Author results

1H5P
  • Download 1h5p
  • View 1h5p
Molmil generated image of 1h5p
SOLUTION STRUCTURE OF THE HUMAN SP100B SAND DOMAIN BY HETERONUCLEAR NMR.
Descriptor:NUCLEAR AUTOANTIGEN SP100-B
Authors:Bottomley, M.J., Liu, Z., Collard, M.W., Huggenvik, J.I., Gibson, T.J., Sattler, M.
Deposit date:2001-05-24
Release date:2001-07-06
Last modified:2018-03-28
Method:SOLUTION NMR
Cite:The SAND domain structure defines a novel DNA-binding fold in transcriptional regulation.
Nat. Struct. Biol., 8, 2001
1XWH
  • Download 1xwh
  • View 1xwh
Molmil generated image of 1xwh
NMR STRUCTURE OF THE FIRST PHD FINGER OF AUTOIMMUNE REGULATOR PROTEIN (AIRE1): INSIGHTS INTO APECED
Descriptor:Autoimmune regulator, ZINC ION
Authors:Bottomley, M.J., Stier, G., Krasotkina, J., Legube, G., Simon, B., Akhtar, A., Sattler, M., Musco, G.
Deposit date:2004-11-01
Release date:2005-01-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease
J.Biol.Chem., 280, 2005
2UV0
  • Download 2uv0
  • View 2uv0
Molmil generated image of 2uv0
STRUCTURE OF THE P. AERUGINOSA LASR LIGAND-BINDING DOMAIN BOUND TO ITS AUTOINDUCER
Descriptor:TRANSCRIPTIONAL ACTIVATOR PROTEIN LASR, N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE
Authors:Bottomley, M.J., Muraglia, E., Bazzo, R., Carfi, A.
Deposit date:2007-03-08
Release date:2007-03-27
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular Insights Into Quorum Sensing in the Human Pathogen Pseudomonas Aeruginosa from the Structure of the Virulence Regulator Lasr Bound to its Autoinducer.
J.Biol.Chem., 282, 2007
2VQJ
  • Download 2vqj
  • View 2vqj
Molmil generated image of 2vqj
STRUCTURE OF HDAC4 CATALYTIC DOMAIN BOUND TO A TRIFLUOROMETHYLKETONE INHBITOR
Descriptor:HISTONE DEACETYLASE 4, 1,4-DIETHYLENE DIOXIDE, POTASSIUM ION, ...
Authors:Bottomley, M.J., Lo Surdo, P., Di Giovine, P., Cirillo, A., Scarpelli, R., Ferrigno, F., Jones, P., Neddermann, P., De Francesco, R., Steinkuhler, C., Gallinari, P., Carfi, A.
Deposit date:2008-03-17
Release date:2008-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain.
J.Biol.Chem., 283, 2008
2VQM
  • Download 2vqm
  • View 2vqm
Molmil generated image of 2vqm
STRUCTURE OF HDAC4 CATALYTIC DOMAIN BOUND TO A HYDROXAMIC ACID INHBITOR
Descriptor:HISTONE DEACETYLASE 4, POTASSIUM ION, N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamide, ...
Authors:Bottomley, M.J., Lo Surdo, P., Di Giovine, P., Cirillo, A., Scarpelli, R., Ferrigno, F., Jones, P., Neddermann, P., De Francesco, R., Steinkuhler, C., Gallinari, P., Carfi, A.
Deposit date:2008-03-17
Release date:2008-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain.
J.Biol.Chem., 283, 2008
2VQO
  • Download 2vqo
  • View 2vqo
Molmil generated image of 2vqo
STRUCTURE OF HDAC4 CATALYTIC DOMAIN WITH A GAIN-OF-FUNCTION MUATION BOUND TO A TRIFLUOROMETHYLKETONE INHBITOR
Descriptor:HISTONE DEACETYLASE 4, SULFATE ION, POTASSIUM ION, ...
Authors:Bottomley, M.J., Lo Surdo, P., Di Giovine, P., Cirillo, A., Scarpelli, R., Ferrigno, F., Jones, P., Neddermann, P., De Francesco, R., Steinkuhler, C., Gallinari, P., Carfi, A.
Deposit date:2008-03-18
Release date:2008-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain.
J.Biol.Chem., 283, 2008
2VQQ
  • Download 2vqq
  • View 2vqq
Molmil generated image of 2vqq
STRUCTURE OF HDAC4 CATALYTIC DOMAIN (A DOUBLE CYSTEINE-TO-ALANINE MUTANT) BOUND TO A TRIFLUOROMETHYLKETONE INHBITOR
Descriptor:HISTONE DEACETYLASE 4, SULFATE ION, POTASSIUM ION, ...
