Author results

6GY5
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CRYSTAL STRUCTURE OF THE KELCH DOMAIN OF HUMAN KLHL20 IN COMPLEX WITH DAPK1 PEPTIDE
Descriptor:Kelch-like protein 20, Death-associated protein kinase 1, CHLORIDE ION, ...
Authors:Chen, Z., Hozjan, V., Strain-Damerell, C., Williams, E., Wang, D., Cooper, C.D.O., Sanvitale, C.E., Fairhead, M., Carpenter, E.P., Pike, A.C.W., Krojer, T., Srikannathasan, V., Sorrell, F., Johansson, C., Mathea, S., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N.
Deposit date:2018-06-28
Release date:2018-08-08
Last modified:2019-09-18
Method:X-RAY DIFFRACTION (1.086 Å)
Cite:Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase.
Structure, 27, 2019
2JC5
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APURINIC APYRIMIDINIC (AP) ENDONUCLEASE (NAPE) FROM NEISSERIA MENINGITIDIS
Descriptor:EXODEOXYRIBONUCLEASE, MAGNESIUM ION, BICINE, ...
Authors:Carpenter, E.P., Corbett, A., Thomson, H., Adacha, J., Jensen, K., Bergeron, J., Kasampalidis, I., Exley, R., Winterbotham, M., Tang, C., Baldwin, G.S., Freemont, P.
Deposit date:2006-12-19
Release date:2007-03-06
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Ap Endonuclease Paralogues with Distinct Activities in DNA Repair and Bacterial Pathogenesis.
Embo J., 26, 2007
2VOC
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THIOREDOXIN A ACTIVE SITE MUTANTS FORM MIXED DISULFIDE DIMERS THAT RESEMBLE ENZYME-SUBSTRATE REACTION INTERMEDIATE
Descriptor:THIOREDOXIN, DI(HYDROXYETHYL)ETHER
Authors:Kouwen, T.R.H.M., Andrell, J., Schrijver, R., Dubois, J.Y.F., Maher, M.J., Iwata, S., Carpenter, E.P., van Dijl, J.M.
Deposit date:2008-02-13
Release date:2009-03-10
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Thioredoxin A active-site mutants form mixed disulfide dimers that resemble enzyme-substrate reaction intermediates.
J. Mol. Biol., 379, 2008
4B4C
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CRYSTAL STRUCTURE OF THE DNA-BINDING DOMAIN OF HUMAN CHD1.
Descriptor:CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1, SULFATE ION, 1,2-ETHANEDIOL, ...
Authors:Allerston, C.K., Cooper, C.D.O., Shrestha, L., Vollmar, M., Burgess-Brown, N., Yue, W.W., Carpenter, E.P., Arrowsmith, C.H., Edwards, A., Bountra, C., von Delft, F., Gileadi, O.
Deposit date:2012-07-30
Release date:2012-08-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Crystal Structure of the DNA-Binding Domain of Human Chd1.
To be Published
1DQS
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CRYSTAL STRUCTURE OF DEHYDROQUINATE SYNTHASE (DHQS) COMPLEXED WITH CARBAPHOSPHONATE, NAD+ AND ZN2+
Descriptor:PROTEIN (3-DEHYDROQUINATE SYNTHASE), ZINC ION, CHLORIDE ION, ...
Authors:Carpenter, E.P., Hawkins, A.R., Frost, J.W., Brown, K.A.
Deposit date:1998-04-09
Release date:1999-07-26
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of dehydroquinate synthase reveals an active site capable of multistep catalysis.
Nature, 394, 1998
2C53
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A COMPARATIVE STUDY OF URACIL DNA GLYCOSYLASES FROM HUMAN AND HERPES SIMPLEX VIRUS TYPE 1
Descriptor:URACIL DNA GLYCOSYLASE, 2'-DEOXYURIDINE, GLYCEROL
Authors:Krusong, K., Carpenter, E.P., Bellmy, S.R.W., Savva, R., Baldwin, G.S.
