Author results

1ANT
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BIOLOGICAL IMPLICATIONS OF A 3 ANGSTROMS STRUCTURE OF DIMERIC ANTITHROMBIN
Descriptor:ANTITHROMBIN
Authors:Carrell, R.W., Stein, P.E., Fermi, G., Wardell, M.R.
Deposit date:1994-02-28
Release date:1995-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Biological implications of a 3 A structure of dimeric antithrombin.
Structure, 2, 1994
1AZX
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ANTITHROMBIN/PENTASACCHARIDE COMPLEX
Descriptor:ANTITHROMBIN, N-ACETYL-D-GLUCOSAMINE, HEPARIN PENTASACCHARIDE
Authors:Jin, L., Abrahams, J.P., Skinner, R., Petitou, M., Pike, R.N., Carrell, R.W.
Deposit date:1997-11-23
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The anticoagulant activation of antithrombin by heparin.
Proc.Natl.Acad.Sci.USA, 94, 1997
1BR8
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IMPLICATIONS FOR FUNCTION AND THERAPY OF A 2.9A STRUCTURE OF BINARY-COMPLEXED ANTITHROMBIN
Descriptor:PROTEIN (ANTITHROMBIN-III), PROTEIN (PEPTIDE)
Authors:Skinner, R., Chang, W.S.W., Jin, L., Pei, X.Y., Huntington, J.A., Abrahams, J.P., Carrell, R.W., Lomas, D.A.
Deposit date:1998-08-26
Release date:1998-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin.
J.Mol.Biol., 283, 1998
1DZG
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N135Q-S380C-ANTITHROMBIN-III
Descriptor:ANTITHROMBIN-III, N-ACETYL-D-GLUCOSAMINE, GLYCEROL
Authors:McCoy, A.J., Huntington, J.A., Carrell, R.W.
Deposit date:2000-02-28
Release date:2000-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Conformational Activation of Antithrombin. A 2. 85-A Structure of a Fluorescein Derivative Reveals an Electrostatic Link between the Hinge and Heparin Binding Regions.
J.Biol.Chem., 275, 2000
1DZH
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P14-FLUORESCEIN-N135Q-S380C-ANTITHROMBIN-III
Descriptor:ANTITHROMBIN-III, N-ACETYL-D-GLUCOSAMINE, GLYCEROL, ...
Authors:Mccoy, A.J., Huntington, J.A., Carrell, R.W.
Deposit date:2000-02-28
Release date:2000-05-26
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The Conformational Activation of Antithrombin. A 2. 85-A Structure of a Fluorescein Derivative Reveals an Electrostatic Link between the Hinge and Heparin Binding Regions.
J.Biol.Chem., 275, 2000
1E03
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PLASMA ALPHA ANTITHROMBIN-III AND PENTASACCHARIDE
Descriptor:ANTITHROMBIN-III, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:McCoy, A.J., Jin, L., Abrahams, J.-P., Skinner, R., Carrell, R.W.
Deposit date:2000-03-09
Release date:2000-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of Beta-Antithrombin and the Effect of Glycosylation on Antithrombin'S Heparin Affinity and Activity.
J.Mol.Biol., 326, 2003
1E04
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PLASMA BETA ANTITHROMBIN-III
Descriptor:ANTITHROMBIN-III, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Mccoy, A.J., Skinner, R., Abrahams, J.-P., Pei, X.Y., Carrell, R.W.
Deposit date:2000-03-09
Release date:2000-06-02
Last modified:2011-08-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of Beta-Antithrombin and the Effect of Glycosylation on Antithrombin'S Heparin Affinity and Activity.
J.Mol.Biol., 326, 2003
1E05
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PLASMA ALPHA ANTITHROMBIN-III
Descriptor:ANTITHROMBIN-III, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:McCoy, A.J., Skinner, R., Abrahams, J.-P., Pei, X.Y., Carrell, R.W.
Deposit date:2000-03-09
Release date:2000-06-02
Last modified:2011-11-09
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structure of Beta-Antithrombin and the Effect of Glycosylation on Antithrombin'S Heparin Affinity and Activity.
J.Mol.Biol., 326, 2003
1EZX
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CRYSTAL STRUCTURE OF A SERPIN:PROTEASE COMPLEX
Descriptor:ALPHA-1-ANTITRYPSIN, TRYPSIN
Authors:Huntington, J.A., Carrell, R.W.
