descriptor:Major envelope protein E
Authors:Mukherjee, M., Dutta, K., White, M.A., Cowburn, D., Fox, R.O.
Deposit date:2005-03-21
Release date:2006-03-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR solution structure and backbone dynamics of domain III of the E protein of tick-borne Langat flavivirus suggests a potential site for molecular recognition.
Protein Sci., 15, 2006
2GG1
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NMR SOLUTION STRUCTURE OF DOMAIN III OF THE E-PROTEIN OF TICK-BORNE LANGAT FLAVIVIRUS (INCLUDES RDC RESTRAINTS)
Descriptor:Genome polyprotein
Authors:Mukherjee, M., Dutta, K., White, M.A., Cowburn, D., Fox, R.O.
Deposit date:2006-03-23
Release date:2006-04-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR solution structure and backbone dynamics of domain III of the E protein of tick-borne Langat flavivirus suggests a potential site for molecular recognition.
Protein Sci., 15, 2006
2GGR
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SOLUTION STRUCTURE OF THE C-TERMINAL SH3 DOMAIN OF C-CRKII
Descriptor:Proto-oncogene C-crk
Authors:Muralidharan, V., Dutta, K., Muir, T.W., Cowburn, D.
Deposit date:2006-03-24
Release date:2006-08-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure and Folding Characteristics of the C-Terminal SH3 Domain of c-Crk-II
Biochemistry, 45, 2006
2K6X
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AUTOREGULATION OF A GROUP 1 BACTERIAL SIGMA FACTOR INVOLVES THE FORMATION OF A REGION 1.1- INDUCED COMPACTED STRUCTURE
Descriptor:RNA polymerase sigma factor rpoD
Authors:Schwartz, E.C., Shekhtman, A., Dutta, K., Pratt, M.R., Cowburn, D., Darst, S., Muir, T.W.
Deposit date:2008-07-28
Release date:2008-10-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Autoregulation of a Group 1 Bacterial Sigma Factor Involves the Formation of a Region 1.1 - Induced Compacted Structure
Chem.Biol., 15, 2008
2KJD
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SOLUTION STRUCTURE OF EXTENDED PDZ2 DOMAIN FROM NHERF1 (150-270)
Descriptor:Sodium/hydrogen exchange regulatory cofactor NHE-RF1
Authors:Bhattacharya, S., Cowburn, D., Bu, Z.
Deposit date:2009-05-27
Release date:2009-12-29
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A dynamic intramolecular conformational switch autoregulates the scaffolding protein NHERF1
To be Published
2KRG
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SOLUTION STRUCTURE OF HUMAN SODIUM/ HYDROGEN EXCHANGE REGULATORY FACTOR 1(150-358)
Descriptor:Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Authors:Bhattacharya, S., Dai, Z., Li, J., Baxter, S., Callaway, D.J.E., Cowburn, D., Bu, Z.
Deposit date:2009-12-17
Release date:2009-12-29
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A conformational switch in the sodium/ hydrogen exchange regulatory factor 1(NHERF1) controls autoinhibition and complex formation.
J.Biol.Chem., 2010
2L6E
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NMR STRUCTURE OF THE MONOMERIC MUTANT C-TERMINAL DOMAIN OF HIV-1 CAPSID IN COMPLEX WITH STAPLED PEPTIDE INHIBITOR
Descriptor:Capsid protein p24, NYAD-13 stapled peptide inhibitor
Authors:Bhattacharya, S., Zhang, H., Debnath, A.K., Cowburn, D.
Deposit date:2010-11-18
Release date:2010-12-29
Last modified:2012-12-12
Method:SOLUTION NMR
Cite:Solution structure of a hydrocarbon stapled peptide inhibitor in complex with monomeric C-terminal domain of HIV-1 capsid.
J.Biol.Chem., 283, 2008
2M0T
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STRUCTURAL CHARACTERIZATION OF THE EXTENDED PDZ1 DOMAIN FROM NHERF1
Descriptor:Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Authors:Bhattacharya, S., Ju, J.H., Cowburn, D., Bu, Z.
Deposit date:2012-11-06
Release date:2013-04-24
Last modified:2013-07-17
Method:SOLUTION NMR
Cite:Ligand-Induced Dynamic Changes in Extended PDZ Domains from NHERF1.
J.Mol.Biol., 425, 2013
2M0U
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COMPLEX STRUCTURE OF C-TERMINAL CFTR PEPTIDE AND EXTENDED PDZ1 DOMAIN FROM NHERF1
Descriptor:Na(+)/H(+) exchange regulatory cofactor NHE-RF1, C-terminal CFTR peptide
Authors:Bhattacharya, S., Ju, J.H., Cowburn, D., Bu, Z.
Deposit date:2012-11-06
Release date:2013-04-24
Last modified:2013-07-17
Method:SOLUTION NMR
Cite:Ligand-Induced Dynamic Changes in Extended PDZ Domains from NHERF1.
J.Mol.Biol., 425, 2013
2M0V
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COMPLEX STRUCTURE OF C-TERMINAL CFTR PEPTIDE AND EXTENDED PDZ2 DOMAIN FROM NHERF1
Descriptor:Na(+)/H(+) exchange regulatory cofactor NHE-RF1, C-terminal CFTR peptide
Authors:Bhattacharya, S., Ju, J.H., Cowburn, D., Bu, Z.
Deposit date:2012-11-06
Release date:2013-04-24
Last modified:2013-07-17
Method:SOLUTION NMR
Cite:Ligand-Induced Dynamic Changes in Extended PDZ Domains from NHERF1.
J.Mol.Biol., 425, 2013
3BRH
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PROTEIN TYROSINE PHOSPHATASE PTPN-22 (LYP) BOUND TO THE MONO-PHOSPHORYLATED LCK ACTIVE SITE PEPTIDE
Descriptor:Tyrosine-protein phosphatase non-receptor type 22, Lck Active Site Peptide, PHOSPHATE ION
Authors:Seidel, R.D., Love, J., Piserchio, A., Cowburn, D.
Deposit date:2007-12-21
Release date:2009-02-17
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Lyp/PTPN22 Phosphatase Domain: Substrate Recognition and Specificity for Src family kinases
To be Published
4HDI
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CRYSTAL STRUCTURE OF 3E5 IGG3 FAB FROM MUS MUSCULUS
Descriptor:Kappa light chain variable region, Anti-colorectal carcinoma light chain, Ig heavy chain V region RF, ...
Authors:Janda, A., Eryilmaz, E., Kim, J., Cordero, R.J.B., Cowburn, D., Casadevall, A.
Deposit date:2012-10-02
Release date:2013-04-17
Last modified:2013-08-21
Method:X-RAY DIFFRACTION (2.449 Å)
Cite:Global structures of IgG isotypes expressing identical variable regions.
Mol.Immunol., 56, 2013
5TVZ
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SOLUTION NMR STRUCTURE OF SACCHAROMYCES CEREVISIAE POM152 IG-LIKE REPEAT, RESIDUES 718-820
Descriptor:Nucleoporin POM152
Authors:Dutta, K., Sampathkumar, P., Cowburn, D., Almo, S.C., Rout, M.P., Fernandez-Martinez, J.
Deposit date:2016-11-10
Release date:2017-02-22
Last modified:2017-09-27
Method:SOLUTION NMR
Cite:Molecular Architecture of the Major Membrane Ring Component of the Nuclear Pore Complex.
Structure, 25, 2017
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