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1PCP
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BU of 1pcp by Molmil
SOLUTION STRUCTURE OF A TREFOIL-MOTIF-CONTAINING CELL GROWTH FACTOR, PORCINE SPASMOLYTIC PROTEIN
Descriptor: PORCINE SPASMOLYTIC PROTEIN
Authors:Carr, M.D, Bauer, C.J, Gradwell, M.J, Feeney, J.
Deposit date:1993-02-04
Release date:1994-05-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of a trefoil-motif-containing cell growth factor, porcine spasmolytic protein.
Proc.Natl.Acad.Sci.USA, 91, 1994
1NYO
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BU of 1nyo by Molmil
Solution structure of the antigenic TB protein MPT70/MPB70
Descriptor: Immunogenic protein MPT70
Authors:Bloemink, M.J, Dentten, E, Hewinson, R.G, Williamson, R.A, Carr, M.D, TB Structural Genomics Consortium (TBSGC)
Deposit date:2003-02-13
Release date:2003-08-19
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structure of the Mycobacterium tuberculosis complex protein MPB70: from tuberculosis pathogenesis to inherited human corneal desease
J.Biol.Chem., 278, 2003
1A5J
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BU of 1a5j by Molmil
CHICKEN B-MYB DNA BINDING DOMAIN, REPEAT 2 AND REPEAT3, NMR, 32 STRUCTURES
Descriptor: B-MYB
Authors:Mcintosh, P.B, Carr, M.D, Wollborn, U, Frenkiel, T.A, Feeney, J, Mccormick, J.E, Klempnauer, K.H.
Deposit date:1998-02-16
Release date:1998-07-01
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Solution structure of the B-Myb DNA-binding domain: a possible role for conformational instability of the protein in DNA binding and control of gene expression.
Biochemistry, 37, 1998
5O57
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BU of 5o57 by Molmil
Solution Structure of the N-terminal Region of Dkk4
Descriptor: Dickkopf-related protein 4
Authors:Waters, L.C, Patel, S, Barkell, A.M, Muskett, F.W, Robinson, M.K, Holdsworth, G, Carr, M.D.
Deposit date:2017-06-01
Release date:2018-06-13
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins.
J. Biol. Chem., 293, 2018
7OW1
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BU of 7ow1 by Molmil
Crystal Structure of TAP01 in complex with amyloid beta peptide
Descriptor: Amyloid-beta precursor protein, CITRATE ANION, TAP01 family antibody heavy chain, ...
Authors:Hall, G, Cowan, R, Carr, M.D.
Deposit date:2021-06-16
Release date:2022-06-29
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Discovery of a novel pseudo beta-hairpin structure of N-truncated amyloid-beta for use as a vaccine against Alzheimer's disease.
Mol Psychiatry, 27, 2022
7OXN
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BU of 7oxn by Molmil
Crystal Structure of TAP01 in complex with cyclised amyloid beta peptide
Descriptor: 1,2-ETHANEDIOL, Amyloid-beta precursor protein, TAP01 family antibody heavy chain, ...
Authors:Hall, G, Cowan, R, Carr, M.D.
Deposit date:2021-06-22
Release date:2022-06-29
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of a novel pseudo beta-hairpin structure of N-truncated amyloid-beta for use as a vaccine against Alzheimer's disease.
Mol Psychiatry, 27, 2022
2TMP
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BU of 2tmp by Molmil
N-TERMINAL DOMAIN OF TISSUE INHIBITOR OF METALLOPROTEINASE-2 (N-TIMP-2), NMR, 49 STRUCTURES
Descriptor: TISSUE INHIBITOR OF METALLOPROTEINASES-2
Authors:Muskett, F.W, Frenkiel, T.A, Feeney, J, Freedman, R.B, Carr, M.D, Williamson, R.A.
Deposit date:1998-05-26
Release date:1998-12-09
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:High resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 and characterization of its interaction site with matrix metalloproteinase-3.