Deposit date:2005-10-25
Release date:2005-11-28
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A Comparative Study of Uracil-DNA Glycosylases from Human and Herpes Simplex Virus Type 1.
J.Biol.Chem., 281, 2006
2JC4
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3'-5' EXONUCLEASE (NEXO) FROM NEISSERIA MENINGITIDIS
Descriptor:EXODEOXYRIBONUCLEASE III, MAGNESIUM ION, SODIUM ION, ...
Authors:Carpenter, E.P., Corbett, A., Thomson, H., Adacha, J., Jensen, K., Bergeron, J., Kasampalidis, I., Exley, R., Winterbotham, M., Tang, C., Baldwin, G., Freemont, P.
Deposit date:2006-12-19
Release date:2007-03-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Ap Endonuclease Paralogues with Distinct Activities in DNA Repair and Bacterial Pathogenesis.
Embo J., 26, 2007
2JH1
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CRYSTAL STRUCTURE OF TOXOPLASMA GONDII MICRONEMAL PROTEIN 1
Descriptor:MICRONEMAL PROTEIN 1, ACETATE ION, CHLORIDE ION, ...
Authors:Blumenschein, T.M.A., Friedrich, N., Childs, R.A., Saouros, S., Carpenter, E.P., Campanero-Rhodes, M.A., Simpson, P., Koutroukides, T., Blackman, M.J., Feizi, T., Soldati-Favre, D., Matthews, S.
Deposit date:2007-02-19
Release date:2007-05-22
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Atomic Resolution Insight Into Host Cell Recognition by Toxoplasma Gondii.
Embo J., 26, 2007
3FVQ
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CRYSTAL STRUCTURE OF THE NUCLEOTIDE BINDING DOMAIN FBPC COMPLEXED WITH ATP
Descriptor:Fe(3+) ions import ATP-binding protein fbpC, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION
Authors:Newstead, S., Bilton, P., Carpenter, E.P., Campopiano, D., Iwata, S.
Deposit date:2009-01-16
Release date:2009-08-25
Last modified:2012-10-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Insights into how nucleotide-binding domains power ABC transport.
Structure, 17, 2009
3URJ
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TYPE IV NATIVE ENDOTHIAPEPSIN
Descriptor:Endothiapepsin, SULFATE ION
Authors:Bailey, D., Cooper, J.B.
Deposit date:2011-11-22
Release date:2012-04-04
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:An analysis of subdomain orientation, conformational change and disorder in relation to crystal packing of aspartic proteinases.
Acta Crystallogr.,Sect.D, 68, 2012
2XDG
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN GROWTH HORMONE RELEASING HORMONE RECEPTOR.
Descriptor:GROWTH HORMONE-RELEASING HORMONE RECEPTOR, MAGNESIUM ION, 1,2-ETHANEDIOL
Authors:Pike, A.C.W., Quigley, A., Barr, A.J., Burgess Brown, N., Shrestha, L., Yang, J., Chaikuad, A., Vollmar, M., Muniz, J.R.C., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Carpenter, E.P.
Deposit date:2010-04-30
Release date:2010-06-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of the Extracellular Domain of Human Growth Hormone Releasing Hormone Receptor.
To be Published
3F53
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CRYSTAL STRUCTURE OF TOXOPLASMA GONDII MICRONEMAL PROTEIN 1 BOUND TO 2F-3'SIALACNAC
Descriptor:Micronemal protein 1, CHLORIDE ION, O-SIALIC ACID, ...
Authors:Garnett, J.A.
Deposit date:2008-11-03
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Detailed insights from microarray and crystallographic studies into carbohydrate recognition by microneme protein 1 (MIC1) of Toxoplasma gondii.
Protein Sci., 18, 2009
3F5A
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CRYSTAL STRUCTURE OF TOXOPLASMA GONDII MICRONEMAL PROTEIN 1 BOUND TO 3'SIALACNAC1-3
Descriptor:Micronemal protein 1, CHLORIDE ION, O-SIALIC ACID, ...
