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1CES
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CRYSTALS OF DEMETALLIZED CONCANAVALIN A SOAKED WITH ZINC HAVE A ZINC ION BOUND IN THE S1 SITE
Descriptor:CONCANAVALIN A, ZINC ION
Authors:Bouckaert, J., Loris, R., Poortmans, F., Wyns, L.
Deposit date:1996-02-15
Release date:1997-02-15
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Sequential structural changes upon zinc and calcium binding to metal-free concanavalin A.
J.Biol.Chem., 271, 1996
1ENQ
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CO-CRYSTALS OF DEMETALLIZED CONCANAVALIN A WITH ZINC HAVING A ZINC ION BOUND IN THE S1 SITE
Descriptor:CONCANAVALIN A, ZINC ION
Authors:Bouckaert, J., Loris, R., Poortmans, F., Wyns, L.
Deposit date:1996-03-20
Release date:1996-08-17
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Sequential structural changes upon zinc and calcium binding to metal-free concanavalin A.
J.Biol.Chem., 271, 1996
1ENR
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CO-CRYSTALS OF DEMETALLIZED CONCANAVALIN A WITH ZINC AND CALCIUM HAVING A ZINC ION BOUND IN THE S1 SITE AND A CALCIUM ION BOUND IN THE S2 SITE
Descriptor:CONCANAVALIN A, CALCIUM ION, ZINC ION
Authors:Bouckaert, J., Loris, R., Poortmans, F., Wyns, L.
Deposit date:1996-03-20
Release date:1996-08-17
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Sequential structural changes upon zinc and calcium binding to metal-free concanavalin A.
J.Biol.Chem., 271, 1996
1ENS
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CRYSTALS OF DEMETALLIZED CONCANAVALIN A SOAKED WITH COBALT HAVING A COBALT ION BOUND IN THE S1 SITE
Descriptor:CONCANAVALIN A, COBALT (II) ION
Authors:Bouckaert, J., Loris, R., Poortmans, F., Wyns, L.
Deposit date:1996-03-20
Release date:1996-08-17
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Sequential structural changes upon zinc and calcium binding to metal-free concanavalin A.
J.Biol.Chem., 271, 1996
1QDC
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MAN(APLHA1-6)MAN(ALPHA1-O)METHYL CONCANAVALIN A COMPLEX
Descriptor:PROTEIN (CONCANAVALIN A), ALPHA-D-MANNOSE, O1-METHYL-MANNOSE, ...
Authors:Bouckaert, J., Loris, R., Wyns, L.
Deposit date:1998-07-14
Release date:1999-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structures of Man(alpha1-3)Man(alpha1-O)Me and Man(alpha1-6)Man(alpha1-O)Me in complex with concanavalin A.
J.Biol.Chem., 274, 1999
1QDO
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MAN(APLHA1-3)MAN(ALPHA1-O)METHYL CONCANAVALIN A COMPLEX
Descriptor:PROTEIN (CONCANAVALIN A), ALPHA-D-MANNOSE, O1-METHYL-MANNOSE, ...
Authors:Bouckaert, J., Loris, R., Wyns, L.
Deposit date:1999-05-24
Release date:1999-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The crystal structures of Man(alpha1-3)Man(alpha1-O)Me and Man(alpha1-6)Man(alpha1-O)Me in complex with concanavalin A.
J.Biol.Chem., 274, 1999
2ENR
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CO-CRYSTALS OF DEMETALLIZED CONCANAVALIN A WITH CADMIUM HAVING A CADMIUM ION BOUND IN BOTH THE S1 SITE AND THE S2 SITE
Descriptor:CONCANAVALIN A, CADMIUM ION
Authors:Bouckaert, J., Loris, R., Wyns, L.
Deposit date:1998-07-14
Release date:1999-02-16
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Zinc/calcium- and cadmium/cadmium-substituted concanavalin A: interplay of metal binding, pH and molecular packing.
Acta Crystallogr.,Sect.D, 56, 2000
1TR7
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FIMH ADHESIN RECEPTOR BINDING DOMAIN FROM UROPATHOGENIC E. COLI
Descriptor:FimH protein, BUTYL ALPHA-D-MANNOPYRANOSIDE, CACODYLATE ION, ...
Authors:Bouckaert, J., Berglund, J., Schembri, M., De Genst, E., Cools, L., Wuhrer, M., Hung, C.S., Pinkner, J., Slattegard, R., Zavialov, A., Choudhury, D., Langermann, S., Hultgren, S.J., Wyns, L., Klemm, P., Oscarson, S., Knight, S.D., De Greve, H.
Deposit date:2004-06-21
Release date:2005-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin
Mol.Microbiol., 55, 2005
1UWF
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1.7 A RESOLUTION STRUCTURE OF THE RECEPTOR BINDING DOMAIN OF THE FIMH ADHESIN FROM UROPATHOGENIC E. COLI
Descriptor:FIMH PROTEIN, BUTYL ALPHA-D-MANNOPYRANOSIDE, GLYCEROL
Authors:Bouckaert, J., Berglund, J., Genst, E.D., Cools, L., Hung, C.-S., Wuhrer, M., Zavialov, A., Langermann, S., Hultgren, S., Wyns, L., Oscarson, S., Knight, S.D., De Greve, H.
