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5IBS
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BU of 5ibs by Molmil
Structure of E76Q, a Cancer-Associated Mutation of the Oncogenic Phosphatase SHP2
Descriptor: Tyrosine-protein phosphatase non-receptor type 11
Authors:Blacklow, S.C, Stams, T, Fodor, M, LaRochelle, J.R.
Deposit date:2016-02-22
Release date:2016-04-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2.
Biochemistry, 55, 2016
5IBM
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BU of 5ibm by Molmil
Structure of S502P, a Cancer-Associated Mutation of the Oncogenic Phosphatase SHP2
Descriptor: Tyrosine-protein phosphatase non-receptor type 11
Authors:Blacklow, S.C, Stams, T, Fodor, M, LaRochelle, J.R.
Deposit date:2016-02-22
Release date:2016-04-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2.
Biochemistry, 55, 2016
6BN5
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BU of 6bn5 by Molmil
Non-receptor Protein Tyrosine Phosphatase SHP2 F285S in Complex with Allosteric Inhibitor JLR-2
Descriptor: 3-benzyl-8-chloro-2-hydroxy-4H-pyrimido[2,1-b][1,3]benzothiazol-4-one, Tyrosine-protein phosphatase non-receptor type 11
Authors:Blacklow, S.C, Stams, T, Fodor, M, LaRochelle, J.R.
Deposit date:2017-11-16
Release date:2017-12-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2.
Bioorg. Med. Chem., 25, 2017
1AJJ
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BU of 1ajj by Molmil
LDL RECEPTOR LIGAND-BINDING MODULE 5, CALCIUM-COORDINATING
Descriptor: CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, SULFATE ION
Authors:Fass, D, Blacklow, S.C, Kim, P.S, Berger, J.M.
Deposit date:1997-05-04
Release date:1997-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module.
Nature, 388, 1997
8ESV
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BU of 8esv by Molmil
Structure of human ADAM10-Tspan15 complex bound to 11G2 vFab
Descriptor: 11G2 Fab Heavy Chain, 11G2 Fab Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lipper, C.H, Blacklow, S.C.
Deposit date:2022-10-14
Release date:2023-06-14
Last modified:2023-08-30
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for membrane-proximal proteolysis of substrates by ADAM10.
Cell, 186, 2023
1D2J
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BU of 1d2j by Molmil
LDL RECEPTOR LIGAND-BINDING MODULE 6
Descriptor: CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR
Authors:North, C.L, Blacklow, S.C.
Deposit date:1999-09-23
Release date:2000-03-22
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:Solution structure of the sixth LDL-A module of the LDL receptor.
Biochemistry, 39, 2000
6PY8
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BU of 6py8 by Molmil
Crystal structure of the RBPJ-NOTCH1-NRARP ternary complex bound to DNA
Descriptor: DNA, Neurogenic locus notch homolog protein 1, Notch-regulated ankyrin repeat-containing protein, ...
Authors:Jarrett, S.M, Seegar, T.C.M, Blacklow, S.C.
Deposit date:2019-07-29
Release date:2019-08-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.75 Å)
Cite:Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling.
Sci.Signal., 12, 2019
7JIC
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BU of 7jic by Molmil
Structure of human CD19-CD81 co-receptor complex bound to coltuximab Fab fragment
Descriptor: B-lymphocyte antigen CD19, CD81 antigen, Coltuximab Heavy Chain, ...
Authors:Susa, K.J, Rawson, S, Kruse, A.C, Blacklow, S.C.
Deposit date:2020-07-23
Release date:2021-01-20
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81
Science, 371, 2021
5L2Q
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BU of 5l2q by Molmil
Serine/threonine-protein kinase 40 (STK40) kinase homology domain
Descriptor: Serine/threonine-protein kinase 40
Authors:Durzynska, I, Uljon, S, Blacklow, S.C.
Deposit date:2016-08-02
Release date:2017-02-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.
