Author results

1FEW
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CRYSTAL STRUCTURE OF SMAC/DIABLO
Descriptor:SECOND MITOCHONDRIA-DERIVED ACTIVATOR OF CASPASES
Authors:Chai, J., Shi, Y.
Deposit date:2000-07-23
Release date:2000-09-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and biochemical basis of apoptotic activation by Smac/DIABLO.
Nature, 406, 2000
1G73
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CRYSTAL STRUCTURE OF SMAC BOUND TO XIAP-BIR3 DOMAIN
Descriptor:SECOND MITOCHONDRIA-DERIVED ACTIVATOR OF CASPASES, INHIBITORS OF APOPTOSIS-LIKE PROTEIN ILP, ZINC ION
Authors:Wu, G., Chai, J., Suber, T.L., Wu, J.-W., Shi, Y.
Deposit date:2000-11-08
Release date:2001-01-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of IAP recognition by Smac/DIABLO.
Nature, 408, 2000
1I51
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CRYSTAL STRUCTURE OF CASPASE-7 COMPLEXED WITH XIAP
Descriptor:CASPASE-7 SUBUNIT P20, CASPASE-7 SUBUNIT P11, X-LINKED INHIBITOR OF APOPTOSIS PROTEIN
Authors:Chai, J., Shi, Y.
Deposit date:2001-02-23
Release date:2002-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural basis of caspase-7 inhibition by XIAP.
Cell(Cambridge,Mass.), 104, 2001
1JD4
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CRYSTAL STRUCTURE OF DIAP1-BIR2
Descriptor:APOPTOSIS 1 INHIBITOR, ZINC ION
Authors:Wu, J.W., Cocina, A.E., Chai, J., Hay, B.A., Shi, Y.
Deposit date:2001-06-12
Release date:2001-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides.
Mol.Cell, 8, 2001
1JD5
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CRYSTAL STRUCTURE OF DIAP1-BIR2/GRIM
Descriptor:APOPTOSIS 1 INHIBITOR, cell death protein GRIM, ZINC ION
Authors:Wu, J.W., Cocina, A.E., Chai, J., Hay, B.A., Shi, Y.
Deposit date:2001-06-12
Release date:2001-12-05
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides.
Mol.Cell, 8, 2001
1JD6
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CRYSTAL STRUCTURE OF DIAP1-BIR2/HID COMPLEX
Descriptor:APOPTOSIS 1 INHIBITOR, head involution defective protein, ZINC ION
Authors:Wu, J.W., Cocina, A.E., Chai, J., Hay, B.A., Shi, Y.
Deposit date:2001-06-12
Release date:2001-12-05
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides.
Mol.Cell, 8, 2001
1K86
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CRYSTAL STRUCTURE OF CASPASE-7
Descriptor:caspase-7
Authors:Chai, J., Wu, Q., Shiozaki, E., Srinivasa, S.M., Alnemri, E.S., Shi, Y.
Deposit date:2001-10-23
Release date:2001-11-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding
Cell(Cambridge,Mass.), 107, 2001
1K88
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CRYSTAL STRUCTURE OF PROCASPASE-7
Descriptor:procaspase-7
Authors:Chai, J., Wu, Q., Shiozaki, E., Srinivasa, S.M., Alnemri, E.S., Shi, Y.
Deposit date:2001-10-23
Release date:2001-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding
Cell(Cambridge,Mass.), 107, 2001
1KHX
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CRYSTAL STRUCTURE OF A PHOSPHORYLATED SMAD2
Descriptor:Smad2
Authors:Wu, J.-W., Hu, M., Chai, J., Seoane, J., Huse, M., Kyin, S., Muir, T.W., Fairman, R., Massague, J., Shi, Y.
Deposit date:2001-12-01
Release date:2002-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling.
Mol.Cell, 8, 2001
1LCY
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CRYSTAL STRUCTURE OF THE MITOCHONDRIAL SERINE PROTEASE HTRA2
Descriptor:HtrA2 serine protease
Authors:Li, W., Srinivasula, S.M., Chai, J., Li, P., Wu, J.W., Zhang, Z., Alnemri, E.S., Shi, Y.
Deposit date:2002-04-07
Release date:2002-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi.
Nat.Struct.Biol., 9, 2002
1MR1
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CRYSTAL STRUCTURE OF A SMAD4-SKI COMPLEX
Descriptor:Mothers against decapentaplegic homolog 4, Ski oncogene, ZINC ION
Authors:Wu, J.-W., Krawitz, A.R., Chai, J., Li, W., Zhang, F., Luo, K., Shi, Y.
Deposit date:2002-09-17
Release date:2003-01-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural Mechanism of Smad4 Recognition by the Nuclear Oncoprotein Ski: Insights on Ski-mediated Repression of TGF-beta Signaling
Cell(Cambridge,Mass.), 111, 2002
1NW9
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STRUCTURE OF CASPASE-9 IN AN INHIBITORY COMPLEX WITH XIAP-BIR3
Descriptor:Baculoviral IAP repeat-containing protein 4, caspase 9, apoptosis-related cysteine protease, ...
Authors:Shiozaki, E.N., Chai, J., Rigotti, D.J., Riedl, S.J., Li, P., Srinivasula, S.M., Alnemri, E.S., Fairman, R., Shi, Y.
Deposit date:2003-02-05
Release date:2003-03-25
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Mechanism of XIAP-Mediated Inhibition of Caspase-9
Mol.Cell, 11, 2003
1OZJ
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CRYSTAL STRUCTURE OF SMAD3-MH1 BOUND TO DNA AT 2.4 A RESOLUTION
Descriptor:Smad binding element, SMAD 3, ZINC ION
Authors:Chai, J., Wu, J.-W., Yan, N., Massague, J., Pavletich, N.P., Shi, Y.
