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1ANT
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BU of 1ant by Molmil
BIOLOGICAL IMPLICATIONS OF A 3 ANGSTROMS STRUCTURE OF DIMERIC ANTITHROMBIN
Descriptor: ANTITHROMBIN
Authors:Carrell, R.W, Stein, P.E, Fermi, G, Wardell, M.R.
Deposit date:1994-02-28
Release date:1995-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Biological implications of a 3 A structure of dimeric antithrombin.
Structure, 2, 1994
1JVQ
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BU of 1jvq by Molmil
Crystal structure at 2.6A of the ternary complex between antithrombin, a P14-P8 reactive loop peptide, and an exogenous tetrapeptide
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, ...
Authors:Zhou, A, Huntington, J.A, Lomas, D.A, Carrell, R.W, Stein, P.E.
Deposit date:2001-08-31
Release date:2003-06-03
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:How small peptides block and reverse serpin polymerisation
J.Mol.Biol., 342, 2004
1JMO
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BU of 1jmo by Molmil
Crystal Structure of the Heparin Cofactor II-S195A Thrombin Complex
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Baglin, T.P, Carrell, R.W, Esmon, C.T, Huntington, J.A.
Deposit date:2001-07-19
Release date:2002-08-30
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.
Proc.Natl.Acad.Sci.USA, 99, 2002
1JMJ
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BU of 1jmj by Molmil
Crystal Structure of Native Heparin Cofactor II
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, HEPARIN COFACTOR II, ...
Authors:Baglin, T.P, Carrell, R.W, Church, F.C, Huntington, J.A.
Deposit date:2001-07-18
Release date:2002-08-30
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.
Proc.Natl.Acad.Sci.USA, 99, 2002
1LK6
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BU of 1lk6 by Molmil
Structure of dimeric antithrombin complexed with a P14-P9 reactive loop peptide and an exogenous tripeptide
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
Authors:Zhou, A, Huntington, J.A, Lomas, D.A, Carrell, R.W, Stein, P.E.
Deposit date:2002-04-24
Release date:2003-06-03
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Serpin Polymerization Is Prevented by a Hydrogen Bond Network That Is Centered on His-334 and Stabilized by Glycerol
J.Biol.Chem., 278, 2003
1OC0
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BU of 1oc0 by Molmil
plasminogen activator inhibitor-1 complex with somatomedin B domain of vitronectin
Descriptor: PLASMINOGEN ACTIVATOR INHIBITOR-1, VITRONECTIN
Authors:Read, R.J, Zhou, A, Huntington, J.A, Pannu, N.S, Carrell, R.W.
Deposit date:2003-02-03
Release date:2003-06-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:How Vitronectin Binds Pai-1 to Modulate Fibrinolysis and Cell Migration
Nat.Struct.Biol., 10, 2003
2X0B
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BU of 2x0b by Molmil
Crystal structure of human angiotensinogen complexed with renin
Descriptor: ANGIOTENSINOGEN, RENIN
Authors:Zhou, A, Wei, Z, Yan, Y, Carrell, R.W, Read, R.J.
Deposit date:2009-12-08
Release date:2010-10-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (4.33 Å)
Cite:A Redox Switch in Angiotensinogen Modulates Angiotensin Release.
Nature, 468, 2010
2CEO
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BU of 2ceo by Molmil
thyroxine-binding globulin complex with thyroxine
Descriptor: 3,5,3',5'-TETRAIODO-L-THYRONINE, GLYCEROL, THYROXINE-BINDING GLOBULIN
Authors:Zhou, A, Wei, Z, Read, R.J, Carrell, R.W.
Deposit date:2006-02-08
Release date:2006-08-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Mechanism for the Carriage and Release of Thyroxine in the Blood.
Proc.Natl.Acad.Sci.USA, 103, 2006
1AZX
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BU of 1azx by Molmil
ANTITHROMBIN/PENTASACCHARIDE COMPLEX
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, ANTITHROMBIN
Authors:Jin, L, Abrahams, J.P, Skinner, R, Petitou, M, Pike, R.N, Carrell, R.W.