Authors:Garnett, J.A., Liu, Y., Feizi, T., Matthews, S.J.
Deposit date:2008-11-03
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Detailed insights from microarray and crystallographic studies into carbohydrate recognition by microneme protein 1 (MIC1) of Toxoplasma gondii.
Protein Sci., 18, 2009
3F5E
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CRYSTAL STRUCTURE OF TOXOPLASMA GONDII MICRONEMAL PROTEIN 1 BOUND TO 2'F-3'SIALACNAC1-3
Descriptor:Micronemal protein 1, CHLORIDE ION, O-SIALIC ACID, ...
Authors:Garnett, J.A., Liu, Y., Feizi, T., Matthews, S.J.
Deposit date:2008-11-03
Release date:2009-07-28
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Detailed insights from microarray and crystallographic studies into carbohydrate recognition by microneme protein 1 (MIC1) of Toxoplasma gondii.
Protein Sci., 18, 2009
3URL
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ENDOTHIAPEPSIN-DB6 COMPLEX.
Descriptor:Endothiapepsin, DB6 peptide, SULFATE ION
Authors:Bailey, D., Sanz-Aparicio, J., Albert, A., Cooper, J.B.
Deposit date:2011-11-22
Release date:2012-04-18
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:An analysis of subdomain orientation, conformational change and disorder in relation to crystal packing of aspartic proteinases.
Acta Crystallogr.,Sect.D, 68, 2012
5A14
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HUMAN CDK2 WITH TYPE II INHIBITOR
Descriptor:CYCLIN-DEPENDENT KINASE 2, 1-[4-(2-azanylpyrimidin-4-yl)oxyphenyl]-3-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]urea
Authors:Alexander, L.T., Elkins, J.M., Kopec, J., Fedorov, O., Savitsky, P.A., Moebitz, H., Cowan-Jacob, S.W., Szklarz, M., Pike, A.C.W., Carpenter, E.P., Krojer, T., Bountra, C., Edwards, A.M., Knapp, S.
Deposit date:2015-04-27
Release date:2015-07-22
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Type II Inhibitors Targeting Cdk2.
Acs Chem.Biol., 10, 2015
4B5F
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SUBSTRATE BOUND NEISSERIA AP ENDONUCLEASE IN ABSENCE OF METAL IONS (CRYSTAL FORM 1)
Descriptor:PUTATIVE EXODEOXYRIBONUCLEASE, 5'-D(*GP*CP*TP*AP*CP*3DRP*GP*AP*TP*CP*GP)-3', 5'-D(*CP*GP*AP*TP*CP*GP*GP*TP*AP*GP*CP)-3'
Authors:Lu, D., Silhan, J., MacDonald, J.T., Carpenter, E.P., Jensen, K., Tang, C.M., Baldwin, G.S., Freemont, P.S.
Deposit date:2012-08-03
Release date:2012-10-17
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.005 Å)
Cite:Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis.
Proc. Natl. Acad. Sci. U.S.A., 109, 2012
2XVT
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STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN RAMP2
Descriptor:RECEPTOR ACTIVITY-MODIFYING PROTEIN 2, CALCIUM ION
Authors:Quigley, A., Pike, A.C.W., Burgess-Brown, N., Krojer, T., Shrestha, L., Goubin, S., Kim, J., Das, S., Muniz, J.R.C., Canning, P., Chaikuad, A., Vollmar, M., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Bountra, C., Barr, A.J., Carpenter, E.P.
Deposit date:2010-10-31
Release date:2010-12-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of the Extracellular Domain of Human Ramp2
To be Published
2JH7
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CRYSTAL STRUCTURE OF TOXOPLASMA GONDII MICRONEMAL PROTEIN 1 BOUND TO 6'-SIALYL-N-ACETYLLACTOSAMINE
Descriptor:MICRONEMAL PROTEIN 1, O-SIALIC ACID, BETA-D-GALACTOSE, ...
