Author results

1IDS
  • Download 1ids
  • View 1ids
Molmil generated image of 1ids
X-RAY STRUCTURE ANALYSIS OF THE IRON-DEPENDENT SUPEROXIDE DISMUTASE FROM MYCOBACTERIUM TUBERCULOSIS AT 2.0 ANGSTROMS RESOLUTIONS REVEALS NOVEL DIMER-DIMER INTERACTIONS
Descriptor:IRON SUPEROXIDE DISMUTASE, FE (III) ION
Authors:Cooper, J.B., Mcintyre, K., Wood, S.P., Zhang, Y., Young, D.
Deposit date:1994-09-29
Release date:1994-12-20
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structure analysis of the iron-dependent superoxide dismutase from Mycobacterium tuberculosis at 2.0 Angstroms resolution reveals novel dimer-dimer interactions.
J.Mol.Biol., 246, 1995
2ER0
  • Download 2er0
  • View 2er0
Molmil generated image of 2er0
X-RAY STUDIES OF ASPARTIC PROTEINASE-STATINE INHIBITOR COMPLEXES
Descriptor:ENDOTHIAPEPSIN, L364,099
Authors:Cooper, J.B., Foundling, S.I., Boger, J., Blundell, T.L.
Deposit date:1990-10-20
Release date:1991-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-ray studies of aspartic proteinase-statine inhibitor complexes.
Biochemistry, 28, 1989
2ER9
  • Download 2er9
  • View 2er9
Molmil generated image of 2er9
X-RAY STUDIES OF ASPARTIC PROTEINASE-STATINE INHIBITOR COMPLEXES.
Descriptor:ENDOTHIAPEPSIN, L363,564
Authors:Cooper, J.B., Foundling, S.I., Boger, J., Blundell, T.L.
Deposit date:1990-10-20
Release date:1991-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray studies of aspartic proteinase-statine inhibitor complexes.
Biochemistry, 28, 1989
5ER1
  • Download 5er1
  • View 5er1
Molmil generated image of 5er1
A RATIONAL APPROACH TO THE DESIGN OF ANTIHYPERTENSIVES. X-RAY STUDIES OF COMPLEXES BETWEEN ASPARTIC PROTEINASES AND AMINOALCOHOL RENIN INHIBITORS
Descriptor:ENDOTHIAPEPSIN, methyl N-[(2S,3S)-3-amino-2-hydroxy-5-methylhexyl]-L-valyl-L-isoleucyl-L-phenylalaninate
Authors:Cooper, J.B., Foundling, S.I., Blundell, T.L.
Deposit date:1990-11-07
Release date:1991-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Rational Approach to the Design of Antihypertensives. X-Ray Studies of Complexes between Aspartic Proteinases and Aminoalcohol Renin Inhibitors
Topics in Medicinal Chemistry, 1988
5PEP
  • Download 5pep
  • View 5pep
Molmil generated image of 5pep
X-RAY ANALYSES OF ASPARTIC PROTEASES. II. THREE-DIMENSIONAL STRUCTURE OF THE HEXAGONAL CRYSTAL FORM OF PORCINE PEPSIN AT 2.3 ANGSTROMS RESOLUTION
Descriptor:PEPSIN
Authors:Cooper, J.B., Khan, G., Taylor, G., Tickle, I.J., Blundell, T.L.
Deposit date:1990-05-30
Release date:1990-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:X-ray analyses of aspartic proteinases. II. Three-dimensional structure of the hexagonal crystal form of porcine pepsin at 2.3 A resolution.
J.Mol.Biol., 214, 1990
1GN6
  • Download 1gn6
  • View 1gn6
Molmil generated image of 1gn6
G152A MUTANT OF MYCOBACTERIUM TUBERCULOSIS IRON-SUPEROXIDE DISMUTASE.
Descriptor:SUPEROXIDE DISMUTASE, FE (III) ION
Authors:Bunting, K.A., Cooper, J.B., Saward, S., Erskine, P.T., Badasso, M.O., Wood, S.P., Zhang, Y., Young, D.B.
