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3IO8
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BIML12F IN COMPLEX WITH BCL-XL
Descriptor:Bcl-2-like protein 1, Bcl-2-like protein 11, ZINC ION
Authors:Colman, P.M., Lee, E.F., Fairlie, W.D., Smith, B.J., Czabotar, P.E., Yang, H., Sleebs, B.E., Lessene, G.
Deposit date:2009-08-14
Release date:2009-09-01
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.
J.Biol.Chem., 284, 2009
4CIM
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COMPLEX OF A BCL-W BH3 MUTANT WITH A BH3 DOMAIN
Descriptor:BCL-2-LIKE PROTEIN 2, 1,2-ETHANEDIOL
Authors:Colman, P.M., Lee, E.F., Fairlie, W.D.
Deposit date:2013-12-12
Release date:2014-11-12
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The Functional Differences of Pro-Survival and Pro-Apoptotic B Cell Lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 (Bh3) Domains
J.Biol.Chem., 289, 2014
4CIN
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COMPLEX OF BCL-XL WITH ITS BH3 DOMAIN
Descriptor:BCL-2-LIKE PROTEIN 1, CALCIUM ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Colman, P.M., Lee, E.F., Fairlie, W.D.
Deposit date:2013-12-12
Release date:2014-11-12
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.693 Å)
Cite:The Functional Differences of Pro-Survival and Pro-Apoptotic B Cell Lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 (Bh3) Domains
J.Biol.Chem., 289, 2014
7NN9
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NATIVE INFLUENZA VIRUS NEURAMINIDASE SUBTYPE N9 (TERN)
Descriptor:NEURAMINIDASE N9, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Varghese, J.N., Colman, P.M.
Deposit date:1995-03-15
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase.
Protein Sci., 4, 1995
1NNC
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INFLUENZA VIRUS NEURAMINIDASE SUBTYPE N9 (TERN) COMPLEXED WITH 4-GUANIDINO-NEU5AC2EN INHIBITOR
Descriptor:NEURAMINIDASE N9, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N., Colman, P.M.
Deposit date:1995-03-15
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase.
Protein Sci., 4, 1995
3NN9
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REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS
Descriptor:NEURAMINIDASE N9, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Tulip, W.R., Varghese, J.N., Baker, A.T., Vandonkelaar, A., Laver, W.G., Webster, R.G., Colman, P.M.
Deposit date:1991-03-28
Release date:1992-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants.
J.Mol.Biol., 221, 1991
4NN9
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REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS
Descriptor:NEURAMINIDASE N9, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Tulip, W.R., Varghese, J.N., Baker, A.T., Vandonkelaar, A., Laver, W.G., Webster, R.G., Colman, P.M.
Deposit date:1991-03-28
Release date:1992-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants.
J.Mol.Biol., 221, 1991
5NN9
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REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS
Descriptor:NEURAMINIDASE N9, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Tulip, W.R., Varghese, J.N., Baker, A.T., Vandonkelaar, A., Laver, W.G., Webster, R.G., Colman, P.M.
Deposit date:1991-03-28
Release date:1992-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants.
J.Mol.Biol., 221, 1991
6NN9
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REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS
Descriptor:NEURAMINIDASE N9, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Tulip, W.R., Varghese, J.N., Baker, A.T., Vandonkelaar, A., Laver, W.G., Webster, R.G., Colman, P.M.
Deposit date:1991-03-28
Release date:1992-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants.
J.Mol.Biol., 221, 1991
1NCA
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REFINED CRYSTAL STRUCTURE OF THE INFLUENZA VIRUS N9 NEURAMINIDASE-NC41 FAB COMPLEX
Descriptor:INFLUENZA A SUBTYPE N9 NEURAMINIDASE, IGG2A-KAPPA NC41 FAB (LIGHT CHAIN), IGG2A-KAPPA NC41 FAB (HEAVY CHAIN), ...
Authors:Tulip, W.R., Varghese, J.N., Colman, P.M.
Deposit date:1992-01-21
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex.
