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1PPT
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X-RAY ANALYSIS (1.4-ANGSTROMS RESOLUTION) OF AVIAN PANCREATIC POLYPEPTIDE. SMALL GLOBULAR PROTEIN HORMONE
分子名称:AVIAN PANCREATIC POLYPEPTIDE, ZINC ION
著者Blundell, T.L., Pitts, J.E., Tickle, I.J., Wood, S.P.
登録日1981-01-16
公開日1981-02-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.37 Å)
主引用文献X-ray analysis (1. 4-A resolution) of avian pancreatic polypeptide: Small globular protein hormone.
Proc.Natl.Acad.Sci.Usa, 78, 1981
1ENT
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X-RAY ANALYSES OF ASPARTIC PROTEINASES. THE THREE-DIMENSIONAL STRUCTURE AT 2.1 ANGSTROMS RESOLUTION OF ENDOTHIAPEPSIN
分子名称:ENDOTHIAPEPSIN, N-(tert-butoxycarbonyl)-L-phenylalanyl-N-{(1S)-1-[(R)-hydroxy(2-{[(2S)-2-methylbutyl]amino}-2-oxoethyl)phosphoryl]-3-methylbutyl}-3-(1H-imidazol-3-ium-4-yl)-L-alaninamide, SULFATE ION
著者Blundell, T.L., Dealwis, C.G.
登録日1992-03-11
公開日1994-01-31
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献X-ray analyses of aspartic proteinases. The three-dimensional structure at 2.1 A resolution of endothiapepsin.
J.Mol.Biol., 211, 1990
1EED
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X-RAY CRYSTALLOGRAPHIC ANALYSIS OF INHIBITION OF ENDOTHIAPEPSIN BY CYCLOHEXYL RENIN INHIBITORS
分子名称:ENDOTHIAPEPSIN, (2S)-2-[[(3S,4S)-5-cyclohexyl-4-[[(4S,5S)-5-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxidanyl-6-phenyl-hexanoyl]amino]-3-oxidanyl-pentanoyl]amino]-4-methyl-pentanoic acid
著者Blundell, T.L., Frazao, C., Cooper, J.B.
登録日1992-06-15
公開日1994-01-31
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献X-ray crystallographic analysis of inhibition of endothiapepsin by cyclohexyl renin inhibitors.
Biochemistry, 31, 1992
3SI5
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KINETOCHORE-BUBR1 KINASE COMPLEX
分子名称:Mitotic checkpoint serine/threonine-protein kinase BUB1 beta, Protein CASC5
著者Blundell, T.L., Chirgadze, D.Y., Bolanos-Garcia, V.M.
登録日2011-06-17
公開日2011-10-26
最終更新日2011-11-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site.
Structure, 19, 2011
2ER0
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X-RAY STUDIES OF ASPARTIC PROTEINASE-STATINE INHIBITOR COMPLEXES
分子名称:ENDOTHIAPEPSIN, L364,099
著者Cooper, J.B., Foundling, S.I., Boger, J., Blundell, T.L.
登録日1990-10-20
公開日1991-01-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献X-ray studies of aspartic proteinase-statine inhibitor complexes.
Biochemistry, 28, 1989
2ER7
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X-RAY ANALYSES OF ASPARTIC PROTEINASES.III. THREE-DIMENSIONAL STRUCTURE OF ENDOTHIAPEPSIN COMPLEXED WITH A TRANSITION-STATE ISOSTERE INHIBITOR OF RENIN AT 1.6 ANGSTROMS RESOLUTION
分子名称:ENDOTHIAPEPSIN, TRANSITION-STATE ISOSTERE INHIBITOR OF RENIN, SULFATE ION
著者Veerapandian, B., Cooper, J.B., Szelke, M., Blundell, T.L.
登録日1990-11-12
公開日1991-01-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献X-ray analyses of aspartic proteinases. III Three-dimensional structure of endothiapepsin complexed with a transition-state isostere inhibitor of renin at 1.6 A resolution.
J.Mol.Biol., 216, 1990
2ER9
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X-RAY STUDIES OF ASPARTIC PROTEINASE-STATINE INHIBITOR COMPLEXES.
分子名称:ENDOTHIAPEPSIN, L363,564
著者Cooper, J.B., Foundling, S.I., Boger, J., Blundell, T.L.
登録日1990-10-20
公開日1991-01-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献X-ray studies of aspartic proteinase-statine inhibitor complexes.
Biochemistry, 28, 1989
4ER4
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HIGH-RESOLUTION X-RAY ANALYSES OF RENIN INHIBITOR-ASPARTIC PROTEINASE COMPLEXES
分子名称:ENDOTHIAPEPSIN, H-142
著者Foundling, S.I., Watson, F.E., Szelke, M., Blundell, T.L.
登録日1991-01-05
公開日1991-04-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes.