Deposit date:2001-10-03
Release date:2001-10-05
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:X-Ray Structure Analysis of an Engineered Fe-Superoxide Dismutase Gly-Ala Mutant with Significantly Reduced Stability to Denaturant
FEBS Lett., 387, 1996
1EPO
  • Download 1epo
  • View 1epo
Molmil generated image of 1epo
ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH CP-81,282 (MOR PHE NLE CHF NME)
Descriptor:ENDOTHIAPEPSIN, N-(morpholin-4-ylcarbonyl)-L-phenylalanyl-N-[(1R)-1-(cyclohexylmethyl)-3,3-difluoro-2,2-dihydroxy-4-(methylamino)-4-oxobutyl]-L-norleucinamide
Authors:Veerapandian, B., Cooper, J.B., Blundell, T.L.
Deposit date:1994-07-27
Release date:1994-12-20
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Direct observation by X-ray analysis of the tetrahedral intermediate of aspartic proteinases.
Protein Sci., 1, 1992
1EPP
  • Download 1epp
  • View 1epp
Molmil generated image of 1epp
ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH PD-130,693 (MAS PHE LYS+MTF STA MBA)
Descriptor:ENDOTHIAPEPSIN, SULFATE ION, N-(dimethylsulfamoyl)-L-phenylalanyl-N-[(1S,2S)-2-hydroxy-4-{[(2S)-2-methylbutyl]amino}-1-(2-methylpropyl)-4-oxobutyl]-N~6~-(methylcarbamothioyl)-L-lysinamide
Authors:Wallace, B.A., Cooper, J.B., Blundell, T.L.
Deposit date:1994-07-27
Release date:1994-12-20
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors.
J.Med.Chem., 36, 1993
1EPQ
  • Download 1epq
  • View 1epq
Molmil generated image of 1epq
ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH PD-133,450 (SOT PHE GLY+SCC GCL)
Descriptor:ENDOTHIAPEPSIN, N-[(1R)-2-{[(1R,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]amino}-1-(ethylsulfanyl)-2-oxoethyl]-Nalpha-(morpholin-4-ylsulfonyl)-D-phenylalaninamide, SULFATE ION
Authors:Dealwis, C., Cooper, J.B., Blundell, T.L.
Deposit date:1994-07-27
Release date:1994-12-20
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors.
J.Med.Chem., 36, 1993
1EPL
  • Download 1epl
  • View 1epl
Molmil generated image of 1epl
A STRUCTURAL COMPARISON OF 21 INHIBITOR COMPLEXES OF THE ASPARTIC PROTEINASE FROM ENDOTHIA PARASITICA
Descriptor:ENDOTHIAPEPSIN, PS1, PRO-LEU-GLU-PSA-ARG-LEU
Authors:Al-Karadaghi, S., Cooper, J.B., Strop, P., Blundell, T.L.
Deposit date:1994-07-27
Release date:1994-12-20
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:A structural comparison of 21 inhibitor complexes of the aspartic proteinase from Endothia parasitica.
Protein Sci., 3, 1994
1EPM
  • Download 1epm
  • View 1epm
Molmil generated image of 1epm
A STRUCTURAL COMPARISON OF 21 INHIBITOR COMPLEXES OF THE ASPARTIC PROTEINASE FROM ENDOTHIA PARASITICA
Descriptor:ENDOTHIAPEPSIN, PS2, THR-PHE-GLN-ALA-PSA-LEU-ARG-GLU, ...
Authors:Crawford, M., Cooper, J.B., Strop, P., Blundell, T.L.
Deposit date:1994-07-27
Release date:1994-12-20
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A structural comparison of 21 inhibitor complexes of the aspartic proteinase from Endothia parasitica.
Protein Sci., 3, 1994
1EPN
  • Download 1epn
  • View 1epn
Molmil generated image of 1epn
A STRUCTURAL COMPARISON OF 21 INHIBITOR COMPLEXES OF THE ASPARTIC PROTEINASE FROM ENDOTHIA PARASITICA
Descriptor:ENDOTHIAPEPSIN, N-(morpholin-4-ylcarbonyl)-L-phenylalanyl-N-[(1R,2S)-1-(cyclohexylmethyl)-2-hydroxy-3-(1-methylethoxy)-3-oxopropyl]-S-methyl-L-cysteinamide, SULFATE ION
Authors:Crawford, M., Cooper, J.B., Blundell, T.L.
Deposit date:1994-07-27
Release date:1994-12-20
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A structural comparison of 21 inhibitor complexes of the aspartic proteinase from Endothia parasitica.
