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1CCV
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BU of 1ccv by Molmil
NMR SOLUTION STRUCTURE OF APIS MELLIFERA CHYMOTRYPSIN INHIBITOR (AMCI).
Descriptor: CHYMOTRYPSIN INHIBITOR
Authors:Cierpicki, T, Otlewski, J.
Deposit date:1999-03-02
Release date:1999-03-12
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:NMR solution structure of Apis mellifera chymotrypsin/cathepsin G inhibitor-1 (AMCI-1): structural similarity with Ascaris protease inhibitors
Protein Sci., 9, 2000
1DWM
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BU of 1dwm by Molmil
Solution structure of Linum usitatissinum trypsin inhibitor (LUTI)
Descriptor: LINUM USITATISSINUM TRYPSIN INHIBITOR
Authors:Cierpicki, T, Otlewski, J.
Deposit date:1999-12-08
Release date:1999-12-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Determination of a High Precision Structure of a Novel Protein, Linum Usitatissimum Trypsin Inhibitor (Luti), Using Computer-Aided Assignment of Noesy Cross-Peaks
J.Mol.Biol., 302, 2000
1LD5
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BU of 1ld5 by Molmil
STRUCTURE OF BPTI MUTANT A16V
Descriptor: PANCREATIC TRYPSIN INHIBITOR
Authors:Cierpicki, T, Otlewski, J.
Deposit date:2002-04-08
Release date:2002-09-11
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:NMR structures of two variants of bovine pancreatic trypsin inhibitor (BPTI) reveal unexpected influence of mutations on protein structure and stability.
J.Mol.Biol., 321, 2002
1LD6
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BU of 1ld6 by Molmil
STRUCTURE OF BPTI_8A MUTANT
Descriptor: PANCREATIC TRYPSIN INHIBITOR
Authors:Cierpicki, T, Otlewski, J.
Deposit date:2002-04-08
Release date:2002-09-11
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:NMR structures of two variants of bovine pancreatic trypsin inhibitor (BPTI) reveal unexpected influence of mutations on protein structure and stability.
J.Mol.Biol., 321, 2002
2GE4
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BU of 2ge4 by Molmil
High-resolution solution structure of outer membrane protein A transmembrane domain
Descriptor: Outer membrane protein A
Authors:Cierpicki, T, Liang, B, Tamm, L.K, Bushweller, J.H.
Deposit date:2006-03-17
Release date:2006-04-11
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:Increasing the accuracy of solution NMR structures of membrane proteins by application of residual dipolar couplings. High-resolution structure of outer membrane protein A.
J.Am.Chem.Soc., 128, 2006
2JYI
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BU of 2jyi by Molmil
Solution structure of MLL CXXC domain
Descriptor: ZINC ION, Zinc finger protein HRX
Authors:Cierpicki, T, Bushweller, J.H.
Deposit date:2007-12-13
Release date:2008-12-09
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structural basis for maintenance of unmethylated CpG elements by the CXXC domain of MLL and its critical contributions to MLL-AF9 immortalization activity
To be Published
2KKF
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BU of 2kkf by Molmil
Solution structure of MLL CXXC domain in complex with palindromic CPG DNA
Descriptor: 5'-D(*CP*CP*CP*TP*GP*CP*GP*CP*AP*GP*GP*G)-3', Histone-lysine N-methyltransferase HRX, ZINC ION
Authors:Cierpicki, T, Riesbeck, J.E, Grembecka, J.E, Lukasik, S.M, Popovic, R, Omonkowska, M, Shultis, D.S, Zeleznik-Le, N.J, Bushweller, J.H.
Deposit date:2009-06-18
Release date:2009-12-08
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia.
Nat.Struct.Mol.Biol., 17, 2010
7ND1
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BU of 7nd1 by Molmil
First-in-class small molecule inhibitors of Polycomb Repressive Complex 1 (PRC1) RING domain
Descriptor: 3-(2-chlorophenyl)-4-ethyl-5-(1~{H}-indol-4-yl)-1~{H}-pyrrole-2-carboxylic acid, E3 ubiquitin-protein ligase RING2, Polycomb complex protein BMI-1, ...
Authors:Cierpicki, T, Lund, G, Jaremko, L.