Structure, 25, 2017
4TSE
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BU of 4tse by Molmil
Crystal Structure of the Mib Repeat Domain of Mind bomb 1
Descriptor: E3 ubiquitin-protein ligase MIB1
Authors:McMillan, B.J, Blacklow, S.C.
Deposit date:2014-06-18
Release date:2015-03-18
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.057 Å)
Cite:A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb e3 ligases.
Mol.Cell, 57, 2015
6NCM
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BU of 6ncm by Molmil
Crystal structure of the human FOXN3 DNA binding domain in complex with a forkhead-like (FHL) DNA sequence
Descriptor: DNA (5'-D(*AP*TP*AP*GP*CP*GP*TP*CP*TP*TP*AP*GP*CP*AP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*TP*GP*CP*TP*AP*AP*GP*AP*CP*GP*CP*TP*A)-3'), Forkhead box protein N3, ...
Authors:Rogers, J.M, Jarrett, S.M, Seegar, T.C, Waters, C.T, Hallworth, A.N, Blacklow, S.C, Bulyk, M.L.
Deposit date:2018-12-11
Release date:2019-02-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.704 Å)
Cite:Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes.
Mol. Cell, 74, 2019
6NCE
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BU of 6nce by Molmil
Crystal structure of the human FOXN3 DNA binding domain in complex with a forkhead DNA sequence
Descriptor: DNA (5'-D(*AP*CP*AP*TP*TP*GP*TP*TP*TP*AP*CP*TP*TP*AP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*TP*AP*AP*GP*TP*AP*AP*AP*CP*AP*AP*TP*G)-3'), Forkhead box protein N3, ...
Authors:Rogers, J.M, Jarrett, S.M, Seegar, T.C, Waters, C.T, Hallworth, A.N, Blacklow, S.C, Bulyk, M.L.
Deposit date:2018-12-11
Release date:2019-02-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.598 Å)
Cite:Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes.
Mol. Cell, 74, 2019
7RDB
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BU of 7rdb by Molmil
Crystal structure of Tspan15 large extracellular loop (Tspan15 LEL)
Descriptor: Tetraspanin-15
Authors:Lipper, C.H, Gabriel, K.H, Seegar, T.C.M, Durr, K.L, Tomlinson, M.G, Blacklow, S.C.
Deposit date:2021-07-09
Release date:2021-11-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site.
Structure, 30, 2022
7RD5
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BU of 7rd5 by Molmil
Crystal structure of Tspan15 large extracellular loop (Tspan15 LEL) in complex with 1C12 Fab
Descriptor: 1C12 Fab Heavy Chain, 1C12 Fab Light Chain, Tetraspanin-15
Authors:Lipper, C.H, Gabriel, K.H, Seegar, T.C.M, Durr, K.L, Tomlinson, M.G, Blacklow, S.C.
Deposit date:2021-07-09
Release date:2021-11-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site.
Structure, 30, 2022
3ETO
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BU of 3eto by Molmil
2 Angstrom Xray structure of the NOTCH1 Negative Regulatory Region (NRR)
Descriptor: CALCIUM ION, CHLORIDE ION, GLYCEROL, ...
Authors:Gordon, W.R, Blacklow, S.C.
Deposit date:2008-10-08
Release date:2008-12-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL.
Blood, 113, 2009
2OO4
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BU of 2oo4 by Molmil
Structure of LNR-HD (Negative Regulatory Region) from human Notch 2
Descriptor: CALCIUM ION, GLYCEROL, Neurogenic locus notch homolog protein 2, ...
Authors:Gordon, W.R, Vardar-Ulu, D, Histen, G, Sanchez-Irizarry, C, Aster, J.C, Blacklow, S.C.
Deposit date:2007-01-25
Release date:2007-04-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:Structural basis for autoinhibition of Notch
Nat.Struct.Mol.Biol., 14, 2007
3I08
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BU of 3i08 by Molmil
Crystal structure of the S1-cleaved Notch1 Negative Regulatory Region (NRR)
Descriptor: CALCIUM ION, CHLORIDE ION, Neurogenic locus notch homolog protein 1
Authors:Gordon, W.R, Blacklow, S.C.