J.Biol.Chem., 273, 1998
1WA8
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BU of 1wa8 by Molmil
Solution Structure of the CFP-10.ESAT-6 Complex. Major Virulence Determinants of Pathogenic Mycobacteria
Descriptor: 6 KDA EARLY SECRETORY ANTIGENIC TARGET (ESAT-6), ESAT-6 LIKE PROTEIN ESXB
Authors:Renshaw, P.S, Lightbody, K.L, Veverka, V, Muskett, F.W, Kelly, G, Frenkiel, T.A, Gordon, S.V, Hewinson, R.G, Burke, B, Norman, J, Williamson, R.A, Carr, M.D, TB Structural Genomics Consortium (TBSGC)
Deposit date:2004-10-25
Release date:2005-06-27
Last modified:2019-08-21
Method:SOLUTION NMR
Cite:Structure and Function of the Complex Formed by the Tuberculosis Virulence Factors Cfp-10 and Esat-6
Embo J., 24, 2005
2HM8
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BU of 2hm8 by Molmil
Solution Structure of the C-terminal MA-3 domain of Pdcd4
Descriptor: Pdcd4 C-terminal MA-3 domain
Authors:Waters, L.C, Veverka, V, Bohm, M, Muskett, F.W, Choong, P.T, Klempnauer, K.H, Carr, M.D.
Deposit date:2006-07-11
Release date:2007-02-20
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Structure of the C-terminal MA-3 domain of the tumour suppressor protein Pdcd4 and characterization of its interaction with eIF4A
Oncogene, 26, 2007
2KH2
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BU of 2kh2 by Molmil
Solution structure of a scFv-IL-1B complex
Descriptor: Interleukin-1 beta, scFv
Authors:Wilkinson, I.C, Hall, C.J, Veverka, V, Muskett, F.W, Stephens, P.E, Taylor, R.J, Henry, A.J, Carr, M.D.
Deposit date:2009-03-23
Release date:2009-09-08
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:High resolution NMR-based model for the structure of a scFv-IL-1beta complex: potential for NMR as a key tool in therapeutic antibody design and development.
J.Biol.Chem., 284, 2009
2K8P
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BU of 2k8p by Molmil
Characterisation of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation
Descriptor: Sclerostin
Authors:Veverka, V, Henry, A.J, Slocombe, P.M, Ventom, A, Mulloy, B, Muskett, F.W, Muzylak, M, Greenslade, K, Moore, A, Zhang, L, Gong, J, Qian, X, Paszty, C, Taylor, R.J, Robinson, M.K, Carr, M.D.
Deposit date:2008-09-18
Release date:2009-02-17
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Characterization of the Structural Features and Interactions of Sclerostin: Molecular insight into a key regulator of Wnt-mediated bone formation
J.Biol.Chem., 284, 2009
2L3Y
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BU of 2l3y by Molmil
Solution structure of mouse IL-6
Descriptor: Interleukin-6
Authors:Veverka, V, Redpath, N.T, Carrington, B, Muskett, F.W, Taylor, R.J, Henry, A.J, Carr, M.D.
Deposit date:2010-09-25
Release date:2011-09-28
Last modified:2013-01-02
Method:SOLUTION NMR
Cite:Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention.
J.Biol.Chem., 287, 2012
2KZT
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BU of 2kzt by Molmil
Structure of the Tandem MA-3 Region of Pdcd4
Descriptor: Programmed cell death protein 4
Authors:Waters, L.C, Strong, S.L, Oka, O, Muskett, F.W, Veverka, V, Banerjee, S, Schmedt, T, Henry, A.J, Klempnauer, K.H, Carr, M.D.
Deposit date:2010-06-24
Release date:2011-03-16
Last modified:2011-11-23
Method:SOLUTION NMR
Cite:Structure of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumor suppressor
J.Biol.Chem., 286, 2011
2M4V
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BU of 2m4v by Molmil
Mycobacterium tuberculosis RNA polymerase binding protein A (RbpA) and its interactions with sigma factors
Descriptor: Putative uncharacterized protein
Authors:Bortoluzzi, A, Muskett, F.W, Waters, L.C, Addis, P.W, Rieck, B, Munder, T, Schleier, S, Forti, F, Ghisotti, D, Carr, M.D, O'Hare, H.M.
Deposit date:2013-02-11
Release date:2013-04-17
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Mycobacterium tuberculosis RNA polymerase-binding protein A (RbpA) and its interactions with sigma factors.
J.Biol.Chem., 288, 2013
2M2D
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BU of 2m2d by Molmil
Human programmed cell death 1 receptor
Descriptor: Programmed cell death protein 1
Authors:Veverka, V, Cheng, X, Waters, L.C, Muskett, F.W, Morgan, S, Lesley, A, Griffiths, M, Stubberfield, C, Griffin, R, Henry, A.J, Robinson, M.K, Jansson, A, Ladbury, J.E, Ikemizu, S, Davis, S.J, Carr, M.D.
