Author results

4UV8
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LSD1(KDM1A)-COREST IN COMPLEX WITH 1-BENZYL-TRANYLCYPROMINE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [[(2R,3S,4S)-5-[(4aS,10aS)-4a-[(1S)-3-azanylidene-1,4-diphenyl-butyl]-7,8-dimethyl-2,4-bis(oxidanylidene)-5,10a-dihydro-1H-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentoxy]-oxidanyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate
著者Vianello, P., Botrugno, O., Cappa, A., Ciossani, G., Dessanti, P., Mai, A., Mattevi, A., Meroni, G., Minucci, S., Thaler, F., Tortorici, M., Trifiro, P., Valente, S., Villa, M., Varasi, M., Mercurio, C.
登録日2014-08-05
公開日2014-09-10
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A.
Eur.J.Med.Chem., 86C, 2014
4UV9
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LSD1(KDM1A)-COREST IN COMPLEX WITH 1-ETHYL-TRANYLCYPROMINE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(4aS,10aS)-4a-[(1S,3E)-3-imino-1-phenylpentyl]-7,8-dimethyl-2,4-dioxo-1,3,4,4a,5,10a-hexahydrobenzo[g]pteridin-10(2H)-yl]pentyl dihydrogen diphosphate
著者Vianello, P., Botrugno, O., Cappa, A., Ciossani, G., Dessanti, P., Mai, A., Mattevi, A., Meroni, G., Minucci, S., Thaler, F., Tortorici, M., Trifiro, P., Valente, S., Villa, M., Varasi, M., Mercurio, C.
登録日2014-08-05
公開日2014-09-10
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A.
Eur.J.Med.Chem., 86C, 2014
4UVA
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LSD1(KDM1A)-COREST IN COMPLEX WITH 1-METHYL-TRANYLCYPROMINE (1R,2S)
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(4aS)-4a-[(1S,3E)-3-imino-1-phenylbutyl]-7,8-dimethyl-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]pentyl dihydrogen diphosphate
著者Vianello, P., Botrugno, O., Cappa, A., Ciossani, G., Dessanti, P., Mai, A., Mattevi, A., Meroni, G., Minucci, S., Thaler, F., Tortorici, M., Trifiro, P., Valente, S., Villa, M., Varasi, M., Mercurio, C.
登録日2014-08-05
公開日2014-09-10
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A.
Eur.J.Med.Chem., 86C, 2014
4UVB
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LSD1(KDM1A)-COREST IN COMPLEX WITH 1-METHYL-TRANYLCYPROMINE (1S,2R)
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[(1R,3S,3aS,7aS)-1-amino-1,10,11-trimethyl-4,6-dioxo-3-phenyl-2,3,5,6,7,7a-hexahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate
著者Vianello, P., Botrugno, O., Cappa, A., Ciossani, G., Dessanti, P., Mai, A., Mattevi, A., Meroni, G., Minucci, S., Thaler, F., Tortorici, M., Trifiro, P., Valente, S., Villa, M., Varasi, M., Mercurio, C.
登録日2014-08-05
公開日2014-09-10
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A.
Eur.J.Med.Chem., 86C, 2014
4UVC
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LSD1(KDM1A)-COREST IN COMPLEX WITH 1-PHENYL-TRANYLCYPROMINE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4S)-5-[5-[(1S)-1-azanyl-1,3-diphenyl-propyl]-7,8-dimethyl-2,4-bis(oxidanylidene)-4aH-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate
著者Vianello, P., Botrugno, O., Cappa, A., Ciossani, G., Dessanti, P., Mai, A., Mattevi, A., Meroni, G., Minucci, S., Thaler, F., Tortorici, M., Trifiro, P., Valente, S., Villa, M., Varasi, M., Mercurio, C.
登録日2014-08-05
公開日2014-09-10
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A.