J.Mol.Biol., 227, 1992
1NCB
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CRYSTAL STRUCTURES OF TWO MUTANT NEURAMINIDASE-ANTIBODY COMPLEXES WITH AMINO ACID SUBSTITUTIONS IN THE INTERFACE
Descriptor:INFLUENZA A SUBTYPE N9 NEURAMINIDASE, IGG2A-KAPPA NC41 FAB (LIGHT CHAIN), IGG2A-KAPPA NC41 FAB (HEAVY CHAIN), ...
Authors:Tulip, W.R., Varghese, J.N., Colman, P.M.
Deposit date:1992-01-21
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface.
J.Mol.Biol., 227, 1992
1NCC
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CRYSTAL STRUCTURES OF TWO MUTANT NEURAMINIDASE-ANTIBODY COMPLEXES WITH AMINO ACID SUBSTITUTIONS IN THE INTERFACE
Descriptor:INFLUENZA A SUBTYPE N9 NEURAMINIDASE, IGG2A-KAPPA NC41 FAB (LIGHT CHAIN), IGG2A-KAPPA NC41 FAB (HEAVY CHAIN), ...
Authors:Tulip, W.R., Varghese, J.N., Colman, P.M.
Deposit date:1992-01-21
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface.
J.Mol.Biol., 227, 1992
1NCD
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REFINED CRYSTAL STRUCTURE OF THE INFLUENZA VIRUS N9 NEURAMINIDASE-NC41 FAB COMPLEX
Descriptor:INFLUENZA A SUBTYPE N9 NEURAMINIDASE, IGG2A-KAPPA NC41 FAB (LIGHT CHAIN), IGG2A-KAPPA NC41 FAB (HEAVY CHAIN), ...
Authors:Tulip, W.R., Varghese, J.N., Colman, P.M.
Deposit date:1992-01-21
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex.
J.Mol.Biol., 227, 1992
1NMB
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THE STRUCTURE OF A COMPLEX BETWEEN THE NC10 ANTIBODY AND INFLUENZA VIRUS NEURAMINIDASE AND COMPARISON WITH THE OVERLAPPING BINDING SITE OF THE NC41 ANTIBODY
Descriptor:N9 NEURAMINIDASE, FAB NC10, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Malby, R.L., Tulip, W.R., Colman, P.M.
Deposit date:1995-01-17
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of a complex between the NC10 antibody and influenza virus neuraminidase and comparison with the overlapping binding site of the NC41 antibody
Structure, 2, 1994
1L7F
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CRYSTAL STRUCTURE OF INFLUENZA VIRUS NEURAMINIDASE IN COMPLEX WITH BCX-1812
Descriptor:neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Smith, B.J., McKimm-Breshkin, J.L., McDonald, M., Fernley, R.T., Varghese, J.N., Colman, P.M.
Deposit date:2002-03-15
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural studies of the resistance of influenza virus neuramindase to inhibitors.
J.Med.Chem., 45, 2002
1A14
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COMPLEX BETWEEN NC10 ANTI-INFLUENZA VIRUS NEURAMINIDASE SINGLE CHAIN ANTIBODY WITH A 5 RESIDUE LINKER AND INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, NC10 FV (HEAVY CHAIN), NC10 FV (LIGHT CHAIN), ...
Authors:Malby, R.L., Mccoy, A.J., Kortt, A.A., Hudson, P.J., Colman, P.M.
Deposit date:1997-12-21
Release date:1998-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Three-dimensional structures of single-chain Fv-neuraminidase complexes.
J.Mol.Biol., 279, 1998
1F8C
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NATIVE INFLUENZA NEURAMINIDASE IN COMPLEX WITH 4-AMINO-2-DEOXY-2,3-DEHYDRO-N-NEURAMINIC ACID
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Smith, B.J., Colman, P.M., Von Itzstein, M., Danylec, B., Varghese, J.N.
Deposit date:2000-06-30
Release date:2001-04-11
Last modified:2015-03-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Analysis of inhibitor binding in influenza virus neuraminidase.
Protein Sci., 10, 2001
1F8D
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NATIVE INFLUENZA NEURAMINIDASE IN COMPLEX WITH 9-AMINO-2-DEOXY-2,3-DEHYDRO-N-NEURAMINIC ACID
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Smith, B.J., Colman, P.M., Von Itzstein, M., Danylec, B., Varghese, J.N.