Deposit date:2009-06-24
Release date:2009-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2.
Plos One, 4, 2009
3NBN
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BU of 3nbn by Molmil
Crystal structure of a dimer of Notch Transcription Complex trimers on HES1 DNA
Descriptor: DNA, HES1 promoter, Mastermind-like protein 1, ...
Authors:Arnett, K.L, Blacklow, S.C.
Deposit date:2010-06-03
Release date:2010-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes.
Nat.Struct.Mol.Biol., 17, 2010
4ZLP
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BU of 4zlp by Molmil
Crystal Structure of Notch3 Negative Regulatory Region
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CALCIUM ION, ...
Authors:Xu, X, Blacklow, S.C.
Deposit date:2015-05-01
Release date:2015-08-19
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.479 Å)
Cite:Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region.
Structure, 23, 2015
1IJQ
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BU of 1ijq by Molmil
Crystal Structure of the LDL Receptor YWTD-EGF Domain Pair
Descriptor: LOW-DENSITY LIPOPROTEIN RECEPTOR
Authors:Jeon, H, Meng, W, Takagi, J, Eck, M.J, Springer, T.A, Blacklow, S.C.
Deposit date:2001-04-27
Release date:2001-05-23
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair.
Nat.Struct.Biol., 8, 2001
1L3Y
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BU of 1l3y by Molmil
INTEGRIN EGF-LIKE MODULE 3 FROM THE BETA-2 SUBUNIT
Descriptor: Integrin beta-2:CYSTEINE-RICH MODULE 3
Authors:Beglova, N, Blacklow, S.C, Takagi, J, Springer, T.A.
Deposit date:2002-03-03
Release date:2002-04-01
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation.
Nat.Struct.Biol., 9, 2002
2FCW
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BU of 2fcw by Molmil
Structure of a Complex Between the Pair of the LDL Receptor Ligand-Binding Modules 3-4 and the Receptor Associated Protein (RAP).
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Alpha-2-macroglobulin receptor-associated protein, CALCIUM ION, ...
Authors:Beglova, N, Fisher, C, Blacklow, S.C.
Deposit date:2005-12-12
Release date:2006-05-16
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Structure of an LDLR-RAP Complex Reveals a General Mode for Ligand Recognition by Lipoprotein Receptors
Mol.Cell, 22, 2006
2F8Y
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BU of 2f8y by Molmil
Crystal structure of human Notch1 ankyrin repeats to 1.55A resolution.
Descriptor: Notch homolog 1, translocation-associated (Drosophila), SULFATE ION
Authors:Nam, Y, Sliz, P, Blacklow, S.C.
Deposit date:2005-12-04
Release date:2006-04-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
Cell(Cambridge,Mass.), 124, 2006
2F8X
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BU of 2f8x by Molmil
Crystal structure of activated Notch, CSL and MAML on HES-1 promoter DNA sequence
Descriptor: 5'-D(*GP*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*AP*AP*A)-3', 5'-D(*TP*TP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*AP*GP*TP*AP*AP*C)-3', Mastermind-like protein 1, ...
Authors:Nam, Y, Sliz, P, Blacklow, S.C.
Deposit date:2005-12-04
Release date:2006-04-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
Cell(Cambridge,Mass.), 124, 2006
6CIS
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BU of 6cis by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG047
Descriptor: 1,2-ETHANEDIOL, 11-cyclopentyl-5-methyl-2-({4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]-2-[(propan-2-yl)oxy]phenyl}amino)-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Bromodomain-containing protein 4, ...
Authors:Xu, X, Blacklow, S.C.
Deposit date:2018-02-25
Release date:2018-08-29
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.
ACS Chem. Biol., 13, 2018

 

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