Eur.J.Med.Chem., 86C, 2014
4UXN
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LSD1(KDM1A)-COREST IN COMPLEX WITH Z-PRO DERIVATIVE OF MC2580
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Rodriguez, V., Valente, S., Stazi, G., Lucidi, A., Mercurio, C., Vianello, P., Ciossani, G., Mattevi, A., Botrugno, O.A., Dessanti, P., Minucci, S., Varasi, M., Mai, A.
登録日2014-08-27
公開日2015-02-25
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Pyrrole- and Indole-Containing Tranylcypromine Derivatives as Novel Lysine-Specific Demethylase 1 Inhibitors Active on Cancer Cells
Chemmedchem, 6, 2015
5LGN
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THIENO[3,2-B]PYRROLE-5-CARBOXAMIDES AS NOVEL REVERSIBLE INHIBITORS OF HISTONE LYSINE DEMETHYLASE KDM1A/LSD1: COMPOUND 19
分子名称:Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Mattevi, A., Ciossani, G.
登録日2016-07-07
公開日2017-02-22
最終更新日2017-03-22
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration.
J. Med. Chem., 60, 2017
5LGT
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THIENO[3,2-B]PYRROLE-5-CARBOXAMIDES AS NOVEL REVERSIBLE INHIBITORS OF HISTONE LYSINE DEMETHYLASE KDM1A/LSD1: COMPOUND 15
分子名称:Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Mattevi, A., Ciossani, G.
登録日2016-07-08
公開日2017-02-22
最終更新日2017-03-22
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.
J. Med. Chem., 60, 2017
5LGU
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THIENO[3,2-B]PYRROLE-5-CARBOXAMIDES AS NOVEL REVERSIBLE INHIBITORS OF HISTONE LYSINE DEMETHYLASE KDM1A/LSD1: COMPOUND 34
分子名称:Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Mattevi, A., Ciossani, G.
登録日2016-07-08
公開日2017-02-22
最終更新日2017-03-22
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.
J. Med. Chem., 60, 2017
6HHE
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CRYSTAL STRUCTURE OF THE MEDFLY ODORANT BINDING PROTEIN CCAPOBP22/CCAPOBP69A
分子名称:Odorant binding protein OBP69a, SULFATE ION, 2-(2-METHOXYETHOXY)ETHANOL
著者Falchetto, M., Ciossani, G., Nenci, S., Mattevi, A., Gasperi, G., Forneris, F.
登録日2018-08-28
公開日2018-12-26
最終更新日2019-01-30
実験手法X-RAY DIFFRACTION (1.516 Å)
主引用文献Structural and biochemical evaluation of Ceratitis capitata odorant-binding protein 22 affinity for odorants involved in intersex communication.
Insect Mol. Biol., 2018
2XAF
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CRYSTAL STRUCTURE OF LSD1-COREST IN COMPLEX WITH PARA-BROMO-(+)-CIS-2- PHENYLCYCLOPROPYL-1-AMINE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Binda, C., Valente, S., Romanenghi, M., Pilotto, S., Cirilli, R., Karytinos, A., Ciossani, G., Botrugno, O.A., Forneris, F., Tardugno, M., Edmondson, D.E., Minucci, S., Mattevi, A., Mai, A.
登録日2010-03-31
公開日2010-05-05
最終更新日2011-10-12
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
2XAG
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CRYSTAL STRUCTURE OF LSD1-COREST IN COMPLEX WITH PARA-BROMO-(-)-TRANS- 2-PHENYLCYCLOPROPYL-1-AMINE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Binda, C., Valente, S., Romanenghi, M., Pilotto, S., Cirilli, R., Karytinos, A., Ciossani, G., Botrugno, O.A., Forneris, F., Tardugno, M., Edmondson, D.E., Minucci, S., Mattevi, A., Mai, A.
