Author results

1ECM
  • Download 1ecm
  • View 1ecm
Molmil generated image of 1ecm
ATOMIC STRUCTURE OF THE BURIED CATALYTIC POCKET OF ESCHERICHIA COLI CHORISMATE MUTASE
Descriptor:ENDO-OXABICYCLIC TRANSITION STATE ANALOGUE, 8-HYDROXY-2-OXA-BICYCLO[3.3.1]NON-6-ENE-3,5-DICARBOXYLIC ACID
Authors:Clardy, J., Lee, A.Y.
Deposit date:1994-11-28
Release date:1995-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:ATOMIC-STRUCTURE OF THE BURIED CATALYTIC POCKET OF ESCHERICHIA-COLI CHORISMATE MUTASE.
J.Am.Chem.Soc., 117, 1995
1EI9
  • Download 1ei9
  • View 1ei9
Molmil generated image of 1ei9
CRYSTAL STRUCTURE OF PALMITOYL PROTEIN THIOESTERASE 1
Descriptor:PALMITOYL PROTEIN THIOESTERASE 1, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, N-ACETYL-D-GLUCOSAMINE
Authors:Bellizzi III, J.J., Widom, J., Kemp, C., Lu, J.Y., Das, A.K., Hofmann, S.L., Clardy, J.
Deposit date:2000-02-24
Release date:2000-04-26
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis.
Proc.Natl.Acad.Sci.USA, 97, 2000
1FKG
  • Download 1fkg
  • View 1fkg
Molmil generated image of 1fkg
DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12
Descriptor:FK506 BINDING PROTEIN, 1,3-DIPHENYL-1-PROPYL-1-(3,3-DIMETHYL-1,2-DIOXYPENTYL)-2-PIPERIDINE CARBOXYLATE
Authors:Holt, D.A., Luengo, J.I., Yamashita, D.S., Oh, H.-J., Konialian, A.L., Yen, H.-K., Rozamus, L.W., Brandt, M., Bossard, M.J., Levy, M.A., Eggleston, D.S., Stout, T.J., Liang, J., Schultz, L.W., Clardy, J.
Deposit date:1993-08-05
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12.
J.Am.Chem.Soc., 115, 1993
1FKH
  • Download 1fkh
  • View 1fkh
Molmil generated image of 1fkh
DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12
Descriptor:FK506 BINDING PROTEIN, 1-CYCLOHEXYL-3-PHENYL-1-PROPYL-1-(3,3-DIMETHYL-1,2-DIOXYPENTYL)-2-PIPERIDINE CARBOXYLATE
Authors:Holt, D.A., Luengo, J.I., Yamashita, D.S., Oh, H.-J., Konialian, A.L., Yen, H.-K., Rozamus, L.W., Brandt, M., Bossard, M.J., Levy, M.A., Eggleston, D.S., Stout, T.J., Liang, J., Schultz, L.W., Clardy, J.
Deposit date:1993-08-05
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12.
J.Am.Chem.Soc., 115, 1993
1FKI
  • Download 1fki
  • View 1fki
Molmil generated image of 1fki
DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12
Descriptor:FK506 BINDING PROTEIN, (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE
Authors:Holt, D.A., Luengo, J.I., Yamashita, D.S., Oh, H.-J., Konialian, A.L., Yen, H.-K., Rozamus, L.W., Brandt, M., Bossard, M.J., Levy, M.A., Eggleston, D.S., Stout, T.J., Liang, J., Schultz, L.W., Clardy, J.
Deposit date:1993-08-05
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12.
J.Am.Chem.Soc., 115, 1993
1NSG
  • Download 1nsg
  • View 1nsg
Molmil generated image of 1nsg
THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-RAPAMYCIN COMPLEX INTERACTING WITH HUMAN FRAP
Descriptor:FK506-BINDING PROTEIN, FKBP-RAPAMYCIN ASSOCIATED PROTEIN (FRAP), C49-METHYL RAPAMYCIN
Authors:Liang, J., Choi, J., Clardy, J.
Deposit date:1997-07-01
Release date:1998-03-18
Last modified:2013-09-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
1PBK
  • Download 1pbk
  • View 1pbk
Molmil generated image of 1pbk
HOMOLOGOUS DOMAIN OF HUMAN FKBP25
Descriptor:FKBP25, RAPAMYCIN IMMUNOSUPPRESSANT DRUG
Authors:Liang, J., Hung, D.T., Schreiber, S.L., Clardy, J.
Deposit date:1995-09-01
Release date:1996-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the human 25 kDa FK506 binding protein complexed with rapamycin.