Authors:Bottomley, M.J., Lo Surdo, P., Di Giovine, P., Cirillo, A., Scarpelli, R., Ferrigno, F., Jones, P., Neddermann, P., De Francesco, R., Steinkuhler, C., Gallinari, P., Carfi, A.
Deposit date:2008-03-18
Release date:2008-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain.
J.Biol.Chem., 283, 2008
2VQV
  • Download 2vqv
  • View 2vqv
Molmil generated image of 2vqv
STRUCTURE OF HDAC4 CATALYTIC DOMAIN WITH A GAIN-OF-FUNCTION MUTATION BOUND TO A HYDROXAMIC ACID INHIBITOR
Descriptor:HISTONE DEACETYLASE 4, SULFATE ION, POTASSIUM ION, ...
Authors:Bottomley, M.J., Lo Surdo, P., Di Giovine, P., Cirillo, A., Scarpelli, R., Ferrigno, F., Jones, P., Neddermann, P., De Francesco, R., Steinkuhler, C., Gallinari, P., Carfi, A.
Deposit date:2008-03-19
Release date:2008-07-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Structural Zinc-Binding Domain.
J.Biol.Chem., 283, 2008
2VQW
  • Download 2vqw
  • View 2vqw
Molmil generated image of 2vqw
STRUCTURE OF INHIBITOR-FREE HDAC4 CATALYTIC DOMAIN (WITH GAIN-OF- FUNCTION MUTATION HIS332TYR)
Descriptor:HISTONE DEACETYLASE 4, POTASSIUM ION, ZINC ION
Authors:Bottomley, M.J., Lo Surdo, P., Di Giovine, P., Cirillo, A., Scarpelli, R., Ferrigno, F., Jones, P., Neddermann, P., De Francesco, R., Steinkuhler, C., Gallinari, P., Carfi, A.
Deposit date:2008-03-19
Release date:2008-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Structural Zinc-Binding Domain.
J.Biol.Chem., 283, 2008
2W2M
  • Download 2w2m
  • View 2w2m
Molmil generated image of 2w2m
WT PCSK9-DELTAC BOUND TO WT EGF-A OF LDLR
Descriptor:PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9, LOW-DENSITY LIPOPROTEIN RECEPTOR, CALCIUM ION
Authors:Bottomley, M.J., Cirillo, A., Orsatti, L., Ruggeri, L., Fisher, T.S., Santoro, J.C., Cummings, R.T., Cubbon, R.M., Lo Surdo, P., Calzetta, A., Noto, A., Baysarowich, J., Mattu, M., Talamo, F., De Francesco, R., Sparrow, C.P., Sitlani, A., Carfi, A.
Deposit date:2008-11-03
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
J.Biol.Chem., 284, 2009
2W2N
  • Download 2w2n
  • View 2w2n
Molmil generated image of 2w2n
WT PCSK9-DELTAC BOUND TO EGF-A H306Y MUTANT OF LDLR
Descriptor:PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9, LOW-DENSITY LIPOPROTEIN RECEPTOR, CALCIUM ION
Authors:Bottomley, M.J., Cirillo, A., Orsatti, L., Ruggeri, L., Fisher, T.S., Santoro, J.C., Cummings, R.T., Cubbon, R.M., Lo Surdo, P., Calzetta, A., Noto, A., Baysarowich, J., Mattu, M., Talamo, F., De Francesco, R., Sparrow, C.P., Sitlani, A., Carfi, A.
Deposit date:2008-11-03
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
J.Biol.Chem., 284, 2009
2W2O
  • Download 2w2o
  • View 2w2o
Molmil generated image of 2w2o
PCSK9-DELTAC D374Y MUTANT BOUND TO WT EGF-A OF LDLR
Descriptor:PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9, LOW-DENSITY LIPOPROTEIN RECEPTOR, CALCIUM ION
Authors:Bottomley, M.J., Cirillo, A., Orsatti, L., Ruggeri, L., Fisher, T.S., Santoro, J.C., Cummings, R.T., Cubbon, R.M., Lo Surdo, P., Calzetta, A., Noto, A., Baysarowich, J., Mattu, M., Talamo, F., De Francesco, R., Sparrow, C.P., Sitlani, A., Carfi, A.
