Author results

2N5H
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PLTL-HOLO
Descriptor:Peptidyl carrier protein PltL, 4'-PHOSPHOPANTETHEINE
Authors:Jaremko, M.J., Lee, D.J., Burkart, M.D.
Deposit date:2015-07-17
Release date:2015-09-16
Last modified:2015-09-30
Method:SOLUTION NMR
Cite:Structure and Substrate Sequestration in the Pyoluteorin Type II Peptidyl Carrier Protein PltL.
J.Am.Chem.Soc., 137, 2015
2N5I
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PLTL-PYRROLYL
Descriptor:Peptidyl carrier protein PltL, (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(1H-pyrrol-2-ylcarbonyl)amino]ethyl}amino)propyl]amino}butyl dihydrogen phosphate
Authors:Jaremko, M.J., Lee, D.J., Burkart, M.D.
Deposit date:2015-07-17
Release date:2015-09-16
Last modified:2015-09-30
Method:SOLUTION NMR
Cite:Structure and Substrate Sequestration in the Pyoluteorin Type II Peptidyl Carrier Protein PltL.
J.Am.Chem.Soc., 137, 2015
4QJK
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CRYSTAL STRUCTURE OF M. TUBERCULOSIS PHOSPHOPANTETHEINYL TRANSFERASE PPTT
Descriptor:Phosphopantetheinyl transferase PptT, COENZYME A, SULFATE ION
Authors:Noel, J.P., Burkart, M.D., Vickery, C.R.
Deposit date:2014-06-04
Release date:2014-07-16
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Structure, biochemistry, and inhibition of essential 4'-phosphopantetheinyl transferases from two species of mycobacteria.
Acs Chem.Biol., 9, 2014
4QJL
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CRYSTAL STRUCTURE OF M. ULCERANS PHOSPHOPANTETHEINYL TRANSFERASE MUPPT
Descriptor:Phosphopantetheinyl transferase, PptII, COENZYME A, ...
Authors:Noel, J.P., Burkart, M.D., Vickery, C.R.
Deposit date:2014-06-04
Release date:2014-07-16
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure, biochemistry, and inhibition of essential 4'-phosphopantetheinyl transferases from two species of mycobacteria.
Acs Chem.Biol., 9, 2014
5JDX
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PIGG HOLO
Descriptor:Putative peptidyl carrier protein, 4'-PHOSPHOPANTETHEINE
Authors:Jaremko, M.J., Lee, D.J., Burkart, M.D.
Deposit date:2016-04-17
Release date:2017-08-23
Last modified:2017-09-27
Method:SOLUTION NMR
Cite:PigG holo
To Be Published
5KBZ
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STRUCTURE OF THE PKSA PRODUCT TEMPLATE DOMAIN IN COMPLEX WITH A PHOSPHOPANTETHEINE MIMETIC
Descriptor:Noranthrone synthase, (14R)-14-hydroxy-15,15-dimethyl-1-[5-({[(5-methyl-1,2-oxazol-3-yl)methyl]sulfanyl}methyl)-1,2-oxazol-3-yl]-4,9,13-trioxo-2-thia-5,8,12-triazahexadecan-16-yl dihydrogen phosphate
Authors:Tsai, S.C., Burkart, M.D., Townsend, C.A., Barajas, J.F., Shakya, G., Topper, C.L., Moreno, G., Jackson, D.R., Rivera, H., La Clair, J.J., Vagstad, A.
Deposit date:2016-06-03
Release date:2017-05-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.803 Å)
Cite:Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4KEH
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CROSSLINKED CRYSTAL STRUCTURE OF TYPE II FATTY SYNTHASE DEHYDRATASE, FABA, AND ACYL CARRIER PROTEIN, ACPP
Descriptor:N-{3-[DIHYDROXY(NONYL)-LAMBDA~4~-SULFANYL]PROPYL}-N~3~-[(2R)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANINAMIDE, Acyl carrier protein, N-{3-[dihydroxy(nonyl)-lambda~4~-sulfanyl]propyl}-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide
Authors:Nguyen, C., Haushalter, R., Finzel, K., Leong, J., Le, B.C., Burkart, M., Tsai, S.C.
Deposit date:2013-04-25
Release date:2013-12-25
Last modified:2014-01-29
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Trapping the dynamic acyl carrier protein in fatty acid biosynthesis.
Nature, 505, 2014
1OFN
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PURIFICATION, CRYSTALLISATION AND PRELIMINARY STRUCTURAL STUDIES OF DTDP-4-KETO-6-DEOXY-GLUCOSE-5-EPIMERASE (EVAD) FROM AMYCOLATOPSIS ORIENTALIS; THE FOURTH ENZYME IN THE DTDP-L-EPIVANCOSAMINE BIOSYNTHETIC PATHWAY.
Descriptor:PCZA361.16, GLYCEROL
Authors:Merkel, A.B., Naismith, J.H.
Deposit date:2003-04-17
Release date:2004-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Purification, Crystallization and Preliminary Structural Studies of Dtdp-4-Keto-6-Deoxy-Glucose-5-Epimerase (Evad) from Amycolatopsis Orientalis, the Fourth Enzyme in the Dtdp-L-Epivancosamine Biosynthetic Pathway.
