Author results

4O67
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HUMAN CYCLIC GMP-AMP SYNTHASE (CGAS) IN COMPLEX WITH GAMP
Descriptor:Cyclic GMP-AMP synthase, cGAMP, ZINC ION
Authors:Zhang, X., Chen, Z., Zhang, X.W., Chen, Z.J.
Deposit date:2013-12-20
Release date:2014-02-05
Last modified:2015-08-05
Method:X-RAY DIFFRACTION (2.444 Å)
Cite:The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop.
Cell Rep, 6, 2014
4O68
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STRUCTURE OF HUMAN CYCLIC GMP-AMP SYNTHASE (CGAS)
Descriptor:Cyclic GMP-AMP synthase, ZINC ION
Authors:Zhang, X., Chen, Z., Zhang, X.W., Chen, Z.J.
Deposit date:2013-12-20
Release date:2014-02-05
Last modified:2014-03-05
Method:X-RAY DIFFRACTION (2.436 Å)
Cite:The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop.
Cell Rep, 6, 2014
4O69
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HUMAN CYCLIC GMP-AMP SYNTHASE (CGAS) IN COMPLEX WITH SULFATE ION
Descriptor:Cyclic GMP-AMP synthase, ZINC ION, SULFATE ION
Authors:Zhang, X., Chen, Z., Zhang, X.W., Chen, Z.J.
Deposit date:2013-12-20
Release date:2014-02-05
Last modified:2014-03-05
Method:X-RAY DIFFRACTION (2.252 Å)
Cite:The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop.
Cell Rep, 6, 2014
4O6A
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MOUSE CYCLIC GMP-AMP SYNTHASE (CGAS) IN COMPLEX WITH DNA
Descriptor:Cyclic GMP-AMP synthase, DNA1, DNA2, ...
Authors:Zhang, X., Chen, Z., Zhang, X.W., Chen, Z.J.
Deposit date:2013-12-20
Release date:2014-02-05
Last modified:2014-03-05
Method:X-RAY DIFFRACTION (1.859 Å)
Cite:The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop.
Cell Rep, 6, 2014
5BQX
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CRYSTAL STRUCTURE OF HUMAN STING IN COMPLEX WITH 3'2'-CGAMP
Descriptor:Stimulator of interferon genes protein, 3'2'-cGAMP
Authors:Wu, J., Zhang, X., Chen, Z.J., Chen, C.
Deposit date:2015-05-29
Release date:2015-06-24
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING.
Proc.Natl.Acad.Sci.USA, 112, 2015
4KSY
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CRYSTAL STRUCTURE OF STING IN COMPLEX WITH CGAMP
Descriptor:Stimulator of interferon genes protein, cGAMP
Authors:Zhang, X., Chen, Z.J., Zhang, X.W.
Deposit date:2013-05-18
Release date:2013-06-12
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.881 Å)
Cite:Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING.
Mol.Cell, 51, 2013
3J6C
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CRYO-EM STRUCTURE OF MAVS CARD FILAMENT
Descriptor:Mitochondrial antiviral-signaling protein
Authors:Xu, H., He, X., Zheng, H., Huang, L.J., Hou, F., Yu, Z., de la Cruz, M.J., Borkowski, B., Zhang, X., Chen, Z.J., Jiang, Q.-X.
Deposit date:2014-02-04
Release date:2014-03-05
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (9.6 Å)
Cite:Structural basis for the prion-like MAVS filaments in antiviral innate immunity.
Elife, 3, 2014
6NT5
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CRYO-EM STRUCTURE OF FULL-LENGTH HUMAN STING IN THE APO STATE
Descriptor:Stimulator of interferon protein
Authors:Shang, G., Zhang, C., Chen, Z.J., Bai, X., Zhang, X.
Deposit date:2019-01-28
Release date:2019-03-06
Last modified:2019-04-03
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.
Nature, 567, 2019
6NT6
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CRYO-EM STRUCTURE OF FULL-LENGTH CHICKEN STING IN THE APO STATE
Descriptor:Stimulator of interferon genes protein
Authors:Shang, G., Zhang, C., Chen, Z.J., Bai, X., Zhang, X.