Deposit date:2021-01-29
Release date:2021-06-16
Last modified:2021-07-07
Method:SOLUTION NMR
Cite:Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain.
Nat.Chem.Biol., 17, 2021
2MTN
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BU of 2mtn by Molmil
Solution structure of MLL-IBD complex
Descriptor: Histone-lysine N-methyltransferase 2A, PC4 and SFRS1-interacting protein fusion
Authors:Cierpicki, T, Pollock, J, Murai, M.
Deposit date:2014-08-23
Release date:2014-12-03
Last modified:2015-04-22
Method:SOLUTION NMR
Cite:The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV.
Blood, 124, 2014
2NA1
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BU of 2na1 by Molmil
ULD complex
Descriptor: Polycomb complex protein BMI-1, Polyhomeotic-like 2
Authors:Cierpicki, T, Gray, F, Cho, H.
Deposit date:2015-12-17
Release date:2016-11-16
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization.
Nat Commun, 7, 2016
4X5Y
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BU of 4x5y by Molmil
Menin in complex with MI-503
Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-methyl-1-(1H-pyrazol-4-ylmethyl)-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile, ...
Authors:Pollock, J, Borkin, D, Cierpicki, T, Grembecka, J.
Deposit date:2014-12-06
Release date:2015-04-15
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo.
Cancer Cell, 27, 2015
7T58
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BU of 7t58 by Molmil
Crystal structure of Miz1 BTB domain
Descriptor: DIMETHYL SULFOXIDE, Zinc finger and BTB domain-containing protein 17
Authors:Linhares, B.M, Cierpicki, T.
Deposit date:2021-12-11
Release date:2022-12-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.05333114 Å)
Cite:Prediction of BTB domain ligandability guided by protein dynamics
To Be Published
4WH9
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BU of 4wh9 by Molmil
Structure of the CDC25B Phosphatase Catalytic Domain with Bound Inhibitor
Descriptor: 2-[(2-cyano-3-fluoro-5-hydroxyphenyl)sulfanyl]ethanesulfonic acid, GLYCEROL, M-phase inducer phosphatase 2, ...
Authors:Lund, G.L, Dudkin, S, Borkin, D, Ni, W, Grembecka, J, Cierpicki, T.
Deposit date:2014-09-20
Release date:2014-12-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Inhibition of CDC25B Phosphatase Through Disruption of Protein-Protein Interaction.
Acs Chem.Biol., 10, 2015
4WH7
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BU of 4wh7 by Molmil
Structure of the CDC25B Phosphatase Catalytic Domain with Bound Ligand
Descriptor: 2-fluoro-4-hydroxybenzonitrile, GLYCEROL, M-phase inducer phosphatase 2, ...
Authors:Lund, G.L, Dudkin, S, Borkin, D, Ni, W, Grembecka, J, Cierpicki, T.
Deposit date:2014-09-20
Release date:2014-12-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Inhibition of CDC25B Phosphatase Through Disruption of Protein-Protein Interaction.
Acs Chem.Biol., 10, 2015
6WI7
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BU of 6wi7 by Molmil
RING1B-BMI1 fusion in closed conformation
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, E3 ubiquitin-protein ligase RING2, Polycomb complex protein BMI-1 chimera, ...
Authors:Cho, H.J, Cierpicki, T.
Deposit date:2020-04-08
Release date:2021-04-14
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.702 Å)
Cite:Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain.
Nat.Chem.Biol., 17, 2021
6WI8
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BU of 6wi8 by Molmil
Inhibitor compound-induced confrontational change in Ring1b-Bmi1 domain structure
Descriptor: E3 ubiquitin-protein ligase RING2,Polycomb complex protein BMI-1 chimera, ZINC ION
Authors:Cho, H.J, Cierpicki, T.
Deposit date:2020-04-09
Release date:2021-04-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.092 Å)
Cite:Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain.
Nat.Chem.Biol., 17, 2021
6WZW
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BU of 6wzw by Molmil
Ash1L SET domain in complex with AS-85
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Histone-lysine N-methyltransferase ASH1L, N-{[3-(3-carbamothioylphenyl)-1-{1-[(trifluoromethyl)sulfonyl]piperidin-4-yl}-1H-indol-6-yl]methyl}azetidine-3-carboxamide, ...