登録日2010-03-31
公開日2010-05-05
最終更新日2011-10-12
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
2XAH
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CRYSTAL STRUCTURE OF LSD1-COREST IN COMPLEX WITH (+)-TRANS-2- PHENYLCYCLOPROPYL-1-AMINE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Binda, C., Valente, S., Romanenghi, M., Pilotto, S., Cirilli, R., Karytinos, A., Ciossani, G., Botrugno, O.A., Forneris, F., Tardugno, M., Edmondson, D.E., Minucci, S., Mattevi, A., Mai, A.
登録日2010-03-31
公開日2010-05-05
最終更新日2011-10-12
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
2XAJ
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CRYSTAL STRUCTURE OF LSD1-COREST IN COMPLEX WITH (-)-TRANS-2- PHENYLCYCLOPROPYL-1-AMINE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Binda, C., Valente, S., Romanenghi, M., Pilotto, S., Cirilli, R., Karytinos, A., Ciossani, G., Botrugno, O.A., Forneris, F., Tardugno, M., Edmondson, D.E., Minucci, S., Mattevi, A., Mai, A.
登録日2010-03-31
公開日2010-05-05
最終更新日2011-10-12
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
2XAQ
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CRYSTAL STRUCTURE OF LSD1-COREST IN COMPLEX WITH A TRANYLCYPROMINE DERIVATIVE (MC2584, 13B)
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Binda, C., Valente, S., Romanenghi, M., Pilotto, S., Cirilli, R., Karytinos, A., Ciossani, G., Botrugno, O.A., Forneris, F., Tardugno, M., Edmondson, D.E., Minucci, S., Mattevi, A., Mai, A.
登録日2010-03-31
公開日2010-05-05
最終更新日2011-10-12
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
2XAS
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CRYSTAL STRUCTURE OF LSD1-COREST IN COMPLEX WITH A TRANYLCYPROMINE DERIVATIVE (MC2580, 14E)
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Binda, C., Valente, S., Romanenghi, M., Pilotto, S., Cirilli, R., Karytinos, A., Ciossani, G., Botrugno, O.A., Forneris, F., Tardugno, M., Edmondson, D.E., Minucci, S., Mattevi, A., Mai, A.
登録日2010-03-31
公開日2010-05-05
最終更新日2011-10-12
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
3ZMS
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LSD1-COREST IN COMPLEX WITH INSM1 PEPTIDE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, INSULINOMA-ASSOCIATED PROTEIN 1, ...
著者Tortorici, M., Borrello, M.T., Tardugno, M., Chiarelli, L.R., Pilotto, S., Ciossani, G., Vellore, N.A., Cowan, J., O'Connell, M., Mai, A., Baron, R., Ganesan, A., Mattevi, A.
登録日2013-02-12
公開日2013-06-12
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (2.96 Å)
主引用文献Protein Recognition by Small Peptide Reversible Inhibitors of the Chromatin-Modifying Lsd1/Corest Lysine Demethylase.
Acs Chem.Biol., 8, 2013
3ZMT
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LSD1-COREST IN COMPLEX WITH PRSFLV PEPTIDE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, PEPTIDE, ...
著者Tortorici, M., Borrello, M.T., Tardugno, M., Chiarelli, L.R., Pilotto, S., Ciossani, G., Vellore, N.A., Cowan, J., O'Connell, M., Mai, A., Baron, R., Ganesan, A., Mattevi, A.
登録日2013-02-12
公開日2013-06-12
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Protein Recognition by Small Peptide Reversible Inhibitors of the Chromatin-Modifying Lsd1/Corest Lysine Demethylase.
Acs Chem.Biol., 8, 2013
3ZMU
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LSD1-COREST IN COMPLEX WITH PKSFLV PEPTIDE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, PKSFLV PEPTIDE, ...
著者Tortorici, M., Borrello, M.T., Tardugno, M., Chiarelli, L.R., Pilotto, S., Ciossani, G., Vellore, N.A., Cowan, J., O'Connell, M., Mai, A., Baron, R., Ganesan, A., Mattevi, A.
