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2C0Z
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THE 1.6 A RESOLUTION CRYSTAL STRUCTURE OF NOVW: A 4-KETO-6-DEOXY SUGAR EPIMERASE FROM THE NOVOBIOCIN BIOSYNTHETIC GENE CLUSTER OF STREPTOMYCES SPHEROIDES
Descriptor:NOVW, SULFATE ION, 1,2-ETHANEDIOL
Authors:Jakimowicz, P., Tello, M., Freel-Meyers, C.L., Walsh, C.T., Buttner, M.J., Field, R.A., Lawson, D.M.
Deposit date:2005-09-09
Release date:2006-01-25
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The 1.6 A Resolution Crystal Structure of Novw: A 4-Keto-6-Deoxy Sugar Epimerase from the Novobiocin Biosynthetic Gene Cluster of Streptomyces Spheroides
Proteins, 63, 2006
2Y3P
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CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF GYRA WITH THE ANTIBIOTIC SIMOCYCLINONE D8
Descriptor:DNA GYRASE SUBUNIT A, MAGNESIUM ION, SIMOCYCLINONE D8
Authors:Edwards, M.J., Flatman, R.H., Mitchenall, L.A., Stevenson, C.E.M., Le, T.B.K., Clarke, T.A., McKay, A.R., Fiedler, H.-P., Buttner, M.J., Lawson, D.M., Maxwell, A.
Deposit date:2010-12-22
Release date:2010-12-29
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:A Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8, Bound to DNA Gyrase.
Science, 326, 2009
1H3L
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N-TERMINAL FRAGMENT OF SIGR FROM STREPTOMYCES COELICOLOR
Descriptor:RNA POLYMERASE SIGMA FACTOR
Authors:Li, W., Stevenson, C.E.M., Burton, N., Jakimowicz, P., Paget, M.S.B., Buttner, M.J., Lawson, D.M., Kleanthous, C.
Deposit date:2002-09-10
Release date:2002-10-03
Last modified:2015-09-23
Method:X-RAY DIFFRACTION (2.375 Å)
Cite:Identification and Structure of the Anti-Sigma Factor-Binding Domain of the Disulfide-Stress Regulated Sigma Factor Sigma(R) from Streptomyces Coelicolor
J.Mol.Biol., 323, 2002
2Y2Z
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LIGAND-FREE FORM OF TETR-LIKE REPRESSOR SIMR
Descriptor:PUTATIVE REPRESSOR SIMREG2
Authors:Le, T.B.K., Stevenson, C.E.M., Fiedler, H.-P., Maxwell, A., Lawson, D.M., Buttner, M.J.
Deposit date:2010-12-17
Release date:2011-03-09
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the Tetr-Like Simocyclinone Efflux Pump Repressor, Simr, and the Mechanism of Ligand-Mediated Derepression.
J.Mol.Biol., 408, 2011
2Y30
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SIMOCYCLINONE D8 BOUND FORM OF TETR-LIKE REPRESSOR SIMR
Descriptor:PUTATIVE REPRESSOR SIMREG2, SIMOCYCLINONE D8, CHLORIDE ION
Authors:Le, T.B.K., Stevenson, C.E.M., Fiedler, H.-P., Maxwell, A., Lawson, D.M., Buttner, M.J.
Deposit date:2010-12-17
Release date:2011-03-09
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the Tetr-Like Simocyclinone Efflux Pump Repressor, Simr, and the Mechanism of Ligand-Mediated Derepression.
J.Mol.Biol., 408, 2011
2Y31
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SIMOCYCLINONE C4 BOUND FORM OF TETR-LIKE REPRESSOR SIMR
Descriptor:PUTATIVE REPRESSOR SIMREG2, SIMOCYCLINONE C4, PENTAETHYLENE GLYCOL, ...
Authors:Le, T.B.K., Stevenson, C.E.M., Fiedler, H.-P., Maxwell, A., Lawson, D.M., Buttner, M.J.
Deposit date:2010-12-17
Release date:2011-03-09
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the Tetr-Like Simocyclinone Efflux Pump Repressor, Simr, and the Mechanism of Ligand-Mediated Derepression.
J.Mol.Biol., 408, 2011
3ZQL
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DNA-BOUND FORM OF TETR-LIKE REPRESSOR SIMR
Descriptor:PUTATIVE REPRESSOR SIMREG2, 5'-D(*DTP*TP*CP*GP*TP*AP*CP*GP*CP*CP*GP*TP*AP*DCP *GP*AP*A)-3', 5'-D(*DTP*TP*CP*GP*TP*AP*CP*GP*GP*CP*GP*TP*AP*DCP *GP*AP*A)-3'
Authors:Le, T.B.K., Schumacher, M.A., Lawson, D.M., Brennan, R.G., Buttner, M.J.
Deposit date:2011-06-10
Release date:2011-08-31
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:The Crystal Structure of the Tetr Family Transcriptional Repressor Simr Bound to DNA and the Role of a Flexible N-Terminal Extension in Minor Groove Binding.
Nucleic Acids Res., 39, 2011
5L3Z
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POLYKETIDE KETOREDUCTASE SIMC7 - BINARY COMPLEX WITH NADP+
Descriptor:polyketide ketoreductase SimC7, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Schafer, M., Stevenson, C.E.M., Wilkinson, B., Lawson, D.M., Buttner, M.J.
Deposit date:2016-05-24
Release date:2016-10-05
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate.
