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4CRO
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BU of 4cro by Molmil
PROTEIN-DNA CONFORMATIONAL CHANGES IN THE CRYSTAL STRUCTURE OF A LAMBDA CRO-OPERATOR COMPLEX
Descriptor: DNA (5'-D(*TP*AP*TP*CP*AP*CP*CP*GP*CP*GP*GP*GP*TP*GP*AP*TP*A)-3'), PROTEIN (LAMBDA CRO)
Authors:Brennan, R.G, Roderick, S.L, Takeda, Y, Matthews, B.W.
Deposit date:1992-01-15
Release date:1992-01-15
Last modified:2022-11-23
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Protein-DNA conformational changes in the crystal structure of a lambda Cro-operator complex.
Proc.Natl.Acad.Sci.USA, 87, 1990
1DN8
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BU of 1dn8 by Molmil
STRUCTURE OF A Z-DNA WITH TWO DIFFERENT BACKBONE CHAIN CONFORMATIONS. STABILIZATION OF THE DECADEOXYOLIGONUCLEOTIDE D(CGTACGTACG) BY (CO(NH3)6)3+ BINDING TO THE GUANINE
Descriptor: COBALT HEXAMMINE(III), DNA (5'-D(*P*CP*GP*TP*AP*CP*GP*TP*AP*CP*G)-3')
Authors:Brennan, R.G, Westhof, E, Sundaralingam, M.
Deposit date:1987-05-12
Release date:1988-04-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of a Z-DNA with two different backbone chain conformations. Stabilization of the decadeoxyoligonucleotide d(CGTACGTACG) by [Co(NH3)6]3+ binding to the guanine.
J.Biomol.Struct.Dyn., 3, 1986
2PEX
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BU of 2pex by Molmil
Structure of reduced C22S OhrR from Xanthamonas Campestris
Descriptor: FORMIC ACID, Transcriptional regulator OhrR
Authors:Brennan, R.G, Newberry, K.J.
Deposit date:2007-04-03
Release date:2007-12-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Mechanism of Organic Hydroperoxide Induction of the Transcription Regulator OhrR.
Mol.Cell, 28, 2007
2PFB
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BU of 2pfb by Molmil
Structure of oxidized OhrR from Xanthamonas campestris
Descriptor: Transcriptional regulator OhrR
Authors:Brennan, R.G, Newberry, K.J.
Deposit date:2007-04-04
Release date:2007-12-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural Mechanism of Organic Hydroperoxide Induction of the Transcription Regulator OhrR.
Mol.Cell, 28, 2007
3ECO
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BU of 3eco by Molmil
Crystal structure of MepR, a transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA
Descriptor: MepR, SULFATE ION
Authors:Brennan, R.G, Kumaraswami, M.
Deposit date:2008-09-01
Release date:2009-02-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and biochemical characterization of MepR, a multidrug binding transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA.
Nucleic Acids Res., 37, 2009
8SSH
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BU of 8ssh by Molmil
MtrR from Neisseria gonorrhoeae bound to Ethinyl Estradiol
Descriptor: Ethinyl estradiol, HTH-type transcriptional regulator MtrR, PHOSPHATE ION
Authors:Hooks, G.M, Brennan, R.G.
Deposit date:2023-05-08
Release date:2024-02-14
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of Neisseria gonorrhoeae transcriptional regulator, MtrR, bound to ethinyl estradiol, at 3.2 Angstroms resolution
To Be Published
1BDH
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BU of 1bdh by Molmil
PURINE REPRESSOR MUTANT-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX
Descriptor: DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), HYPOXANTHINE, PROTEIN (PURINE REPRESSOR)
Authors:Glasfeld, A, Schumacher, M.A, Choi, K.Y, Zalkin, H, Brennan, R.G.
Deposit date:1996-07-25
Release date:1997-04-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A Positively Charged Residue Bound in the Minor Groove Does not Alter the Bending of a DNA Duplex
J.Am.Chem.Soc., 118, 1996
1BDI
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BU of 1bdi by Molmil
PURINE REPRESSOR MUTANT-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX
Descriptor: DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), HYPOXANTHINE, PROTEIN (PURINE REPRESSOR)
Authors:Glasfeld, A, Schumacher, M.A, Choi, K.Y, Zalkin, H, Brennan, R.G.