Nature, 327, 1987
5ER1
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A RATIONAL APPROACH TO THE DESIGN OF ANTIHYPERTENSIVES. X-RAY STUDIES OF COMPLEXES BETWEEN ASPARTIC PROTEINASES AND AMINOALCOHOL RENIN INHIBITORS
分子名称:ENDOTHIAPEPSIN, methyl N-[(2S,3S)-3-amino-2-hydroxy-5-methylhexyl]-L-valyl-L-isoleucyl-L-phenylalaninate
著者Cooper, J.B., Foundling, S.I., Blundell, T.L.
登録日1990-11-07
公開日1991-01-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A Rational Approach to the Design of Antihypertensives. X-Ray Studies of Complexes between Aspartic Proteinases and Aminoalcohol Renin Inhibitors
Topics in Medicinal Chemistry, 1988
5ER2
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HIGH-RESOLUTION X-RAY DIFFRACTION STUDY OF THE COMPLEX BETWEEN ENDOTHIAPEPSIN AND AN OLIGOPEPTIDE INHIBITOR. THE ANALYSIS OF THE INHIBITOR BINDING AND DESCRIPTION OF THE RIGID BODY SHIFT IN THE ENZYME
分子名称:ENDOTHIAPEPSIN, 6-ammonio-N-{[(2R,3R)-3-{[N-(tert-butoxycarbonyl)-L-phenylalanyl-3-(1H-imidazol-3-ium-4-yl)-L-alanyl]amino}-4-cyclohexyl-2-hydroxybutyl](2-methylpropyl)carbamoyl}-L-norleucyl-L-phenylalanine
著者Sali, A., Veerapandian, B., Cooper, J.B., Foundling, S.I., Hoover, D.J., Blundell, T.L.
登録日1991-01-02
公開日1991-04-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献High-resolution X-ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor: the analysis of the inhibitor binding and description of the rigid body shift in the enzyme.
EMBO J., 8, 1989
3ER5
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THE ACTIVE SITE OF ASPARTIC PROTEINASES
分子名称:ENDOTHIAPEPSIN, H-189
著者Bailey, D., Veerapandian, B., Cooper, J., Szelke, M., Blundell, T.L.
登録日1991-01-05
公開日1991-04-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献X-ray-crystallographic studies of complexes of pepstatin A and a statine-containing human renin inhibitor with endothiapepsin.
Biochem.J., 289 ( Pt 2), 1993
2ER6
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THE STRUCTURE OF A SYNTHETIC PEPSIN INHIBITOR COMPLEXED WITH ENDOTHIAPEPSIN.
分子名称:ENDOTHIAPEPSIN, H-256 peptide
著者Cooper, J.B., Foundling, S.I., Szelke, M., Blundell, T.L.
登録日1990-10-13
公開日1991-01-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The structure of a synthetic pepsin inhibitor complexed with endothiapepsin
Eur.J.Biochem., 169, 1987
1ER8
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THE ACTIVE SITE OF ASPARTIC PROTEINASES
分子名称:Endothiapepsin, H-77
著者Hemmings, A.M., Veerapandian, B., Szelke, M., Cooper, J.B., Blundell, T.L.
登録日1989-10-16
公開日1991-10-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Active Site of Aspartic Proteinases
FEBS Lett., 174, 1984
3ER3
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THE ACTIVE SITE OF ASPARTIC PROTEINASES
分子名称:ENDOTHIAPEPSIN, 6-ammonio-N-[(2R,4R,5R)-5-{[N-(tert-butoxycarbonyl)-L-phenylalanyl-3-(1H-imidazol-3-ium-4-yl)-L-alanyl]amino}-6-cyclohexyl-4-hydroxy-2-(2-methylpropyl)hexanoyl]-L-norleucylphenylalanine
著者Al-Karadaghi, S., Cooper, J.B., Veerapandian, B., Hoover, D., Blundell, T.L.
登録日1991-01-02
公開日1991-04-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Active Site of Aspartic Proteinases
FEBS Lett., 174, 1984
4APE
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THE ACTIVE SITE OF ASPARTIC PROTEINASES
分子名称:ENDOTHIAPEPSIN
著者Pearl, L.H., Sewell, B.T., Jenkins, J.A., Cooper, J.B., Blundell, T.L.
登録日1986-06-09
公開日1986-07-14
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The Active Site of Aspartic Proteinases
FEBS Lett., 174, 1984
4ER1
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THE ACTIVE SITE OF ASPARTIC PROTEINASES
分子名称:ENDOTHIAPEPSIN, N-[(1R,2R,4R)-1-(cyclohexylmethyl)-2-hydroxy-6-methyl-4-{[(2R)-2-methylbutyl]carbamoyl}heptyl]-3-(1H-imidazol-3-ium-4-yl)-N~2~-[3-naphthalen-1-yl-2-(naphthalen-1-ylmethyl)propanoyl]-L-alaninamide
著者Quail, J.W., Cooper, J.B., Szelke, M., Blundell, T.L.
登録日1990-10-14
公開日1991-01-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The active site of aspartic proteinases
FEBS Lett., 174, 1984
4ER2
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THE ACTIVE SITE OF ASPARTIC PROTEINASES
分子名称:ENDOTHIAPEPSIN, PEPSTATIN, SULFATE ION
著者Bailey, D., Veerapandian, B., Cooper, J.B., Blundell, T.L.