Deposit date:2008-11-03
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
J.Biol.Chem., 284, 2009
2W2P
  • Download 2w2p
  • View 2w2p
Molmil generated image of 2w2p
PCSK9-DELTAC D374A MUTANT BOUND TO WT EGF-A OF LDLR
Descriptor:PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9, LOW-DENSITY LIPOPROTEIN RECEPTOR, CALCIUM ION
Authors:Bottomley, M.J., Cirillo, A., Orsatti, L., Ruggeri, L., Fisher, T.S., Santoro, J.C., Cummings, R.T., Cubbon, R.M., Lo Surdo, P., Calzetta, A., Noto, A., Baysarowich, J., Mattu, M., Talamo, F., De Francesco, R., Sparrow, C.P., Sitlani, A., Carfi, A.
Deposit date:2008-11-03
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
J.Biol.Chem., 284, 2009
2W2Q
  • Download 2w2q
  • View 2w2q
Molmil generated image of 2w2q
PCSK9-DELTAC D374H MUTANT BOUND TO WT EGF-A OF LDLR
Descriptor:PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9, LOW-DENSITY LIPOPROTEIN RECEPTOR, CALCIUM ION
Authors:Bottomley, M.J., Cirillo, A., Orsatti, L., Ruggeri, L., Fisher, T.S., Santoro, J.C., Cummings, R.T., Cubbon, R.M., Lo Surdo, P., Calzetta, A., Noto, A., Baysarowich, J., Mattu, M., Talamo, F., De Francesco, R., Sparrow, C.P., Sitlani, A., Carfi, A.
Deposit date:2008-11-03
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
J.Biol.Chem., 284, 2009
1VCA
  • Download 1vca
  • View 1vca
Molmil generated image of 1vca
CRYSTAL STRUCTURE OF AN INTEGRIN-BINDING FRAGMENT OF VASCULAR CELL ADHESION MOLECULE-1 AT 1.8 ANGSTROMS RESOLUTION
Descriptor:HUMAN VASCULAR CELL ADHESION MOLECULE-1
Authors:Jones, E.Y., Harlos, K., Bottomley, M.J., Robinson, R.C., Driscoll, P.C., Edwards, R.M., Clements, J.M., Dudgeon, T.J., Stuart, D.I.
Deposit date:1995-03-21
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 A resolution.
Nature, 373, 1995
1D8B
  • Download 1d8b
  • View 1d8b
Molmil generated image of 1d8b
NMR STRUCTURE OF THE HRDC DOMAIN FROM SACCHAROMYCES CEREVISIAE RECQ HELICASE
Descriptor:SGS1 RECQ HELICASE
Authors:Liu, Z., Macias, M.J., Bottomley, M.J., Stier, G., Linge, J.P., Nilges, M., Bork, P., Sattler, M.
Deposit date:1999-10-21
Release date:2000-01-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins.
Structure Fold.Des., 7, 1999
1K1G
  • Download 1k1g
  • View 1k1g
Molmil generated image of 1k1g
STRUCTURAL BASIS FOR RECOGNITION OF THE INTRON BRANCH SITE RNA BY SPLICING FACTOR 1
Descriptor:5'-R(*UP*AP*UP*AP*CP*UP*AP*AP*CP*AP*A)-3', SF1-Bo isoform
Authors:Liu, Z., Luyten, I., Bottomley, M.J., Messias, A.C., Houngninou-Molango, S., Sprangers, R., Zanier, K., Kramer, A., Sattler, M.
Deposit date:2001-09-25
Release date:2001-11-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for recognition of the intron branch site RNA by splicing factor 1.
Science, 294, 2001
1OQJ
  • Download 1oqj
  • View 1oqj
Molmil generated image of 1oqj
CRYSTAL STRUCTURE OF THE SAND DOMAIN FROM GLUCOCORTICOID MODULATORY ELEMENT BINDING PROTEIN-1 (GMEB1)
Descriptor:Glucocorticoid Modulatory Element Binding protein-1, ZINC ION
Authors:Surdo, P.L., Bottomley, M.J., Sattler, M., Scheffzek, K.
Deposit date:2003-03-10
Release date:2003-11-11
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions
MOL.ENDOCRINOL., 17, 2003
2Y7S
  • Download 2y7s
  • View 2y7s
Molmil generated image of 2y7s
STRUCTURE OF A DESIGNED MENINGOCOCCAL ANTIGEN (FACTOR H BINDING PROTEIN, MUTANT G1) INDUCING BROAD PROTECTIVE IMMUNITY
Descriptor:FACTOR H BINDING PROTEIN
Authors:Malito, E., Spraggon, G., Bottomley, M.J.
