Author results

2ODJ
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CRYSTAL STRUCTURE OF THE OUTER MEMBRANE PROTEIN OPRD FROM PSEUDOMONAS AERUGINOSA
Descriptor:Porin D, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE
Authors:Biswas, S., van den Berg, B.
Deposit date:2006-12-22
Release date:2007-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural insight into OprD substrate specificity.
Nat.Struct.Mol.Biol., 14, 2007
2QTK
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CRYSTAL STRUCTURE OF THE OUTER MEMBRANE PROTEIN OPDK FROM PSEUDOMONAS AERUGINOSA
Descriptor:Probable porin, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE
Authors:Biswas, S., Van den Berg, B.
Deposit date:2007-08-02
Release date:2008-06-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the Outer Membrane Protein OpdK from Pseudomonas aeruginosa.
Structure, 16, 2008
3O85
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GIARDIA LAMBLIA 15.5KD RNA BINDING PROTEIN
Descriptor:Ribosomal protein L7Ae
Authors:Biswas, S., Maxwell, E.S.
Deposit date:2010-08-02
Release date:2011-03-16
Last modified:2011-09-07
Method:X-RAY DIFFRACTION (1.806 Å)
Cite:Comparative analysis of the 15.5kD box C/D snoRNP core protein in the primitive eukaryote Giardia lamblia reveals unique structural and functional features.
Biochemistry, 50, 2011
3PAF
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M. JANNASCHII L7AE MUTANT
Descriptor:50S ribosomal protein L7Ae, SULFATE ION, ACETATE ION
Authors:Biswas, S., Maxwell, E.S.
Deposit date:2010-10-19
Release date:2011-11-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure and stability of M.jannaschii L7Ae El9 KtoQ mutant
To be Published
3R16
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HUMAN CAII BOUND TO N-(4-SULFAMOYLPHENYL)-2-(THIOPHEN-2-YL) ACETAMIDE
Descriptor:Carbonic anhydrase 2, ZINC ION, GLYCEROL, ...
Authors:Biswas, S., McKenna, R., Supuran, C.T.
Deposit date:2011-03-09
Release date:2011-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms.
Bioorg.Med.Chem., 19, 2011
3R17
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HCARBONIC ANHYDRASE II BOUND TO N-(2-FLUORO.4-SULFAMOYLPHENYL)-2-(THIOPHEN-2-YL) ACETAMIDE
Descriptor:Carbonic anhydrase 2, ZINC ION, GLYCEROL, ...
Authors:Biswas, S., McKenna, R.
Deposit date:2011-03-09
Release date:2011-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms.
Bioorg.Med.Chem., 19, 2011
4ILX
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STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH AN ADAMANTYL SULFONAMIDE INHIBITOR
Descriptor:Carbonic anhydrase 2, ZINC ION, GLYCEROL, ...
Authors:Biswas, S., McKenna, R.
Deposit date:2013-01-01
Release date:2013-02-13
Last modified:2013-05-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition.
Bioorg.Med.Chem., 21, 2013
4IWZ
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STRUCTURE OF HCAII IN COMPLEX WITH AN ACETAZOLAMIDE DERIVATIVE
Descriptor:Carbonic anhydrase 2, N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-2-(thiophen-2-yl)acetamide, ZINC ION, ...
Authors:Biswas, S., McKenna, R.
Deposit date:2013-01-24
Release date:2013-12-11
Method:X-RAY DIFFRACTION (1.598 Å)
Cite:Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII.
Bioorg.Med.Chem.Lett., 23, 2013
4K0S
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STRUCTURE OF HCAIX MIMIC (HCAII WITH 5 MUTATIONS IN ACTIVE SITE) IN COMPLEX WITH ACETAZOLAMIDE
Descriptor:Carbonic anhydrase 2, ZINC ION, 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE
Authors:Biswas, S., McKenna, R.
Deposit date:2013-04-04
Release date:2014-04-09
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Developing isoform specific inhibitors against hCAIX using CAIX mimic
To be Published
4K0T
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STRUCTURE OF HCAIX MIMIC (HCAII WITH 5 MUTATIONS IN ACTIVE SITE) IN COMPLEX WITH CHLORZOLAMIDE
Descriptor:Carbonic anhydrase 2, ZINC ION, DIMETHYL SULFOXIDE, ...
