Author results

6OCE
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STRUCTURE OF THE RICE HYPEROSMOLALITY-GATED ION CHANNEL OSCA1.2
Descriptor:stress-gated cation channel 1.2
Authors:Maity, K., Heumann, J.M., McGrath, A.P., Chang, G., Stowell, M.H.
Deposit date:2019-03-23
Release date:2019-07-03
Last modified:2019-07-24
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Cryo-EM structure of OSCA1.2 fromOryza sativaelucidates the mechanical basis of potential membrane hyperosmolality gating.
Proc.Natl.Acad.Sci.USA, 116, 2019
6MYV
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SIALIDASE26 CO-CRYSTALLIZED WITH DANA-GC
Descriptor:Sialidase26, 2,6-anhydro-3,5-dideoxy-5-[(hydroxyacetyl)amino]-D-glycero-L-altro-non-2-enonic acid
Authors:Zaramela, L.S., Martino, C., Alisson-Silva, F., Rees, S.D., Diaz, S.L., Chuzel, L., Ganatra, M.B., Taron, C.H., Zuniga, C., Huang, J., Siegel, D., Chang, G., Varki, A., Zengler, K.
Deposit date:2018-11-02
Release date:2019-10-02
Last modified:2019-10-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates.
Nat Microbiol, 2019
6MRX
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SIALIDASE26 APO
Descriptor:Sialidase26
Authors:Zaramela, L.S., Martino, C., Alisson-Silva, F., Rees, S.D., Diaz, S.L., Chuzel, L., Ganatra, M.B., Taron, C.H., Zuniga, C., Chang, G., Varki, A., Zengler, K.
Deposit date:2018-10-15
Release date:2019-10-02
Last modified:2019-10-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates.
Nat Microbiol, 2019
6MRV
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SIALIDASE26 CO-CRYSTALLIZED WITH DANA
Descriptor:Sialidase26, 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID
Authors:Zaramela, L.S., Martino, C., Alisson-Silva, F., Rees, S.D., Diaz, S.L., Chuzel, L., Ganatra, M.B., Taron, C.H., Zuniga, C., Chang, G., Varki, A., Zengler, K.
Deposit date:2018-10-15
Release date:2019-10-02
Last modified:2019-10-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates.
Nat Microbiol, 2019
6MNJ
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HADZA MICROBIAL SIALIDASE HZ136
Descriptor:Hz136
Authors:Rees, S.D., Zaramela, L., Zengler, K., Chang, G.
Deposit date:2018-10-01
Release date:2019-10-02
Last modified:2019-10-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates.
Nat Microbiol, 2019
6MHF
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GALPHAI3 CO-CRYSTALLIZED WITH GIV/GIRDIN
Descriptor:Guanine nucleotide-binding protein G(k) subunit alpha, Girdin, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Rees, S.D., Kalogriopoulos, N.A., Ngo, T., Kopcho, N., Ilatovskiy, A., Sun, N., Komives, E., Chang, G., Ghosh, P., Kufareva, I.
Deposit date:2018-09-17
Release date:2019-07-31
Last modified:2019-08-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for GPCR-independent activation of heterotrimeric Gi proteins.
Proc.Natl.Acad.Sci.USA, 116, 2019
6MHE
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GALPHAI3 CO-CRYSTALLIZED WITH KB752
Descriptor:Guanine nucleotide-binding protein G(k) subunit alpha, KB752 peptide, GLYCEROL, ...
Authors:Rees, S.D., Kalogriopoulos, N.A., Ngo, T., Kopcho, N., Ilatovskiy, A., Sun, N., Komives, E., Chang, G., Ghosh, P., Kufareva, I.
Deposit date:2018-09-17
Release date:2019-07-31
Last modified:2019-08-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for GPCR-independent activation of heterotrimeric Gi proteins.
Proc.Natl.Acad.Sci.USA, 116, 2019
4XWK
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P-GLYCOPROTEIN CO-CRYSTALLIZED WITH BDE-100
Descriptor:Multidrug resistance protein 1A, 2,4-dibromophenyl 2,4,6-tribromophenyl ether
Authors:McGrath, A.P., Rees, S.D., Chang, G.
Deposit date:2015-01-28
Release date:2016-04-27
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure.