Protein Sci., 3, 1994
1EPR
  • Download 1epr
  • View 1epr
Molmil generated image of 1epr
ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH PD-135,040
Descriptor:ENDOTHIAPEPSIN, N~2~-[(2R)-2-benzyl-3-(tert-butylsulfonyl)propanoyl]-N-{(1R)-1-(cyclohexylmethyl)-3,3-difluoro-2,2-dihydroxy-4-[(2-morpholin-4-ylethyl)amino]-4-oxobutyl}-3-(1H-imidazol-3-ium-4-yl)-L-alaninamide
Authors:Badasso, M., Crawford, M., Cooper, J.B., Blundell, T.L.
Deposit date:1994-07-27
Release date:1994-12-20
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A structural comparison of 21 inhibitor complexes of the aspartic proteinase from Endothia parasitica.
Protein Sci., 3, 1994
1FQ4
  • Download 1fq4
  • View 1fq4
Molmil generated image of 1fq4
CRYSTAL STRUCTURE OF A COMPLEX BETWEEN HYDROXYETHYLENE INHIBITOR CP-108,420 AND YEAST ASPARTIC PROTEINASE A
Descriptor:SACCHAROPEPSIN, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Cronin, N.B., Badasso, M.O., Tickle, I.J., Dreyer, T., Hoover, D.J., Rosati, R.L., Humblet, C.C., Lunney, E.A., Cooper, J.B.
Deposit date:2000-09-03
Release date:2000-09-20
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity.
J.Mol.Biol., 303, 2000
1FQ5
  • Download 1fq5
  • View 1fq5
Molmil generated image of 1fq5
X-RAY STRUCTURE OF A CYCLIC STATINE INHIBITOR PD-129,541 BOUND TO YEAST PROTEINASE A
Descriptor:SACCHAROPEPSIN, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Cronin, N.B., Badasso, M.O., Tickle, I.J., Dreyer, T., Hoover, D.J., Rosati, R.L., Humblet, C.C., Lunney, E.A., Cooper, J.B.
Deposit date:2000-09-03
Release date:2000-09-20
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity.
J.Mol.Biol., 303, 2000
1FQ6
  • Download 1fq6
  • View 1fq6
Molmil generated image of 1fq6
X-RAY STRUCTURE OF GLYCOL INHIBITOR PD-133,450 BOUND TO SACCHAROPEPSIN
Descriptor:SACCHAROPEPSIN, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Cronin, N.B., Badasso, M.O., Tickle, I.J., Dreyer, T., Hoover, D.J., Rosati, R.L., Humblet, C.C., Lunney, E.A., Cooper, J.B.
Deposit date:2000-09-03
Release date:2000-09-20
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity.
J.Mol.Biol., 303, 2000
1FQ7
  • Download 1fq7
  • View 1fq7
Molmil generated image of 1fq7
X-RAY STRUCTURE OF INHIBITOR CP-72,647 BOUND TO SACCHAROPEPSIN
Descriptor:SACCHAROPEPSIN, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Cronin, N.B., Badasso, M.O., Tickle, I.J., Dreyer, T., Hoover, D.J., Rosati, R.L., Humblet, C.C., Lunney, E.A., Cooper, J.B.
Deposit date:2000-09-04
Release date:2000-09-20
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity.
J.Mol.Biol., 303, 2000
1FQ8
  • Download 1fq8
  • View 1fq8
Molmil generated image of 1fq8
X-RAY STRUCTURE OF DIFLUOROSTATINE INHIBITOR CP81,198 BOUND TO SACCHAROPEPSIN
Descriptor:SACCHAROPEPSIN, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Cronin, N.B., Badasso, M.O., Tickle, I.J., Dreyer, T., Hoover, D.J., Rosati, R.L., Humblet, C.C., Lunney, E.A., Cooper, J.B.
Deposit date:2000-09-04
Release date:2000-09-20
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity.
J.Mol.Biol., 303, 2000
1GN2
  • Download 1gn2
  • View 1gn2
Molmil generated image of 1gn2
S123C MUTANT OF THE IRON-SUPEROXIDE DISMUTASE FROM MYCOBACTERIUM TUBERCULOSIS.
Descriptor:SUPEROXIDE DISMUTASE, FE (III) ION
Authors:Bunting, K.A., Cooper, J.B., Tickle, I.J., Young, D.B.
Deposit date:2001-10-02
Release date:2001-10-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Engineering of an Intersubunit Disulfide Bridge in the Iron-Superoxide Dismutase of Mycobacterium Tuberculosis.