Deposit date:2000-05-12
Release date:2000-10-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of a serpin-protease complex shows inhibition by deformation.
Nature, 407, 2000
1JMJ
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CRYSTAL STRUCTURE OF NATIVE HEPARIN COFACTOR II
Descriptor:HEPARIN COFACTOR II, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Baglin, T.P., Carrell, R.W., Church, F.C., Huntington, J.A.
Deposit date:2001-07-18
Release date:2002-08-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.
Proc.Natl.Acad.Sci.USA, 99, 2002
1JMO
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CRYSTAL STRUCTURE OF THE HEPARIN COFACTOR II-S195A THROMBIN COMPLEX
Descriptor:Thrombin, light chain, heavy chain, ...
Authors:Baglin, T.P., Carrell, R.W., Esmon, C.T., Huntington, J.A.
Deposit date:2001-07-19
Release date:2002-08-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.
Proc.Natl.Acad.Sci.USA, 99, 2002
1JVQ
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CRYSTAL STRUCTURE AT 2.6A OF THE TERNARY COMPLEX BETWEEN ANTITHROMBIN, A P14-P8 REACTIVE LOOP PEPTIDE, AND AN EXOGENOUS TETRAPEPTIDE
Descriptor:ANTITHROMBIN-III, P14-P8 reactive loop peptide, exogenous Cholecystokinin tetrapeptide, ...
Authors:Zhou, A., Huntington, J.A., Lomas, D.A., Carrell, R.W., Stein, P.E.
Deposit date:2001-08-31
Release date:2003-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:How small peptides block and reverse serpin polymerisation
J.Mol.Biol., 342, 2004
1LK6
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STRUCTURE OF DIMERIC ANTITHROMBIN COMPLEXED WITH A P14-P9 REACTIVE LOOP PEPTIDE AND AN EXOGENOUS TRIPEPTIDE
Descriptor:antithrombin-III, antithrombin P14-P9 peptide, exogenous tripeptide formyl-MLF, ...
Authors:Zhou, A., Huntington, J.A., Lomas, D.A., Carrell, R.W., Stein, P.E.
Deposit date:2002-04-24
Release date:2003-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Serpin Polymerization Is Prevented by a Hydrogen Bond Network That Is Centered on His-334 and Stabilized by Glycerol
J.Biol.Chem., 278, 2003
1OC0
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PLASMINOGEN ACTIVATOR INHIBITOR-1 COMPLEX WITH SOMATOMEDIN B DOMAIN OF VITRONECTIN
Descriptor:PLASMINOGEN ACTIVATOR INHIBITOR-1, VITRONECTIN
Authors:Read, R.J., Zhou, A., Huntington, J.A., Pannu, N.S., Carrell, R.W.
Deposit date:2003-02-03
Release date:2003-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:How Vitronectin Binds Pai-1 to Modulate Fibrinolysis and Cell Migration
Nat.Struct.Biol., 10, 2003
1PSI
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INTACT RECOMBINED ALPHA1-ANTITRYPSIN MUTANT PHE 51 TO LEU
Descriptor:ALPHA=1=-ANTITRYPSIN
Authors:Abrahams, J.P., Elliott, P.R., Lomas, D.A., Carrell, R.W.
Deposit date:1996-06-11
Release date:1996-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Inhibitory conformation of the reactive loop of alpha 1-antitrypsin.
Nat.Struct.Biol., 3, 1996
1QMB
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CLEAVED ALPHA-1-ANTITRYPSIN POLYMER
Descriptor:ALPHA-1-ANTITRYPSIN
Authors:Huntington, J.A., Pannu, N.S., Hazes, B., Read, R.J., Lomas, D.A., Carrell, R.W.
Deposit date:1999-09-24
Release date:2000-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A 2.6A Structure of a Serpin Polymer and Implications for Conformational Disease
J.Mol.Biol., 293, 1999
1R1L
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STRUCTURE OF DIMERIC ANTITHROMBIN COMPLEXED WITH A P14-P9 REACTIVE LOOP PEPTIDE AND AN EXOGENOUS TRIPEPTIDE (FORMYL-NORLEUCINE-LF)
Descriptor:Antithrombin-III, Antithrombin P14-P9 peptide, EXOGENOUS TRIPEPTIDE formyl-(NLE)LF, ...
