Author results

1COM
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THE MONOFUNCTIONAL CHORISMATE MUTASE FROM BACILLUS SUBTILIS: STRUCTURE DETERMINATION OF CHORISMATE MUTASE AND ITS COMPLEXES WITH A TRANSITION STATE ANALOG AND PREPHENATE, AND IMPLICATIONS ON THE MECHANISM OF ENZYMATIC REACTION
Descriptor:CHORISMATE MUTASE, PREPHENIC ACID
Authors:Chook, Y.M., Ke, H., Lipscomb, W.N.
Deposit date:1994-04-08
Release date:1994-06-22
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The monofunctional chorismate mutase from Bacillus subtilis. Structure determination of chorismate mutase and its complexes with a transition state analog and prephenate, and implications for the mechanism of the enzymatic reaction.
J.Mol.Biol., 240, 1994
1QBK
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STRUCTURE OF THE KARYOPHERIN BETA2-RAN GPPNHP NUCLEAR TRANSPORT COMPLEX
Descriptor:KARYOPHERIN BETA2, RAN, MAGNESIUM ION, ...
Authors:Chook, Y.M., Blobel, G.
Deposit date:1999-04-23
Release date:1999-06-01
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp.
Nature, 399, 1999
2CHS
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CRYSTAL STRUCTURES OF THE MONOFUNCTIONAL CHORISMATE MUTASE FROM BACILLUS SUBTILIS AND ITS COMPLEX WITH A TRANSITION STATE ANALOG
Descriptor:CHORISMATE MUTASE
Authors:Chook, Y.M., Ke, H., Lipscomb, W.N.
Deposit date:1994-04-08
Release date:1994-07-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of the monofunctional chorismate mutase from Bacillus subtilis and its complex with a transition state analog.
Proc.Natl.Acad.Sci.USA, 90, 1993
2CHT
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CRYSTAL STRUCTURES OF THE MONOFUNCTIONAL CHORISMATE MUTASE FROM BACILLUS SUBTILIS AND ITS COMPLEX WITH A TRANSITION STATE ANALOG
Descriptor:CHORISMATE MUTASE, 8-HYDROXY-2-OXA-BICYCLO[3.3.1]NON-6-ENE-3,5-DICARBOXYLIC ACID
Authors:Chook, Y.M., Ke, H., Lipscomb, W.N.
Deposit date:1994-04-08
Release date:1994-07-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of the monofunctional chorismate mutase from Bacillus subtilis and its complex with a transition state analog.
Proc.Natl.Acad.Sci.USA, 90, 1993
2H4M
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KARYOPHERIN BETA2/TRANSPORTIN-M9NLS
Descriptor:Transportin-1, Heterogeneous nuclear ribonucleoprotein A1
Authors:Chook, Y.M., Cansizoglu, A.E.
Deposit date:2006-05-24
Release date:2006-10-24
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Rules for nuclear localization sequence recognition by karyopherin beta 2.
Cell(Cambridge,Mass.), 126, 2006
4FDD
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CRYSTAL STRUCTURE OF KAP BETA2-PY-NLS
Descriptor:Transportin-1, RNA-binding protein FUS
Authors:Zhang, Z.C., Chook, Y.M.
Deposit date:2012-05-28
Release date:2012-07-18
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS).
Proc.Natl.Acad.Sci.USA, 109, 2012
3GB8
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CRYSTAL STRUCTURE OF CRM1/SNURPORTIN-1 COMPLEX
Descriptor:Exportin-1, Snurportin-1
Authors:Dong, X., Biswas, A., Suel, K.E., Jackson, L.K., Martinez, R., Gu, H., Chook, Y.M.
Deposit date:2009-02-19
Release date:2009-03-31
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for leucine-rich nuclear export signal recognition by CRM1.
Nature, 458, 2009
2M4M
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SOLUTION STRUCTURE OF THE RRM DOMAIN OF THE HYPOTHETICAL PROTEIN CAGL0M09691G FROM CANDIDA GLABRATA
Descriptor:hypothetical protein
Authors:Harris, R., Hillerich, B., Ahmed, M., Bonanno, J.B., Chamala, S., Evans, B., Lafleur, J., Hammonds, J., Washington, E., Stead, M., Love, J., Attonito, J., Patel, H., Seidel, R.D., Chook, Y.M., Rout, M.P., Girvin, M.E., Almo, S.C., New York Structural Genomics Research Consortium (NYSGRC), Nucleocytoplasmic Transport: a Target for Cellular Control (NPCXstals)
Deposit date:2013-02-07
Release date:2013-02-27
Method:SOLUTION NMR
Cite:Solution structure of the RRM domain of the hypothetical protein CAGL0M09691g from Candida glabrata
To be Published
2OT8
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KARYOPHERIN BETA2/TRANSPORTIN-HNRNPM NLS COMPLEX
Descriptor:Transportin-1, Heterogeneous nuclear ribonucleoprotein M
Authors:Cansizoglu, A.E., Chook, Y.M.