Authors:Blumenschein, T.M.A., Friedrich, N., Childs, R.A., Saouros, S., Carpenter, E.P., Campanero-Rhodes, M.A., Simpson, P., Koutroukides, T., Blackman, M.J., Feizi, T., Soldati-Favre, D., Matthews, S.
Deposit date:2007-02-20
Release date:2007-05-22
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Atomic Resolution Insight Into Host Cell Recognition by Toxoplasma Gondii.
Embo J., 26, 2007
2XD7
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CRYSTAL STRUCTURE OF THE MACRO DOMAIN OF HUMAN CORE HISTONE H2A
Descriptor:CORE HISTONE MACRO-H2A.2
Authors:Vollmar, M., Phillips, C., Carpenter, E.P., Muniz, J.R.C., Krojer, T., Ugochukwu, E., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Gileadi, O.
Deposit date:2010-04-29
Release date:2010-05-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Crystal Structure of the Macro Domain of Human Core Histone H2A
To be Published
2C56
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A COMPARATIVE STUDY OF URACIL DNA GLYCOSYLASES FROM HUMAN AND HERPES SIMPLEX VIRUS TYPE 1
Descriptor:URACIL DNA GLYCOSYLASE, SUCROSE
Authors:Krusong, K., Carpenter, E.P., Bellamy, S.R.W., Savva, R., Baldwin, G.S.
Deposit date:2005-10-26
Release date:2005-11-28
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Comparative Study of Uracil-DNA Glycosylases from Human and Herpes Simplex Virus Type 1.
J.Biol.Chem., 281, 2006
2X57
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2
Descriptor:VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2
Authors:Pike, A.C.W., Barr, A.J., Quigley, A., Burgess Brown, N., de Riso, A., Bullock, A., Berridge, G., Muniz, J.R.C., Chaikaud, A., Vollmar, M., Krojer, T., Ugochukwu, E., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Carpenter, E.P.
Deposit date:2010-02-05
Release date:2010-03-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of the Extracellular Domain of Human Vasoactive Intestinal Polypeptide Receptor 2
To be Published
3URI
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ENDOTHIAPEPSIN-DB5 COMPLEX.
Descriptor:Endothiapepsin, DB5 peptide
Authors:Bailey, D., Sanz-Aparicio, J., Albert, A., Cooper, J.B.
Deposit date:2011-11-22
Release date:2012-04-18
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:An analysis of subdomain orientation, conformational change and disorder in relation to crystal packing of aspartic proteinases.
Acta Crystallogr.,Sect.D, 68, 2012
4B5J
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NEISSERIA AP ENDONUCLEASE BOUND TO THE SUBSTRATE WITH AN ORPHAN ADENINE BASE
Descriptor:PUTATIVE EXODEOXYRIBONUCLEASE, 5'-D(*GP*CP*TP*AP*CP*(3DR)P*CP*AP*TP*CP*GP)-3', 5'-D(*CP*GP*AP*TP*GP*AP*GP*TP*AP*GP*CP)-3'
Authors:Lu, D., Silhan, J., MacDonald, J.T., Carpenter, E.P., Jensen, K., Tang, C.M., Baldwin, G.S., Freemont, P.S.
Deposit date:2012-08-03
Release date:2012-10-17
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis.
Proc. Natl. Acad. Sci. U.S.A., 109, 2012
4B87
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CRYSTAL STRUCTURE OF HUMAN DNA CROSS-LINK REPAIR 1A
Descriptor:DNA CROSS-LINK REPAIR 1A PROTEIN, ZINC ION, 1,2-ETHANEDIOL
Authors:Allerston, C.K., Berridge, G., Carpenter, E.P., Kochan, G., Krojer, T., Mahajan, P., Vollmar, M., Yue, W.W., Arrowsmith, C.H., Edwards, A., Bountra, C., von Delft, F., Gileadi, O.
Deposit date:2012-08-24
Release date:2012-11-28
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Crystal Structure of Human DNA Cross-Link Repair 1A
To be Published
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