J.Am.Chem.Soc., 118, 1996
2FAP
  • Download 2fap
  • View 2fap
Molmil generated image of 2fap
THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-(C16)-ETHOXY RAPAMYCIN COMPLEX INTERACTING WITH HUMA
Descriptor:FK506-BINDING PROTEIN, FRAP, C49-METHYL RAPAMYCIN
Authors:Liang, J., Choi, J., Clardy, J.
Deposit date:1998-09-22
Release date:1999-05-18
Last modified:2013-09-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
1A7X
  • Download 1a7x
  • View 1a7x
Molmil generated image of 1a7x
FKBP12-FK1012 COMPLEX
Descriptor:FKBP12, BENZYL-CARBAMIC ACID [8-DEETHYL-ASCOMYCIN-8-YL]ETHYL ESTER
Authors:Schultz, L.W., Clardy, J.
Deposit date:1998-03-18
Release date:1998-06-17
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Chemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12.
Bioorg.Med.Chem.Lett., 8, 1998
2B0M
  • Download 2b0m
  • View 2b0m
Molmil generated image of 2b0m
HUMAN DIHYDROOROTATE DEHYDROGENASE BOUND TO A NOVEL INHIBITOR
Descriptor:Dihydroorotate dehydrogenase, mitochondrial, 3-AMIDO-5-BIPHENYL-BENZOIC ACID, ...
Authors:Hurt, D.E., Sutton, A.E., Clardy, J.
Deposit date:2005-09-14
Release date:2005-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase.
Bioorg.Med.Chem.Lett., 16, 2006
1CMI
  • Download 1cmi
  • View 1cmi
Molmil generated image of 1cmi
STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE
Descriptor:PROTEIN INHIBITOR OF NEURONAL NITRIC OXIDE SYNTHASE, Nitric oxide synthase, brain
Authors:Liang, J., Guo, W., Jaffery, S., Snyder, S., Clardy, J.
Deposit date:1999-05-06
Release date:2000-02-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the PIN/LC8 dimer with a bound peptide.
Nat.Struct.Biol., 6, 1999
1EH5
  • Download 1eh5
  • View 1eh5
Molmil generated image of 1eh5
CRYSTAL STRUCTURE OF PALMITOYL PROTEIN THIOESTERASE 1 COMPLEXED WITH PALMITATE
Descriptor:PALMITOYL PROTEIN THIOESTERASE 1, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Bellizzi III, J.J., Widom, J., Kemp, C., Lu, J.Y., Das, A.K., Hofmann, S.L., Clardy, J.
Deposit date:2000-02-18
Release date:2000-04-26
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis.
Proc.Natl.Acad.Sci.USA, 97, 2000
1FAP
  • Download 1fap
  • View 1fap
Molmil generated image of 1fap
THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-RAPAMYCIN COMPLEX INTERACTING WITH HUMAN FRAP
Descriptor:FK506-BINDING PROTEIN, FRAP, RAPAMYCIN IMMUNOSUPPRESSANT DRUG
Authors:Choi, J., Chen, J., Schreiber, S.L., Clardy, J.
Deposit date:1996-03-15
Release date:1997-07-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP.
Science, 273, 1996
1KL9
  • Download 1kl9
  • View 1kl9
Molmil generated image of 1kl9
CRYSTAL STRUCTURE OF THE N-TERMINAL SEGMENT OF HUMAN EUKARYOTIC INITIATION FACTOR 2ALPHA
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1, ZINC ION
Authors:Nonato, M.C., Widom, J., Clardy, J.
Deposit date:2001-12-11
Release date:2002-03-11
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha
J.Biol.Chem., 277, 2002
1KQ0
  • Download 1kq0
  • View 1kq0
Molmil generated image of 1kq0
HUMAN METHIONINE AMINOPEPTIDASE TYPE II IN COMPLEX WITH D-METHIONINE
Descriptor:Methionine aminopeptidase 2, ZINC ION, D-METHIONINE, ...
Authors:Nonato, M.C., Widom, J., Clardy, J.
Deposit date:2002-01-03
Release date:2003-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Human methionine aminopeptidase type 2 in complex with L- and D-methionine
Bioorg.Med.Chem.Lett., 16, 2006
1KQ9
  • Download 1kq9
  • View 1kq9
Molmil generated image of 1kq9
HUMAN METHIONINE AMINOPEPTIDASE TYPE II IN COMPLEX WITH L-METHIONINE
Descriptor:Methionine aminopeptidase 2, ZINC ION, METHIONINE, ...
Authors:Nonato, M.C., Widom, J., Clardy, J.
Deposit date:2002-01-04
Release date:2003-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Human methionine aminopeptidase type 2 in complex with L- and D-methionine
Bioorg.Med.Chem.Lett., 16, 2006
1N52
  • Download 1n52
  • View 1n52
Molmil generated image of 1n52
CAP BINDING COMPLEX
Descriptor:80 kDa nuclear cap binding protein, 20 kDa nuclear cap binding protein, MAGNESIUM ION, ...