Deposit date:2019-01-28
Release date:2019-03-06
Last modified:2019-04-03
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.
Nature, 567, 2019
6NT7
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CRYO-EM STRUCTURE OF FULL-LENGTH CHICKEN STING IN THE CGAMP-BOUND DIMERIC STATE
Descriptor:Stimulator of interferon genes protein, cGAMP
Authors:Shang, G., Zhang, C., Chen, Z.J., Bai, X., Zhang, X.
Deposit date:2019-01-28
Release date:2019-03-06
Last modified:2019-04-03
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.
Nature, 567, 2019
6NT8
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CRYO-EM STRUCTURE OF FULL-LENGTH CHICKEN STING IN THE CGAMP-BOUND TETRAMERIC STATE
Descriptor:Stimulator of interferon genes protein, cGAMP
Authors:Shang, G., Zhang, C., Chen, Z.J., Bai, X., Zhang, X.
Deposit date:2019-01-28
Release date:2019-03-06
Last modified:2019-04-03
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.
Nature, 567, 2019
6NT9
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CRYO-EM STRUCTURE OF THE COMPLEX BETWEEN HUMAN TBK1 AND CHICKEN STING
Descriptor:Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein
Authors:Shang, G., Zhang, C., Chen, Z.J., Bai, X., Zhang, X.
Deposit date:2019-01-28
Release date:2019-03-06
Last modified:2019-04-03
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis of STING binding with and phosphorylation by TBK1.
Nature, 567, 2019
2VCY
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CRYSTAL STRUCTURE OF 2-ENOYL THIOESTER REDUCTASE OF HUMAN FAS II
Descriptor:TRANS-2-ENOYL-COA REDUCTASE, SULFATE ION
Authors:Haapalainen, A.M., Pudas, R., Smart, O.S., Wierenga, R.K.
Deposit date:2007-09-28
Release date:2008-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Structural Enzymological Studies of 2-Enoyl Thioester Reductase of the Human Mitochondrial Fas II Pathway: New Insights Into its Substrate Recognition Properties.
J.Mol.Biol., 379, 2008
6JFW
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CRYSTAL STRUCTURE OF PA0833 PERIPLASMIC DOMAIN FROM PSEUDOMONAS AERUGINOSA REVEALS AN UNEXPECTED ENLARGED PEPTIDOGLYCAN BINDING POCKET
Descriptor:PA0833-PD protein
Authors:Lin, X., Ye, F., Lin, S., Yang, F.L., Chen, Z.M., Cao, Y., Chen, Z.J., Gu, J., Lu, G.W.
Deposit date:2019-02-12
Release date:2019-03-20
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Crystal structure of PA0833 periplasmic domain from Pseudomonas aeruginosa reveals an unexpected enlarged peptidoglycan binding pocket.
Biochem. Biophys. Res. Commun., 511, 2019
4JBO
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NOVEL AURORA KINASE INHIBITORS REVEAL MECHANISMS OF HURP IN NUCLEATION OF CENTROSOMAL AND KINETOCHORE MICROTUBULES
Descriptor:Aurora kinase A, 1-(4-{2-[(6-{4-[2-(dimethylamino)ethoxy]phenyl}furo[2,3-d]pyrimidin-4-yl)amino]ethyl}phenyl)-3-phenylurea
Authors:Wu, J.S., Leou, J.S., Peng, Y.H., Hsueh, C.C., Hsieh, H.P., Wu, S.Y.
Deposit date:2013-02-20
Release date:2013-06-05
Method:X-RAY DIFFRACTION (2.493 Å)
Cite:Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules.
Proc.Natl.Acad.Sci.USA, 110, 2013
4JBP
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NOVEL AURORA KINASE INHIBITORS REVEAL MECHANISMS OF HURP IN NUCLEATION OF CENTROSOMAL AND KINETOCHORE MICROTUBULES
Descriptor:Aurora Kinase A, 1-(4-{2-[(6-{4-[2-(4-hydroxypiperidin-1-yl)ethoxy]phenyl}furo[2,3-d]pyrimidin-4-yl)amino]ethyl}phenyl)-3-phenylurea
Authors:Wu, J.S., Leou, J.S., Peng, Y.H., Hsueh, C.C., Hsieh, H.P., Wu, S.Y.
