Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
4TQN
DownloadVisualize
BU of 4tqn by Molmil
Crystal structure of the bromodomain of human CREBBP in complex with UL04
Descriptor: 1,2-ETHANEDIOL, 3-[(5-acetyl-2-ethoxyphenyl)carbamoyl]benzoic acid, CREB-binding protein
Authors:Dong, J, Caflisch, A.
Deposit date:2014-06-11
Release date:2015-06-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of CREBBP Bromodomain Inhibitors by High-Throughput Docking and Hit Optimization Guided by Molecular Dynamics.
J.Med.Chem., 59, 2016
5H85
DownloadVisualize
BU of 5h85 by Molmil
Crystal structure of the bromodomain of human CREBBP in complex with UO37D
Descriptor: CREB-binding protein, methyl 3-(7~{H}-purin-6-ylcarbamoyl)benzoate
Authors:Dong, J, Caflisch, A.
Deposit date:2015-12-23
Release date:2017-01-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.701 Å)
Cite:Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9, 2018
8BS6
DownloadVisualize
BU of 8bs6 by Molmil
Crystal structure of YTHDF3 disulfide mutant (closed conformation)
Descriptor: YTH domain-containing family protein 3
Authors:Bedi, R.K, Li, Y, Caflisch, A.
Deposit date:2022-11-24
Release date:2023-12-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal structure of YTHDF3 disulfide mutant (closed conformation)
To Be Published
8BS5
DownloadVisualize
BU of 8bs5 by Molmil
Crystal structure of YTHDF3 YTH domain open conformation
Descriptor: DI(HYDROXYETHYL)ETHER, L(+)-TARTARIC ACID, YTH domain-containing family protein 3
Authors:Bedi, R.K, Caflisch, A.
Deposit date:2022-11-24
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Crystal structure of YTHDF3 YTH domain open conformation
To Be Published
8BS4
DownloadVisualize
BU of 8bs4 by Molmil
Crystal structure of YTHDF1 YTH domain dimer
Descriptor: ACETATE ION, GLYCEROL, YTH domain-containing family protein 1
Authors:Bedi, R.K, Caflisch, A.
Deposit date:2022-11-24
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of YTHDF1 YTH domain dimer
To Be Published
4D49
DownloadVisualize
BU of 4d49 by Molmil
Crystal structure of computationally designed armadillo repeat proteins for modular peptide recognition.
Descriptor: ARGININE, ARMADILLO REPEAT PROTEIN ARM00027, POLY ARG DECAPEPTIDE
Authors:Reichen, C, Forzani, C, Zhou, T, Parmeggiani, F, Fleishman, S.J, Mittl, P.R.E, Madhurantakam, C, Honegger, A, Ewald, C, Zerbe, O, Baker, D, Caflisch, A, Pluckthun, A.
Deposit date:2014-10-27
Release date:2016-01-13
Last modified:2016-11-09
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition.
J.Mol.Biol., 428, 2016
4D4E
DownloadVisualize
BU of 4d4e by Molmil
Crystal structure of computationally designed armadillo repeat proteins for modular peptide recognition.
Descriptor: ARMADILLO REPEAT PROTEIN ARM00016, GLYCEROL
Authors:Reichen, C, Forzani, C, Zhou, T, Parmeggiani, F, Fleishman, S.J, Mittl, P.R.E, Madhurantakam, C, Honegger, A, Ewald, C, Zerbe, O, Baker, D, Caflisch, A, Pluckthun, A.
Deposit date:2014-10-28
Release date:2016-01-13
Last modified:2016-11-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition.
J.Mol.Biol., 428, 2016
5HCL
DownloadVisualize
BU of 5hcl by Molmil
Crystal Structure of the first bromodomain of BRD4 in complex with DMA
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N},~{N}-dimethylethanamide
Authors:Dong, J, Weber, F.E, Caflisch, A.
Deposit date:2016-01-04
Release date:2017-01-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:N,N Dimethylacetamide a drug excipient that acts as bromodomain ligand for osteoporosis treatment.
Sci Rep, 7, 2017
4TS8
DownloadVisualize
BU of 4ts8 by Molmil
Crystal structure of the bromodomain of human CREBBP in complex with XZ08
Descriptor: 1,2-ETHANEDIOL, 4-(1-acetyl-1H-indol-3-yl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one, CREB-binding protein
Authors:Dong, J, Gartenmann, L, Spiliotopoulos, D, Caflisch, A.
Deposit date:2014-06-18
Release date:2015-07-01
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the bromodomain of human CREBBP in complex with XZ08
To Be Published
4TWO
DownloadVisualize
BU of 4two by Molmil
Human EphA3 Kinase domain in complex with compound 164
Descriptor: 5-{[3-carbamoyl-4-(3,4-dimethylphenyl)-5-methylthiophen-2-yl]amino}-5-oxopentanoic acid, Ephrin type-A receptor 3
Authors:Dong, J, Caflisch, A.