Sci Adv, 2, 2016
4Q9L
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P-GLYCOPROTEIN COCRYSTALLISED WITH QZ-PHE
Descriptor:Multidrug resistance protein 1A, (30F)F(30F)F(30F)F Peptide
Authors:McGrath, A.P., Szewczyk, P., Chang, G.
Deposit date:2014-05-01
Release date:2015-03-04
Last modified:2016-05-25
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein.
Acta Crystallogr.,Sect.D, 71, 2015
4Q9K
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P-GLYCOPROTEIN COCRYSTALLISED WITH QZ-LEU
Descriptor:Multidrug resistance protein 1A, (30F)L(30F)L(30F)L Peptide
Authors:McGrath, A.P., Szewczyk, P., Chang, G.
Deposit date:2014-05-01
Release date:2015-03-04
Last modified:2016-05-25
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein.
Acta Crystallogr.,Sect.D, 71, 2015
4Q9J
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P-GLYCOPROTEIN COCRYSTALLISED WITH QZ-VAL
Descriptor:Multidrug resistance protein 1A, N-{[5-AMINO-1-(5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-1H-IMIDAZOL-4-YL]CARBONYL}-L-ASPARTIC ACID
Authors:McGrath, A.P., Szewczyk, P., Chang, G.
Deposit date:2014-05-01
Release date:2015-03-04
Last modified:2015-03-18
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein.
Acta Crystallogr.,Sect.D, 71, 2015
4Q9I
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P-GLYCOPROTEIN COCRYSTALLISED WITH QZ-ALA
Descriptor:Multidrug resistance protein 1A, (30F)A(30F)A(30F)A Peptide
Authors:McGrath, A.P., Szewczyk, P., Chang, G.
Deposit date:2014-05-01
Release date:2015-03-04
Last modified:2016-05-25
Method:X-RAY DIFFRACTION (3.781 Å)
Cite:Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein.
Acta Crystallogr.,Sect.D, 71, 2015
4Q9H
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P-GLYCOPROTEIN AT 3.4 A RESOLUTION
Descriptor:Multidrug resistance protein 1A
Authors:McGrath, A.P., Szewczyk, P., Chang, G.
Deposit date:2014-05-01
Release date:2015-03-04
Last modified:2015-03-18
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein.
Acta Crystallogr.,Sect.D, 71, 2015
4LSG
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STRUCTURE OF MOUSE P-GLYCOPROTEIN
Descriptor:Multidrug resistance protein 1A, MERCURY (II) ION
Authors:Chang, G., Szewczyk, P.
Deposit date:2013-07-22
Release date:2013-07-31
Last modified:2013-08-07
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:

4KSD
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STRUCTURES OF P-GLYCOPROTEIN REVEAL ITS CONFORMATIONAL FLEXIBILITY AND AN EPITOPE ON THE NUCLEOTIDE-BINDING DOMAIN
Descriptor:Multidrug resistance protein 1A, R2 protein
Authors:Ward, A., Szewczyk, P., Grimard, V., Lee, C.-W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., Swartz, D.J., Falson, P., Urbatsch, I., Govaerts, C., Steyaert, J., Chang, G.
Deposit date:2013-05-17
Release date:2013-07-31
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (4.1001 Å)
Cite:Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013
4KSC
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STRUCTURES OF P-GLYCOPROTEIN REVEAL ITS CONFORMATIONAL FLEXIBILITY AND AN EPITOPE ON THE NUCLEOTIDE-BINDING DOMAIN
Descriptor:Multidrug resistance protein 1A
Authors:Ward, A., Szewczyk, P., Grimard, V., Lee, C.-W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., Swartz, D.J., Falson, P., Urbatsch, I., Govaerts, C., Steyaert, J., Chang, G.
Deposit date:2013-05-17
Release date:2013-07-31
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013
4KSB
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STRUCTURES OF P-GLYCOPROTEIN REVEAL ITS CONFORMATIONAL FLEXIBILITY AND AN EPITOPE ON THE NUCLEOTIDE-BINDING DOMAIN
Descriptor:Multidrug resistance protein 1A
Authors:Ward, A., Szewczyk, P., Grimard, V., Lee, C.-W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., Swartz, D.J., Falson, P., Urbatsch, I., Govaerts, C., Steyaert, J., Chang, G.