Acta Crystallogr.,Sect.D, 58, 2002
1OI6
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STRUCTURE DETERMINATION OF THE TMP-COMPLEX OF EVAD
Descriptor:PCZA361.16, GLYCEROL, THYMIDINE-5'-PHOSPHATE
Authors:Merkel, A.B., Naismith, J.H.
Deposit date:2003-06-09
Release date:2004-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Position of a Key Tyrosine in Dtdp-4-Keto-6-Deoxy-D-Glucose-5-Epimerase (Evad) Alters the Substrate Profile for This Rmlc-Like Enzyme
J.Biol.Chem., 279, 2004
4CL6
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CRYSTAL STRUCTURE OF 3-HYDROXYDECANOYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABA) FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH N-(4- CHLOROBENZYL)-3-(2-FURYL)-1H-1,2,4-TRIAZOL-5-AMINE
Descriptor:3-HYDROXYDECANOYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE, N-(4-chlorobenzyl)-5-(furan-2-yl)-1H-1,2,4-triazol-3-amine
Authors:Moynie, L., McMahon, S.A., Duthie, F.G., Naismith, J.H.
Deposit date:2014-01-13
Release date:2015-01-21
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:A Substrate Mimic Allows High Throughput Assay of the Faba Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas Aeruginosa Faba.
J.Mol.Biol., 428, 2016
4DBZ
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CRYSTAL STRUCTURE OF V151L ACTINORHODIN POLYKETIDE KETOREDUCTASE WITH NADPH
Descriptor:Ketoacyl reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Javidpour, P., Tsai, S.-C.
Deposit date:2012-01-16
Release date:2013-01-16
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (2.643 Å)
Cite:The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase.
Chem.Biol., 20, 2013
4DC0
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CRYSTAL STRUCTURE OF F189W ACTINORHODIN POLYKETIDE KETOREDUCTASE WITH NADPH
Descriptor:Ketoacyl reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Javidpour, P., Tsai, S.-C.
Deposit date:2012-01-16
Release date:2013-01-16
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (2.813 Å)
Cite:The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase.
Chem.Biol., 20, 2013
4DC1
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CRYSTAL STRUCTURE OF Y202F ACTINORHODIN POLYKETIDE KETOREDUCTASE WITH NADPH
Descriptor:Ketoacyl reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Javidpour, P., Tsai, S.-C.
Deposit date:2012-01-16
Release date:2013-01-16
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase.
Chem.Biol., 20, 2013
5IK0
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH FPP
Descriptor:5-epi-aristolochene synthase, MAGNESIUM ION, FARNESYL DIPHOSPHATE
Authors:Koo, H.J., Xu, Y., Louie, G.V., Bowman, M., Noel, J.P.
Deposit date:2016-03-03
Release date:2016-10-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants.
J.Antibiot., 69, 2016
5IK6
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH GERMACRENE A AND PPI
Descriptor:5-epi-aristolochene synthase, MAGNESIUM ION, GERMACRENE A, ...
Authors:Koo, H.J., Xu, Y., Louie, G.V., Bowman, M., Noel, J.P.
Deposit date:2016-03-03
Release date:2016-10-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants.
J.Antibiot., 69, 2016
5IK9
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TOBACCO 5-EPI-ARISTOLOCHENE WITH FARNESYL MONOPHOSPHATE
Descriptor:5-epi-aristolochene synthase, MAGNESIUM ION, (2E,6Z)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl dihydrogen phosphate
Authors:Koo, H.J., Xu, Y., Louie, G.V., Bowman, M., Noel, J.P.
Deposit date:2016-03-03
Release date:2016-10-05
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants.
J.Antibiot., 69, 2016
5IKA
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH PPI
Descriptor:5-epi-aristolochene synthase, MAGNESIUM ION, DIPHOSPHATE
Authors:Koo, H.J., Xu, Y., Louie, G.V., Bowman, M., Noel, J.P.
Deposit date:2016-03-03
Release date:2016-10-05
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants.
J.Antibiot., 69, 2016
5IKH
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE M4 MUTANT WITH (-)-PREMNASPIRODIENE
Descriptor:5-epi-aristolochene synthase, (2R,5S,10R)-6,10-dimethyl-2-(prop-1-en-2-yl)spiro[4.5]dec-6-ene, MAGNESIUM ION
Authors:Koo, H.J., O'Maille, P.E., Louie, G.V., Bowman, M., Noel, J.P.
Deposit date:2016-03-03
Release date:2016-10-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants.
J.Antibiot., 69, 2016
6N3P
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CROSSLINKED ACPP=FABZ COMPLEX FROM E. COLI TYPE II FAS
Descriptor:3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, Acyl carrier protein, N~3~-{(2R)-4-[(dihydroxyphosphanyl)oxy]-2-hydroxy-3,3-dimethylbutanoyl}-N-(3-{[(1Z)-pent-1-en-1-yl]sulfonyl}propyl)-beta-alaninamide
Authors:Smith, J.L., Dodge, G.J.
Deposit date:2018-11-15
Release date:2019-03-13
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and dynamical rationale for fatty acid unsaturation inEscherichia coli.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
1WA4
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CRYSTAL STRUCTURE OF THE M131F L135A EVAD DOUBLE MUTANT
Descriptor:PCZA361.16, GLYCEROL
Authors:Merkel, A.B., Naismith, J.H.
Deposit date:2004-10-22
Release date:2007-01-30
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of the M131F L135A Evad Double Mutant
To be Published