Deposit date:1996-07-25
Release date:1997-04-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:A Positively Charged Residue Bound in the Minor Groove Does not Alter the Bending of a DNA Duplex
J.Am.Chem.Soc., 118, 1996
8FHW
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BU of 8fhw by Molmil
Cryo-EM structure of Cryptococcus neoformans trehalose-6-phosphate synthase homotetramer in complex with uridine diphosphate and glucose-6-phosphate
Descriptor: 6-O-phosphono-alpha-D-glucopyranose, Alpha,alpha-trehalose-phosphate synthase (UDP-forming), URIDINE-5'-DIPHOSPHATE
Authors:Washington, E.J, Brennan, R.G.
Deposit date:2022-12-15
Release date:2023-12-20
Last modified:2023-12-27
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogen Cryptococcus neoformans : a target for novel antifungals.
Biorxiv, 2023
8FO1
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BU of 8fo1 by Molmil
Cryo-EM structure of Cryptococcus neoformans trehalose-6-phosphate synthase homotetramer in apo form
Descriptor: Alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Authors:Washington, E.J, Brennan, R.G.
Deposit date:2022-12-29
Release date:2024-01-10
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structure of Cryptococcus neoformans trehalose-6-phosphate synthase homotetramer in apo form
To Be Published
8FW8
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BU of 8fw8 by Molmil
MtrR from Neisseria gonorrhoeae bound to Progesterone
Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, HTH-type transcriptional regulator MtrR, PHOSPHATE ION, ...
Authors:Hooks, G.H, Brennan, R.G.
Deposit date:2023-01-20
Release date:2024-01-24
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structure of Neisseria gonorrhoeae transcriptional regulator, MtrR, bound to progesterone, at 2.31 Angstroms resolution
To Be Published
7LQ4
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BU of 7lq4 by Molmil
Rr (RsiG)2-(c-di-GMP)2-WhiG complex
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), RsiG, WhiG
Authors:Schumacher, M.A, Brennan, R.G.
Deposit date:2021-02-12
Release date:2021-07-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Evolution of a sigma-(c-di-GMP)-anti-sigma switch.
Proc.Natl.Acad.Sci.USA, 118, 2021
7LQ2
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BU of 7lq2 by Molmil
Apo Rr RsiG- crystal form 1
Descriptor: ISOPROPYL ALCOHOL, MAGNESIUM ION, RR RsiG
Authors:Schumacher, M.A, Brennan, R.G.
Deposit date:2021-02-12
Release date:2021-07-14
Last modified:2021-08-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Evolution of a sigma-(c-di-GMP)-anti-sigma switch.
Proc.Natl.Acad.Sci.USA, 118, 2021
7LQ3
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BU of 7lq3 by Molmil
Evolution of a sigma-(c-di-GMP)-antisigma switch
Descriptor: MAGNESIUM ION, RsiG, SULFATE ION
Authors:Schumacher, M.A, Brennan, R.G.
Deposit date:2021-02-12
Release date:2021-07-14
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Evolution of a sigma-(c-di-GMP)-anti-sigma switch.
Proc.Natl.Acad.Sci.USA, 118, 2021
8FW3
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BU of 8fw3 by Molmil
MtrR from Neisseria gonorrhoeae bound to Testosterone
Descriptor: HTH-type transcriptional regulator MtrR, PHOSPHATE ION, TESTOSTERONE
Authors:Hooks, G.H, Brennan, R.G.
Deposit date:2023-01-20
Release date:2024-01-24
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structure of Neisseria gonorrhoeae transcriptional regulator, MtrR, bound to testosterone, at 2.22 Angstroms resolution
To Be Published
6OF0
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BU of 6of0 by Molmil
Structural basis for multidrug recognition and antimicrobial resistance by MTRR, an efflux pump regulator from Neisseria Gonorrhoeae
Descriptor: HTH-type transcriptional regulator MtrR, PHOSPHATE ION
Authors:Beggs, G.A, Kumaraswami, M, Shafer, W, Brennan, R.G.
Deposit date:2019-03-28
Release date:2019-07-31
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural, Biochemical, and In Vivo Characterization of MtrR-Mediated Resistance to Innate Antimicrobials by the Human Pathogen Neisseria gonorrhoeae .
J.Bacteriol., 201, 2019
1BD3
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BU of 1bd3 by Molmil
STRUCTURE OF THE APO URACIL PHOSPHORIBOSYLTRANSFERASE, 2 MUTANT C128V
Descriptor: PHOSPHATE ION, URACIL PHOSPHORIBOSYLTRANSFERASE
Authors:Schumacher, M.A, Carter, D, Scott, D, Roos, D, Ullman, B, Brennan, R.G.