Authors:Biswas, S., McKenna, R.
Deposit date:2013-04-04
Release date:2014-04-09
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Designing isoform specific inhibitors against hCAIX using CAIX mimic
To be Published
4K0Z
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STRUCTURE OF HCAIX MIMIC (HCAII WITH 5 MUTATIONS IN ACTIVE SITE) IN COMPLEX WITH METHAZOLAMIDE
Descriptor:Carbonic anhydrase 2, ZINC ION, DIMETHYL SULFOXIDE, ...
Authors:Biswas, S., McKenna, R.
Deposit date:2013-04-04
Release date:2014-04-09
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Developing isoform specific inhibitors for hCAIX using CAIX mimic
To be Published
4K13
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STRUCTURE OF HCAIX MIMIC (HCAII WITH 5 MUTATIONS IN ACTIVE SITE) IN COMPLEX WITH DORZOLAMIDE
Descriptor:Carbonic anhydrase 2, ZINC ION, DIMETHYL SULFOXIDE, ...
Authors:Biswas, S., McKenna, R.
Deposit date:2013-04-04
Release date:2014-04-09
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Developing isoform specific inhibitors for hCAIX using CAIX mimic
To be Published
4K1Q
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STRUCTURE OF HCAIX MIMIC (HCAII WITH 5 MUTATIONS IN ACTIVE SITE)
Descriptor:Carbonic anhydrase 2, ZINC ION
Authors:Biswas, S., McKenna, R.
Deposit date:2013-04-05
Release date:2014-04-09
Method:X-RAY DIFFRACTION (1.699 Å)
Cite:Developing isoform specific inhibitors for hCAIX using CAIX mimic
To be Published
5Z5O
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STRUCTURE OF PYCNONODYSOSTOSIS DISEASE RELATED I249T MUTANT OF HUMAN CATHEPSIN K
Descriptor:Cathepsin K, GLYCEROL, 1,2-ETHANEDIOL, ...
Authors:Biswas, S., Roy, S.
Deposit date:2018-01-19
Release date:2018-09-26
Last modified:2018-12-12
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Not all pycnodysostosis-related mutants of human cathepsin K are inactive - crystal structure and biochemical studies of an active mutant I249T.
FEBS J., 285, 2018
1IWD
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PROPOSED AMINO ACID SEQUENCE AND THE 1.63 ANGSTROM X-RAY CRYSTAL STRUCTURE OF A PLANT CYSTEINE PROTEASE ERVATAMIN B: INSIGHT INTO THE STRUCTURAL BASIS OF ITS STABILITY AND SUBSTRATE SPECIFICITY.
Descriptor:ERVATAMIN B, THIOSULFATE
Authors:Chakrabarti, C., Biswas, S., Dattagupta, J.K.
Deposit date:2002-05-02
Release date:2003-05-06
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Proposed amino acid sequence and the 1.63 A X-ray crystal structure of a plant cysteine protease, ervatamin B: Some insights into the structural basis of its stability and substrate specificity
Proteins, 51, 2003
3T7Z
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STRUCTURE OF METHANOCALDOCOCCUS JANNASCHII NOP N-TERMINAL DOMAIN
Descriptor:Nucleolar protein Nop 56/58, ACETATE ION, SODIUM ION, ...
Authors:Biswas, S., Maxwell, S.
Deposit date:2011-07-31
Release date:2012-04-11
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structurally Conserved Nop56/58 N-terminal Domain Facilitates Archaeal Box C/D Ribonucleoprotein-guided Methyltransferase Activity.
J.Biol.Chem., 287, 2012
4ITP
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STRUCTURE OF HUMAN CARBONIC ANHYDRASE II BOUND TO A BENZENE SULFONAMIDE
Descriptor:Carbonic anhydrase 2, GLYCEROL, ZINC ION, ...
Authors:Biswas, S., McKenna, R.
Deposit date:2013-01-18
Release date:2014-01-01
Method:X-RAY DIFFRACTION (1.697 Å)
Cite:Structural study of the location of the phenyl tail of benzene sulfonamides and the effect on human carbonic anhydrase inhibition.
