Author results

1TMC
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THE THREE-DIMENSIONAL STRUCTURE OF A CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE MISSING THE ALPHA3 DOMAIN OF THE HEAVY CHAIN
Descriptor:CLASS I HISTOCOMPATIBILITY ANTIGEN (HLA-AW68), BETA 2-MICROGLOBULIN, DECAMERIC PEPTIDE (EVAPPEYHRK)
Authors:Collins, E.J., Garboczi, D.N., Karpusas, M.N., Wiley, D.C.
Deposit date:1994-12-19
Release date:1995-03-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The three-dimensional structure of a class I major histocompatibility complex molecule missing the alpha 3 domain of the heavy chain.
Proc.Natl.Acad.Sci.USA, 92, 1995
2CLR
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THREE DIMENSIONAL STRUCTURE OF A PEPTIDE EXTENDING OUT ONE END OF A CLASS I MHC BINDING SITE
Descriptor:CLASS I HISTOCOMPATIBILITY ANTIGEN (HLA-A 0201) (ALPHA CHAIN), BETA 2-MICROGLOBULIN, DECAMERIC PEPTIDE FROM CALRETICULIN
Authors:Collins, E.J., Garboczi, D.N., Wiley, D.C.
Deposit date:1994-08-01
Release date:1995-03-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Three-dimensional structure of a peptide extending from one end of a class I MHC binding site.
Nature, 371, 1994
3KFY
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DYNAMIC SWITCHING AND PARTIAL OCCUPANCIES OF A SMALL MOLECULE INHIBITOR COMPLEX OF DHFR
Descriptor:Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[(4-chlorophenyl)sulfanyl]quinazoline-2,4-diamine, ...
Authors:Collins, E.J., Lee, A.L., Carroll, M.J., Gromova, A.V., Miller, K.R., Singleton, S.F.
Deposit date:2009-10-28
Release date:2010-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Dynamic switching and partial occupancies of a small molecule inhibitor complex of DHFR
To be Published
3V5D
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HLA-A2.1 KVAELVHFL
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Collins, E.J., Lee, H.Y.
Deposit date:2011-12-16
Release date:2012-12-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Prediction of conformation and immunogenicity of peptides bound to MHC molecules
To be Published
3V5H
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HLA-A2.1 KVAEIVHFL
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Collins, E.J., Lee, H.Y.
Deposit date:2011-12-16
Release date:2012-12-05
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Prediction of immunogenicity of altered-peptide ligands for HIV therapy
To be Published
3V5K
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HLA2.1 KVAELVWFL
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Collins, E.J., Lee, H.Y.
Deposit date:2011-12-16
Release date:2012-12-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Prediction of Immunogenicity of altered-peptide ligands to HIV bound to MHC
To be Published
3QYL
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SENSITIVITY OF RECEPTOR INTERNAL MOTIONS TO LIGAND BINDING AFFINITY AND KINETIC OFF-RATE
Descriptor:Dihydrofolate reductase, (7S)-7-methyl-5,6,7,8-tetrahydroquinazoline-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Collins, E.J., Lee, A.L., Carroll, M.J., Mauldin, R.V., Gromova, A.V., Singleton, S.F.
Deposit date:2011-03-03
Release date:2012-01-18
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Evidence for dynamics in proteins as a mechanism for ligand dissociation.
Nat.Chem.Biol., 8, 2012
3QYO
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SENSITIVITY OF RECEPTOR INTERNAL MOTIONS TO LIGAND BINDING AFFINITY AND KINETIC OFF-RATE
Descriptor:Dihydrofolate reductase, quinazoline-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Collins, E.J., Lee, A.L., Carroll, M.J., Mauldin, R.V., Gromova, A.V., Singleton, S.F.
Deposit date:2011-03-03
Release date:2012-01-18
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Evidence for dynamics in proteins as a mechanism for ligand dissociation.
Nat.Chem.Biol., 8, 2012
3R33
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EVIDENCE FOR DYNAMIC MOTION IN PROTEINS AS A MECHANISM FOR LIGAND DISSOCIATION
Descriptor:Dihydrofolate reductase, (6S)-6-methyl-5,6,7,8-tetrahydroquinazoline-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Collins, E.J., Lee, A.L., Carroll, M.J., Mauldin, R.V., Gromova, A.V., Singleton, S.F.
Deposit date:2011-03-15
Release date:2012-01-25
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Evidence for dynamics in proteins as a mechanism for ligand dissociation.
