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6PIS
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BU of 6pis by Molmil
Mouse two pore domain K+ channel TRAAK (K2P4.1) - Fab complex structure
Descriptor: ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, POTASSIUM ION, ...
Authors:Brohawn, S.G.
Deposit date:2019-06-27
Release date:2019-12-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier.
Elife, 8, 2019
4I9W
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BU of 4i9w by Molmil
Human two pore domain K+ channel TRAAK (K2P4.1) - Fab complex structure
Descriptor: ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
Authors:Brohawn, S.G, Mackinnon, R.
Deposit date:2012-12-05
Release date:2013-01-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel.
Proc.Natl.Acad.Sci.USA, 110, 2013
4WFG
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BU of 4wfg by Molmil
Human TRAAK K+ channel in a Tl+ bound conductive conformation
Descriptor: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
Authors:Brohawn, S.G, MacKinnon, R.
Deposit date:2014-09-15
Release date:2014-12-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
4WFH
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BU of 4wfh by Molmil
Human TRAAK K+ channel in a Tl+ bound nonconductive conformation
Descriptor: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
Authors:Brohawn, S.G, MacKinnon, R.
Deposit date:2014-09-15
Release date:2014-12-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
4WFE
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BU of 4wfe by Molmil
Human TRAAK K+ channel in a K+ bound conductive conformation
Descriptor: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
Authors:Brohawn, S.G, MacKinnon, R.
Deposit date:2014-09-15
Release date:2014-12-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
4WFF
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BU of 4wff by Molmil
Human TRAAK K+ channel in a K+ bound nonconductive conformation
Descriptor: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
Authors:Brohawn, S.G, MacKinnon, R.
Deposit date:2014-09-15
Release date:2014-12-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
3UM7
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BU of 3um7 by Molmil
Crystal structure of the human two pore domain K+ ion channel TRAAK (K2P4.1)
Descriptor: POTASSIUM ION, Potassium channel subfamily K member 4
Authors:Brohawn, S.G, MacKinnon, R.
Deposit date:2011-11-12
Release date:2012-02-08
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel.
Science, 335, 2012
3EWE
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BU of 3ewe by Molmil
Crystal Structure of the Nup85/Seh1 Complex
Descriptor: Nucleoporin NUP85, Nucleoporin SEH1
Authors:Brohawn, S.G, Leksa, N.C, Rajashankar, K.R, Schwartz, T.U.
Deposit date:2008-10-14
Release date:2008-11-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural evidence for common ancestry of the nuclear pore complex and vesicle coats.
Science, 322, 2008
3JRP
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BU of 3jrp by Molmil
SEC13 with NUP145C (AA109-179) insertion blade
Descriptor: FUSION PROTEIN OF PROTEIN TRANSPORT PROTEIN SEC13 AND NUCLEOPORIN NUP145
Authors:Brohawn, S.G, Gogola, M, Schwartz, T.U.
Deposit date:2009-09-08
Release date:2009-10-27
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular architecture of the Nup84-Nup145C-Sec13 edge element in the nuclear pore complex lattice.
Nat.Struct.Mol.Biol., 16, 2009
3JRO
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BU of 3jro by Molmil
NUP84-NUP145C-SEC13 edge element of the NPC lattice
Descriptor: Fusion Protein of Protein Transport Protein SEC13 and Nucleoporin NUP145, Nucleoporin NUP84
Authors:Brohawn, S.G, Schwartz, T.U.
Deposit date:2009-09-08
Release date:2009-10-27
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (4.004 Å)
Cite:Molecular architecture of the Nup84-Nup145C-Sec13 edge element in the nuclear pore complex lattice.
Nat.Struct.Mol.Biol., 16, 2009
7KJR
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BU of 7kjr by Molmil
Cryo-EM structure of SARS-CoV-2 ORF3a
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Apolipoprotein A-I, ORF3a protein
Authors:Kern, D.M, Hoel, C.M, Kotecha, A, Brohawn, S.G.
Deposit date:2020-10-26
Release date:2020-11-18
Last modified:2022-08-31
Method:ELECTRON MICROSCOPY (2.08 Å)
Cite:Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs.
Nat.Struct.Mol.Biol., 28, 2021
6XDC
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BU of 6xdc by Molmil
Cryo-EM structure of SARS-CoV-2 ORF3a
Descriptor: ORF3a protein
Authors:Kern, D.M, Hoel, C.M, Brohawn, S.G.
Deposit date:2020-06-10
Release date:2020-06-17
Last modified:2022-08-31
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs.
Nat.Struct.Mol.Biol., 28, 2021
8CTJ
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BU of 8ctj by Molmil
Cryo-EM structure of TMEM87A
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Transmembrane protein 87A
Authors:Hoel, C.M, Zhang, L, Brohawn, S.G.
Deposit date:2022-05-15
Release date:2022-07-20
Last modified:2022-11-30
Method:ELECTRON MICROSCOPY (4.74 Å)
Cite:Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A.