Bioorg.Med.Chem., 21, 2013
3TNX
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STRUCTURE OF THE PRECURSOR OF A THERMOSTABLE VARIANT OF PAPAIN AT 2.6 ANGSTROEM RESOLUTION
Descriptor:Papain, CHLORIDE ION
Authors:Roy, S., Choudhury, D., Dattagupta, J.K., Biswas, S.
Deposit date:2011-09-02
Release date:2012-09-12
Last modified:2012-11-28
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:The structure of a thermostable mutant of pro-papain reveals its activation mechanism
Acta Crystallogr.,Sect.D, 68, 2012
3USV
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STRUCTURE OF THE PRECURSOR OF A THERMOSTABLE VARIANT OF PAPAIN AT 3.8 A RESOLUTION FROM A CRYSTAL SOAKED AT PH 4
Descriptor:Papain
Authors:Roy, S., Choudhury, D., Biswas, S., Dattagupta, J.K.
Deposit date:2011-11-24
Release date:2012-11-28
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Crystallographic analysis of pro-papain variant elucidates the structural basis of the step-wise activation mechanism of the zymogen
To be Published
4FJR
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MODE OF INTERACTION OF MEROCYANINE 540 WITH HEW LYSOZYME
Descriptor:Lysozyme C, CHLORIDE ION, 3-[(2E)-2-[(2Z)-4-(1,3-dibutyl-4,6-dioxo-2-thioxotetrahydropyrimidin-5(2H)-ylidene)but-2-en-1-ylidene]-1,3-benzoxazol-3(2H)-yl]propane-1-sulfonic acid
Authors:Mitra, P., Banerjee, M., Basu, S., Biswas, S.
Deposit date:2012-06-12
Release date:2013-07-03
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Mode of interaction of Merocyanine 540 dye with lysozyme
To be Published
4KXI
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CRYSTALLOGRAPHIC STUDY OF THE COMPLEX OF NI(II) SCHIFF BASE COMPLEX AND HEW LYSOZYME
Descriptor:Lysozyme C, NICKEL (II) ION, (N1E, ...
Authors:Koley Seth, B., Ray, A., Basu, S., Biswas, S.
Deposit date:2013-05-27
Release date:2014-05-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystallographic study of the complex of Ni(II) Schiff base complex and HEW Lysozyme
To be Published
4QRG
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CRYSTAL STRUCTURE OF I86L MUTANT OF PAPAIN
Descriptor:Papain, SODIUM ION, CHLORIDE ION
Authors:Dutta, S., Choudhury, D., Roy, S., Biswas, S.
Deposit date:2014-07-01
Release date:2015-08-05
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.497 Å)
Cite:Pro-peptide regulates the substrate specificity and zymogen activation process of papain: A structural and mechanistic insight
To be Published
4QRX
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CRYSTAL STRUCTURE OF PRO-PAPAIN MUTANT AT PH 4.0
Descriptor:pro-papain
Authors:Dutta, S., Choudhury, D., Roy, S., Biswas, S.
Deposit date:2014-07-02
Release date:2015-08-05
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.138 Å)
Cite:Pro-peptide regulates the substrate specificity and zymogen activation process of papain: A structural and mechanistic insight
to be published
2PRE
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CRYSTAL STRUCTURE OF PLANT CYSTEINE PROTEASE ERVATAMIN-C COMPLEXED WITH IRREVERSIBLE INHIBITOR E-64 AT 2.7 A RESOLUTION
Descriptor:Ervatamin-C, SULFATE ION, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE
Authors:Ghosh, R., Chakrabarti, C., Dattagupta, J.K., Biswas, S.
Deposit date:2007-05-04
Release date:2008-01-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural insights into the substrate specificity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria.
Febs J., 275, 2008
3BCN
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CRYSTAL STRUCTURE OF A PAPAIN-LIKE CYSTEINE PROTEASE ERVATAMIN-A COMPLEXED WITH IRREVERSIBLE INHIBITOR E-64
Descriptor:Ervatamin-A, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE, BETA-MERCAPTOETHANOL
Authors:Ghosh, R., Chakrabarti, C., Dattagupta, J.K., Biswas, S.
Deposit date:2007-11-13
Release date:2007-11-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural insights into the substrate specificity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria
Febs J., 275, 2008
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