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1COM
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THE MONOFUNCTIONAL CHORISMATE MUTASE FROM BACILLUS SUBTILIS: STRUCTURE DETERMINATION OF CHORISMATE MUTASE AND ITS COMPLEXES WITH A TRANSITION STATE ANALOG AND PREPHENATE, AND IMPLICATIONS ON THE MECHANISM OF ENZYMATIC REACTION
分子名称:CHORISMATE MUTASE, PREPHENIC ACID
著者Chook, Y.M., Ke, H., Lipscomb, W.N.
登録日1994-04-08
公開日1994-06-22
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The monofunctional chorismate mutase from Bacillus subtilis. Structure determination of chorismate mutase and its complexes with a transition state analog and prephenate, and implications for the mechanism of the enzymatic reaction.
J.Mol.Biol., 240, 1994
1QBK
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STRUCTURE OF THE KARYOPHERIN BETA2-RAN GPPNHP NUCLEAR TRANSPORT COMPLEX
分子名称:KARYOPHERIN BETA2, RAN, MAGNESIUM ION, ...
著者Chook, Y.M., Blobel, G.
登録日1999-04-23
公開日1999-06-01
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp.
Nature, 399, 1999
2CHS
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CRYSTAL STRUCTURES OF THE MONOFUNCTIONAL CHORISMATE MUTASE FROM BACILLUS SUBTILIS AND ITS COMPLEX WITH A TRANSITION STATE ANALOG
分子名称:CHORISMATE MUTASE
著者Chook, Y.M., Ke, H., Lipscomb, W.N.
登録日1994-04-08
公開日1994-07-31
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structures of the monofunctional chorismate mutase from Bacillus subtilis and its complex with a transition state analog.
Proc.Natl.Acad.Sci.USA, 90, 1993
2CHT
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CRYSTAL STRUCTURES OF THE MONOFUNCTIONAL CHORISMATE MUTASE FROM BACILLUS SUBTILIS AND ITS COMPLEX WITH A TRANSITION STATE ANALOG
分子名称:CHORISMATE MUTASE, 8-HYDROXY-2-OXA-BICYCLO[3.3.1]NON-6-ENE-3,5-DICARBOXYLIC ACID
著者Chook, Y.M., Ke, H., Lipscomb, W.N.
登録日1994-04-08
公開日1994-07-31
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structures of the monofunctional chorismate mutase from Bacillus subtilis and its complex with a transition state analog.
Proc.Natl.Acad.Sci.USA, 90, 1993
2H4M
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KARYOPHERIN BETA2/TRANSPORTIN-M9NLS
分子名称:Transportin-1, Heterogeneous nuclear ribonucleoprotein A1
著者Chook, Y.M., Cansizoglu, A.E.
登録日2006-05-24
公開日2006-10-24
最終更新日2017-06-14
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Rules for nuclear localization sequence recognition by karyopherin beta 2.
Cell(Cambridge,Mass.), 126, 2006
4FDD
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CRYSTAL STRUCTURE OF KAP BETA2-PY-NLS
分子名称:Transportin-1, RNA-binding protein FUS
著者Zhang, Z.C., Chook, Y.M.
登録日2012-05-28
公開日2012-07-18
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS).
Proc.Natl.Acad.Sci.USA, 109, 2012
3GB8
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CRYSTAL STRUCTURE OF CRM1/SNURPORTIN-1 COMPLEX
分子名称:Exportin-1, Snurportin-1
著者Dong, X., Biswas, A., Suel, K.E., Jackson, L.K., Martinez, R., Gu, H., Chook, Y.M.
登録日2009-02-19
公開日2009-03-31
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis for leucine-rich nuclear export signal recognition by CRM1.
Nature, 458, 2009
2M4M
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SOLUTION STRUCTURE OF THE RRM DOMAIN OF THE HYPOTHETICAL PROTEIN CAGL0M09691G FROM CANDIDA GLABRATA
分子名称:hypothetical protein
著者Harris, R., Hillerich, B., Ahmed, M., Bonanno, J.B., Chamala, S., Evans, B., Lafleur, J., Hammonds, J., Washington, E., Stead, M., Love, J., Attonito, J., Patel, H., Seidel, R.D., Chook, Y.M., Rout, M.P., Girvin, M.E., Almo, S.C., New York Structural Genomics Research Consortium (NYSGRC), Nucleocytoplasmic Transport: a Target for Cellular Control (NPCXstals)
登録日2013-02-07
公開日2013-02-27
実験手法SOLUTION NMR
主引用文献Solution structure of the RRM domain of the hypothetical protein CAGL0M09691g from Candida glabrata
To be Published
2OT8
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KARYOPHERIN BETA2/TRANSPORTIN-HNRNPM NLS COMPLEX
分子名称:Transportin-1, Heterogeneous nuclear ribonucleoprotein M
著者Cansizoglu, A.E., Chook, Y.M.
登録日2007-02-07
公開日2007-04-10
最終更新日2017-08-02
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure-based design of a pathway-specific nuclear import inhibitor.