Elife, 11, 2022
8CTK
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BU of 8ctk by Molmil
Cryo-EM structure of SARS-CoV-2 M protein in a lipid nanodisc
Descriptor: Membrane protein
Authors:Dolan, K.A, Brohawn, S.G.
Deposit date:2022-05-15
Release date:2022-06-22
Last modified:2022-11-02
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:Structure of SARS-CoV-2 M protein in lipid nanodiscs.
Elife, 11, 2022
6WLV
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BU of 6wlv by Molmil
TASK2 in MSP1D1 lipid nanodisc at pH 6.5
Descriptor: POTASSIUM ION, Potassium channel TASK2
Authors:Li, B, Brohawn, S.G.
Deposit date:2020-04-20
Release date:2020-07-15
Last modified:2020-10-28
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Structural basis for pH gating of the two-pore domain K + channel TASK2.
Nature, 586, 2020
6WM0
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BU of 6wm0 by Molmil
TASK2 in MSP1D1 lipid nanodisc at pH 8.5
Descriptor: POTASSIUM ION, Potassium channel TASK2
Authors:Li, B, Brohawn, S.G.
Deposit date:2020-04-20
Release date:2020-07-15
Last modified:2020-10-28
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:Structural basis for pH gating of the two-pore domain K + channel TASK2.
Nature, 586, 2020
6UKN
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BU of 6ukn by Molmil
Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs
Descriptor: CHLORIDE ION, POTASSIUM ION, Solute carrier family 12 member 7, ...
Authors:Reid, M.S, Kern, D.M, Brohawn, S.G.
Deposit date:2019-10-05
Release date:2020-06-10
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs.
Elife, 9, 2020
7SK1
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BU of 7sk1 by Molmil
TWIK1 in MSP1E3D1 Lipid Nanodisc at pH 5.5
Descriptor: N-OCTANE, POTASSIUM ION, Potassium channel subfamily K member 1, ...
Authors:Turney, T.S, Brohawn, S.G.
Deposit date:2021-10-19
Release date:2021-11-24
Last modified:2022-06-22
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Structural Basis for pH-gating of the K + channel TWIK1 at the selectivity filter.
Nat Commun, 13, 2022
7SK0
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BU of 7sk0 by Molmil
TWIK1 in MSP1D1 lipid nanodisc at pH 7.4
Descriptor: N-OCTANE, POTASSIUM ION, Potassium channel subfamily K member 1
Authors:Turney, T.S, Brohawn, S.G.
Deposit date:2021-10-19
Release date:2021-11-24
Last modified:2022-06-22
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:Structural Basis for pH-gating of the K + channel TWIK1 at the selectivity filter.
Nat Commun, 13, 2022
3HXR
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BU of 3hxr by Molmil
Nucleoporin Nup120 from S.cerevisiae (aa 1-757)
Descriptor: Nucleoporin NUP120
Authors:Leksa, N.C, Brohawn, S.G, Schwartz, T.U.
Deposit date:2009-06-21
Release date:2009-07-28
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of the scaffold nucleoporin Nup120 reveals a new and unexpected domain architecture.
Structure, 17, 2009
6NZZ
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BU of 6nzz by Molmil
LRRC8A-DCPIB in MSP1E3D1 nanodisc expanded state
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}butanoic acid, Volume-regulated anion channel subunit LRRC8A
Authors:Kern, D.M, Hite, R.K, Brohawn, S.G.
Deposit date:2019-02-14
Release date:2019-02-27
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs.
Elife, 8, 2019
6O00
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BU of 6o00 by Molmil
apo-LRRC8A in MSP2N2 nanodisc constricted state
Descriptor: Volume-regulated anion channel subunit LRRC8A
Authors:Kern, D.M, Hite, R.K, Brohawn, S.G.
Deposit date:2019-02-14
Release date:2019-02-27
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.18 Å)
Cite:Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs.
Elife, 8, 2019
6NZW
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BU of 6nzw by Molmil
LRRC8A-DCPIB in MSP1E3D1 nanodisc constricted state
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}butanoic acid, Volume-regulated anion channel subunit LRRC8A
Authors:Kern, D.M, Hite, R.K, Brohawn, S.G.
Deposit date:2019-02-14
Release date:2019-02-27
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs.
Elife, 8, 2019
7M19
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BU of 7m19 by Molmil
SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-2)
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 7-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}heptanoic acid, Volume-regulated anion channel subunit LRRC8A
Authors:Kern, D.M, Gerber, E.E, Brohawn, S.G.
Deposit date:2021-03-12
Release date:2021-03-24
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (3.69 Å)
Cite:Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes.
Nat Commun, 13, 2022
7M17
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BU of 7m17 by Molmil
SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-1)
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 7-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}heptanoic acid, Volume-regulated anion channel subunit LRRC8A
Authors:Kern, D.M, Gerber, E.E, Brohawn, S.G.
Deposit date:2021-03-12
Release date:2021-03-24
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes.
Nat Commun, 13, 2022

 

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