Authors:Zhou, A., Huntington, J.A., Lomas, D.A., Stein, P.E., Carrell, R.W.
Deposit date:2003-09-24
Release date:2004-10-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Serpins and the design of peptides to block intermolecular beta-linkages
To be Published
2ANT
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THE 2.6 A STRUCTURE OF ANTITHROMBIN INDICATES A CONFORMATIONAL CHANGE AT THE HEPARIN BINDING SITE
Descriptor:ANTITHROMBIN, N-ACETYL-D-ALLOSAMINE
Authors:Skinner, R., Abrahams, J.-P., Whisstock, J.C., Lesk, A.M., Carrell, R.W., Wardell, M.R.
Deposit date:1997-01-28
Release date:1997-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site.
J.Mol.Biol., 266, 1997
2CEO
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THYROXINE-BINDING GLOBULIN COMPLEX WITH THYROXINE
Descriptor:THYROXINE-BINDING GLOBULIN, 3,5,3',5'-TETRAIODO-L-THYRONINE, GLYCEROL
Authors:Zhou, A., Wei, Z., Read, R.J., Carrell, R.W.
Deposit date:2006-02-08
Release date:2006-08-14
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Mechanism for the Carriage and Release of Thyroxine in the Blood.
Proc.Natl.Acad.Sci.USA, 103, 2006
2RIV
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CRYSTAL STRUCTURE OF THE REACTIVE LOOP CLEAVED HUMAN THYROXINE BINDING GLOBULIN
Descriptor:Thyroxine-binding globulin, GLYCEROL, SULFATE ION
Authors:Zhou, A., Wei, Z., Stanley, P.L.D., Read, R.J., Stein, P.E., Carrell, R.W.
Deposit date:2007-10-12
Release date:2008-10-14
Last modified:2013-01-16
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins
J.Biol.Chem., 286, 2011
2RIW
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THE REACTIVE LOOP CLEAVED HUMAN THYROXINE BINDING GLOBULIN COMPLEXED WITH THYROXINE
Descriptor:Thyroxine-binding globulin, 3,5,3',5'-TETRAIODO-L-THYRONINE
Authors:Zhou, A., Wei, Z., Stanley, P.L.D., Read, R.J., Stein, P.E., Carrell, R.W.
Deposit date:2007-10-12
Release date:2008-10-14
Last modified:2013-01-16
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins
J.Biol.Chem., 286, 2011
2WXW
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CRYSTAL STRUCTURE OF HUMAN ANGIOTENSINOGEN
Descriptor:ANGIOTENSINOGEN
Authors:Zhou, A., Wei, Z., Carrell, R.W., Read, R.J.
Deposit date:2009-11-11
Release date:2010-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:A Redox Switch in Angiotensinogen Modulates Angiotensin Release.
Nature, 468, 2010
2WXX
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CRYSTAL STRUCTURE OF MOUSE ANGIOTENSINOGEN IN THE OXIDISED FORM
Descriptor:ANGIOTENSINOGEN
Authors:Zhou, A., Wei, Z., Carrell, R.W., Read, R.J.
Deposit date:2009-11-11
Release date:2010-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:A Redox Switch in Angiotensinogen Modulates Angiotensin Release.
Nature, 468, 2010
2WXY
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CRYSTAL STRUCTURE OF MOUSE ANGIOTENSINOGEN IN THE REDUCED FORM
Descriptor:ANGIOTENSINOGEN, SODIUM ION, 1,2-ETHANEDIOL
Authors:Zhou, A., Wei, Z., Carrell, R.W., Read, R.J.
Deposit date:2009-11-11
Release date:2010-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Redox Switch in Angiotensinogen Modulates Angiotensin Release.
Nature, 468, 2010
2WXZ
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CRYSTAL STRUCTURE OF RAT ANGIOTENSINOGEN IN C2 SPACE GROUP
Descriptor:ANGIOTENSINOGEN
Authors:Zhou, A., Wei, Z., Carrell, R.W., Read, R.J.
Deposit date:2009-11-11
Release date:2010-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A Redox Switch in Angiotensinogen Modulates Angiotensin Release.
Nature, 468, 2010
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