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2H2D
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THE STRUCTURAL BASIS FOR SIRTUIN SUBSTRATE AFFINITY
Descriptor:NAD-dependent deacetylase, Cellular tumor antigen p53 peptide, ZINC ION
Authors:Cosgrove, M.S., Wolberger, C.
Deposit date:2006-05-18
Release date:2006-09-19
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:On the Structural Basis of Sirtuin Substrate Affinity
Biochemistry, 45, 2006
2H2F
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THE STRUCTURAL BASIS FOR SIRTUIN SUBSTRATE AFFINITY
Descriptor:NAD-dependent deacetylase, Cellular tumor antigen p53, ZINC ION
Authors:Cosgrove, M.S., Wolberger, C.
Deposit date:2006-05-18
Release date:2006-12-05
Last modified:2012-06-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structural basis of sirtuin substrate affinity
Biochemistry, 45, 2006
2H2G
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THE STRUCTURAL BASIS OF SIRTUIN SUBSTRATE AFFINITY
Descriptor:NAD-dependent deacetylase, HISTONE H3 PEPTIDE, ZINC ION
Authors:Cosgrove, M.S., Wolberger, C.
Deposit date:2006-05-18
Release date:2006-11-28
Last modified:2012-06-27
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:The structural basis of sirtuin substrate affinity
Biochemistry, 45, 2006
2H2H
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THE STRUCTURAL BASIS OF SIRTUIN SUBSTRATE SPECIFICITY
Descriptor:NAD-dependent deacetylase, Histone H4, ZINC ION
Authors:Cosgrove, M.S., Wolberger, C.
Deposit date:2006-05-18
Release date:2006-12-05
Last modified:2012-06-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structural basis of sirtuin substrate affinity
Biochemistry, 45, 2006
2H2I
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THE STRUCTURAL BASIS OF SIRTUIN SUBSTRATE AFFINITY
Descriptor:NAD-dependent deacetylase, ZINC ION, (2S,5R,8R,11S,14S,17S,21R)-5,8,11,14,17-PENTAMETHYL-4,7,10,13,16,19-HEXAOXADOCOSANE-2,21-DIOL
Authors:Cosgrove, M.S., Wolberger, C.
Deposit date:2006-05-18
Release date:2006-12-05
Last modified:2012-06-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structural basis of sirtuin substrate affinity
Biochemistry, 45, 2006
1E7M
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ACTIVE SITE MUTANT (D177->N) OF GLUCOSE 6-PHOSPHATE DEHYDROGENASE FROM LEUCONOSTOC MESENTEROIDES
Descriptor:GLUCOSE 6-PHOSPHATE 1-DEHYDROGENASE, CALCIUM ION
Authors:Adams, M.J., Cosgrove, M.S., Gover, S.
Deposit date:2000-08-30
Release date:2000-12-11
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:An Examination of the Role of Asp-177 in the His-Asp Catalytic Dyad of Leuconostoc Mesenteroides Glucose 6-Phosphate Dehydrogenase: X-Ray Structure and Ph Dependence of Kinetic Parameters of the D177N Mutant Enzyme
Biochemistry, 39, 2000
1E7Y
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ACTIVE SITE MUTANT (D177->N) OF GLUCOSE 6-PHOSPHATE DEHYDROGENASE FROM LEUCONOSTOC MESENTEROIDES COMPLEXED WITH SUBSTRATE AND NADPH
Descriptor:GLUCOSE 6-PHOSPHATE 1-DEHYDROGENASE, BETA-D-GLUCOSE-6-PHOSPHATE, CALCIUM ION, ...
Authors:Adams, M.J., Cosgrove, M.S., Gover, S.
Deposit date:2000-09-12
Release date:2000-12-11
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:An Examination of the Role of Asp-177 in the His-Asp Catalytic Dyad of Leuconostoc Mesenteroides Glucose 6-Phosphate Dehydrogenase: X-Ray Structure and Ph Dependence of Kinetic Parameters of the D177N Mutant Enzyme
Biochemistry, 39, 2000
3EG6
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STRUCTURE OF WDR5 BOUND TO MLL1 PEPTIDE
Descriptor:WD repeat-containing protein 5, MLL-1 peptide, SULFATE ION
Authors:Patel, A., Dharmarajan, V., Cosgrove, M.S.