Arch.Biochem.Biophys., 397, 2002
1AW5
  • Download 1aw5
  • View 1aw5
Molmil generated image of 1aw5
5-AMINOLEVULINATE DEHYDRATASE FROM SACCHAROMYCES CEREVISIAE
Descriptor:5-AMINOLEVULINATE DEHYDRATASE, ZINC ION
Authors:Erskine, P.T., Cooper, J.B., Wood, S.P.
Deposit date:1997-10-09
Release date:1998-10-21
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:X-ray structure of 5-aminolaevulinate dehydratase, a hybrid aldolase.
Nat.Struct.Biol., 4, 1997
1B4E
  • Download 1b4e
  • View 1b4e
Molmil generated image of 1b4e
X-RAY STRUCTURE OF 5-AMINOLEVULINIC ACID DEHYDRATASE COMPLEXED WITH THE INHIBITOR LEVULINIC ACID
Descriptor:PROTEIN (5-AMINOLEVULINIC ACID DEHYDRATASE), SULFATE ION, ZINC ION, ...
Authors:Erskine, P.T., Cooper, J.B., Lewis, G., Spencer, P., Wood, S.P., Shoolingin-Jordan, P.M.
Deposit date:1998-12-19
Release date:1999-12-17
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structure of 5-aminolevulinic acid dehydratase from Escherichia coli complexed with the inhibitor levulinic acid at 2.0 A resolution.
Biochemistry, 38, 1999
1E51
  • Download 1e51
  • View 1e51
Molmil generated image of 1e51
CRYSTAL STRUCTURE OF NATIVE HUMAN ERYTHROCYTE 5-AMINOLAEVULINIC ACID DEHYDRATASE
Descriptor:DELTA-AMINOLEVULINIC ACID DEHYDRATASE, 3-[5-(AMINOMETHYL)-4-(CARBOXYMETHYL)-1H-PYRROL-3-YL]PROPANOIC ACID, ZINC ION, ...
Authors:Mills-Davies, N.L., Thompson, D., Cooper, J.B., Shoolingin-Jordan, P.M.
Deposit date:2000-07-13
Release date:2001-07-12
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:The Crystal Structure of Human Ala-Dehydratase
To be Published
1EB3
  • Download 1eb3
  • View 1eb3
Molmil generated image of 1eb3
YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE 4,7-DIOXOSEBACIC ACID COMPLEX
Descriptor:5-AMINOLAEVULINIC ACID DEHYDRATASE, 4,7-DIOXOSEBACIC ACID, ZINC ION
Authors:Erskine, P.T., Coates, L., Newbold, R., Brindley, A.A., Stauffer, F., Wood, S.P., Warren, M.J., Cooper, J.B., Shoolingin-Jordan, P.M., Neier, R.
Deposit date:2001-07-18
Release date:2001-08-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The X-Ray Structure of Yeast 5-Aminolaevulinic Acid Dehydratase Complexed with Two Diacid Inhibitors
FEBS Lett., 503, 2001
1GJP
  • Download 1gjp
  • View 1gjp
Molmil generated image of 1gjp
SCHIFF-BASE COMPLEX OF YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE WITH 4-OXOSEBACIC ACID
Descriptor:5-AMINOLAEVULINIC ACID DEHYDRATASE, 4-OXODECANEDIOIC ACID, ZINC ION
Authors:Erskine, P.T., Coates, L., Newbold, R., Brindley, A.A., Wood, S.P., Warren, M.J., Cooper, J.B., Shoolingin-Jordan, P.M., Neier, R.
Deposit date:2001-08-01
Release date:2001-08-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The X-Ray Structure of Yeast 5-Aminolaevulinic Acid Dehydratase Complexed with Two Diacid Inhibitors
FEBS Lett., 503, 2001
1GKT
  • Download 1gkt
  • View 1gkt
Molmil generated image of 1gkt
NEUTRON LAUE DIFFRACTION STRUCTURE OF ENDOTHIAPEPSIN COMPLEXED WITH TRANSITION STATE ANALOGUE INHIBITOR H261
Descriptor:ENDOTHIAPEPSIN, INHIBITOR, H261
Authors:Coates, L., Erskine, P.T., Wood, S.P., Myles, D.A.A., Cooper, J.B.
Deposit date:2001-08-20
Release date:2001-11-20
Last modified:2018-02-14
Method:NEUTRON DIFFRACTION (2.1 Å)
Cite:A Neutron Laue Diffraction Study of Endothiapepsin: Implications for the Aspartic Proteinase Mechanism
Biochemistry, 40, 2001