Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
3OR7
DownloadVisualize
BU of 3or7 by Molmil
On the structural basis of modal gating behavior in K+channels - E71I
Descriptor: POTASSIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ...
Authors:Chakrapani, S, Cordero-Morales, J.F, Jogini, V, Pan, A.C, Cortes, D.M, Roux, B, Perozo, E.
Deposit date:2010-09-06
Release date:2011-01-05
Last modified:2018-08-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:On the structural basis of modal gating behavior in K(+) channels.
Nat.Struct.Mol.Biol., 18, 2011
3OR6
DownloadVisualize
BU of 3or6 by Molmil
On the structural basis of modal gating behavior in K+channels - E71Q
Descriptor: POTASSIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ...
Authors:Chakrapani, S, Cordero-Morales, J.F, Jogini, V, Perozo, E.
Deposit date:2010-09-06
Release date:2011-01-05
Last modified:2018-08-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:On the structural basis of modal gating behavior in K(+) channels.
Nat.Struct.Mol.Biol., 18, 2011
4YEU
DownloadVisualize
BU of 4yeu by Molmil
ELIC-GLIC chimera in the resting conformation
Descriptor: Cys-loop ligand-gated ion channel,Proton-gated ion channel
Authors:Schmandt, N, Vivien, Y, Lodowski, D, Chakrapani, S.
Deposit date:2015-02-24
Release date:2015-09-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (4.6 Å)
Cite:An ELIC-GLIC Chimera Reveals Distinct Pathways of Activation in the Cys-loop receptors
To Be Published
6W1J
DownloadVisualize
BU of 6w1j by Molmil
Cryo-EM structure of 5HT3A receptor in presence of Alosetron
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(4-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ...
Authors:Basak, S, Chakrapani, S.
Deposit date:2020-03-04
Release date:2021-01-13
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:High-resolution structures of multiple 5-HT 3A R-setron complexes reveal a novel mechanism of competitive inhibition.
Elife, 9, 2020
5J0Z
DownloadVisualize
BU of 5j0z by Molmil
Crystal structure of GLIC in complex with DHA
Descriptor: ACETATE ION, CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ...
Authors:Basak, S, Schmandt, N, Chakrapani, S.
Deposit date:2016-03-28
Release date:2017-03-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel.
Elife, 6, 2017
6VM3
DownloadVisualize
BU of 6vm3 by Molmil
Full length Glycine receptor reconstituted in lipid nanodisc in Gly/IVM-conformation (State-3)
Descriptor: (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, ...
Authors:Kumar, A, Basak, S, Chakrapani, S.
Deposit date:2020-01-27
Release date:2020-07-29
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs.
Nat Commun, 11, 2020
6NP0
DownloadVisualize
BU of 6np0 by Molmil
Cryo-EM structure of 5HT3A receptor in presence of granisetron
Descriptor: 1-methyl-N-[(1R,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Basak, S, Chakrapani, S.
Deposit date:2019-01-17
Release date:2019-07-24
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:Molecular mechanism of setron-mediated inhibition of full-length 5-HT3Areceptor.
Nat Commun, 10, 2019
6DG8
DownloadVisualize
BU of 6dg8 by Molmil
Full-length 5-HT3A receptor in a serotonin-bound conformation- State 2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, SEROTONIN, ...
Authors:Basak, S, Chakrapani, S.
Deposit date:2018-05-17
Release date:2018-11-07
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.89 Å)
Cite:Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3Areceptor.
Nature, 563, 2018
6DG7
DownloadVisualize
BU of 6dg7 by Molmil
Full-length 5-HT3A receptor in a serotonin-bound conformation- State 1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, SEROTONIN, ...
Authors:Basak, S, Chakrapani, S.
Deposit date:2018-05-17
Release date:2018-11-07
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3Areceptor.
