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8DGG
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BU of 8dgg by Molmil
Structure of glycosylated LAG-3 homodimer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Silberstein, J.L, Mathews, I.I, Frank, J.A, Chan, K.-W, Fernandez, D, Du, J, Wang, J, Kong, X.-P, Cochran, J.R.
Deposit date:2022-06-23
Release date:2022-08-17
Last modified:2022-08-31
Method:X-RAY DIFFRACTION (3.78 Å)
Cite:Structural basis for LAG-3 dimeric association and inhibition of T cell function
To Be Published
4RA0
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BU of 4ra0 by Molmil
An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:Kariolis, M.S, Kapur, S, Mathews, I.I, Cochran, J.R.
Deposit date:2014-09-09
Release date:2014-09-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.07 Å)
Cite:An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis.
Nat.Chem.Biol., 10, 2014
6MM4
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BU of 6mm4 by Molmil
Solution NMR Structure of Engineered Cystine Knot Protein 2.5F
Descriptor: Engineered Cystine Knot Protein 2.5F
Authors:Cochran, F.V, Cochran, J.R.
Deposit date:2018-09-29
Release date:2019-10-02
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution NMR Structure of Engineered Cystine Knot Protein 2.5F
To be published
5VXZ
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BU of 5vxz by Molmil
High-affinity AXL decoy receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:Mathrews, I.I, Kapur, S, Kariolis, M.S, Cochran, J.R.
Deposit date:2017-05-24
Release date:2017-06-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies.
J. Clin. Invest., 127, 2017
6OIL
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BU of 6oil by Molmil
Crystal structure of human VISTA extracellular domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, V-type immunoglobulin domain-containing suppressor of T-cell activation
Authors:Mehta, N, Cochran, J.R, Mathews, I.I.
Deposit date:2019-04-09
Release date:2019-09-11
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure and Functional Binding Epitope of V-domain Ig Suppressor of T Cell Activation.
Cell Rep, 28, 2019
6MSL
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BU of 6msl by Molmil
Integrin AlphaVBeta3 ectodomain bound to EETI-II 2.5D
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cystine Knot Protein 2.5D, ...
Authors:van Agthoven, J.F, Arnaout, M.A.
Deposit date:2018-10-16
Release date:2019-10-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.104 Å)
Cite:Structural Basis of the Differential Binding of Engineered Knottins to Integrins alpha V beta 3 and alpha 5 beta 1.
Structure, 27, 2019
6MSU
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BU of 6msu by Molmil
Integrin alphaVBeta3 in complex with EETI-II 2.5F
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:van Agthoven, J.F, Arnaout, M.A.
Deposit date:2018-10-18
Release date:2019-10-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Structural Basis of the Differential Binding of Engineered Knottins to Integrins alpha V beta 3 and alpha 5 beta 1.
Structure, 27, 2019
8TCG
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BU of 8tcg by Molmil
Integrin alpha-v beta-6 in complex with minibinder B6_BP_dslf
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Integrin alpha-V heavy chain, ...
Authors:Campbell, M.G, Fernandez, A, Roy, A, Kraft, J, Baker, D.
Deposit date:2023-06-30
Release date:2023-09-27
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:De novo design of highly selective miniprotein inhibitors of integrins alpha v beta 6 and alpha v beta 8.
Nat Commun, 14, 2023
8TCF
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BU of 8tcf by Molmil
Integrin alpha-v beta-8 in complex with minibinder B8_BP_dsulf
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Campbell, M.G, Fernandez, A, Roy, A, Kraft, J, Baker, D.
Deposit date:2023-06-30
Release date:2023-09-27
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:De novo design of highly selective miniprotein inhibitors of integrins alpha v beta 6 and alpha v beta 8.
Nat Commun, 14, 2023
7LMV
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BU of 7lmv by Molmil
SPECIFIC INHIBITOR OF INTEGRIN ALPHA-V BETA-6
Descriptor: Integrin inhibitor
Authors:Dong, X, Bera, A.K, Roy, A, Shi, L, Springer, T.A, Baker, D.
Deposit date:2021-02-05
Release date:2022-08-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:De novo design of highly selective miniprotein inhibitors of integrins alpha v beta 6 and alpha v beta 8.
Nat Commun, 14, 2023
7LMX
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BU of 7lmx by Molmil
A HIGHLY SPECIFIC INHIBITOR OF INTEGRIN ALPHA-V BETA-6 WITH A DISULFIDE
Descriptor: Integrin inhibitor
Authors:Dong, X, Bera, A.K, Roy, A, Shi, L, Springer, T.A, Baker, D.
Deposit date:2021-02-06
Release date:2022-08-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:De novo design of highly selective miniprotein inhibitors of integrins alpha v beta 6 and alpha v beta 8.
Nat Commun, 14, 2023
3G5X
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BU of 3g5x by Molmil
Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR
Descriptor: 806 heavy chain, 806 light chain
Authors:Garrett, T.P.J, Burgess, A.W.
Deposit date:2009-02-05
Release date:2009-12-15
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Antibodies specifically targeting a locally misfolded region of tumor associated EGFR
Proc.Natl.Acad.Sci.USA, 106, 2009
3G5V
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BU of 3g5v by Molmil
Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR
Descriptor: 806 light chain, 808 heavy chain, ACETATE ION, ...
Authors:Garrett, T.P.J, Burgess, A.W, Huyton, T, Xu, Y.
Deposit date:2009-02-05
Release date:2010-02-09
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Antibodies specifically targeting a locally misfolded region of tumor associated EGFR
Proc.Natl.Acad.Sci.USA, 106, 2009
3G5Y
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BU of 3g5y by Molmil
Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR
Descriptor: 175 heavy chain, 175 light chain, EGFR peptide
Authors:Garrett, T.P.J, Burgess, A.W.
Deposit date:2009-02-05
Release date:2010-02-09
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Antibodies specifically targeting a locally misfolded region of tumor associated EGFR
Proc.Natl.Acad.Sci.USA, 106, 2009
3G5Z
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BU of 3g5z by Molmil
Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR
Descriptor: 175 heavy chain, 175 light chain
Authors:Garrett, T.P.J, Burgess, A.W.
Deposit date:2009-02-05
Release date:2010-02-09
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Antibodies specifically targeting a locally misfolded region of tumor associated EGFR
Proc.Natl.Acad.Sci.USA, 106, 2009

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PDB entries from 2024-03-27

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