Cell Chem Biol, 23, 2016
5L40
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POLYKETIDE KETOREDUCTASE SIMC7 - APO CRYSTAL FORM 1
Descriptor:polyketide ketoreductase SimC7
Authors:Schafer, M., Stevenson, C.E.M., Wilkinson, B., Lawson, D.M., Buttner, M.J.
Deposit date:2016-05-24
Release date:2016-10-05
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate.
Cell Chem Biol, 23, 2016
5L45
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POLYKETIDE KETOREDUCTASE SIMC7 - APO CRYSTAL FORM 2
Descriptor:SimC7, TETRAETHYLENE GLYCOL, GLYCEROL
Authors:Schafer, M., Stevenson, C.E.M., Wilkinson, B., Lawson, D.M., Buttner, M.J.
Deposit date:2016-05-25
Release date:2016-10-05
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate.
Cell Chem Biol, 23, 2016
5L4L
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POLYKETIDE KETOREDUCTASE SIMC7 - TERNARY COMPLEX WITH NADP+ AND 7-OXO-SD8
Descriptor:SimC7, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Schafer, M., Stevenson, C.E.M., Wilkinson, B., Lawson, D.M., Buttner, M.J.
Deposit date:2016-05-25
Release date:2016-10-05
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate.
Cell Chem Biol, 23, 2016
4OAY
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BLDD CTD-C-DI-GMP COMPLEX
Descriptor:DNA-binding protein, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)
Authors:Schumacher, M.A., Tschowri, N., Buttner, M., Brennan, R.G.
Deposit date:2014-01-06
Release date:2014-11-19
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development.
Cell(Cambridge,Mass.), 158, 2014
4OAZ
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BLDD CTD-C-DI-GMP COMPLEX
Descriptor:Putative DNA-binding protein, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)
Authors:Schumacher, M.A., Tschowri, N., Buttner, M., Brennan, R.G.
Deposit date:2014-01-06
Release date:2014-11-19
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development.
Cell(Cambridge,Mass.), 158, 2014
4OB4
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STRUCTURE OF THE S. VENEZULAE BLDD DNA-BINDING DOMAIN
Descriptor:Putative DNA-binding protein
Authors:schumacher, M.A., Tschowri, N., Buttner, M., Brennan, R.
Deposit date:2014-01-06
Release date:2014-11-19
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development.
Cell(Cambridge,Mass.), 158, 2014
6DXO
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1.8 A STRUCTURE OF RSBN-BLDN COMPLEX.
Descriptor:RNA polymerase ECF-subfamily sigma factor, BldN
Authors:Schumacher, M.A.
Deposit date:2018-06-29
Release date:2018-07-11
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The crystal structure of the RsbN-sigma BldN complex from Streptomyces venezuelae defines a new structural class of anti-sigma factor.
Nucleic Acids Res., 46, 2018
6AMA
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STRUCTURE OF S. COELICOLOR/S. VENEZUELAE BLDC-SMEA-SSFA COMPLEX TO 3.09 ANGSTROM
Descriptor:Putative DNA-binding protein, DNA (99-MER)
Authors:Schumacher, M.A.
Deposit date:2017-08-09
Release date:2018-03-28
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development.
Nat Commun, 9, 2018
6AMK
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STRUCTURE OF STREPTOMYCES VENEZUELAE BLDC-WHII OPT COMPLEX
Descriptor:Putative DNA-binding protein, DNA (5'-D(*TP*TP*CP*AP*AP*TP*TP*CP*GP*GP*GP*TP*AP*AP*TP*TP*CP*GP*GP*GP*CP*A)-3'), DNA (5'-D(*AP*AP*TP*GP*TP*CP*CP*GP*AP*AP*TP*TP*AP*CP*CP*CP*GP*AP*AP*TP*TP*G)-3')
Authors:Schumacher, M.A.
Deposit date:2017-08-09
Release date:2018-03-28
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (3.288 Å)
Cite:The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development.
Nat Commun, 9, 2018
5KHD
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STRUCTURE OF 1.75 A BLDD C-DOMAIN-C-DI-GMP COMPLEX
Descriptor:DNA-binding protein, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)
Authors:Schumacher, M.
Deposit date:2016-06-14
Release date:2016-06-29
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.7501 Å)
Cite:Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development.
Cell, 158, 2014
5TZD
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STRUCTURE OF THE WT S. VENEZULAE BLDD-(CTD-C-DI-GMP)2 ASSEMBLY INTERMEDIATE
Descriptor:DNA-binding protein, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)
Authors:Schumacher, M.
Deposit date:2016-11-21
Release date:2017-04-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.749 Å)
Cite:The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex.
Nucleic Acids Res., 45, 2017
5TZF
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STRUCTURE OF THE BLDD CTD(D116A)-(C-DI-GMP)2 INTERMEDIATE, FORM 1
Descriptor:DNA-binding protein, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)
Authors:Schumacher, M.A.
Deposit date:2016-11-21
Release date:2017-04-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex.
Nucleic Acids Res., 45, 2017
5TZG
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STRUCTURE OF THE BLDD CTD(D116A)-(C-DI-GMP)2, FORM 2
Descriptor:DNA-binding protein, ZINC ION, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)
Authors:Schumacher, M.A.
Deposit date:2016-11-21
Release date:2017-04-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex.
Nucleic Acids Res., 45, 2017