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5H02
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CRYSTAL STRUCTURE OF METHANOHALOPHILUS PORTUCALENSIS GLYCINE SARCOSINE N-METHYLTRANSFERASE TETRAMUTANT (H21G, E23T, E24N, L28S)
Descriptor:Glycine sarcosine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, TRIMETHYL GLYCINE
Authors:Lee, Y.R., Lin, T.S., Lai, S.J., Liu, M.S., Lai, M.C., Chan, N.L.
Deposit date:2016-10-02
Release date:2016-11-23
Last modified:2017-01-18
Method:X-RAY DIFFRACTION (1.776 Å)
Cite:Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity.
Sci Rep, 6, 2016
1BUW
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CRYSTAL STRUCTURE OF S-NITROSO-NITROSYL HUMAN HEMOGLOBIN A
Descriptor:PROTEIN (HEMOGLOBIN), PROTOPORPHYRIN IX CONTAINING FE, NITRIC OXIDE
Authors:Chan, N.-L., Rogers, P.H., Arnone, A.
Deposit date:1998-09-06
Release date:1998-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the S-nitroso form of liganded human hemoglobin.
Biochemistry, 37, 1998
5HII
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CRYSTAL STRUCTURE OF GLYCINE SARCOSINE N-METHYLTRANSFERASE (GSMT) FROM METHANOHALOPHILUS PORTUCALENSIS (APO FORM)
Descriptor:Glycine sarcosine N-methyltransferase, 1,2-ETHANEDIOL
Authors:Lee, Y.R., Lin, T.S., Lai, S.J., Liu, M.S., Lai, M.C., Chan, N.L.
Deposit date:2016-01-12
Release date:2016-11-23
Last modified:2017-01-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
Sci Rep, 6, 2016
1RQ3
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CRYSTALLOGRAPHIC ANALYSIS OF THE INTERACTION OF NITRIC OXIDE WITH QUATERNARY-T HUMAN DEOXYHEMOGLOBIN, DEOXYHEMOGLOBIN
Descriptor:Hemoglobin alpha chain, Hemoglobin beta chain, PROTOPORPHYRIN IX CONTAINING FE
Authors:Chan, N.L., Kavanaugh, J.S., Rogers, P.H., Arnone, A.
Deposit date:2003-12-04
Release date:2003-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Crystallographic analysis of the interaction of nitric oxide with quaternary-T human hemoglobin.
Biochemistry, 43, 2004
5HIJ
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CRYSTAL STRUCTURE OF GLYCINE SARCOSINE N-METHYLTRANSFERASE FROM METHANOHALOPHILUS PORTUCALENSIS IN COMPLEX WITH BETAINE
Descriptor:Glycine sarcosine N-methyltransferase, TRIMETHYL GLYCINE
Authors:Lee, Y.R., Lin, T.S., Lai, S.J., Liu, M.S., Lai, M.C., Chan, N.L.
Deposit date:2016-01-12
Release date:2016-11-23
Last modified:2017-01-18
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
Sci Rep, 6, 2016
5Y7R
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QUATERNARY COMPLEX OF ASQJ-FE3+-2OG-CYCLOPEPTIN
Descriptor:Iron/alpha-ketoglutarate-dependent dioxygenase asqJ, FE (III) ION, 2-OXOGLUTARIC ACID, ...
Authors:Liao, H.J., Lin, T.S.
Deposit date:2017-08-17
Release date:2018-01-24
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Insights into the Desaturation of Cyclopeptin and its C3 Epimer Catalyzed by a non-Heme Iron Enzyme: Structural Characterization and Mechanism Elucidation.
Angew. Chem. Int. Ed. Engl., 57, 2018
5Y7T
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QUATERNARY COMPLEX OF ASQJ-FE3+-2OG-D-CYCLOPEPTIN
Descriptor:Iron/alpha-ketoglutarate-dependent dioxygenase asqJ, FE (III) ION, (3R)-4-methyl-3-(phenylmethyl)-1,3-dihydro-1,4-benzodiazepine-2,5-dione, ...
Authors:Liao, H.J.
Deposit date:2017-08-18
Release date:2018-01-24
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Insights into the Desaturation of Cyclopeptin and its C3 Epimer Catalyzed by a non-Heme Iron Enzyme: Structural Characterization and Mechanism Elucidation.
Angew. Chem. Int. Ed. Engl., 57, 2018
1RQ4
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CRYSTALLOGRAPHIC ANALYSIS OF THE INTERACTION OF NITRIC OXIDE WITH QUATERNARY-T HUMAN HEMOGLOBIN, HEMOGLOBIN EXPOSED TO NO UNDER AEROBIC CONDITIONS
Descriptor:Hemoglobin alpha chain, Hemoglobin beta chain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Chan, N.L., Kavanaugh, J.S., Rogers, P.H., Arnone, A.
Deposit date:2003-12-04
Release date:2003-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Crystallographic analysis of the interaction of nitric oxide with quaternary-T human hemoglobin.
Biochemistry, 43, 2004
3QX3
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HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA AND ETOPOSIDE
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C., Li, T.K., Farh, L., Lin, L.Y., Lin, T.S., Yu, Y.J., Yen, T.J., Chiang, C.W., Chan, N.L.
Deposit date:2011-03-01
Release date:2011-07-06
Last modified:2012-01-25
Method:X-RAY DIFFRACTION (2.162 Å)
Cite:Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide
Science, 333, 2011
3L6V
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CRYSTAL STRUCTURE OF THE XANTHOMONAS CAMPESTRIS GYRASE A C-TERMINAL DOMAIN
Descriptor:DNA gyrase subunit A
Authors:Hsieh, T.J., Yen, T.J., Lin, T.S., Chang, H.T., Huang, S.Y., Farh, L., Chan, N.L.
Deposit date:2009-12-26
Release date:2010-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Twisting of the DNA binding surface by a beta-strand-bearing proline modulates DNA gyrase activity
To be Published
5GWX
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CRYSTAL STRUCTURE OF GLYCINE SARCOSINE N-METHYLTRANSFERASE FROM METHANOHALOPHILUS PORTUCALENSIS IN COMPLEX WITH S-ADENOSYLMETHIONINE AND SARCOSINE
Descriptor:Glycine sarcosine N-methyltransferase, S-ADENOSYLMETHIONINE, SARCOSINE, ...
Authors:Lee, Y.R., Lin, T.S., Lai, S.J., Liu, M.S., Lai, M.C., Chan, N.L.
Deposit date:2016-09-14
Release date:2016-11-23
Last modified:2017-01-18
Method:X-RAY DIFFRACTION (2.205 Å)
Cite:Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity.
Sci Rep, 6, 2016
4J3N
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HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C., Li, T.K., Li, Y.C., Chan, N.L.
Deposit date:2013-02-06
Release date:2013-10-02
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013
5ZRF
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CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE II BETA IN COMPLEX WITH 5-IODOURIDINE-CONTAINING-DNA AND ETOPOSIDE IN SPACE GROUP P21
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA/RNA (5'-R(P*(IU))-D(P*GP*CP*AP*GP*C)-R(P*(IU))-D(P*CP*GP*GP*C)-R(P*(IU))-3'), ...
Authors:Chen, S.F., Wang, Y.R., Wu, C.C., Chan, N.L.
Deposit date:2018-04-24
Release date:2018-08-08
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.
Nat Commun, 9, 2018
5HIM
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CRYSTAL STRUCTURE OF GLYCINE SARCOSINE N-METHYLTRANSFERASE FROM METHANOHALOPHILUS PORTUCALENSIS IN COMPLEX WITH S-ADENOSYLHOMOCYSTEINE AND DIMETHYLGLYCINE
Descriptor:Glycine sarcosine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, N,N-DIMETHYLGLYCINE, ...
Authors:Lee, Y.R., Lin, T.S., Lai, S.J., Liu, M.S., Lai, M.C., Chan, N.L.
Deposit date:2016-01-12
Release date:2016-11-23
Last modified:2017-01-18
Method:X-RAY DIFFRACTION (2.338 Å)
Cite:Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
Sci Rep, 6, 2016
5HIK
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CRYSTAL STRUCTURE OF GLYCINE SARCOSINE N-METHYLTRANSFERASE FROM METHANOHALOPHILUS PORTUCALENSIS IN COMPLEX WITH S-ADENOSYLMETHIONINE
Descriptor:Glycine sarcosine N-methyltransferase, S-ADENOSYLMETHIONINE, 1,2-ETHANEDIOL
Authors:Lee, Y.R., Lin, T.S., Lai, S.J., Liu, M.S., Lai, M.C., Chan, N.L.
Deposit date:2016-01-12
Release date:2016-11-23
Last modified:2017-01-18
Method:X-RAY DIFFRACTION (2.354 Å)
Cite:Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
Sci Rep, 6, 2016
2GSC
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CRYSTAL STRUCTURE OF THE CONSERVED HYPOTHETICAL CYTOSOLIC PROTEIN XCC0516 FROM XANTHOMONAS CAMPESTRIS
Descriptor:Putative uncharacterized protein XCC0516
Authors:Lin, L.Y., Ching, C.L., Chin, K.H., Chou, S.H., Chan, N.L.
Deposit date:2006-04-26
Release date:2006-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of the conserved hypothetical cytosolic protein Xcc0516 from Xanthomonas campestris reveals a novel quaternary structure assembled by five four-helix bundles.
Proteins, 65, 2006
5HIL
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CRYSTAL STRUCTURE OF GLYCINE SARCOSINE N-METHYLTRANSFERASE FROM METHANOHALOPHILUS PORTUCALENSIS IN COMPLEX WITH S-ADENOSYLHOMOCYSTEINE AND SARCOSINE
Descriptor:Glycine sarcosine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, SARCOSINE, ...
Authors:Lee, Y.R., Lin, T.S., Lai, S.J., Liu, M.S., Lai, M.C., Chan, N.L.
Deposit date:2016-01-12
Release date:2016-11-23
Last modified:2017-01-18
Method:X-RAY DIFFRACTION (2.471 Å)
Cite:Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
Sci Rep, 6, 2016
4G0V
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HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA AND MITOXANTRONE
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C., Li, T.K., Li, Y.C., Chan, N.L.
Deposit date:2012-07-10
Release date:2013-07-17
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.548 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013
4UA1
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CRYSTAL STRUCTURE OF DUAL FUNCTION TRANSCRIPTIONAL REGULATOR MERR FORM BACILLUS MEGATERIUM MB1 IN COMPLEX WITH MERCURY (II) ION
Descriptor:Regulatory protein, MERCURY (II) ION
Authors:Chang, C.C., Lin, L.Y., Zou, X.W., Huang, C.C., Chan, N.L.
Deposit date:2014-08-07
Release date:2015-07-22
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Structural basis of the mercury(II)-mediated conformational switching of the dual-function transcriptional regulator MerR
Nucleic Acids Res., 43, 2015
5GWJ
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STRUCTURE OF A HUMAN TOPOISOMERASE IIBETA FRAGMENT IN COMPLEX WITH DNA AND E7873S
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wang, Y.R., Chen, S.F., Wu, C.C., Chan, N.L.
Deposit date:2016-09-12
Release date:2017-08-23
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.566 Å)
Cite:Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45, 2017
4UA2
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CRYSTAL STRUCTURE OF DUAL FUNCTION TRANSCRIPTIONAL REGULATOR MERR FROM BACILLUS MEGATERIUM MB1
Descriptor:Regulatory protein
Authors:Lin, L.Y., Chang, C.C., Zou, X.W., Huang, C.C., Chan, N.L.
Deposit date:2014-08-07
Release date:2015-07-22
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structural basis of the mercury(II)-mediated conformational switching of the dual-function transcriptional regulator MerR
Nucleic Acids Res., 43, 2015
4ZGY
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STRUCTURE OF HUMAN ORNITHINE DECARBOXYLASE IN COMPLEX WITH A C-TERMINAL FRAGMENT OF ANTIZYME
Descriptor:Ornithine decarboxylase, Ornithine decarboxylase antizyme 1, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Wu, H.Y., Chan, N.L.
Deposit date:2015-04-24
Release date:2015-09-02
Last modified:2015-10-14
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Structural basis of antizyme-mediated regulation of polyamine homeostasis
Proc.Natl.Acad.Sci.USA, 112, 2015
4G0W
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HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA AND AMETANTRONE
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C., Li, T.K., Li, Y.C., Chan, N.L.
Deposit date:2012-07-10
Release date:2013-07-17
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.696 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013
4G0U
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HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA AND AMSACRINE
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C., Li, T.K., Li, Y.C., Chan, N.L.
Deposit date:2012-07-10
Release date:2013-07-17
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013
5GWI
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STRUCTURE OF A HUMAN TOPOISOMERASE IIBETA FRAGMENT IN COMPLEX WITH DNA AND E7873R
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wang, Y.R., Chen, S.F., Wu, C.C., Chan, N.L.
Deposit date:2016-09-12
Release date:2017-08-23
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.737 Å)
Cite:Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45, 2017
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