Deposit date:1998-05-12
Release date:1999-05-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding.
EMBO J., 17, 1998
1BD4
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BU of 1bd4 by Molmil
UPRT-URACIL COMPLEX
Descriptor: PHOSPHATE ION, URACIL, URACIL PHOSPHORIBOSYLTRANSFERASE
Authors:Schumacher, M.A, Carter, D, Scott, D, Roos, D, Ullman, B, Brennan, R.G.
Deposit date:1998-05-12
Release date:1999-05-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding.
EMBO J., 17, 1998
6WMT
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BU of 6wmt by Molmil
F. tularensis RNAPs70-(MglA-SspA)-ppGpp-PigR-iglA DNA complex
Descriptor: DNA NT-strand, DNA NT-strand downstream, DNA T-strand, ...
Authors:Travis, B.A, Brennan, R.G, Schumacher, M.A.
Deposit date:2020-04-21
Release date:2020-11-11
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.43 Å)
Cite:Structural Basis for Virulence Activation of Francisella tularensis.
Mol.Cell, 81, 2021
1BOW
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BU of 1bow by Molmil
MULTIDRUG-BINDING DOMAIN OF TRANSCRIPTION ACTIVATOR BMRR (APO FORM)
Descriptor: MANGANESE (II) ION, MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR BMRR
Authors:Zheleznova, E.E, Markham, P.N, Neyfakh, A.A, Brennan, R.G.
Deposit date:1998-08-06
Release date:1999-08-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter.
Cell(Cambridge,Mass.), 96, 1999
6WMP
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BU of 6wmp by Molmil
F. tularensis RNAPs70-iglA DNA complex
Descriptor: DNA NT-strand, DNA T-strand, DNA-directed RNA polymerase subunit alpha 1, ...
Authors:Travis, B.A, Brennan, R.G, Schumacher, M.A.
Deposit date:2020-04-21
Release date:2020-11-11
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Structural Basis for Virulence Activation of Francisella tularensis.
Mol.Cell, 81, 2021
6WMU
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BU of 6wmu by Molmil
E. coli RNAPs70-SspA-gadA DNA complex
Descriptor: DNA NT-strand, DNA NT-strand downstream, DNA T-strand, ...
Authors:Travis, B.A, Brennan, R.G, Schumacher, M.A.
Deposit date:2020-04-21
Release date:2020-11-11
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.18 Å)
Cite:Structural Basis for Virulence Activation of Francisella tularensis.
Mol.Cell, 81, 2021
6WMR
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BU of 6wmr by Molmil
F. tularensis RNAPs70-(MglA-SspA)-iglA DNA complex
Descriptor: DNA NT-strand, DNA NT-strand downstream, DNA T-strand, ...
Authors:Travis, B.A, Brennan, R.G, Schumacher, M.A.
Deposit date:2020-04-21
Release date:2020-11-11
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Structural Basis for Virulence Activation of Francisella tularensis.
Mol.Cell, 81, 2021
3IHQ
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BU of 3ihq by Molmil
Crystal Structure of Reduced C10S Spx in Complex with the Alpha C-terminal Domain of RNA Polymeras
Descriptor: DNA-directed RNA polymerase subunit alpha, IMIDAZOLE, Regulatory protein spx
Authors:Newberry, K.J, Brennan, R.G.
Deposit date:2009-07-30
Release date:2010-02-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Promoter recognition by a complex of Spx and the C-terminal domain of the RNA polymerase alpha subunit.
Plos One, 5, 2010
1WET
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BU of 1wet by Molmil
STRUCTURE OF THE PURR-GUANINE-PURF OPERATOR COMPLEX
Descriptor: DNA (5'-D(*AP*AP*CP*GP*AP*AP*AP*AP*CP*GP*TP*TP*TP*TP*CP*GP*T )-3'), GUANINE, PROTEIN (PURINE REPRESSOR)
Authors:Schumacher, M.A, Glasfeld, A, Zalkin, H, Brennan, R.G.
Deposit date:1997-04-27
Release date:1997-11-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The X-ray structure of the PurR-guanine-purF operator complex reveals the contributions of complementary electrostatic surfaces and a water-mediated hydrogen bond to corepressor specificity and binding affinity.
J.Biol.Chem., 272, 1997

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