Deposit date:2011-02-01
Release date:2011-07-27
Last modified:2012-11-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Rational Design of a Meningococcal Antigen Inducing Broad Protective Immunity.
Sci.Transl.Med, 3, 2011
2YPV
  • Download 2ypv
  • View 2ypv
Molmil generated image of 2ypv
CRYSTAL STRUCTURE OF THE MENINGOCOCCAL VACCINE ANTIGEN FACTOR H BINDING PROTEIN IN COMPLEX WITH A BACTERICIDAL ANTIBODY
Descriptor:LIPOPROTEIN, FAB 12C1, 1,2-ETHANEDIOL
Authors:Malito, E., Veggi, D., Bottomley, M.J.
Deposit date:2012-11-01
Release date:2013-02-20
Last modified:2013-03-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Defining a Protective Epitope on Factor H Binding Protein, a Key Meningococcal Virulence Factor and Vaccine Antigen.
Proc.Natl.Acad.Sci.USA, 110, 2013
3P5B
  • Download 3p5b
  • View 3p5b
Molmil generated image of 3p5b
THE STRUCTURE OF THE LDLR/PCSK9 COMPLEX REVEALS THE RECEPTOR IN AN EXTENDED CONFORMATION
Descriptor:Proprotein convertase subtilisin/kexin type 9, Low density lipoprotein receptor variant, CALCIUM ION
Authors:Lo Surdo, P., Bottomley, M.J., Calzetta, A., Settembre, E.C., Cirillo, A., Pandit, S., Ni, Y., Hubbard, B., Sitlani, A., Carfi, A.
Deposit date:2010-10-08
Release date:2011-10-26
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.
Embo Rep., 12, 2011
3P5C
  • Download 3p5c
  • View 3p5c
Molmil generated image of 3p5c
THE STRUCTURE OF THE LDLR/PCSK9 COMPLEX REVEALS THE RECEPTOR IN AN EXTENDED CONFORMATION
Descriptor:Proprotein convertase subtilisin/kexin type 9, Low density lipoprotein receptor variant, CALCIUM ION
Authors:Lo Surdo, P., Bottomley, M.J., Calzetta, A., Settembre, E.C., Cirillo, A., Pandit, S., Ni, Y., Hubbard, B., Sitlani, A., Carfi, A.
Deposit date:2010-10-08
Release date:2011-10-26
Last modified:2015-05-27
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.
Embo Rep., 12, 2011
4B8Y
  • Download 4b8y
  • View 4b8y
Molmil generated image of 4b8y
FERRICHROME-BOUND FHUD2
Descriptor:FHUD2, VIRULENCE FACTOR, 1,2-ETHANEDIOL, ...
Authors:Malito, E., Bottomley, M.J., Spraggon, G.
Deposit date:2012-08-31
Release date:2012-11-21
Last modified:2013-01-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Functional Characterization of the Staphylococcus Aureus Virulence Factor and Vaccine Candidate Fhud2.
Biochem.J., 449, 2013
4BIG
  • Download 4big
  • View 4big
Molmil generated image of 4big
CRYSTAL STRUCTURE OF THE CONSERVED STAPHYLOCOCCAL ANTIGEN 1B, CSA1B
Descriptor:UNCHARACTERIZED LIPOPROTEIN SAOUHSC_00053
Authors:Malito, E., Bottomley, M.J., Schluepen, C., Liberatori, S.
Deposit date:2013-04-10
Release date:2013-08-07
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (2.274 Å)
Cite:Mining the Bacterial Unknown Proteome: Identification and Characterization of a Novel Family of Highly Conserved Protective Antigens in Staphylococcus Aureus
Biochem.J., 455, 2013
4BIH
  • Download 4bih
  • View 4bih
Molmil generated image of 4bih
CRYSTAL STRUCTURE OF THE CONSERVED STAPHYLOCOCCAL ANTIGEN 1A, CSA1A
Descriptor:UNCHARACTERIZED LIPOPROTEIN SAOUHSC_00053, CALCIUM ION
Authors:Malito, E., Bottomley, M.J., Spraggon, G., Schluepen, C., Liberatori, S.
Deposit date:2013-04-10
Release date:2013-08-07
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (2.459 Å)
Cite:Mining the Bacterial Unknown Proteome: Identification and Characterization of a Novel Family of Highly Conserved Protective Antigens in Staphylococcus Aureus
Biochem.J., 455, 2013
<123>