Deposit date:2000-06-30
Release date:2001-04-11
Last modified:2015-03-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Analysis of inhibitor binding in influenza virus neuraminidase.
Protein Sci., 10, 2001
1F8E
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NATIVE INFLUENZA NEURAMINIDASE IN COMPLEX WITH 4,9-DIAMINO-2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Smith, B.J., Colman, P.M., Von Itzstein, M., Danylec, B., Varghese, J.N.
Deposit date:2000-06-30
Release date:2001-04-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Analysis of inhibitor binding in influenza virus neuraminidase.
Protein Sci., 10, 2001
1L7H
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CRYSTAL STRUCTURE OF R292K MUTANT INFLUENZA VIRUS NEURAMINIDASE IN COMPLEX WITH BCX-1812
Descriptor:neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Smith, B.J., McKimm-Breshkin, J.L., McDonald, M., Fernley, R.T., Varghese, J.N., Colman, P.M.
Deposit date:2002-03-15
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural studies of the resistance of influenza virus neuramindase to inhibitors.
J.Med.Chem., 45, 2002
1NMA
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N9 NEURAMINIDASE COMPLEXES WITH ANTIBODIES NC41 AND NC10: EMPIRICAL FREE-ENERGY CALCULATIONS CAPTURE SPECIFICITY TRENDS OBSERVED WITH MUTANT BINDING DATA
Descriptor:N9 NEURAMINIDASE, FAB NC10, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Tulip, W.R., Varghese, J.N., Colman, P.M.
Deposit date:1994-05-06
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:N9 neuraminidase complexes with antibodies NC41 and NC10: empirical free energy calculations capture specificity trends observed with mutant binding data.
Biochemistry, 33, 1994
1NMC
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COMPLEX BETWEEN NC10 ANTI-INFLUENZA VIRUS NEURAMINIDASE SINGLE CHAIN ANTIBODY WITH A 15 RESIDUE LINKER AND INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, SINGLE CHAIN ANTIBODY, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Malby, R.L., Mccoy, A.J., Kortt, A.A., Hudson, P.J., Colman, P.M.
Deposit date:1997-12-21
Release date:1998-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Three-dimensional structures of single-chain Fv-neuraminidase complexes.
J.Mol.Biol., 279, 1998
1PHS
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THE THREE-DIMENSIONAL STRUCTURE OF THE SEED STORAGE PROTEIN PHASEOLIN AT 3 ANGSTROMS RESOLUTION
Descriptor:PHASEOLIN, BETA-TYPE PRECURSOR
Authors:Lawrence, M.C., Suzuki, E., Varghese, J.N., Davis, P.C., Vandonkelaar, A., Tulloch, P.A., Colman, P.M.
Deposit date:1990-03-21
Release date:1990-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The three-dimensional structure of the seed storage protein phaseolin at 3 A resolution.
EMBO J., 9, 1990
2BAT
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THE STRUCTURE OF THE COMPLEX BETWEEN INFLUENZA VIRUS NEURAMINIDASE AND SIALIC ACID, THE VIRAL RECEPTOR
Descriptor:NEURAMINIDASE N2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N., Colman, P.M.
Deposit date:1992-08-10
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor.
Proteins, 14, 1992
2PHL
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THE STRUCTURE OF PHASEOLIN AT 2.2 ANGSTROMS RESOLUTION: IMPLICATIONS FOR A COMMON VICILIN(SLASH)LEGUMIN STRUCTURE AND THE GENETIC ENGINEERING OF SEED STORAGE PROTEINS
Descriptor:PHASEOLIN, N-ACETYL-D-GLUCOSAMINE, PHOSPHATE ION
Authors:Lawrence, M.C., Izard, T., Beuchat, M., Blagrove, R.J., Colman, P.M.
Deposit date:1994-07-07
Release date:1994-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of phaseolin at 2.2 A resolution. Implications for a common vicilin/legumin structure and the genetic engineering of seed storage proteins.
J.Mol.Biol., 238, 1994