登録日2013-02-12
公開日2013-06-12
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Protein Recognition by Small Peptide Reversible Inhibitors of the Chromatin-Modifying Lsd1/Corest Lysine Demethylase.
Acs Chem.Biol., 8, 2013
3ZMV
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LSD1-COREST IN COMPLEX WITH PLSFLV PEPTIDE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, PKSFLV PEPTIDE, ...
著者Tortorici, M., Borrello, M.T., Tardugno, M., Chiarelli, L.R., Pilotto, S., Ciossani, G., Vellore, N.A., Cowan, J., O'Connell, M., Mai, A., Baron, R., Ganesan, A., Mattevi, A.
登録日2013-02-12
公開日2013-06-12
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Protein Recognition by Small Peptide Reversible Inhibitors of the Chromatin-Modifying Lsd1/Corest Lysine Demethylase.
Acs Chem.Biol., 8, 2013
3ZMZ
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LSD1-COREST IN COMPLEX WITH PRSFAV PEPTIDE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, PEPTIDE, ...
著者Tortorici, M., Borrello, M.T., Tardugno, M., Chiarelli, L.R., Pilotto, S., Ciossani, G., Vellore, N.A., Cowan, J., O'Connell, M., Mai, A., Baron, R., Ganesan, A., Mattevi, A.
登録日2013-02-13
公開日2013-06-12
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Protein Recognition by Small Peptide Reversible Inhibitors of the Chromatin-Modifying Lsd1/Corest Lysine Demethylase.
Acs Chem.Biol., 8, 2013
3ZN0
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LSD1-COREST IN COMPLEX WITH PRSFAA PEPTIDE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, PEPTIDE, ...
著者Tortorici, M., Borrello, M.T., Tardugno, M., Chiarelli, L.R., Pilotto, S., Ciossani, G., Vellore, N.A., Cowan, J., O'Connell, M., Mai, A., Baron, R., Ganesan, A., Mattevi, A.
登録日2013-02-13
公開日2013-06-12
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Protein Recognition by Small Peptide Reversible Inhibitors of the Chromatin-Modifying Lsd1/Corest Lysine Demethylase.
Acs Chem.Biol., 8, 2013
3ZN1
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LSD1-COREST IN COMPLEX WITH PRLYLV PEPTIDE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, PEPTIDE, ...
著者Tortorici, M., Borrello, M.T., Tardugno, M., Chiarelli, L.R., Pilotto, S., Ciossani, G., Vellore, N.A., Cowan, J., O'Connell, M., Mai, A., Baron, R., Ganesan, A., Mattevi, A.
登録日2013-02-13
公開日2013-06-12
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Protein Recognition by Small Peptide Reversible Inhibitors of the Chromatin-Modifying Lsd1/Corest Lysine Demethylase.
Acs Chem.Biol., 8, 2013
4CZZ
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HISTONE DEMETHYLASE LSD1(KDM1A)-COREST3 COMPLEX
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 3, FLAVIN-ADENINE DINUCLEOTIDE
著者Barrios, A.P., Gomez, A.V., Saez, J.E., Ciossani, G., Toffolo, E., Battaglioli, E., Mattevi, A., Andres, M.E.
登録日2014-04-23
公開日2014-06-11
最終更新日2014-10-15
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Differential Properties of Transcriptional Complexes Formed by the Corest Family.
Mol.Cell.Biol., 34, 2014
5L3E
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LSD1-COREST1 IN COMPLEX WITH QUINAZOLINE-DERIVATIVE REVERSIBLE INHIBITOR
分子名称:Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Speranzini, V., Rotili, D., Ciossani, G., Pilotto, S., Forgione, M., Lucidi, A., Forneris, F., Velankar, S., Mai, A., Mattevi, A.
登録日2016-04-10
公開日2016-09-21
最終更新日2016-10-05
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features.
Sci Adv, 2, 2016
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