Deposit date:1997-11-23
Release date:1999-01-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The anticoagulant activation of antithrombin by heparin.
Proc.Natl.Acad.Sci.USA, 94, 1997
1BR8
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BU of 1br8 by Molmil
IMPLICATIONS FOR FUNCTION AND THERAPY OF A 2.9A STRUCTURE OF BINARY-COMPLEXED ANTITHROMBIN
Descriptor: PROTEIN (ANTITHROMBIN-III), PROTEIN (PEPTIDE)
Authors:Skinner, R, Chang, W.S.W, Jin, L, Pei, X.Y, Huntington, J.A, Abrahams, J.P, Carrell, R.W, Lomas, D.A.
Deposit date:1998-08-26
Release date:1998-09-02
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin.
J.Mol.Biol., 283, 1998
1E03
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BU of 1e03 by Molmil
PLASMA ALPHA ANTITHROMBIN-III AND PENTASACCHARIDE
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, ...
Authors:McCoy, A.J, Jin, L, Abrahams, J.-P, Skinner, R, Carrell, R.W.
Deposit date:2000-03-09
Release date:2000-06-02
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of Beta-Antithrombin and the Effect of Glycosylation on Antithrombin'S Heparin Affinity and Activity.
J.Mol.Biol., 326, 2003
1DZH
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BU of 1dzh by Molmil
P14-FLUORESCEIN-N135Q-S380C-ANTITHROMBIN-III
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, ...
Authors:Mccoy, A.J, Huntington, J.A, Carrell, R.W.
Deposit date:2000-02-28
Release date:2000-05-26
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The Conformational Activation of Antithrombin. A 2. 85-A Structure of a Fluorescein Derivative Reveals an Electrostatic Link between the Hinge and Heparin Binding Regions.
J.Biol.Chem., 275, 2000
1E05
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BU of 1e05 by Molmil
PLASMA ALPHA ANTITHROMBIN-III
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, ...
Authors:McCoy, A.J, Skinner, R, Abrahams, J.-P, Pei, X.Y, Carrell, R.W.
Deposit date:2000-03-09
Release date:2000-06-02
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structure of Beta-Antithrombin and the Effect of Glycosylation on Antithrombin'S Heparin Affinity and Activity.
J.Mol.Biol., 326, 2003
1DZG
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BU of 1dzg by Molmil
N135Q-S380C-ANTITHROMBIN-III
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, ...
Authors:McCoy, A.J, Huntington, J.A, Carrell, R.W.
Deposit date:2000-02-28
Release date:2000-05-26
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Conformational Activation of Antithrombin. A 2. 85-A Structure of a Fluorescein Derivative Reveals an Electrostatic Link between the Hinge and Heparin Binding Regions.
J.Biol.Chem., 275, 2000
1E04
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BU of 1e04 by Molmil
PLASMA BETA ANTITHROMBIN-III
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, GLYCEROL, ...
Authors:Mccoy, A.J, Skinner, R, Abrahams, J.-P, Pei, X.Y, Carrell, R.W.
Deposit date:2000-03-09
Release date:2000-06-02
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of Beta-Antithrombin and the Effect of Glycosylation on Antithrombin'S Heparin Affinity and Activity.
J.Mol.Biol., 326, 2003
1EZX
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BU of 1ezx by Molmil
CRYSTAL STRUCTURE OF A SERPIN:PROTEASE COMPLEX
Descriptor: ALPHA-1-ANTITRYPSIN, TRYPSIN
Authors:Huntington, J.A, Carrell, R.W.
Deposit date:2000-05-12
Release date:2000-10-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of a serpin-protease complex shows inhibition by deformation.