Deposit date:2007-02-07
Release date:2007-04-10
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-based design of a pathway-specific nuclear import inhibitor.
Nat.Struct.Mol.Biol., 14, 2007
2QMR
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KARYOPHERIN BETA2/TRANSPORTIN
Descriptor:Transportin-1
Authors:Cansizoglu, A.E., Chook, Y.M.
Deposit date:2007-07-16
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Conformational heterogeneity of karyopherin beta2 is segmental
Structure, 15, 2007
4GMX
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CRYSTAL STRUCTURE OF KPT185 IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-08-16
Release date:2012-10-17
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia.
Blood, 120, 2012
4GPT
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CRYSTAL STRUCTURE OF KPT251 IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-08-21
Release date:2012-09-05
Last modified:2013-01-23
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells.
Leukemia, 27, 2013
4HAT
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR LEPTOMYCIN B IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-09-27
Release date:2013-01-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HAU
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR RATJADONE A IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-09-27
Release date:2013-01-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HAV
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR ANGUINOMYCIN A IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-09-27
Release date:2013-01-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HAW
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR LEPTOMYCIN B IN COMPLEX WITH CRM1(K548A)-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-09-27
Release date:2013-01-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HAX
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR RATJADONE A IN COMPLEX WITH CRM1(K579A)-RAN-RANBP1
Descriptor:Exportin-1, GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-09-27
Release date:2013-01-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HAY
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR LEPTOMYCIN B IN COMPLEX WITH CRM1(K548E,K579Q)-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-09-27
Release date:2013-01-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HAZ
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR LEPTOMYCIN B IN COMPLEX WITH CRM1(R543S,K548E,K579Q)-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-09-27
Release date:2013-01-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HB0
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR LEPTOMYCIN B IN COMPLEX WITH CRM1(K541Q,K542Q,R543S,K545Q,K548Q,K579Q)-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-09-27
Release date:2013-01-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HB2
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CRYSTAL STRUCTURE OF CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-09-27
Release date:2013-01-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HB3
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CRYSTAL STRUCTURE OF CRM1(T539S)-RAN-RANBP1 WITH WEAKLY BOUND UNMODELED LEPTOMYCIN B
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-09-27
Release date:2013-01-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HB4
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CRYSTAL STRUCTURE OF CRM1 INHIBITOR LEPTOMYCIN B IN COMPLEX WITH CRM1(537DLTVK541/GLCEQ)-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Sun, Q., Chook, Y.M.
Deposit date:2012-09-27
Release date:2013-01-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4JLQ
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CRYSTAL STRUCTURE OF HUMAN KARYOPHERIN-BETA2 BOUND TO THE PY-NLS OF SACCHAROMYCES CEREVISIAE NAB2
Descriptor:Transportin-1, Nuclear polyadenylated RNA-binding protein NAB2
Authors:Sampathkumar, P., Gizzi, A., Rout, M.P., Chook, Y.M., Almo, S.C., New York Structural Genomics Research Consortium (NYSGRC), Nucleocytoplasmic Transport: a Target for Cellular Control (NPCXstals)
Deposit date:2013-03-12
Release date:2013-04-03
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Crystal structure of human Karyopherin beta 2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2.
J.Struct.Funct.Genom., 14, 2013
4OO6
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CRYSTAL STRUCTURE OF HUMAN KAP-BETA2 BOUND TO THE NLS OF HCC1 (HEPATO CELLULAR CARCINOMA PROTEIN 1)
Descriptor:Transportin-1, RNA-binding protein 39
Authors:Sampathkumar, P., Brower, A., Soniat, M., Bonanno, J., Hillerich, B., Seidel, R.D., Rout, M.P., Chook, Y.M., Almo, S.C., New York Structural Genomics Research Consortium (NYSGRC), Nucleocytoplasmic Transport: a Target for Cellular Control (NPCXstals)
Deposit date:2014-01-30
Release date:2014-02-12
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma protein 1)
to be published
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