Deposit date:2014-07-01
Release date:2015-05-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.047 Å)
Cite:Structural Analysis of the Binding of Type I, I1/2, and II Inhibitors to Eph Tyrosine Kinases.
Acs Med.Chem.Lett., 6, 2015
4TWN
DownloadVisualize
BU of 4twn by Molmil
Human EphA3 Kinase domain in complex with Birb796
Descriptor: 1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA, Ephrin type-A receptor 3
Authors:Dong, J, Caflisch, A.
Deposit date:2014-07-01
Release date:2015-05-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.706 Å)
Cite:Structural Analysis of the Binding of Type I, I1/2, and II Inhibitors to Eph Tyrosine Kinases.
Acs Med.Chem.Lett., 6, 2015
2MUS
DownloadVisualize
BU of 2mus by Molmil
HADDOCK calculated model of LIN5001 bound to the HET-s amyloid
Descriptor: 3''',4'-bis(carboxymethyl)-2,2':5',2'':5'',2''':5''',2''''-quinquethiophene-5,5''''-dicarboxylic acid, Heterokaryon incompatibility protein s
Authors:Hermann, U.S, Schuetz, A.K, Shirani, H, Saban, D, Nuvolone, M, Huang, D.H, Li, B, Ballmer, B, Aslund, A.K.O, Mason, J.J, Rushing, E, Budka, H, Hammarstrom, P, Bockmann, A, Caflisch, A, Meier, B.H, Nilsson, P.K.R, Hornemann, S, Aguzzi, A.
Deposit date:2014-09-16
Release date:2017-02-01
Last modified:2018-06-13
Method:SOLUTION NMR
Cite:Structure-based drug design identifies polythiophenes as antiprion compounds.
Sci Transl Med, 7, 2015
7Z7F
DownloadVisualize
BU of 7z7f by Molmil
Crystal structure of YTHDF2 with compound YLI_DC1_005
Descriptor: CHLORIDE ION, GLYCEROL, SULFATE ION, ...
Authors:Nai, F, Li, Y, Dolbois, A, Caflisch, A.
Deposit date:2022-03-15
Release date:2022-03-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Fragment Ligands of the m 6 A-RNA Reader YTHDF2.
Acs Med.Chem.Lett., 13, 2022
7Z7B
DownloadVisualize
BU of 7z7b by Molmil
Crystal structure of YTHDF2 with compound YLI_DC1_003
Descriptor: CHLORIDE ION, GLYCEROL, SULFATE ION, ...
Authors:Nai, F, Li, Y, Dolbois, A, Caflisch, A.
Deposit date:2022-03-15
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Fragment Ligands of the m 6 A-RNA Reader YTHDF2.
Acs Med.Chem.Lett., 13, 2022
7Z54
DownloadVisualize
BU of 7z54 by Molmil
Crystal structure of YTHDF2 with compound YLI_DC1_006
Descriptor: 9-cyclopropyl-~{N}-methyl-purin-6-amine, CHLORIDE ION, GLYCEROL, ...
Authors:Nai, F, Li, Y, Dolbois, A, Caflisch, A.
Deposit date:2022-03-07
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Fragment Ligands of the m 6 A-RNA Reader YTHDF2.
Acs Med.Chem.Lett., 13, 2022
4P5Z
DownloadVisualize
BU of 4p5z by Molmil
Human EphA3 Kinase domain in complex with quinoxaline derivatives
Descriptor: 2-amino-1-[4-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl]-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide, Ephrin type-A receptor 3
Authors:Dong, J, Caflisch, A.
Deposit date:2014-03-20
Release date:2014-08-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Pyrrolo[3,2-b]quinoxaline Derivatives as Types I1/2 and II Eph Tyrosine Kinase Inhibitors: Structure-Based Design, Synthesis, and in Vivo Validation.
J.Med.Chem., 57, 2014
4P5Q
DownloadVisualize
BU of 4p5q by Molmil
Human EphA3 Kinase domain in complex with quinoxaline derivatives
Descriptor: 2-amino-1-(2-chlorophenyl)-N-(3-ethoxypropyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide, Ephrin type-A receptor 3
Authors:Dong, J, Caflisch, A.
Deposit date:2014-03-19
Release date:2014-08-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Pyrrolo[3,2-b]quinoxaline Derivatives as Types I1/2 and II Eph Tyrosine Kinase Inhibitors: Structure-Based Design, Synthesis, and in Vivo Validation.
