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3IO8
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BU of 3io8 by Molmil
BimL12F in complex with Bcl-xL
Descriptor: Bcl-2-like protein 1, Bcl-2-like protein 11, ZINC ION
Authors:Colman, P.M, Lee, E.F, Fairlie, W.D, Smith, B.J, Czabotar, P.E, Yang, H, Sleebs, B.E, Lessene, G.
Deposit date:2009-08-14
Release date:2009-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.
J.Biol.Chem., 284, 2009
4CIN
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BU of 4cin by Molmil
Complex of Bcl-xL with its BH3 domain
Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BCL-2-LIKE PROTEIN 1, ...
Authors:Colman, P.M, Lee, E.F, Fairlie, W.D.
Deposit date:2013-12-12
Release date:2014-11-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.693 Å)
Cite:The Functional Differences of Pro-Survival and Pro-Apoptotic B Cell Lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 (Bh3) Domains
J.Biol.Chem., 289, 2014
4CIM
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BU of 4cim by Molmil
Complex of a Bcl-w BH3 mutant with a BH3 domain
Descriptor: 1,2-ETHANEDIOL, BCL-2-LIKE PROTEIN 2
Authors:Colman, P.M, Lee, E.F, Fairlie, W.D.
Deposit date:2013-12-12
Release date:2014-11-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The Functional Differences of Pro-Survival and Pro-Apoptotic B Cell Lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 (Bh3) Domains
J.Biol.Chem., 289, 2014
5NN9
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BU of 5nn9 by Molmil
REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NEURAMINIDASE N9, ...
Authors:Tulip, W.R, Varghese, J.N, Baker, A.T, Vandonkelaar, A, Laver, W.G, Webster, R.G, Colman, P.M.
Deposit date:1991-03-28
Release date:1992-07-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants.
J.Mol.Biol., 221, 1991
7NN9
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BU of 7nn9 by Molmil
NATIVE INFLUENZA VIRUS NEURAMINIDASE SUBTYPE N9 (TERN)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NEURAMINIDASE N9, ...
Authors:Varghese, J.N, Colman, P.M.
Deposit date:1995-03-15
Release date:1996-04-03
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase.
Protein Sci., 4, 1995
7JMT
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BU of 7jmt by Molmil
Crystal structure of schistosome BCL-2 bound to ABT-737
Descriptor: 4-{4-[(4'-CHLOROBIPHENYL-2-YL)METHYL]PIPERAZIN-1-YL}-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLTHIO)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE, BCL-2 protein
Authors:Smith, N.A, Smith, B.J, Lee, E.F, Colman, P.M, Fairlie, W.D.
Deposit date:2020-08-02
Release date:2021-02-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2.
Acs Infect Dis., 7, 2021
4NN9
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BU of 4nn9 by Molmil
REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NEURAMINIDASE N9, ...
Authors:Tulip, W.R, Varghese, J.N, Baker, A.T, Vandonkelaar, A, Laver, W.G, Webster, R.G, Colman, P.M.
Deposit date:1991-03-28
Release date:1992-07-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants.
J.Mol.Biol., 221, 1991
8G1T
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BU of 8g1t by Molmil
Crystal structure of Bax core domain BH3-groove dimer - tetrameric fraction P21
Descriptor: 1,2-ETHANEDIOL, Apoptosis regulator BAX
Authors:Cowan, A.D, Colman, P.M, Czabotar, P.E, Miller, M.S.
Deposit date:2023-02-02
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.092 Å)
Cite:Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 2023
3NN9
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BU of 3nn9 by Molmil
REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NEURAMINIDASE N9, ...
Authors:Tulip, W.R, Varghese, J.N, Baker, A.T, Vandonkelaar, A, Laver, W.G, Webster, R.G, Colman, P.M.
Deposit date:1991-03-28
Release date:1992-07-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants.
J.Mol.Biol., 221, 1991
6NN9
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BU of 6nn9 by Molmil
REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NEURAMINIDASE N9, ...
Authors:Tulip, W.R, Varghese, J.N, Baker, A.T, Vandonkelaar, A, Laver, W.G, Webster, R.G, Colman, P.M.
Deposit date:1991-03-28
Release date:1992-07-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants.
J.Mol.Biol., 221, 1991
6MCY
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BU of 6mcy by Molmil
Crystal structure of mouse Bak
Descriptor: 1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, FORMIC ACID
Authors:Brouwer, J.M, Czabotar, P.E, Colman, P.M.
Deposit date:2018-09-03
Release date:2019-09-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.748 Å)
Cite:A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis.
Nat.Chem.Biol., 15, 2019
1YWG
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BU of 1ywg by Molmil
The structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum
Descriptor: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, glyceraldehyde-3-phosphate dehydrogenase
Authors:Satchell, J.F, Klonis, N, Malby, R.L, Adisa, A, Alpyurek, A.E, Colman, P.M, Tilley, L.
Deposit date:2005-02-17
Release date:2005-11-29
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum.
Acta Crystallogr.,Sect.D, 61, 2005
7LK4
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BU of 7lk4 by Molmil
Crystal structure of BAK L100A in complex with activating antibody fragments
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 7D10 antibody VH fragment, 7D10 antibody VL fragment, ...
Authors:Robin, Y.A, Colman, P.M.
Deposit date:2021-02-01
Release date:2022-02-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the BAK-activating antibody 7D10 bound to BAK reveals an unexpected role for the alpha 1-alpha 2 loop in BAK activation.
Cell Death Differ., 29, 2022
1A14
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BU of 1a14 by Molmil
COMPLEX BETWEEN NC10 ANTI-INFLUENZA VIRUS NEURAMINIDASE SINGLE CHAIN ANTIBODY WITH A 5 RESIDUE LINKER AND INFLUENZA VIRUS NEURAMINIDASE
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NC10 FV (HEAVY CHAIN), ...
Authors:Malby, R.L, Mccoy, A.J, Kortt, A.A, Hudson, P.J, Colman, P.M.
Deposit date:1997-12-21
Release date:1998-05-13
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Three-dimensional structures of single-chain Fv-neuraminidase complexes.
J.Mol.Biol., 279, 1998
4TUH
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BU of 4tuh by Molmil
Bcl-xL in complex with inhibitor (Compound 10)
Descriptor: 1,2-ETHANEDIOL, 2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-5-{3-[4-(1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenoxy]propyl}-1,3-thiazole-4-carboxylic acid, ACETATE ION, ...
Authors:Czabotar, P.E, Lessense, G, Smith, B.J, Colman, P.M.
Deposit date:2014-06-24
Release date:2014-10-15
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL.
Acs Med.Chem.Lett., 5, 2014
4U2V
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BU of 4u2v by Molmil
Bak BH3-in-Groove dimer (GFP)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Green fluorescent protein,Bcl-2 homologous antagonist/killer
Authors:Brouwer, J.M, Colman, P.M, Czabotar, P.E.
Deposit date:2014-07-18
Release date:2014-09-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers.
Mol.Cell, 55, 2014
4U2U
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BU of 4u2u by Molmil
Bak domain swapped dimer induced by BidBH3 with CHAPS
Descriptor: Bcl-2 homologous antagonist/killer
Authors:Brouwer, J.M, Colman, P.M, Czabotar, P.E.
Deposit date:2014-07-18
Release date:2014-09-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers.
Mol.Cell, 55, 2014
2BAT
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BU of 2bat by Molmil
THE STRUCTURE OF THE COMPLEX BETWEEN INFLUENZA VIRUS NEURAMINIDASE AND SIALIC ACID, THE VIRAL RECEPTOR
Descriptor: 2-acetamido-2-deoxy-4-O-sulfo-alpha-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Varghese, J.N, Colman, P.M.
Deposit date:1992-08-10
Release date:1994-01-31
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor.
Proteins, 14, 1992
3PL7
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BU of 3pl7 by Molmil
Crystal structure of Bcl-xL in complex with the BaxBH3 domain
Descriptor: Apoptosis regulator BAX, Bcl-2-like protein 1
Authors:Czabotar, P.E, Colman, P.M.
Deposit date:2010-11-14
Release date:2010-12-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.613 Å)
Cite:Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis
J.Biol.Chem., 286, 2011
3PK1
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BU of 3pk1 by Molmil
Crystal structure of Mcl-1 in complex with the BaxBH3 domain
Descriptor: Apoptosis regulator BAX, CADMIUM ION, Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Czabotar, P.E, Colman, P.M.
Deposit date:2010-11-11
Release date:2010-12-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.486 Å)
Cite:Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis
J.Biol.Chem., 286, 2011
3QBR
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BU of 3qbr by Molmil
BakBH3 in complex with sjA
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Bcl-2 homologous antagonist/killer, SJCHGC06286 protein
Authors:Lee, E.F, Clarke, O.B, Fairlie, W.D, Colman, P.M, Evangelista, M, Feng, Z, Speed, T.P, Tchoubrieva, E, Strasser, A, Kalinna, B.
Deposit date:2011-01-13
Release date:2011-04-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes.
Proc.Natl.Acad.Sci.USA, 108, 2011
5FMK
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BU of 5fmk by Molmil
Bcl-xL with Bak BH3 complex
Descriptor: BCL-2 HOMOLOGOUS ANTAGONIST/KILLER, BCL-XL, GLYCEROL
Authors:Fairlie, W.D, Lee, E.F, Smith, B.J, Czabotar, P.E, Colman, P.M.
Deposit date:2015-11-06
Release date:2016-06-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.731 Å)
Cite:Physiological Restraint of Bak by Bcl-Xl is Essential for Cell Survival.
Genes Dev., 30, 2016
3INQ
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BU of 3inq by Molmil
Crystal structure of BCL-XL in complex with W1191542
Descriptor: 1,2-ETHANEDIOL, 4-[4-(biphenyl-3-ylmethyl)piperazin-1-yl]-N-{[4-({(1R)-3-(dimethylamino)-1-[(phenylsulfanyl)methyl]propyl}amino)-3-nitrophenyl]sulfonyl}benzamide, Bcl-2-like protein 1, ...
Authors:Fairlie, W.D, Smith, B.J, Colman, P.M, Czabotar, P.E, Lee, E.F.
Deposit date:2009-08-12
Release date:2009-09-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands
J. Biol. Chem., 284, 2009
3IO9
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BU of 3io9 by Molmil
BimL12Y in complex with Mcl-1
Descriptor: Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION
Authors:Czabotar, P.E, Lee, E.F, Yang, H, Sleebs, B.E, Lessene, G, Colman, P.M, Smith, B.J, Fairlie, W.D.
Deposit date:2009-08-14
Release date:2009-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.
J.Biol.Chem., 284, 2009
1NNC
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BU of 1nnc by Molmil
INFLUENZA VIRUS NEURAMINIDASE SUBTYPE N9 (TERN) COMPLEXED WITH 4-GUANIDINO-NEU5AC2EN INHIBITOR
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NEURAMINIDASE N9, ...
Authors:Varghese, J.N, Colman, P.M.
Deposit date:1995-03-15
Release date:1996-04-03
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase.
Protein Sci., 4, 1995

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