Authors:Li, H, Deng, J, Cierpicki, T, Grembecka, J.
Deposit date:2020-05-14
Release date:2021-04-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity.
Nat Commun, 12, 2021
6X0P
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BU of 6x0p by Molmil
Ash1L SET domain Q2265A mutant in complex with AS-5
Descriptor: 3-[6-(aminomethyl)-1-(2-hydroxyethyl)-1H-indol-3-yl]benzene-1-carbothioamide, Histone-lysine N-methyltransferase ASH1L, S-ADENOSYLMETHIONINE, ...
Authors:Rogawski, D.S, Li, H, Borkin, D, Cierpicki, T, Grembecka, J.
Deposit date:2020-05-17
Release date:2021-04-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity.
Nat Commun, 12, 2021
6BY8
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BU of 6by8 by Molmil
Menin in complex with MI-1482
Descriptor: 1,2-ETHANEDIOL, 4-methyl-1-{[(2R)-5-oxomorpholin-2-yl]methyl}-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile, DIMETHYL SULFOXIDE, ...
Authors:Borkin, T, Klossowski, S, Pollock, J, Linhares, B, Cierpicki, T, Grembecka, J.
Deposit date:2017-12-20
Release date:2018-11-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction.
J.Med.Chem., 61, 2018
4GQ3
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BU of 4gq3 by Molmil
Human menin with bound inhibitor MI-2
Descriptor: 4-[4-(5,5-dimethyl-4,5-dihydro-1,3-thiazol-2-yl)piperazin-1-yl]-6-propylthieno[2,3-d]pyrimidine, DI(HYDROXYETHYL)ETHER, Menin, ...
Authors:Shi, A, Murai, M.J, He, S, Lund, G.L, Hartley, T, Purohit, T, Reddy, G, Chruszcz, M, Grembecka, J, Cierpicki, T.
Deposit date:2012-08-22
Release date:2012-09-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.
Blood, 120, 2012
4GQ4
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BU of 4gq4 by Molmil
Human menin with bound inhibitor MI-2-2
Descriptor: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-[4-(5,5-dimethyl-4,5-dihydro-1,3-thiazol-2-yl)piperazin-1-yl]-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine, ...
Authors:Shi, A, Murai, M.J, He, S, Lund, G.L, Hartley, T, Purohit, T, Reddy, G, Chruszcz, M, Grembecka, J, Cierpicki, T.
Deposit date:2012-08-22
Release date:2012-09-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.
Blood, 120, 2012
4GQ6
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BU of 4gq6 by Molmil
Human menin in complex with MLL peptide
Descriptor: Histone-lysine N-methyltransferase MLL, Menin, PENTAETHYLENE GLYCOL, ...
Authors:Shi, A, Murai, M.J, He, S, Lund, G.L, Hartley, T, Purohit, T, Reddy, G, Chruszcz, M, Grembecka, J, Cierpicki, T.
Deposit date:2012-08-22
Release date:2012-09-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.
Blood, 120, 2012
4GPQ
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BU of 4gpq by Molmil
Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, Menin, ...
Authors:Shi, A, Murai, M.J, He, S, Lund, G.L, Hartley, T, Purohit, T, Reddy, G, Chruszcz, M, Grembecka, J, Cierpicki, T.
Deposit date:2012-08-21
Release date:2012-09-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.
Blood, 120, 2012
5VNA
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BU of 5vna by Molmil
Crystal structure of human YEATS domain
Descriptor: 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, SULFATE ION, ...
Authors:Cho, H.J, Cierpicki, T.
Deposit date:2017-04-29
Release date:2018-09-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding Mode.
ACS Chem. Biol., 13, 2018
5VNB
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BU of 5vnb by Molmil
YEATS in complex with histone H3
Descriptor: 1,2-ETHANEDIOL, H3K23acK27ac peptide, SULFATE ION, ...
Authors:Cho, H.J, Cierpicki, T.
Deposit date:2017-04-29
Release date:2018-09-05
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding Mode.
ACS Chem. Biol., 13, 2018

 

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