Nat.Chem.Biol., 8, 2012
1EEY
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CRYSTAL STRUCTURE DETERMINATION OF HLA A2 COMPLEXED TO PEPTIDE GP2 WITH THE SUBSTITUTION (I2L/V5L/L9V)
Descriptor:HLA-A2.1 MHC CLASS I (HEAVY CHAIN), BETA-2-MICROGLOBULIN (LIGHT CHAIN), GP2 PEPTIDE
Authors:Sharma, A.K., Kuhns, J.J., Collins, E.J.
Deposit date:2000-02-04
Release date:2003-06-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Class I major histocompatibility complex anchor substitutions alter the conformation of T cell receptor contacts.
J.Biol.Chem., 276, 2001
1EEZ
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CRYSTAL STRUCTURE DETERMINATION OF HLA-A2.1 COMPLEXED TO GP2 PEPTIDE VARIANT(I2L/V5L)
Descriptor:HLA-A2.1 MHC CLASS I (HEAVY CHAIN), BETA-2-MICROGLOBULIN (LIGHT CHAIN), GP2 PEPTIDE
Authors:Sharma, A.K., Kuhns, J.J., Collins, E.J.
Deposit date:2000-02-04
Release date:2003-06-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Class I major histocompatibility complex anchor substitutions alter the conformation of T cell receptor contacts.
J.Biol.Chem., 276, 2001
1FFN
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CRYSTAL STRUCTURE OF MURINE CLASS I H-2DB COMPLEXED WITH PEPTIDE GP33(C9M)
Descriptor:H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, D-B ALPHA CHAIN, BETA-2 MICROGLOBULIN, ...
Authors:Wang, B., Sharma, A., Maile, R., Saad, M., Collins, E.J., Frelinger, J.A.
Deposit date:2000-07-25
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Peptidic termini play a significant role in TCR recognition
J.IMMUNOL., 169, 2002
1FFO
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CRYSTAL STRUCTURE OF MURINE CLASS I H-2DB COMPLEXED WITH SYNTHETIC PEPTIDE GP33 (C9M/K1A)
Descriptor:H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, D-B, ALPHA CHAIN, ...
Authors:Wang, B., Sharma, A., Maile, R., Saad, M., Collins, E.J., Frelinger, J.A.
Deposit date:2000-07-25
Release date:2002-12-11
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Peptidic termini play a significant role in TCR recognition.
J.Immunol., 169, 2002
1FFP
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CRYSTAL STRUCTURE OF MURINE CLASS I H-2DB COMPLEXED WITH PEPTIDE GP33 (C9M/K1S)
Descriptor:H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, D-B, ALPHA CHAIN, ...
Authors:Wang, B., Sharma, A., Maile, R., Saad, M., Collins, E.J., Frelinger, J.A.
Deposit date:2000-07-25
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Peptidic termini play a significant role in TCR recognition
J.IMMUNOL., 169, 2002
2AAI
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CRYSTALLOGRAPHIC REFINEMENT OF RICIN TO 2.5 ANGSTROMS
Descriptor:RICIN (A CHAIN), RICIN (B CHAIN), BETA-D-GALACTOSE, ...
Authors:Rutenber, E., Katzin, B.J., Montfort, W., Villafranca, J.E., Ernst, S.R., Collins, E.J., Mlsna, D., Monzingo, A.F., Ready, M.P., Robertus, J.D.
Deposit date:1993-09-07
Release date:1994-01-31
Last modified:2013-08-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystallographic refinement of ricin to 2.5 A.
Proteins, 10, 1991
1B0G
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CLASS I HISTOCOMPATIBILITY ANTIGEN (HLA-A2.1)/BETA 2-MICROGLOBULIN/PEPTIDE P1049 COMPLEX
Descriptor:CLASS I HISTOCOMPATIBILITY ANTIGEN, BETA 2-MICROGLOBULIN, PEPTIDE P1049 (ALWGFFPVL)
Authors:Zhao, R., Collins, E.J.
Deposit date:1998-11-09
Release date:1998-11-18
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural evidence of T cell xeno-reactivity in the absence of molecular mimicry.
J.Exp.Med., 189, 1999
1BZ9
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CRYSTAL STRUCTURE OF MURINE CLASS I MHC H2-DB COMPLEXED WITH A SYNTHETIC PEPTIDE P1027
Descriptor:PROTEIN (CLASS I HISTOCOMPATIBILITY ANTIGEN), PROTEIN (PEPTIDE P1027 (FAPGVFPYM))
Authors:Zhao, R., Collins, E.J.
Deposit date:1998-11-06
Release date:1999-05-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural evidence of T cell xeno-reactivity in the absence of molecular mimicry.