Deposit date:2012-12-18
Release date:2013-02-27
Last modified:2013-05-15
Method:SOLUTION NMR
Cite:Structure and interactions of the human programmed cell death 1 receptor.
J.Biol.Chem., 288, 2013
2NPU
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BU of 2npu by Molmil
The solution structure of the rapamycin-binding domain of mTOR (FRB)
Descriptor: FKBP12-rapamycin complex-associated protein
Authors:Veverka, V, Crabbe, T, Bird, I, Lennie, G, Muskett, F.W, Taylor, R.J, Carr, M.D.
Deposit date:2006-10-30
Release date:2007-09-18
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR.
Oncogene, 27, 2008
7BNV
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BU of 7bnv by Molmil
Crystal Structure of the SARS-CoV-2 Receptor Binding Domain in Complex with Antibody ION-300
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain, Light Chain, ...
Authors:Hall, G, Cowan, R, Carr, M.
Deposit date:2021-01-22
Release date:2021-11-17
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses.
Front Immunol, 12, 2021
8B3K
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BU of 8b3k by Molmil
Crystal structure of human Plexin-B1 (20-535) in the unbound state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, Plexin-B1
Authors:Cowan, R, Hall, G, Carr, M.
Deposit date:2022-09-16
Release date:2023-05-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.685 Å)
Cite:Nanobody inhibitors of Plexin-B1 identify allostery in plexin-semaphorin interactions and signaling.
J.Biol.Chem., 299, 2023
8BB7
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BU of 8bb7 by Molmil
Crystal structure of Mouse Plexin-B1 (20-535) in complex with VHH15
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Plexin-B1, VHH15 Nanobody
Authors:Cowan, R, Hall, G, Carr, M.
Deposit date:2022-10-12
Release date:2023-05-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Nanobody inhibitors of Plexin-B1 identify allostery in plexin-semaphorin interactions and signaling.
J.Biol.Chem., 299, 2023
8BF4
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BU of 8bf4 by Molmil
Crystal structure of Mouse Plexin-B1 (20-535) in complex with VHH15 and VHH14
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Cowan, R, Hall, G, Carr, M.
Deposit date:2022-10-24
Release date:2023-05-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Nanobody inhibitors of Plexin-B1 identify allostery in plexin-semaphorin interactions and signaling.
J.Biol.Chem., 299, 2023
7NP1
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BU of 7np1 by Molmil
Crystal Structure of the SARS-CoV-2 Receptor Binding Domain in Complex with Antibody ION-360
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoblobulin light chain, Immunoglobulin gamma-1 heavy chain, ...
Authors:Hall, G, Cowan, R, Carr, M.
Deposit date:2021-02-26
Release date:2021-11-17
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses.
Front Immunol, 12, 2021
6SS4
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BU of 6ss4 by Molmil
Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0021181
Descriptor: Arginase-2, mitochondrial, Fab C0021181 heavy chain (IgG1), ...
Authors:Burschowsky, D, Addyman, A, Fiedler, S, Groves, M, Haynes, S, Seewooruthun, C, Carr, M.
Deposit date:2019-09-06
Release date:2020-06-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action.
Mabs, 12
6SS2
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BU of 6ss2 by Molmil
Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0021158
Descriptor: Arginase-2, mitochondrial, Fab C0021158 heavy chain (IgG1), ...
Authors:Burschowsky, D, Addyman, A, Fiedler, S, Groves, M, Haynes, S, Seewooruthun, C, Carr, M.
Deposit date:2019-09-06
Release date:2020-06-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action.
Mabs, 12
6SS5
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BU of 6ss5 by Molmil
Structure of the arginase-2-inhibitory human antigen-binding fragment Fab C0020187
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ...
Authors:Burschowsky, D, Addyman, A, Fiedler, S, Groves, M, Haynes, S, Seewooruthun, C, Carr, M.
Deposit date:2019-09-06
Release date:2020-06-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation.
Proc.Natl.Acad.Sci.USA, 117, 2020
6SS0
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BU of 6ss0 by Molmil
Structure of the arginase-2-inhibitory human antigen-binding fragment Fab C0021181
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Fab C0021181 heavy chain (IgG1), ...
Authors:Burschowsky, D, Addyman, A, Fiedler, S, Groves, M, Haynes, S, Seewooruthun, C, Carr, M.
Deposit date:2019-09-06
Release date:2020-06-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action.
Mabs, 12

 

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