Deposit date:2004-02-05
Release date:2005-02-16
Last modified:2015-04-15
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Receptor Binding Studies Disclose a Novel Class of High-Affinity Inhibitors of the Escherichia Coli Fimh Adhesin.
Mol.Microbiol., 55, 2005
1APN
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THE CRYSTALLOGRAPHIC STRUCTURE OF METAL-FREE CONCANAVALIN A AT 2.5 ANGSTROMS RESOLUTION
Descriptor:CONCANAVALIN A
Authors:Bouckaert, J., Loris, R., Poortmans, F., Wyns, L.
Deposit date:1995-07-28
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystallographic structure of metal-free concanavalin A at 2.5 A resolution.
Proteins, 23, 1995
1DQ0
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LOCKED, METAL-FREE CONCANAVALIN A, A MINOR SPECIES IN SOLUTION
Descriptor:Concanavalin-Br
Authors:Bouckaert, J., Dewallef, Y., Poortmans, F., Wyns, L., Loris, R.
Deposit date:1999-12-29
Release date:2000-01-19
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The structural features of concanavalin A governing non-proline peptide isomerization
J.Biol.Chem., 275, 2000
1DQ1
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CALCIUM;CALCIUM CONCANAVALIN A
Descriptor:Concanavalin-Br, CALCIUM ION
Authors:Bouckaert, J., Dewallef, Y., Poortmans, F., Wyns, L., Loris, R.
Deposit date:1999-12-29
Release date:2000-01-19
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The structural features of concanavalin A governing non-proline peptide isomerization
J.Biol.Chem., 275, 2000
1DQ2
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UNLOCKED METAL-FREE CONCANAVALIN A
Descriptor:Concanavalin-Br, ACETIC ACID
Authors:Bouckaert, J., Dewallef, Y., Poortmans, F., Wyns, L., Loris, R.
Deposit date:1999-12-29
Release date:2000-01-19
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The structural features of concanavalin A governing non-proline peptide isomerization
J.Biol.Chem., 275, 2000
1DQ4
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A TRANSIENT UNLOCKED CONCANAVALIN A STRUCTURE WITH MN2+ BOUND IN THE TRANSITION METAL ION BINDING SITE S1 AND AN EMPTY CALCIUM BINDING SITE S2
Descriptor:Concanavalin-Br, MANGANESE (II) ION
Authors:Bouckaert, J., Dewallef, Y., Poortmans, F., Wyns, L., Loris, R.
Deposit date:1999-12-30
Release date:2000-01-19
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The structural features of concanavalin A governing non-proline peptide isomerization
J.Biol.Chem., 275, 2000
1DQ5
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MANGANESE;MANGANESE CONCANAVALIN A AT PH 5.0
Descriptor:Concanavalin-Br, MANGANESE (II) ION
Authors:Bouckaert, J., Dewallef, Y., Poortmans, F., Wyns, L., Loris, R.
Deposit date:1999-12-30
Release date:2000-01-19
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structural features of concanavalin A governing non-proline peptide isomerization
J.Biol.Chem., 275, 2000
1DQ6
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MANGANESE;MANGANESE CONCANAVALIN A AT PH 7.0
Descriptor:Concanavalin-A, MANGANESE (II) ION
Authors:Bouckaert, J., Dewallef, Y., Poortmans, F., Wyns, L., Loris, R.
Deposit date:1999-12-30
Release date:2000-01-19
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The structural features of concanavalin A governing non-proline peptide isomerization
J.Biol.Chem., 275, 2000
3ENR
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ZINC-CALCIUM CONCANAVALIN A AT PH 6.15
Descriptor:Concanavalin-A, ZINC ION, CALCIUM ION
Authors:Bouckaert, J., Loris, R., Wyns, L.
Deposit date:1999-02-11
Release date:2000-09-18
Last modified:2017-06-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Zinc/calcium- and cadmium/cadmium-substituted concanavalin A: interplay of metal binding, pH and molecular packing.
Acta Crystallogr.,Sect.D, 56, 2000
1ONA
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CO-CRYSTALS OF CONCANAVALIN A WITH METHYL-3,6-DI-O-(ALPHA-D-MANNOPYRANOSYL)-ALPHA-D-MANNOPYRANOSIDE
Descriptor:CONCANAVALIN A, ALPHA-D-MANNOSE, O1-METHYL-MANNOSE, ...
Authors:Bouckaert, J., Maes, D., Poortmans, F., Wyns, L., Loris, R.
Deposit date:1996-07-07
Release date:1997-09-17
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:A structure of the complex between concanavalin A and methyl-3,6-di-O-(alpha-D-mannopyranosyl)-alpha-D-mannopyranoside reveals two binding modes.