登録日1990-10-20
公開日1991-01-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The active site of aspartic proteinases
FEBS Lett., 174, 1984
2BF9
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ANISOTROPIC REFINEMENT OF AVIAN (TURKEY) PANCREATIC POLYPEPTIDE AT 0. 99 ANGSTROMS RESOLUTION.
分子名称:PANCREATIC HORMONE, ZINC ION
著者Tickle, I., Glover, I., Pitts, J., Wood, S., Blundell, T.L.
登録日2004-12-06
公開日2004-12-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (0.99 Å)
主引用文献Conformational Flexibility in a Small Globular Hormone. X-Ray Analysis of Avian Pancreatic Polypeptide at 0.98 Angstroms Resolution
Biopolymers, 22, 1983
3G04
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CRYSTAL STRUCTURE OF THE TSH RECEPTOR IN COMPLEX WITH A THYROID-STIMULATING AUTOANTIBODY
分子名称:HUMAN THYROID STIMULATING AUTOANTIBODY M22 LIGHT CHAIN, HUMAN THYROID STIMULATING AUTOANTIBODY M22 HEAVY CHAIN, Thyrotropin receptor, ...
著者Sanders, J., Chirgadze, D.Y., Sanders, P., Baker, S., Sullivan, A., Bhardwaja, A., Bolton, J., Reeve, M., Nakatake, N., Evans, M., Richards, T., Powell, M., Miguel, R.N., Blundell, T.L., Furmaniak, J., Smith, B.R.
登録日2009-01-27
公開日2009-08-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody
Thyroid, 17, 2007
1SMR
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THE 3-D STRUCTURE OF MOUSE SUBMAXILLARY RENIN COMPLEXED WITH A DECAPEPTIDE INHIBITOR CH-66 BASED ON THE 4-16 FRAGMENT OF RAT ANGIOTENSINOGEN
分子名称:RENIN, INHIBITOR CH-66
著者Dealwis, C.G., Blundell, T.L.
登録日1992-03-11
公開日1994-01-31
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献X-ray analysis at 2.0 A resolution of mouse submaxillary renin complexed with a decapeptide inhibitor CH-66, based on the 4-16 fragment of rat angiotensinogen.
J.Mol.Biol., 236, 1994
1XY1
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CRYSTAL STRUCTURE ANALYSIS OF DEAMINO-OXYTOCIN. CONFORMATIONAL FLEXIBILITY AND RECEPTOR BINDING
分子名称:BETA-MERCAPTOPROPIONATE-OXYTOCIN
著者Husain, J., Blundell, T.L., Wood, S.P., Tickle, I.J., Cooper, S., Pitts, J.E.
登録日1987-06-05
公開日1988-04-16
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.04 Å)
主引用文献Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding.
Science, 232, 1986
1XY2
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CRYSTAL STRUCTURE ANALYSIS OF DEAMINO-OXYTOCIN. CONFORMATIONAL FLEXIBILITY AND RECEPTOR BINDING
分子名称:OXYTOCIN
著者Cooper, S., Blundell, T.L., Pitts, J.E., Wood, S.P., Tickle, I.J.
登録日1987-06-05
公開日1988-04-16
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding.
Science, 232, 1986
4GCR
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STRUCTURE OF THE BOVINE EYE LENS PROTEIN GAMMA-B (GAMMA-II)-CRYSTALLIN AT 1.47 ANGSTROMS
分子名称:GAMMA-B CRYSTALLIN
著者Slingsby, C., Najmudin, S., Nalini, V., Driessen, H.P.C., Blundell, T.L., Moss, D.S., Lindley, P.
登録日1992-04-02
公開日1993-10-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Structure of the bovine eye lens protein gammaB(gammaII)-crystallin at 1.47 A.
Acta Crystallogr.,Sect.D, 49, 1993
1XES
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CRYSTAL STRUCTURE OF STILBENE SYNTHASE FROM PINUS SYLVESTRIS
分子名称:Dihydropinosylvin synthase, 3-(1H-INDOL-3-YL)-2-OXOPROPANOIC ACID
著者Ng, S.H., Chirgadze, D., Spiteller, D., Li, T.L., Spencer, J.B., Blundell, T.L.
登録日2004-09-12
公開日2006-04-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of stilbene synthase from Pinus sylvestris
To be Published
1XET
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CRYSTAL STRUCTURE OF STILBENE SYNTHASE FROM PINUS SYLVESTRIS, COMPLEXED WITH METHYLMALONYL COA
分子名称:Dihydropinosylvin synthase, 3-(1H-INDOL-3-YL)-2-OXOPROPANOIC ACID, METHYLMALONYL-COENZYME A
著者Ng, S.H., Chirgadze, D., Spiteller, D., Li, T.L., Spencer, J.B., Blundell, T.L.
登録日2004-09-12
公開日2006-04-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of stilbene synthase from Pinus sylvestris, complexed with methylmalonyl CoA
To be Published