Nat.Struct.Mol.Biol., 14, 2007
2QMR
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KARYOPHERIN BETA2/TRANSPORTIN
分子名称:Transportin-1
著者Cansizoglu, A.E., Chook, Y.M.
登録日2007-07-16
公開日2007-10-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Conformational heterogeneity of karyopherin beta2 is segmental
Structure, 15, 2007
4GMX
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CRYSTAL STRUCTURE OF KPT185 IN COMPLEX WITH CRM1-RAN-RANBP1
分子名称:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
著者Sun, Q., Chook, Y.M.
登録日2012-08-16
公開日2012-10-17
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia.
Blood, 120, 2012
4GPT
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CRYSTAL STRUCTURE OF KPT251 IN COMPLEX WITH CRM1-RAN-RANBP1
分子名称:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
著者Sun, Q., Chook, Y.M.
登録日2012-08-21
公開日2012-09-05
最終更新日2013-01-23
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells.
Leukemia, 27, 2013
4HAT
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR LEPTOMYCIN B IN COMPLEX WITH CRM1-RAN-RANBP1
分子名称:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
著者Sun, Q., Chook, Y.M.
登録日2012-09-27
公開日2013-01-09
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HAU
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR RATJADONE A IN COMPLEX WITH CRM1-RAN-RANBP1
分子名称:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
著者Sun, Q., Chook, Y.M.
登録日2012-09-27
公開日2013-01-09
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HAV
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR ANGUINOMYCIN A IN COMPLEX WITH CRM1-RAN-RANBP1
分子名称:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
著者Sun, Q., Chook, Y.M.
登録日2012-09-27
公開日2013-01-09
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HAW
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR LEPTOMYCIN B IN COMPLEX WITH CRM1(K548A)-RAN-RANBP1
分子名称:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
著者Sun, Q., Chook, Y.M.
登録日2012-09-27
公開日2013-01-09
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HAX
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR RATJADONE A IN COMPLEX WITH CRM1(K579A)-RAN-RANBP1
分子名称:Exportin-1, GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, ...
著者Sun, Q., Chook, Y.M.
登録日2012-09-27
公開日2013-01-09
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HAY
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR LEPTOMYCIN B IN COMPLEX WITH CRM1(K548E,K579Q)-RAN-RANBP1
分子名称:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
著者Sun, Q., Chook, Y.M.
登録日2012-09-27
公開日2013-01-09
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HAZ
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR LEPTOMYCIN B IN COMPLEX WITH CRM1(R543S,K548E,K579Q)-RAN-RANBP1
分子名称:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
著者Sun, Q., Chook, Y.M.
登録日2012-09-27
公開日2013-01-09
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HB0
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR LEPTOMYCIN B IN COMPLEX WITH CRM1(K541Q,K542Q,R543S,K545Q,K548Q,K579Q)-RAN-RANBP1
分子名称:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
著者Sun, Q., Chook, Y.M.
登録日2012-09-27
公開日2013-01-09
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HB2
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CRYSTAL STRUCTURE OF CRM1-RAN-RANBP1
分子名称:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
著者Sun, Q., Chook, Y.M.
登録日2012-09-27
公開日2013-01-09
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HB3
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CRYSTAL STRUCTURE OF CRM1(T539S)-RAN-RANBP1 WITH WEAKLY BOUND UNMODELED LEPTOMYCIN B
分子名称:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
著者Sun, Q., Chook, Y.M.
登録日2012-09-27
公開日2013-01-09
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HB4
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR LEPTOMYCIN B IN COMPLEX WITH CRM1(537DLTVK541/GLCEQ)-RAN-RANBP1
分子名称:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
著者Sun, Q., Chook, Y.M.
登録日2012-09-27
公開日2013-01-09
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4JLQ
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CRYSTAL STRUCTURE OF HUMAN KARYOPHERIN-BETA2 BOUND TO THE PY-NLS OF SACCHAROMYCES CEREVISIAE NAB2
分子名称:Transportin-1, Nuclear polyadenylated RNA-binding protein NAB2
著者Sampathkumar, P., Gizzi, A., Rout, M.P., Chook, Y.M., Almo, S.C., New York Structural Genomics Research Consortium (NYSGRC), Nucleocytoplasmic Transport: a Target for Cellular Control (NPCXstals)
登録日2013-03-12
公開日2013-04-03
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Crystal structure of human Karyopherin beta 2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2.
J.Struct.Funct.Genom., 14, 2013
4OO6
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CRYSTAL STRUCTURE OF HUMAN KAP-BETA2 BOUND TO THE NLS OF HCC1 (HEPATO CELLULAR CARCINOMA PROTEIN 1)
分子名称:Transportin-1, RNA-binding protein 39
著者Sampathkumar, P., Brower, A., Soniat, M., Bonanno, J., Hillerich, B., Seidel, R.D., Rout, M.P., Chook, Y.M., Almo, S.C., New York Structural Genomics Research Consortium (NYSGRC), Nucleocytoplasmic Transport: a Target for Cellular Control (NPCXstals)
登録日2014-01-30
公開日2014-02-12
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma protein 1)
to be published
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