J.Biol.Chem., 271, 1996
4AV4
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FIMH LECTIN DOMAIN CO-CRYSTAL WITH A ALPHA-D-MANNOSIDE O-LINKED TO A PROPYNYL PYRIDINE
Descriptor:FIMH, 3-pyridin-3-ylprop-2-yn-1-yl alpha-D-mannopyranoside
Authors:Bouckaert, J., Touaibia, M., Roos, G., Shiao, T.C., Wang, Q., Papadopoulos, A., Roy, R.
Deposit date:2012-05-23
Release date:2012-06-27
Last modified:2012-09-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Tyrosine Gate as a Potential Entropic Lever in the Receptor-Binding Site of the Bacterial Adhesin Fimh.
Biochemistry, 51, 2012
5FS5
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BREAKING DOWN THE WALL: MUTATION OF THE TYROSINE GATE OF THE UNIVERSAL ESCHERICHIA COLI FIMBRIAL ADHESIN FIMH
Descriptor:FIMH, Heptyl Alpha-D-mannopyrannoside, SODIUM ION
Authors:Bouckaert, J.
Deposit date:2015-12-30
Release date:2016-11-30
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Mutation of Tyr137 of the universal Escherichia coli fimbrial adhesin FimH relaxes the tyrosine gate prior to mannose binding.
IUCrJ, 4, 2017
5FWR
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BREAKING DOWN THE WALL: MUTATION OF THE TYROSINE GATE OF THE UNIVERSAL ESCHERICHIA COLI FIMBRIAL ADHESIN FIMH
Descriptor:TYPE 1 FIMBIRAL ADHESIN FIMH, biphenyl-4-yl alpha-D-mannopyranoside
Authors:Bouckaert, J.
Deposit date:2016-02-21
Release date:2016-11-30
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Mutation of Tyr137 of the universal Escherichia coli fimbrial adhesin FimH relaxes the tyrosine gate prior to mannose binding.
IUCrJ, 4, 2017
5FX3
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BREAKING DOWN THE WALL: MUTATION OF THE TYROSINE GATE OF THE UNIVERSAL ESCHERICHIA COLI FIMBRIAL ADHESIN FIMH
Descriptor:PROTEIN FIMH, {[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID
Authors:Bouckaert, J.
Deposit date:2016-02-22
Release date:2017-01-18
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mutation of Tyr137 of the universal Escherichia coli fimbrial adhesin FimH relaxes the tyrosine gate prior to mannose binding.
IUCrJ, 4, 2017
4BWO
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THE FEDF ADHESIN FROM ENTRROTOXIGENIC ESCHERICHIA COLI IS A SULFATE- BINDING LECTIN
Descriptor:F18 FIMBRIAL ADHESIN AC, BROMIDE ION, SULFATE ION
Authors:Lonardi, E., Moonens, K., Buts, L., de Boer, A.R., Olsson, J.D.M., Weiss, M.S., Fabre, E., Guerardel, Y., Deelder, A.M., Oscarson, S., Wuhrer, M., Bouckaert, J.
Deposit date:2013-07-03
Release date:2013-08-28
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Sampling of Glycan Interaction Profiles Reveals Mucosal Receptors for Fimbrial Adhesins of Enterotoxigenic Escherichia Coli
Biology, 2, 2013
1O9V
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F17-AG LECTIN DOMAIN FROM ESCHERICHIA COLI IN COMPLEX WITH A SELENIUM CARBOHYDRATE DERIVATIVE
Descriptor:F17-AG LECTIN DOMAIN, METHYL 2-ACETAMIDO-1,2-DIDEOXY-1-SELENO-BETA-D-GLUCOPYRANOSIDE
Authors:Buts, L., De Genst, E., Loris, R., Oscarson, S., Lahmann, M., Messens, J., Brosens, E., Wyns, L., Bouckaert, J., De Greve, H.
Deposit date:2002-12-20
Release date:2003-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The Fimbrial Adhesin F17-G of Enterotoxigenic Escherichia Coli Has an Immunoglobulin-Like Lectin Domain that Binds N-Acetylglucosamine
Mol.Microbiol., 49, 2003
1O9W
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F17-AG LECTIN DOMAIN FROM ESCHERICHIA COLI IN COMPLEX WITH N-ACETYL-GLUCOSAMINE
Descriptor:F17A-G FIMBRIAL ADHESIN, N-ACETYL-D-GLUCOSAMINE
Authors:Buts, L., De Genst, E., Loris, R., Oscarson, S., Lahmann, M., Messens, J., Brosens, E., Wyns, L., Bouckaert, J., De Greve, H.
Deposit date:2002-12-20
Release date:2003-05-29
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The Fimbrial Adhesin F17-G of Enterotoxigenic Escherichia Coli Has an Immunoglobulin-Like Lectin Domain that Binds N-Acetylglucosamine
Mol.Microbiol., 49, 2003