Deposit date:2013-02-20
Release date:2013-06-05
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules.
Proc.Natl.Acad.Sci.USA, 110, 2013
4JBQ
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NOVEL AURORA KINASE INHIBITORS REVEAL MECHANISMS OF HURP IN NUCLEATION OF CENTROSOMAL AND KINETOCHORE MICROTUBULES
Descriptor:Aurora Kinase A, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE
Authors:Wu, J.S., Leou, J.S., Peng, Y.H., Hsueh, C.C., Hsieh, H.P., Wu, S.Y.
Deposit date:2013-02-20
Release date:2013-06-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules.
Proc.Natl.Acad.Sci.USA, 110, 2013
6D3S
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THERMOSTABILIZED PHOSPHORYLATED CHICKEN CFTR
Descriptor:Cystic fibrosis transmembrane conductance regulator, ADENOSINE-5'-TRIPHOSPHATE
Authors:Fay, J.F., Riordan, J.R., Chen, Z.J.
Deposit date:2018-04-16
Release date:2018-10-17
Last modified:2018-11-07
Method:ELECTRON MICROSCOPY (6.6 Å)
Cite:Cryo-EM Visualization of an Active High Open Probability CFTR Anion Channel.
Biochemistry, 57, 2018
6N34
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CRYSTAL STRUCTURE OF THE BTB DOMAIN OF HUMAN NS1-BP
Descriptor:Influenza virus NS1A-binding protein
Authors:Zhang, K., Shang, G., Padavannil, A., Fontoura, B., Chook, Y.M.
Deposit date:2018-11-14
Release date:2018-12-12
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6N3H
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CRYSTAL STRUCTURE OF KELCH DOMAIN OF THE HUMAN NS1 BINDING PROTEIN
Descriptor:Influenza virus NS1A-binding protein
Authors:Zhang, K., Shang, G., Padavannil, A., Fontoura, B.M.A., Chook, Y.M.
Deposit date:2018-11-15
Release date:2018-12-12
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4F9E
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CYCLIC DI-GMP SENSING VIA THE INNATE IMMUNE SIGNALING PROTEIN STING
Descriptor:Transmembrane protein 173
Authors:Kabaleeswaran, V., Wu, H.
Deposit date:2012-05-18
Release date:2012-07-25
Last modified:2014-01-01
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING.
Mol.Cell, 46, 2012
4F9G
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CRYSTAL STRUCTURE OF STING COMPLEX WITH CYCLIC DI-GMP.
Descriptor:Transmembrane protein 173, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)
Authors:Kabaleeswaran, V., Wu, H.
Deposit date:2012-05-18
Release date:2012-07-25
Last modified:2014-01-01
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING.
Mol.Cell, 46, 2012
4NQK
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STRUCTURE OF AN UBIQUITIN COMPLEX
Descriptor:Probable ATP-dependent RNA helicase DDX58, Ubiquitin
Authors:Peisley, A., Wu, B., Hur, S.
Deposit date:2013-11-25
Release date:2014-03-05
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I.
Nature, 509, 2014
4O9F
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CRYSTAL STRUCTURE OF HORSE MAVS CARD DOMAIN MUTANT R64C
Descriptor:mitochondrial antiviral signaling protein (MAVS)
Authors:Zhang, X., He, X.
Deposit date:2014-01-02
Release date:2014-03-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.348 Å)
Cite:Structural basis for the prion-like MAVS filaments in antiviral innate immunity.
Elife, 3, 2014
4O9L
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CRYSTAL STRUCTURE OF HORSE MAVS CARD DOMAIN MUTANT E26R
Descriptor:mitochondrial antiviral signaling protein (MAVS)
Authors:Zhang, X., He, X.
Deposit date:2014-01-02
Release date:2014-03-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.944 Å)
Cite:Structural basis for the prion-like MAVS filaments in antiviral innate immunity.
Elife, 3, 2014