J.Exp.Med., 189, 1999
1D4Z
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CRYSTAL STRUCTURE OF CHEY-95IV, A HYPERACTIVE CHEY MUTANT
Descriptor:CHEMOTAXIS PROTEIN CHEY, SULFATE ION
Authors:Schuster, M., Zhao, R., Bourret, R.B., Collins, E.J.
Deposit date:1999-10-06
Release date:1999-10-14
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Correlated switch binding and signaling in bacterial chemotaxis.
J.Biol.Chem., 275, 2000
1I1F
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CRYSTAL STRUCTURE OF HUMAN CLASS I MHC (HLA-A2.1) COMPLEXED WITH BETA 2-MICROGLOBULIN AND HIV-RT VARIANT PEPTIDE I1Y
Descriptor:PROTEIN (CLASS I HISTOCOMPATIBILITY ANTIGEN, GOGO-A0201 ALPHA CHAIN), PROTEIN (BETA 2-MICROGLOBULIN), ...
Authors:Kirksey, T.J., Pogue-Caley, R.R., Frelinger, J.A., Collins, E.J.
Deposit date:1999-04-16
Release date:2000-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structural basis for the increased immunogenicity of two HIV-reverse transcriptase peptide variant/class I major histocompatibility complexes.
J.Biol.Chem., 274, 1999
1I1Y
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CRYSTAL STRUCTURE OF HUMAN CLASS I MHC (HLA-A2.1) COMPLEXED WITH BETA 2-MICROGLOBULIN AND HIV-RT VARIANT PEPTIDE I1Y
Descriptor:CLASS I HISTOCOMPATIBILITY ANTIGEN, BETA 2-MICROGLOBULIN, HIV-RT VARIANT PEPTIDE I1Y (YLKEPVHGV)
Authors:Kirksey, T.J., Collins, E.J.
Deposit date:1999-04-16
Release date:2000-01-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structural basis for the increased immunogenicity of two HIV-reverse transcriptase peptide variant/class I major histocompatibility complexes.
J.Biol.Chem., 274, 1999
1I7R
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CRYSTAL STRUCTURE OF CLASS I MHC A2 IN COMPLEX WITH PEPTIDE P1058
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2 ALPHA CHAIN, BETA-2-MICROGLOBULIN, ...
Authors:Busslep, J., Zhao, R., Loftus, D., Appella, E., Collins, E.J.
Deposit date:2001-03-10
Release date:2001-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:T cell activity correlates with oligomeric peptide/MHC binding on T cell surface
J.Biol.Chem., 276, 2001
1I7T
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CRYSTAL STRUCTURE OF CLASS I MHC A2 IN COMPLEX WITH PEPTIDE P1049-5V
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2 ALPHA CHAIN, BETA-2-MICROGLOBULIN, ...
Authors:Busslep, J., Zhao, R., Loftus, D., Appella, E., Collins, E.J.
Deposit date:2001-03-10
Release date:2001-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:T cell activity correlates with oligomeric peptide-major histocompatibility complex binding on T cell surface
J.Biol.Chem., 276, 2001
1I7U
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CRYSTAL STRUCTURE OF CLASS I MHC A2 IN COMPLEX WITH PEPTIDE P1049-6V
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2 ALPHA CHAIN, BETA-2-MICROGLOBULIN, ...
Authors:Busslep, J., Zhao, R., Loftus, D., Appella, E., Collins, E.J.
Deposit date:2001-03-10
Release date:2001-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:T cell activity correlates with oligomeric peptide-major histocompatibility complex binding on T cell surface
J.Biol.Chem., 276, 2001
1KMI
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CRYSTAL STRUCTURE OF AN E.COLI CHEMOTAXIS PROTEIN, CHEZ
Descriptor:Chemotaxis protein cheY, Chemotaxis protein cheZ, MAGNESIUM ION, ...
Authors:Zhao, R., Collins, E.J., Bourret, R.B., Silversmith, R.E.
Deposit date:2001-12-16
Release date:2002-07-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure and catalytic mechanism of the E. coli chemotaxis phosphatase CheZ.
Nat.Struct.Biol., 9, 2002
1LP9
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XENOREACTIVE COMPLEX AHIII 12.2 TCR BOUND TO P1049/HLA-A2.1
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Buslepp, J., Wang, H., Biddison, W.E., Appella, E., Collins, E.J.
Deposit date:2002-05-07
Release date:2003-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A correlation between TCR Valpha docking on MHC and CD8 dependence: implications for T cell selection.
Immunity, 19, 2003
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