1ECM
 
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2B0M
 | | Human dihydroorotate dehydrogenase bound to a novel inhibitor | | Descriptor: | 3-AMIDO-5-BIPHENYL-BENZOIC ACID, Dihydroorotate dehydrogenase, mitochondrial, ... | | Authors: | Hurt, D.E, Sutton, A.E, Clardy, J. | | Deposit date: | 2005-09-14 | | Release date: | 2005-09-27 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase.
Bioorg.Med.Chem.Lett., 16, 2006
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3FAP
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4FAP
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4NNR
 | | FKBP13-FK506 Complex | | Descriptor: | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, Peptidyl-prolyl cis-trans isomerase FKBP2 | | Authors: | Schultz, L.W, Martin, P.K, Liang, J, Schreiber, S.L, Clardy, J. | | Deposit date: | 2013-11-18 | | Release date: | 2014-02-05 | | Last modified: | 2019-11-13 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Atomic structure of the Immunophilin FKBP13-FK506 Complex: Insights into the Composite Binding Surface for Calcineurin
J.Am.Chem.Soc., 116, 1994
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2FAP
 | | THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-(C16)-ETHOXY RAPAMYCIN COMPLEX INTERACTING WITH HUMA | | Descriptor: | C49-METHYL RAPAMYCIN, FK506-BINDING PROTEIN, FRAP | | Authors: | Liang, J, Choi, J, Clardy, J. | | Deposit date: | 1998-09-22 | | Release date: | 1999-05-18 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
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3OGN
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1TV5
 | | Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor | | Descriptor: | (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide, 3,6,9,12,15-PENTAOXATRICOSAN-1-OL, Dihydroorotate dehydrogenase homolog, ... | | Authors: | Hurt, D.E, Widom, J, Clardy, J. | | Deposit date: | 2004-06-27 | | Release date: | 2005-09-06 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor.
Acta Crystallogr.,Sect.D, 62, 2006
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1NSG
 | | THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-RAPAMYCIN COMPLEX INTERACTING WITH HUMAN FRAP | | Descriptor: | C49-METHYL RAPAMYCIN, FK506-BINDING PROTEIN, FKBP-RAPAMYCIN ASSOCIATED PROTEIN (FRAP) | | Authors: | Liang, J, Choi, J, Clardy, J. | | Deposit date: | 1997-07-01 | | Release date: | 1998-03-18 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
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1PBK
 | | HOMOLOGOUS DOMAIN OF HUMAN FKBP25 | | Descriptor: | FKBP25, RAPAMYCIN IMMUNOSUPPRESSANT DRUG | | Authors: | Liang, J, Hung, D.T, Schreiber, S.L, Clardy, J. | | Deposit date: | 1995-09-01 | | Release date: | 1996-10-14 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of the human 25 kDa FK506 binding protein complexed with rapamycin.
J.Am.Chem.Soc., 118, 1996
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1N52
 | | Cap Binding Complex | | Descriptor: | 20 kDa nuclear cap binding protein, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, 80 kDa nuclear cap binding protein, ... | | Authors: | Calero, G, Wilson, K, Ly, T, Rios-Steiner, J, Clardy, J, Cerione, R. | | Deposit date: | 2002-11-04 | | Release date: | 2003-02-18 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.11 Å) | | Cite: | Structural basis of m7GpppG binding to the nuclear cap-binding protein complex.
Nat.Struct.Biol., 9, 2002
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1N54
 | | Cap Binding Complex m7GpppG free | | Descriptor: | 20 kDa nuclear cap binding protein, 80 kDa nuclear cap binding protein, GLYCEROL | | Authors: | Calero, G, Wilson, K, Ly, T, Rios-Steiner, J, Clardy, J, Cerione, R. | | Deposit date: | 2002-11-04 | | Release date: | 2003-02-18 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.72 Å) | | Cite: | Structural basis of m7GpppG binding to the nuclear cap-binding protein complex.
Nat.Struct.Biol., 9, 2002
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2FJY
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2G0B
 | | The structure of FeeM, an N-acyl amino acid synthase from uncultured soil microbes | | Descriptor: | FeeM, N-DODECANOYL-L-TYROSINE | | Authors: | Van Wagoner, R.M, Clardy, J. | | Deposit date: | 2006-02-11 | | Release date: | 2006-09-26 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | FeeM, an N-Acyl Amino Acid Synthase from an Uncultured Soil Microbe: Structure, Mechanism, and Acyl Carrier Protein Binding.
Structure, 14, 2006
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1TPS
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1TYN
 | | ATOMIC STRUCTURE OF THE TRYPSIN-CYCLOTHEONAMIDE A COMPLEX: LESSONS FOR THE DESIGN OF SERINE PROTEASE INHIBITORS | | Descriptor: | BETA-TRYPSIN, CYCLOTHEONAMIDE A | | Authors: | Lee, A.Y, Hagihara, M, Karmacharya, R, Albers, M.W, Schreiber, S.L, Clardy, J. | | Deposit date: | 1994-09-19 | | Release date: | 1995-01-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Atomic Structure of the Trypsin-Cyclotheonamide a Complex: Lessons for the Design of Serine Protease Inhibitors
J.Am.Chem.Soc., 115, 1993
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2MAI
 | | NMR structure of lassomycin | | Descriptor: | Lassomycin | | Authors: | Gavrish, E, Sit, C.S, Kandror, O, Spoering, A, Peoples, A, Ling, L, Fetterman, A, Hughes, D, Cao, S, Bissell, A, Torrey, H, Akopian, T, Mueller, A, Epstein, S, Goldberg, A, Clardy, J, Lewis, K. | | Deposit date: | 2013-07-09 | | Release date: | 2014-05-07 | | Last modified: | 2023-11-15 | | Method: | SOLUTION NMR | | Cite: | Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2.
Chem.Biol., 21, 2014
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1PHT
 | | PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT SH3 DOMAIN, RESIDUES 1-85 | | Descriptor: | PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT | | Authors: | Liang, J, Chen, J.K, Schreiber, S.L, Clardy, J. | | Deposit date: | 1995-08-17 | | Release date: | 1995-12-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of P13K SH3 domain at 20 angstroms resolution.
J.Mol.Biol., 257, 1996
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2P71
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2P70
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1KL9
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1KQ0
 | | Human methionine aminopeptidase type II in complex with D-methionine | | Descriptor: | D-METHIONINE, Methionine aminopeptidase 2, TERTIARY-BUTYL ALCOHOL, ... | | Authors: | Nonato, M.C, Widom, J, Clardy, J. | | Deposit date: | 2002-01-03 | | Release date: | 2003-12-09 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Human methionine aminopeptidase type 2 in complex with L- and D-methionine
Bioorg.Med.Chem.Lett., 16, 2006
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1KQ9
 | | Human methionine aminopeptidase type II in complex with L-methionine | | Descriptor: | METHIONINE, Methionine aminopeptidase 2, TERTIARY-BUTYL ALCOHOL, ... | | Authors: | Nonato, M.C, Widom, J, Clardy, J. | | Deposit date: | 2002-01-04 | | Release date: | 2003-12-09 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Human methionine aminopeptidase type 2 in complex with L- and D-methionine
Bioorg.Med.Chem.Lett., 16, 2006
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1PJA
 | | The crystal structure of palmitoyl protein thioesterase-2 reveals the basis for divergent substrate specificities of the two lysosomal thioesterases (PPT1 and PPT2) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Palmitoyl-protein thioesterase 2 precursor | | Authors: | Calero, G, Gupta, P, Nonato, M.C, Tandel, S, Biehl, E.R, Hofmann, S.L, Clardy, J. | | Deposit date: | 2003-06-02 | | Release date: | 2003-09-02 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2.
J.Biol.Chem., 278, 2003
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1KV3
 | | HUMAN TISSUE TRANSGLUTAMINASE IN GDP BOUND FORM | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Protein-glutamine gamma-glutamyltransferase | | Authors: | Liu, S, Cerione, R.A, Clardy, J. | | Deposit date: | 2002-01-24 | | Release date: | 2002-03-13 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity.
Proc.Natl.Acad.Sci.USA, 99, 2002
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