Authors:Calero, G., Wilson, K., Ly, T., Rios-Steiner, J., Clardy, J., Cerione, R.
Deposit date:2002-11-04
Release date:2003-02-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Structural basis of m7GpppG binding to the nuclear cap-binding protein complex.
Nat.Struct.Biol., 9, 2002
1N54
  • Download 1n54
  • View 1n54
Molmil generated image of 1n54
CAP BINDING COMPLEX M7GPPPG FREE
Descriptor:80 kDa nuclear cap binding protein, 20 kDa nuclear cap binding protein, GLYCEROL
Authors:Calero, G., Wilson, K., Ly, T., Rios-Steiner, J., Clardy, J., Cerione, R.
Deposit date:2002-11-04
Release date:2003-02-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Structural basis of m7GpppG binding to the nuclear cap-binding protein complex.
Nat.Struct.Biol., 9, 2002
1PHT
  • Download 1pht
  • View 1pht
Molmil generated image of 1pht
PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT SH3 DOMAIN, RESIDUES 1-85
Descriptor:PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT
Authors:Liang, J., Chen, J.K., Schreiber, S.L., Clardy, J.
Deposit date:1995-08-17
Release date:1995-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of P13K SH3 domain at 20 angstroms resolution.
J.Mol.Biol., 257, 1996
1TV5
  • Download 1tv5
  • View 1tv5
Molmil generated image of 1tv5
PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE WITH A BOUND INHIBITOR
Descriptor:Dihydroorotate dehydrogenase homolog, mitochondrial, SULFATE ION, ...
Authors:Hurt, D.E., Widom, J., Clardy, J.
Deposit date:2004-06-27
Release date:2005-09-06
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor.
Acta Crystallogr.,Sect.D, 62, 2006
3FAP
  • Download 3fap
  • View 3fap
Molmil generated image of 3fap
ATOMIC STRUCTURES OF THE RAPAMYCIN ANALOGS IN COMPLEX WITH BOTH HUMAN FKBP12 AND FRB DOMAIN OF FRAP
Descriptor:FK506-BINDING PROTEIN, FKBP12-RAPAMYCIN ASSOCIATED PROTEIN, C15-(R)-METHYLTHIENYL RAPAMYCIN
Authors:Liang, J., Clardy, J.
Deposit date:1999-05-06
Release date:2000-09-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
4FAP
  • Download 4fap
  • View 4fap
Molmil generated image of 4fap
ATOMIC STRUCTURES OF THE RAPAMYCIN ANALOGS IN COMPLEX WITH BOTH HUMAN FKBP12 AND FRB DOMAIN OF FRAP
Descriptor:FK506-BINDING PROTEIN, FKBP12-RAPAMYCIN ASSOCIATED PROTEIN, C15-(R)-METHYLTHIENYL RAPAMYCIN
Authors:Liang, J., Clardy, J.
Deposit date:1999-05-06
Release date:2000-09-13
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
4NNR
  • Download 4nnr
  • View 4nnr
Molmil generated image of 4nnr
FKBP13-FK506 COMPLEX
Descriptor:Peptidyl-prolyl cis-trans isomerase FKBP2, 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN
Authors:Schultz, L.W., Martin, P.K., Liang, J., Schreiber, S.L., Clardy, J.
Deposit date:2013-11-18
Release date:2014-02-05
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Atomic structure of the Immunophilin FKBP13-FK506 Complex: Insights into the Composite Binding Surface for Calcineurin
J.Am.Chem.Soc., 116, 1994
1AQ7
  • Download 1aq7
  • View 1aq7
Molmil generated image of 1aq7
TRYPSIN WITH INHIBITOR AERUGINOSIN 98-B
Descriptor:TRYPSIN, AERUGINOSIN 98-B
Authors:Sandler, B., Murakami, M., Clardy, J.
Deposit date:1997-08-07
Release date:1998-02-25
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Atomic Structure of the Trypsin-Aeruginosin 98-B Complex
J.Am.Chem.Soc., 120, 1998
1AUE
  • Download 1aue
  • View 1aue
Molmil generated image of 1aue
FKBP-RAPAMYCIN BINDING DOMAIN (FRB) OF THE FKBP-RAPAMYCIN ASSOCIATED PROTEIN
Descriptor:FKBP-RAPAMYCIN ASSOCIATED PROTEIN
Authors:Odagaki, Y., Clardy, J.
Deposit date:1997-08-25
Release date:1998-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Structural Basis for Peptidomimicry by the Effector Element of Rapamycin
J.Am.Chem.Soc., 119, 1997
<123>