J.Med.Chem., 57, 2014
4P4C
DownloadVisualize
BU of 4p4c by Molmil
Human EphA3 Kinase domain in complex with quinoxaline derivatives
Descriptor: 2-amino-1-(3-methoxyphenyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide, EPH receptor A3
Authors:Dong, J, Caflisch, A.
Deposit date:2014-03-12
Release date:2014-08-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.599 Å)
Cite:Pyrrolo[3,2-b]quinoxaline Derivatives as Types I1/2 and II Eph Tyrosine Kinase Inhibitors: Structure-Based Design, Synthesis, and in Vivo Validation.
J.Med.Chem., 57, 2014
6RT5
DownloadVisualize
BU of 6rt5 by Molmil
The YTH domain of YTHDC1 protein in complex with Gm6AC oligonucleotide
Descriptor: RNA (5'-R(*(6MZ)P*C)-3'), SULFATE ION, YTH domain-containing protein 1
Authors:Bedi, R, Sledz, P, Caflisch, A.
Deposit date:2019-05-22
Release date:2019-11-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.303 Å)
Cite:Flexible Binding of m6A Reader Protein YTHDC1 to Its Preferred RNA Motif.
J Chem Theory Comput, 15, 2019
6RT4
DownloadVisualize
BU of 6rt4 by Molmil
The YTH domain of YTHDC1 protein in complex with m6ACU oligonucleotide
Descriptor: RNA (5'-R(*(6MZ)P*C)-3'), SULFATE ION, YTH domain-containing protein 1
Authors:Bedi, R, Sledz, P, Caflisch, A.
Deposit date:2019-05-22
Release date:2019-11-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Flexible Binding of m6A Reader Protein YTHDC1 to Its Preferred RNA Motif.
J Chem Theory Comput, 15, 2019
6RT6
DownloadVisualize
BU of 6rt6 by Molmil
The YTH domain of YTHDC1 protein in complex with GGm6AC oligonucleotide
Descriptor: RNA (5'-R(*(6MZ)P*C)-3'), SULFATE ION, YTH domain-containing protein 1
Authors:Bedi, R, Sledz, P, Caflisch, A.
Deposit date:2019-05-22
Release date:2019-11-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.461 Å)
Cite:Flexible Binding of m6A Reader Protein YTHDC1 to Its Preferred RNA Motif.
J Chem Theory Comput, 15, 2019
6RT7
DownloadVisualize
BU of 6rt7 by Molmil
The YTH domain of YTHDC1 protein in complex with Gm6ACU oligonucleotide
Descriptor: RNA (5'-R(*(6MZ)P*C)-3'), SULFATE ION, YTH domain-containing protein 1
Authors:Bedi, R, Sledz, P, Caflisch, A.
Deposit date:2019-05-22
Release date:2019-11-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Flexible Binding of m6A Reader Protein YTHDC1 to Its Preferred RNA Motif.
J Chem Theory Comput, 15, 2019
7ACD
DownloadVisualize
BU of 7acd by Molmil
Crystal structure of the human METTL3-METTL14 complex with compound T30 (UZH1a)
Descriptor: 4-[(4,4-dimethylpiperidin-1-yl)methyl]-2-oxidanyl-~{N}-[[(3~{R})-3-oxidanyl-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide, ACETATE ION, MAGNESIUM ION, ...
Authors:Bedi, R.K, Huang, D, Caflisch, A.
Deposit date:2020-09-10
Release date:2020-10-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:METTL3 Inhibitors for Epitranscriptomic Modulation of Cellular Processes.
Chemmedchem, 16, 2021
8PW9
DownloadVisualize
BU of 8pw9 by Molmil
Crystal structure of the human METTL3-METTL14 in complex with a bisubstrate analogue (BA1)
Descriptor: (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[2-[[9-[(2~{R},3~{R},4~{S},5~{S})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-6-yl]amino]ethylamino]methyl]oxolane-3,4-diol, ACETATE ION, MAGNESIUM ION, ...
Authors:Bedi, R.K, Etheve-Quelquejeu, M, Caflisch, A.
Deposit date:2023-07-19
Release date:2023-11-08
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The catalytic mechanism of the RNA methyltransferase METTL3.
Elife, 12, 2024
8PWB
DownloadVisualize
BU of 8pwb by Molmil
Crystal structure of the human METTL3-METTL14 in complex with a bisubstrate analogue (BA6)
Descriptor: (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(7~{H}-purin-6-ylcarbamoyl)amino]-2-azanyl-butanoic acid, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
Authors:Bedi, R.K, Etheve-Quelquejeu, M, Caflisch, A.
Deposit date:2023-07-19
Release date:2023-11-08
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The catalytic mechanism of the RNA methyltransferase METTL3.
Elife, 12, 2024

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon