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1AEY
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BU of 1aey by Molmil
ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN, SOLUTION NMR, 15 STRUCTURES
Descriptor: ALPHA-SPECTRIN
Authors:Blanco, F.J, Ortiz, A.R, Serrano, L.
Deposit date:1997-03-02
Release date:1997-05-15
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:1H and 15N NMR assignment and solution structure of the SH3 domain of spectrin: comparison of unrefined and refined structure sets with the crystal structure.
J.Biomol.NMR, 9, 1997
1PU1
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BU of 1pu1 by Molmil
Solution structure of the Hypothetical protein mth677 from Methanothermobacter Thermautotrophicus
Descriptor: Hypothetical protein MTH677
Authors:Blanco, F.J, Yee, A, Campos-Olivas, R, Devos, D, Valencia, A, Arrowsmith, C.H, Rico, M.
Deposit date:2003-06-23
Release date:2004-06-08
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structure of the hypothetical protein Mth677 from Methanobacterium thermoautotrophicum: A novel {alpha}+{beta} fold
Protein Sci., 13, 2004
2M1R
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BU of 2m1r by Molmil
PHD domain of ING4 N214D mutant
Descriptor: Inhibitor of growth protein 4, ZINC ION
Authors:Blanco, F.J.
Deposit date:2012-12-05
Release date:2012-12-26
Method:SOLUTION NMR
Cite:Functional impact of cancer-associated mutations in the tumor suppressor protein ING4.
Carcinogenesis, 31, 2010
8COK
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BU of 8cok by Molmil
Structural analysis of ING3 protein and its binding to histone H3
Descriptor: Inhibitor of growth protein 3
Authors:Ferreras-Gutierrez, M, Medrano, F.J, Blanco, F.J.
Deposit date:2023-02-28
Release date:2023-05-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Structural analysis of ING3 protein and histone H3 binding.
Int.J.Biol.Macromol., 242, 2023
2XE0
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BU of 2xe0 by Molmil
Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus
Descriptor: 24MER DNA, ACETATE ION, I-CREI V2V3 VARIANT, ...
Authors:Munoz, I.G, Prieto, J, Subramanian, S, Coloma, J, Redondo, P, Villate, M, Merino, N, Marenchino, M, D'Abramo, M, Gervasio, F.L, Grizot, S, Daboussi, F, Smith, J, Chion-Sotine, I, Paques, F, Duchateau, P, Alibes, A, Stricher, F, Serrano, L, Blanco, F.J, Montoya, G.
Deposit date:2010-05-10
Release date:2010-09-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Molecular Basis of Engineered Meganuclease Targeting of the Endogenous Human Rag1 Locus
Nucleic Acids Res., 39, 2011
6HVO
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BU of 6hvo by Molmil
Crystal structure of human PCNA in complex with three peptides of p12 subunit of human polymerase delta
Descriptor: DNA polymerase delta subunit 4, Proliferating cell nuclear antigen, SULFATE ION
Authors:Gonzalez-Magana, A, Romano-Moreno, M, Rojas, A.L, Blanco, F.J, De Biasio, A.
Deposit date:2018-10-11
Release date:2019-01-23
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The p12 subunit of human polymerase delta uses an atypical PIP box for molecular recognition of proliferating cell nuclear antigen (PCNA).
J.Biol.Chem., 294, 2019
4AFL
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BU of 4afl by Molmil
The crystal structure of the ING4 dimerization domain reveals the functional organization of the ING family of chromatin binding proteins.
Descriptor: INHIBITOR OF GROWTH PROTEIN 4
Authors:Culurgioni, S, Munoz, I.G, Moreno, A, Palacios, A, Villate, M, Palmero, I, Montoya, G, Blanco, F.J.
Deposit date:2012-01-19
Release date:2012-02-22
Last modified:2012-07-11
Method:X-RAY DIFFRACTION (2.275 Å)
Cite:Crystal Structure of Inhibitor of Growth 4 (Ing4) Dimerization Domain Reveals Functional Organization of Ing Family of Chromatin-Binding Proteins.
J.Biol.Chem., 287, 2012
7ZMX
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BU of 7zmx by Molmil
Crystal structure of the Plant Homeodomain (PHD) of human ING3
Descriptor: CALCIUM ION, Inhibitor of growth protein 3, ZINC ION
Authors:Ferreras, M.O, Medrano, F.J, Blanco, F.J.
Deposit date:2022-04-20
Release date:2023-05-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural analysis of ING3 protein and histone H3 binding.
Int.J.Biol.Macromol., 242, 2023
6EHT
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BU of 6eht by Molmil
Modulation of PCNA sliding surface by p15PAF suggests a suppressive mechanism for cisplatin-induced DNA lesion bypass by pol eta holoenzyme
Descriptor: DNA (5'-D(P*AP*TP*AP*CP*GP*AP*TP*GP*GP*G)-3'), DNA (5'-D(P*CP*CP*CP*AP*TP*CP*GP*TP*AP*T)-3'), PCNA-associated factor, ...
Authors:De March, M, Barrera-Vilarmau, S, Mentegari, E, Merino, N, Bressan, E, Maga, G, Crehuet, R, Onesti, S, Blanco, F.J, De Biasio, A.
Deposit date:2017-09-15
Release date:2018-08-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:p15PAF binding to PCNA modulates the DNA sliding surface.
Nucleic Acids Res., 46, 2018
5ME8
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BU of 5me8 by Molmil
N-terminal domain of the human tumor suppressor ING5
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, Inhibitor of growth protein 5
Authors:Roversi, P, Blanco, F.J, Rojas, A.L, Buitrago, J.A.R.
Deposit date:2016-11-14
Release date:2018-03-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The Tumor Suppressor ING5 Is a Dimeric, Bivalent Recognition Molecule of the Histone H3K4me3 Mark.
J.Mol.Biol., 431, 2019
5MTO
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BU of 5mto by Molmil
N-terminal domain of the human tumor suppressor ING5 C19S mutant
Descriptor: Inhibitor of growth protein 5, SODIUM ION, SULFATE ION
Authors:Ormaza, G, Buitrago, J.A.R, Roversi, P, Rojas, A.L, Blanco, F.J.
Deposit date:2017-01-10
Release date:2018-02-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The Tumor Suppressor ING5 Is a Dimeric, Bivalent Recognition Molecule of the Histone H3K4me3 Mark.
J.Mol.Biol., 431, 2019
4ZTD
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BU of 4ztd by Molmil
Crystal Structure of Human PCNA in complex with a TRAIP peptide
Descriptor: ALA-GLY-ALA-GLY-ALA, ALA-PHE-GLN-ALA-LYS-LEU-ASP-THR-PHE-LEU-TRP-SER, Proliferating cell nuclear antigen
Authors:Montoya, G, Mortuza, G.B, Blanco, F.J, Ibanez de Opakua, A.
Deposit date:2015-05-14
Release date:2015-12-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress.
J.Cell Biol., 212, 2016
6G52
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BU of 6g52 by Molmil
CRYSTAL STRUCTURE OF THE CNMP BINDING DOMAIN OF THE MAGNESIUM TRANSPORTER CNNM4
Descriptor: Metal transporter CNNM4
Authors:Gimenez, P, Oyenarte, I, Hardy, S, Zubillaga, M, Merino, N, Blanco, F.J, Siliqi, D, Tremblay, M, Muller, D, Martinez-Cruz, L.A.
Deposit date:2018-03-28
Release date:2019-04-10
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (3.691 Å)
Cite:Structural Insights into the Intracellular Region of the Human Magnesium Transport Mediator CNNM4.
Int J Mol Sci, 20, 2019
6GIS
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BU of 6gis by Molmil
Structural basis of human clamp sliding on DNA
Descriptor: DNA (5'-D(P*AP*TP*AP*CP*GP*AP*TP*GP*GP*G)-3'), DNA (5'-D(P*CP*CP*CP*AP*TP*CP*GP*TP*AP*T)-3'), Proliferating cell nuclear antigen
Authors:De March, M, Merino, N, Barrera-Vilarmau, S, Crehuet, R, Onesti, S, Blanco, F.J, De Biasio, A.
Deposit date:2018-05-15
Release date:2018-05-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Structural basis of human PCNA sliding on DNA.
Nat Commun, 8, 2017
5A77
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BU of 5a77 by Molmil
Crystal structure of the homing endonuclease I-CvuI in complex with I- CreI target (C1221) in the presence of 2 mM Mg revealing DNA cleaved
Descriptor: 10MER DNA, 5'-D(*GP*AP*CP*GP*TP*TP*TP*TP* GP*AP*DGP*AP*CP*GP*TP*TP*TP*TP*GP*A)-3', 14MER DNA, ...
Authors:Molina, R, Redondo, P, LopezMendez, B, Villate, M, Merino, N, Blanco, F.J, Valton, J, Grizot, S, Duchateau, P, Prieto, J, Montoya, G.
Deposit date:2015-07-03
Release date:2015-09-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the Homing Endonuclease I-Cvui Provides a New Template for Genome Modification
J.Biol.Chem., 290, 2015
5A74
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BU of 5a74 by Molmil
Crystal structure of the homing endonuclease I-CvuI in complex with its target (Sro1.3) in the presence of 2 mM Mn
Descriptor: 10MER DNA, 5'-D(*GP*AP*CP*GP*TP*TP*CP*TP*GP*AP)-3', 14MER DNA, ...
Authors:Molina, R, Redondo, P, LopezMendez, B, Villate, M, Merino, N, Blanco, F.J, Valton, J, Grizot, S, Duchateau, P, Prieto, J, Montoya, G.
Deposit date:2015-07-02
Release date:2015-09-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the Homing Endonuclease I-Cvui Provides a New Template for Genome Modification
J.Biol.Chem., 290, 2015
4D2G
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BU of 4d2g by Molmil
Crystal structure of human PCNA in complex with p15 peptide
Descriptor: P15, PROLIFERATING CELL NUCLEAR ANTIGEN
Authors:DeBiasio, A, Ibanez, A, Mortuza, G, Molina, R, Cordeiro, T.N, Castillo, F, Villate, M, Merino, N, Lelli, M, Diercks, T, Luque, I, Bernardo, P, Montoya, G, Blanco, F.J.
Deposit date:2014-05-09
Release date:2015-03-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of P15(Paf)-PCNA Complex and Implications for Clamp Sliding During DNA Replication and Repair.
Nat.Commun., 6, 2015
5A78
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BU of 5a78 by Molmil
Crystal structure of the homing endonuclease I-CvuI in complex with I- CreI target (C1221) in the presence of 2 mM Mg revealing DNA not cleaved
Descriptor: 24MER DNA, 5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP *CP*GP*AP*CP*GP*TP*TP*TP*TP*GP*A)-3', DNA ENDONUCLEASE I-CVUI, ...
Authors:Molina, R, Redondo, P, LopezMendez, B, Villate, M, Merino, N, Blanco, F.J, Valton, J, Grizot, S, Duchateau, P, Prieto, J, Montoya, G.
Deposit date:2015-07-03
Release date:2015-09-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the Homing Endonuclease I-Cvui Provides a New Template for Genome Modification
J.Biol.Chem., 290, 2015
5A0M
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BU of 5a0m by Molmil
THE CRYSTAL STRUCTURE OF I-SCEI IN COMPLEX WITH ITS TARGET DNA IN THE PRESENCE OF MN
Descriptor: 5'-D(*CP*AP*CP*GP*CP*TP*AP*GP*GP*GP*AP*TP*AP*AP)-3', 5'-D(*CP*AP*GP*GP*GP*TP*AP*AP*TP*AP*CP)-3', 5'-D(*CP*CP*CP*TP*AP*GP*CP*GP*TP)-3', ...
Authors:Prieto, J, Redondo, P, Merino, N, Villate, M, Blanco, F.J, Molina, R.
Deposit date:2015-04-21
Release date:2016-05-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the I-Scei Nuclease Complexed with its DsDNA Target and Three Catalytic Metal Ions.
Acta Crystallogr.,Sect.F, 72, 2016
5A72
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BU of 5a72 by Molmil
Crystal structure of the homing endonuclease I-CvuI in complex with its target (Sro1.3) in the presence of 2 mM Ca
Descriptor: 24MER DNA, 5'-D(*DTP*CP*AP*GP*AP*AP*CP*GP*TP*CP*GP*TP*AP *DCP*GP*AP*CP*GP*TP*TP*CP*TP*GP*A)-3', CALCIUM ION, ...
Authors:Molina, R, Redondo, P, LopezMendez, B, Villate, M, Merino, N, Blanco, F.J, Valton, J, Grizot, S, Duchateau, P, Prieto, J, Montoya, G.
Deposit date:2015-07-02
Release date:2015-09-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the Homing Endonuclease I-Cvui Provides a New Template for Genome Modification
J.Biol.Chem., 290, 2015
2VNF
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BU of 2vnf by Molmil
MOLECULAR BASIS OF HISTONE H3K4ME3 RECOGNITION BY ING4
Descriptor: (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, HISTONE H3, ...
Authors:Palacios, A, Munoz, I.G, Pantoja-Uceda, D, Marcaida, M.J, Torres, D, Martin-Garcia, J.M, Luque, I, Montoya, G, Blanco, F.J.
Deposit date:2008-02-04
Release date:2008-04-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Molecular Basis of Histone H3K4Me3 Recognition by Ing4
J.Biol.Chem., 283, 2008
2VBO
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BU of 2vbo by Molmil
Molecular basis of human XPC gene recognition and cleavage by engineered homing endonuclease heterodimers
Descriptor: 5'-D(*TP*CP*TP*GP*CP*CP*TP*TP*TP*TP *TP*TP*GP*AP*AP*GP*GP*AP*TP*CP*CP*TP*AP*A)-3', 5'-D(*TP*TP*AP*GP*GP*AP*TP*CP*CP*TP *TP*CP*AP*AP*AP*AP*AP*AP*GP*GP*CP*AP*GP*A)-3', CALCIUM ION, ...
Authors:Redondo, P, Prieto, J, Munoz, I.G, Alibes, A, Stricher, F, Serrano, L, Arnould, S, Perez, C, Cabaniols, J.P, Duchateau, P, Paques, F, Blanco, F.J, Montoya, G.
Deposit date:2007-09-14
Release date:2008-10-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases
Nature, 456, 2008
2VBN
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BU of 2vbn by Molmil
Molecular basis of human XPC gene recognition and cleavage by engineered homing endonuclease heterodimers
Descriptor: 5'-D(*AP*AP*AP*AP*GP*GP*CP*AP*GP*AP)-3', 5'-D(*AP*GP*GP*AP*TP*CP*CP*TP*AP*AP)-3', 5'-D(*TP*CP*TP*GP*CP*CP*TP*TP*TP*TP *TP*TP*GP*AP)-3', ...
Authors:Redondo, P, Prieto, J, Munoz, I.G, Alibes, A, Stricher, F, Serrano, L, Arnould, S, Perez, C, Cabaniols, J.P, Duchateau, P, Paques, F, Blanco, F.J, Montoya, G.
Deposit date:2007-09-14
Release date:2008-10-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases
Nature, 456, 2008
2VBL
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BU of 2vbl by Molmil
Molecular basis of human XPC gene recognition and cleavage by engineered homing endonuclease heterodimers
Descriptor: 5'-D(*DA*DA*DA*DA*DG*DG*DC*DA*DG*DAP)-3', 5'-D(*DA*DG*DG*DA*DT*DC*DC*DT*DA*DAP)-3', 5'-D(*DT*DC*DT*DG*DC*DC*DT*DT*DT*DT*DT*DT *DGP*DAP)-3', ...
Authors:Redondo, P, Prieto, J, Munoz, I.G, Alibes, A, Stricher, F, Serrano, L, Arnould, S, Perez, C, Cabaniols, J.P, Duchateau, P, Paques, F, Blanco, F.J, Montoya, G.
Deposit date:2007-09-14
Release date:2008-10-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases
Nature, 456, 2008
2VBJ
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BU of 2vbj by Molmil
Molecular basis of human XPC gene recognition and cleavage by engineered homing endonuclease heterodimers
Descriptor: 5'-D(*TP*CP*TP*GP*CP*CP*TP*TP*TP*TP *TP*TP*GP*AP*AP*GP*GP*AP*TP*CP*CP*TP*AP*A)-3', 5'-D(*TP*TP*AP*GP*GP*AP*TP*CP*CP*TP *TP*CP*AP*AP*AP*AP*AP*AP*GP*GP*CP*AP*GP*A)-3', CALCIUM ION, ...
Authors:Redondo, P, Prieto, J, Munoz, I.G, Alibes, A, Stricher, F, Serrano, L, Arnould, S, Perez, C, Cabaniols, J.P, Duchateau, P, Paques, F, Blanco, F.J, Montoya, G.
Deposit date:2007-09-14
Release date:2008-10-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases
Nature, 456, 2008

 

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