Deposit date:2013-05-17
Release date:2013-07-31
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (3.8001 Å)
Cite:Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013
3MKU
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STRUCTURE OF A CATION-BOUND MULTIDRUG AND TOXIN COMPOUND EXTRUSION (MATE) TRANSPORTER
Descriptor:Multi antimicrobial extrusion protein (Na(+)/drug antiporter) MATE-like MDR efflux pump, RUBIDIUM ION
Authors:He, X., Szewczyk, P., Karyakin, A., Evin, M., Hong, W.-X., Zhang, Q., Chang, G.
Deposit date:2010-04-15
Release date:2010-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Structure of a cation-bound multidrug and toxic compound extrusion transporter.
Nature, 467, 2010
3MKT
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STRUCTURE OF A CATION-BOUND MULTIDRUG AND TOXIN COMPOUND EXTRUSION (MATE) TRANSPORTER
Descriptor:Multi antimicrobial extrusion protein (Na(+)/drug antiporter) MATE-like MDR efflux pump
Authors:He, X., Szewczyk, P., Karyakin, A., Evin, M., Hong, W.-X., Zhang, Q., Chang, G.
Deposit date:2010-04-15
Release date:2010-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Structure of a cation-bound multidrug and toxic compound extrusion transporter.
Nature, 467, 2010
3G61
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STRUCTURE OF P-GLYCOPROTEIN REVEALS A MOLECULAR BASIS FOR POLY-SPECIFIC DRUG BINDING
Descriptor:Multidrug resistance protein 1a, (4S,11S,18S)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione
Authors:Aller, S.G., Yu, J., Ward, A., Weng, Y., Chittaboina, S., Zhuo, R., Harrell, P.M., Trinh, Y.T., Zhang, Q., Urbatsch, I.L., Chang, G.
Deposit date:2009-02-05
Release date:2009-03-24
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (4.35 Å)
Cite:Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.
Science, 323, 2009
3G60
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STRUCTURE OF P-GLYCOPROTEIN REVEALS A MOLECULAR BASIS FOR POLY-SPECIFIC DRUG BINDING
Descriptor:Multidrug resistance protein 1a, (4R,11R,18R)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione
Authors:Aller, S.G., Yu, J., Ward, A., Weng, Y., Chittaboina, S., Zhuo, R., Harrell, P.M., Trinh, Y.T., Zhang, Q., Urbatsch, I.L., Chang, G.
Deposit date:2009-02-05
Release date:2009-03-24
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (4.4 Å)
Cite:Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.
Science, 323, 2009
3G5U
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STRUCTURE OF P-GLYCOPROTEIN REVEALS A MOLECULAR BASIS FOR POLY-SPECIFIC DRUG BINDING
Descriptor:Multidrug resistance protein 1a, MERCURY (II) ION
Authors:Aller, S.G., Yu, J., Ward, A., Weng, Y., Chittaboina, S., Zhuo, R., Harrell, P.M., Trinh, Y.T., Zhang, Q., Urbatsch, I.L., Chang, G.
Deposit date:2009-02-05
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.
Science, 323, 2009
3B62
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EMRE MULTIDRUG TRANSPORTER IN COMPLEX WITH P4P, P21 CRYSTAL FORM
Descriptor:Multidrug transporter emrE, TETRAPHENYLPHOSPHONIUM
Authors:Chang, G., Chen, Y.J.
Deposit date:2007-10-26
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4.4 Å)
Cite:X-ray structure of EmrE supports dual topology model.
Proc.Natl.Acad.Sci.Usa, 104, 2007
3B61
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EMRE MULTIDRUG TRANSPORTER, APO CRYSTAL FORM
Descriptor:Multidrug transporter emrE
Authors:Chang, G., Chen, Y.J.
Deposit date:2007-10-26
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:X-ray structure of EmrE supports dual topology model.
Proc.Natl.Acad.Sci.Usa, 104, 2007
3B60
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CRYSTAL STRUCTURE OF MSBA FROM SALMONELLA TYPHIMURIUM WITH AMPPNP, HIGHER RESOLUTION FORM
Descriptor:Lipid A export ATP-binding/permease protein msbA, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Ward, A., Reyes, C.L., Yu, J., Roth, C.B., Chang, G.
Deposit date:2007-10-26
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Flexibility in the ABC transporter MsbA: Alternating access with a twist.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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