Nature, 563, 2018
7M6O
DownloadVisualize
BU of 7m6o by Molmil
Full length alpha1 Glycine receptor in presence of 0.1mM Glycine and 32uM Tetrahydrocannabinol
Descriptor: (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, ...
Authors:Kumar, A, Chakrapani, S.
Deposit date:2021-03-26
Release date:2022-08-03
Last modified:2022-09-07
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs.
Nat Commun, 13, 2022
7M6S
DownloadVisualize
BU of 7m6s by Molmil
Full length alpha1 Glycine receptor in presence of 1mM Glycine and 32uM Tetrahydrocannabinol State 3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, Glycine receptor subunit alphaZ1
Authors:Kumar, A, Chakrapani, S.
Deposit date:2021-03-26
Release date:2022-08-03
Last modified:2022-09-07
Method:ELECTRON MICROSCOPY (3.61 Å)
Cite:Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs.
Nat Commun, 13, 2022
7M6P
DownloadVisualize
BU of 7m6p by Molmil
Full length alpha1 Glycine receptor in presence of 1mM Glycine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, Glycine receptor subunit alphaZ1
Authors:Kumar, A, Chakrapani, S.
Deposit date:2021-03-26
Release date:2022-08-03
Last modified:2022-09-07
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs.
Nat Commun, 13, 2022
7M6Q
DownloadVisualize
BU of 7m6q by Molmil
Full length alpha1 Glycine receptor in presence of 1mM Glycine and 32uM Tetrahydrocannabinol State 1
Descriptor: (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, ...
Authors:Kumar, A, Chakrapani, S.
Deposit date:2021-03-26
Release date:2022-08-03
Last modified:2022-09-07
Method:ELECTRON MICROSCOPY (2.91 Å)
Cite:Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs.
Nat Commun, 13, 2022
7M6N
DownloadVisualize
BU of 7m6n by Molmil
Full length alpha1 Glycine receptor in presence of 0.1mM Glycine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, Glycine receptor subunit alphaZ1
Authors:Kumar, A, Chakrapani, S.
Deposit date:2021-03-26
Release date:2022-08-03
Last modified:2022-09-07
Method:ELECTRON MICROSCOPY (2.61 Å)
Cite:Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs.
Nat Commun, 13, 2022
7M6M
DownloadVisualize
BU of 7m6m by Molmil
Full length alpha1 Glycine receptor in presence of 32uM Tetrahydrocannabinol
Descriptor: (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alphaZ1
Authors:Kumar, A, Chakrapani, S.
Deposit date:2021-03-26
Release date:2022-08-03
Last modified:2022-09-07
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs.
Nat Commun, 13, 2022
7M6R
DownloadVisualize
BU of 7m6r by Molmil
Full length alpha1 Glycine receptor in presence of 1mM Glycine and 32uM Tetrahydrocannabinol State 2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, Glycine receptor subunit alphaZ1
Authors:Kumar, A, Chakrapani, S.
Deposit date:2021-03-26
Release date:2022-08-03
Last modified:2022-09-07
Method:ELECTRON MICROSCOPY (3.57 Å)
Cite:Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs.
Nat Commun, 13, 2022
6B5V
DownloadVisualize
BU of 6b5v by Molmil
Structure of TRPV5 in complex with econazole
Descriptor: 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, CALCIUM ION, Transient receptor potential cation channel subfamily V member 5
Authors:Hughes, T.E.T, Lodowski, D.T, Huynh, K.W, Yazici, A, del Rosario, J, Kapoor, A, Basak, S, Samanta, A, Chakrapani, S, Zhou, Z.H, Filizola, M, Rohacs, T, Han, S, Moiseenkova-Bell, V.Y.
Deposit date:2017-09-29
Release date:2017-12-27
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM.
Nat. Struct. Mol. Biol., 25, 2018
3FB7
DownloadVisualize
BU of 3fb7 by Molmil
Open KcsA potassium channel in the presence of Rb+ ion
Descriptor: RUBIDIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ...