Nature, 407, 2000
2RIV
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BU of 2riv by Molmil
Crystal structure of the reactive loop cleaved human Thyroxine Binding Globulin
Descriptor: GLYCEROL, SULFATE ION, Thyroxine-binding globulin
Authors:Zhou, A, Wei, Z, Stanley, P.L.D, Read, R.J, Stein, P.E, Carrell, R.W.
Deposit date:2007-10-12
Release date:2008-10-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins
J.Biol.Chem., 286, 2011
2RIW
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BU of 2riw by Molmil
The Reactive loop cleaved human Thyroxine Binding Globulin complexed with thyroxine
Descriptor: 3,5,3',5'-TETRAIODO-L-THYRONINE, Thyroxine-binding globulin
Authors:Zhou, A, Wei, Z, Stanley, P.L.D, Read, R.J, Stein, P.E, Carrell, R.W.
Deposit date:2007-10-12
Release date:2008-10-14
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins
J.Biol.Chem., 286, 2011
2WY1
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BU of 2wy1 by Molmil
Crystal structure of rat angiotensinogen in P321 space group
Descriptor: ANGIOTENSINOGEN
Authors:Zhou, A, Wei, Z, Carrell, R.W, Read, R.J.
Deposit date:2009-11-11
Release date:2010-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:A Redox Switch in Angiotensinogen Modulates Angiotensin Release.
Nature, 468, 2010
2WXW
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BU of 2wxw by Molmil
Crystal structure of human angiotensinogen
Descriptor: ANGIOTENSINOGEN
Authors:Zhou, A, Wei, Z, Carrell, R.W, Read, R.J.
Deposit date:2009-11-11
Release date:2010-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:A Redox Switch in Angiotensinogen Modulates Angiotensin Release.
Nature, 468, 2010
2WXX
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BU of 2wxx by Molmil
Crystal structure of mouse angiotensinogen in the oxidised form
Descriptor: ANGIOTENSINOGEN
Authors:Zhou, A, Wei, Z, Carrell, R.W, Read, R.J.
Deposit date:2009-11-11
Release date:2010-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:A Redox Switch in Angiotensinogen Modulates Angiotensin Release.
Nature, 468, 2010
2WXY
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Crystal structure of mouse angiotensinogen in the reduced form
Descriptor: 1,2-ETHANEDIOL, ANGIOTENSINOGEN, SODIUM ION
Authors:Zhou, A, Wei, Z, Carrell, R.W, Read, R.J.
Deposit date:2009-11-11
Release date:2010-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Redox Switch in Angiotensinogen Modulates Angiotensin Release.
Nature, 468, 2010
2WY0
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BU of 2wy0 by Molmil
Crystal structure of mouse angiotensinogen in the oxidised form with space group P6122
Descriptor: 1,2-ETHANEDIOL, ANGIOTENSINOGEN, SODIUM ION
Authors:Zhou, A, Wei, Z, Carrell, R.W, Read, R.J.
Deposit date:2009-11-11
Release date:2010-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:A Redox Switch in Angiotensinogen Modulates Angiotensin Release.
Nature, 468, 2010
2WXZ
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Crystal structure of rat angiotensinogen in C2 space group
Descriptor: ANGIOTENSINOGEN
Authors:Zhou, A, Wei, Z, Carrell, R.W, Read, R.J.
Deposit date:2009-11-11
Release date:2010-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A Redox Switch in Angiotensinogen Modulates Angiotensin Release.
Nature, 468, 2010
2ANT
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BU of 2ant by Molmil
THE 2.6 A STRUCTURE OF ANTITHROMBIN INDICATES A CONFORMATIONAL CHANGE AT THE HEPARIN BINDING SITE
Descriptor: 2-acetamido-2-deoxy-beta-D-allopyranose, ANTITHROMBIN
Authors:Skinner, R, Abrahams, J.-P, Whisstock, J.C, Lesk, A.M, Carrell, R.W, Wardell, M.R.
Deposit date:1997-01-28
Release date:1997-06-16
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site.
J.Mol.Biol., 266, 1997

 

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