Deposit date:2008-09-10
Release date:2008-09-30
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide.
J.Biol.Chem., 283, 2008
1MA3
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STRUCTURE OF A SIR2 ENZYME BOUND TO AN ACETYLATED P53 PEPTIDE
Descriptor:Transcriptional regulatory protein, Sir2 family, Cellular tumor antigen p53, ...
Authors:Avalos, J.L., Celic, I., Muhammad, S., Cosgrove, M.S., Boeke, J.D., Wolberger, C.
Deposit date:2002-07-31
Release date:2002-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a Sir2 enzyme bound to an acetylated p53 peptide
Mol.Cell, 10, 2002
4ERQ
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X-RAY STRUCTURE OF WDR5-MLL2 WIN MOTIF PEPTIDE BINARY COMPLEX
Descriptor:WD repeat-containing protein 5, Histone-lysine N-methyltransferase MLL2
Authors:Dharmarajan, V., Lee, J.-H., Patel, A., Skalnik, D.G., Cosgrove, M.S.
Deposit date:2012-04-20
Release date:2012-05-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.906 Å)
Cite:Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
4ERY
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X-RAY STRUCTURE OF WDR5-MLL3 WIN MOTIF PEPTIDE BINARY COMPLEX
Descriptor:WD repeat-containing protein 5, Histone-lysine N-methyltransferase MLL3
Authors:Dharmarajan, V., Lee, J.-H., Patel, A., Skalnik, D.G., Cosgrove, M.S.
Deposit date:2012-04-21
Release date:2012-05-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
4ERZ
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X-RAY STRUCTURE OF WDR5-MLL4 WIN MOTIF PEPTIDE BINARY COMPLEX
Descriptor:WD repeat-containing protein 5, Histone-lysine N-methyltransferase MLL4
Authors:Dharmarajan, V., Lee, J.-H., Patel, A., Skalnik, D.G., Cosgrove, M.S.
Deposit date:2012-04-21
Release date:2012-05-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
4ES0
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X-RAY STRUCTURE OF WDR5-SETD1B WIN MOTIF PEPTIDE BINARY COMPLEX
Descriptor:WD repeat-containing protein 5, Histone-lysine N-methyltransferase SETD1B
Authors:Dharmarajan, V., Lee, J.-H., Patel, A., Skalnik, D.G., Cosgrove, M.S.
Deposit date:2012-04-21
Release date:2012-05-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.817 Å)
Cite:Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
4ESG
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X-RAY STRUCTURE OF WDR5-MLL1 WIN MOTIF PEPTIDE BINARY COMPLEX
Descriptor:WD repeat-containing protein 5, Histone-lysine N-methyltransferase MLL
Authors:Dharmarajan, V., Lee, J.-H., Patel, A., Skalnik, D.G., Cosgrove, M.S.
Deposit date:2012-04-23
Release date:2012-05-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
4EWR
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X-RAY STRUCTURE OF WDR5-SETD1A WIN MOTIF PEPTIDE BINARY COMPLEX
Descriptor:WD repeat-containing protein 5, Histone-lysine N-methyltransferase SETD1A
Authors:Dharmarajan, V., Lee, J.-H., Patel, A., Skalnik, D.G., Cosgrove, M.S.
Deposit date:2012-04-27
Release date:2012-05-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.503 Å)
Cite:Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
5SXM
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WDR5 IN COMPLEX WITH MLL WIN MOTIF PEPTIDOMIMETIC
Descriptor:WD repeat-containing protein 5, ACE-ALA-ARG-THR-GLU-VAL-TYR-NH2
Authors:Alicea-Velazquez, N.L., Shinsky, S.A., Cosgrove, M.S.
Deposit date:2016-08-09
Release date:2016-09-07
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.
J.Biol.Chem., 291, 2016
1E77
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COMPLEX OF ACTIVE MUTANT (Q365->C) OF GLUCOSE 6-PHOSPHATE DEHYDROGENASE FROM LEUCONOSTOC MESENTEROIDES WITH SUBSTRATE
Descriptor:GLUCOSE 6-PHOSPHATE 1-DEHYDROGENASE, BETA-D-GLUCOSE-6-PHOSPHATE, CALCIUM ION
Authors:Adams, M.J., Vandeputte-Rutten, L., Gover, S.
Deposit date:2000-08-24
Release date:2000-12-11
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:An Examination of the Role of Asp-177 in the His-Asp Catalytic Dyad of Leuconostoc Mesenteroides Glucose 6-Phosphate Dehydrogenase: X-Ray Structure and Ph Dependence of Kinetic Parameters of the D177N Mutant Enzyme
Biochemistry, 39, 2000
2DPG
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COMPLEX OF INACTIVE MUTANT (H240->N) OF GLUCOSE 6-PHOSPHATE DEHYDROGENASE FROM LEUCONOSTOC MESENTEROIDES WITH NADP+
Descriptor:GLUCOSE 6-PHOSPHATE DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Adams, M.J., Naylor, C.E., Paludin, S., Gover, S.
Deposit date:1998-04-17
Release date:1998-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:On the mechanism of the reaction catalyzed by glucose 6-phosphate dehydrogenase.
Biochemistry, 37, 1998
1H93
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ACTIVE MUTANT (S215->C) OF GLUCOSE 6-PHOSPHATE DEHYDROGENASE FROM LEUCONOSTOC MESENTEROIDES
Descriptor:GLUCOSE 6-PHOSPHATE 1-DEHYDROGENASE, CALCIUM ION, GLYCEROL
Authors:Adams, M.J., Naylor, C.E., Gover, S.
Deposit date:2001-02-23
Release date:2001-05-03
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Nadp+ and Nad+ Binding to the Dual Coenzyme Specific Enzyme Leuconostoc Mesenteroides Glucose 6-Phosphate Dehydrogenase: Different Interdomain Hinge Angles are Seen in Different Binary and Ternary Complexes
Acta Crystallogr.,Sect.D, 57, 2001
1H94
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COMPLEX OF ACTIVE MUTANT (S215->C) OF GLUCOSE 6-PHOSPHATE DEHYDROGENASE FROM L.MESENTEROIDES WITH COENZYME NAD
Descriptor:GLUCOSE 6-PHOSPHATE 1-DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Adams, M.J., Naylor, C.E., Gover, S.
Deposit date:2001-02-23
Release date:2001-05-03
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Nadp+ and Nad+ Binding to the Dual Coenzyme Specific Enzyme Leuconostoc Mesenteroides Glucose 6-Phosphate Dehydrogenase: Different Interdomain Hinge Angles are Seen in Different Binary and Ternary Complexes
Acta Crystallogr.,Sect.D, 57, 2001
1H9A
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COMPLEX OF ACTIVE MUTANT (Q365->C) OF GLUCOSE 6-PHOSPHATE DEHYDROGENASE FROM L. MESENTEROIDES WITH COENZYME NADP
Descriptor:GLUCOSE 6-PHOSPHATE 1-DEHYDROGENASE, SULFATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Adams, M.J., Naylor, C.E., Gover, S.
Deposit date:2001-03-06
Release date:2001-05-03
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Nadp+ and Nad+ Binding to the Dual Coenzyme Specific Enzyme Leuconostoc Mesenteroides Glucose 6-Phosphate Dehydrogenase: Different Interdomain Hinge Angles are Seen in Different Binary and Ternary Complexes
Acta Crystallogr.,Sect.D, 57, 2001
1H9B
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ACTIVE MUTANT (Q365->C) OF GLUCOSE 6-PHOSPHATE DEHYDROGENASE FROM LEUCONOSTOC MESENTEROIDES
Descriptor:GLUCOSE 6-PHOSPHATE 1-DEHYDROGENASE, SULFATE ION
Authors:Adams, M.J., Naylor, C.E., Gover, S.
Deposit date:2001-03-06
Release date:2001-05-03
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Nadp+ and Nad+ Binding to the Dual Coenzyme Specific Enzyme Leuconostoc Mesenteroides Glucose 6-Phosphate Dehydrogenase: Different Interdomain Hinge Angles are Seen in Different Binary and Ternary Complexes
Acta Crystallogr.,Sect.D, 57, 2001