Deposit date:2003-04-09
Release date:2004-03-23
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding.
J.Biol.Chem., 278, 2003
1Q4Q
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CRYSTAL STRUCTURE OF A DIAP1-DRONC COMPLEX
Descriptor:Apoptosis 1 inhibitor, Nedd2-like caspase CG8091-PA, ZINC ION
Authors:Chai, J., Yan, N., Shi, Y.
Deposit date:2003-08-04
Release date:2003-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination
Nat.Struct.Biol., 10, 2003
1SDZ
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CRYSTAL STRUCTURE OF DIAP1 BIR1 BOUND TO A REAPER PEPTIDE
Descriptor:Apoptosis 1 inhibitor, Reaper, ZINC ION
Authors:Yan, N., Wu, J.W., Shi, Y.
Deposit date:2004-02-15
Release date:2004-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim.
Nat.Struct.Mol.Biol., 11, 2004
1SE0
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CRYSTAL STRUCTURE OF DIAP1 BIR1 BOUND TO A GRIM PEPTIDE
Descriptor:Apoptosis 1 inhibitor, Cell death protein Grim, ZINC ION
Authors:Yan, N., Wu, J.W., Shi, Y.
Deposit date:2004-02-15
Release date:2004-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim.
Nat.Struct.Mol.Biol., 11, 2004
1TW6
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STRUCTURE OF AN ML-IAP/XIAP CHIMERA BOUND TO A 9MER PEPTIDE DERIVED FROM SMAC
Descriptor:Baculoviral IAP repeat-containing protein 7, Diablo homolog, mitochondrial, ...
Authors:Franklin, M.C., Vucic, D., Wallweber, H.J.A., Das, K., Shin, H., Elliott, L.O., Kadkhodayan, S., Deshayes, K., Salvesen, G.S., Fairbrother, W.J.
Deposit date:2004-06-30
Release date:2004-11-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.713 Å)
Cite:Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP
Biochem.J., 385, 2005
1TY4
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CRYSTAL STRUCTURE OF A CED-9/EGL-1 COMPLEX
Descriptor:Apoptosis regulator ced-9, EGg Laying defective EGL-1, programmed cell death activator
Authors:Yan, N., Gu, L., Kokel, D., Xue, D., Shi, Y.
Deposit date:2004-07-07
Release date:2004-09-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural, Biochemical, and Functional Analyses of CED-9 Recognition by the Proapoptotic Proteins EGL-1 and CED-4
Mol.Cell, 15, 2004
2A5Y
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STRUCTURE OF A CED-4/CED-9 COMPLEX
Descriptor:Apoptosis regulator ced-9, ced-4, MAGNESIUM ION, ...
Authors:Yan, N., Liu, Q., Hao, Q., Gu, L., Shi, Y.
Deposit date:2005-07-01
Release date:2005-10-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans.
Nature, 437, 2005
2G99
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STRUCTURAL BASIS FOR THE SPECIFIC RECOGNITION OF METHYLATED HISTONE H3 LYSINE 4 BY THE WD-40 PROTEIN WDR5
Descriptor:WD-repeat protein 5, Histone H3
Authors:Chai, J., Han, Z., Wang, H., Shen, Y.
Deposit date:2006-03-06
Release date:2006-09-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5
To be published
2G9A
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STRUCTURAL BASIS FOR THE SPECIFIC RECOGNITION OF METHYLATED HISTONE H3 LYSINE 4 BY THE WD-40 PROTEIN WDR5
Descriptor:WD-repeat protein 5, Histone H3
Authors:Chai, J., Han, Z., Wang, H., Shen, Y.
Deposit date:2006-03-06
Release date:2006-09-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5
To be published
2NZ0
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CRYSTAL STRUCTURE OF POTASSIUM CHANNEL KV4.3 IN COMPLEX WITH ITS REGULATORY SUBUNIT KCHIP1 (CASP TARGET)
Descriptor:Kv channel-interacting protein 1, Potassium voltage-gated channel subfamily D member 3, CALCIUM ION, ...
Authors:Wang, H., Yan, Y., Shen, Y., Chen, L., Wang, K.
Deposit date:2006-11-22
Release date:2006-12-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for modulation of Kv4 K(+) channels by auxiliary KChIP subunits.
Nat.Neurosci., 10, 2007
2YU1
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CRYSTAL STRUCTURE OF HJHDM1A COMPLEXED WITH A-KETOGLUTARATE
Descriptor:JmjC domain-containing histone demethylation protein 1A, FE (II) ION, 2-OXOGLUTARIC ACID
Authors:Han, Z.
Deposit date:2007-04-05
Release date:2007-04-24
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for histone demethylation by JHDM1
To be Published
2YU2
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CRYSTAL STRUCTURE OF HJHDM1A WITHOUT A-KETOGLUTARATE
Descriptor:JmjC domain-containing histone demethylation protein 1A, FE (II) ION
Authors:Han, Z.
Deposit date:2007-04-05
Release date:2007-04-24
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for histone demethylation by JHDM1
To be Published
2QKW
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STRUCTURAL BASIS FOR ACTIVATION OF PLANT IMMUNITY BY BACTERIAL EFFECTOR PROTEIN AVRPTO
Descriptor:Avirulence protein, Protein kinase
Authors:Xing, W.M., Zou, Y., Liu, Q., Hao, Q., Zhou, J.M., Chai, J.J.
Deposit date:2007-07-11
Release date:2007-08-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The structural basis for activation of plant immunity by bacterial effector protein AvrPto
Nature, 449, 2007