Authors:Cuello, L.G, Jogini, V, Cortes, D.M, Pan, A.C, Gagnon, D.H, Cordero-Morales, J.F, Chakrapani, S, Roux, B, Perozo, E.
Deposit date:2008-11-18
Release date:2010-07-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Open KcsA potassium channel in the presence of Rb+ ion
TO BE PUBLISHED
6BE1
DownloadVisualize
BU of 6be1 by Molmil
Cryo-EM structure of serotonin receptor
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Basak, S, Chakrapani, S.
Deposit date:2017-10-24
Release date:2018-02-07
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.31 Å)
Cite:Cryo-EM structure of 5-HT
Nat Commun, 9, 2018
7TVI
DownloadVisualize
BU of 7tvi by Molmil
Alpha1/BetaB Heteromeric Glycine Receptor in Glycine-Bound State
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, Glycine receptor beta subunit 2, ...
Authors:Gibbs, E, Chakrapani, S, Kumar, A.
Deposit date:2022-02-04
Release date:2023-03-22
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Conformational transitions and allosteric modulation in a heteromeric glycine receptor
Nat Commun, 14, 2023
7TU9
DownloadVisualize
BU of 7tu9 by Molmil
Alpha1/BetaB Heteromeric Glycine Receptor in Strychnine-Bound State
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor beta subunit 2, ...
Authors:Gibbs, E, Kumar, A, Chakrapani, S.
Deposit date:2022-02-02
Release date:2023-03-22
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Conformational transitions and allosteric modulation in a heteromeric glycine receptor
Nat Commun, 14, 2023
6W1M
DownloadVisualize
BU of 6w1m by Molmil
Cryo-EM structure of 5HT3A receptor in presence of Ondansetron
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(4-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ...
Authors:Basak, S, Chakrapani, S.
Deposit date:2020-03-04
Release date:2021-01-13
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:High-resolution structures of multiple 5-HT 3A R-setron complexes reveal a novel mechanism of competitive inhibition.
Elife, 9, 2020
6W1Y
DownloadVisualize
BU of 6w1y by Molmil
Cryo-EM structure of 5HT3A receptor in presence of Palonosetron
Descriptor: (3~{a}~{S})-2-[(3~{S})-1-azabicyclo[2.2.2]octan-3-yl]-3~{a},4,5,6-tetrahydro-3~{H}-benzo[de]isoquinolin-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(4-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Basak, S, Chakrapani, S.
Deposit date:2020-03-04
Release date:2021-01-13
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:High-resolution structures of multiple 5-HT 3A R-setron complexes reveal a novel mechanism of competitive inhibition.
Elife, 9, 2020
8FRW
DownloadVisualize
BU of 8frw by Molmil
Full-length mouse 5-HT3A receptor in complex with ALB148471, pre-activated
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-[(1R,3S,5R)-1-azabicyclo[3.2.2]nonan-3-yl]-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indazol-6-one, 5-hydroxytryptamine receptor 3A
Authors:Felt, K.C, Chakrapani, S.
Deposit date:2023-01-09
Release date:2023-12-27
Last modified:2024-01-17
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:Structural basis for partial agonism in 5-HT 3A receptors.
Nat.Struct.Mol.Biol., 2024
8FSP
DownloadVisualize
BU of 8fsp by Molmil
Full-length mouse 5-HT3A receptor in complex with SMP100, open-like
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-[(1R,3S,4R)-1-azabicyclo[2.2.2]octan-3-yl]-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indazol-6-one, 5-hydroxytryptamine receptor 3A
Authors:Felt, K.C, Chakrapani, S.
Deposit date:2023-01-10
Release date:2023-12-27
Last modified:2024-01-17
Method:ELECTRON MICROSCOPY (3.79 Å)
Cite:Structural basis for partial agonism in 5-HT 3A receptors.
Nat.Struct.Mol.Biol., 2024

 

12>

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon