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4FXL
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BU of 4fxl by Molmil
Crystal structure of the D76N Beta-2 Microglobulin mutant
Descriptor: ACETATE ION, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ...
Authors:Ricagno, S, Bellotti, V, Pepys, M.B, Stoppini, M, Bolognesi, M.
Deposit date:2012-07-03
Release date:2012-08-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Hereditary systemic amyloidosis due to Asp76Asn variant beta-2-microglobulin.
N.Engl.J.Med., 366, 2012
1JNJ
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BU of 1jnj by Molmil
NMR solution structure of the human beta2-microglobulin
Descriptor: beta2-microglobulin
Authors:Verdone, G, Corazza, A, Viglino, P, Pettirossi, F, Giorgetti, S, Mangione, P, Andreola, A, Stoppini, M, Bellotti, V, Esposito, G.
Deposit date:2001-07-24
Release date:2002-02-27
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:The solution structure of human beta2-microglobulin reveals the prodromes of its amyloid transition.
Protein Sci., 11, 2002
1PY4
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BU of 1py4 by Molmil
Beta2 microglobulin mutant H31Y displays hints for amyloid formations
Descriptor: Beta-2-microglobulin precursor
Authors:Rosano, C, Zuccotti, S, Mangione, P, Giorgetti, S, Bellotti, V, Pettirossi, F, Corazza, A, Viglino, P, Esposito, G, Bolognesi, M.
Deposit date:2003-07-08
Release date:2004-05-04
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:beta2-microglobulin H31Y variant 3D structure highlights the protein natural propensity towards intermolecular aggregation
J.Mol.Biol., 335, 2004
2X89
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BU of 2x89 by Molmil
Structure of the Beta2_microglobulin involved in amyloidogenesis
Descriptor: ANTIBODY, BETA-2-MICROGLOBULIN
Authors:Domanska, K, Srinivasan, V, Vanderhaegen, S, Pardon, E, Marquez, J.A, Bellotti, V, Wyns, L, Steyaert, J.
Deposit date:2010-03-07
Release date:2011-01-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Atomic Structure of a Nanobody-Trapped Domain-Swapped Dimer of an Amyloidogenic {Beta}2-Microglobulin Variant.
Proc.Natl.Acad.Sci.USA, 108, 2011
3DHJ
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BU of 3dhj by Molmil
Beta 2 microglobulin mutant W60C
Descriptor: Beta-2-microglobulin
Authors:Ricagno, S, Colombo, M, de Rosa, M, Bolognesi, M, Giorgetti, S, Bellotti, V.
Deposit date:2008-06-18
Release date:2008-11-18
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:DE loop mutations affect beta2-microglobulin stability and amyloid aggregation
Biochem.Biophys.Res.Commun., 377, 2008
3DHM
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BU of 3dhm by Molmil
Beta 2 microglobulin mutant D59P
Descriptor: Beta-2-microglobulin
Authors:Ricagno, S, Colombo, M, de Rosa, M, Bolognesi, M, Giorgetti, S, Bellotti, V.
Deposit date:2008-06-18
Release date:2008-11-18
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:DE loop mutations affect beta2-microglobulin stability and amyloid aggregation
Biochem.Biophys.Res.Commun., 377, 2008
3EKC
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BU of 3ekc by Molmil
structure of W60V beta-2 microglobulin mutant
Descriptor: Beta-2-microglobulin
Authors:Ricagno, S, Sangiovanni, E, Bellotti, V, Bolognesi, M.
Deposit date:2008-09-19
Release date:2009-05-26
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Human beta-2 microglobulin W60V mutant structure: Implications for stability and amyloid aggregation
Biochem.Biophys.Res.Commun., 380, 2009
3QDA
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BU of 3qda by Molmil
Crystal structure of W95L beta-2 microglobulin
Descriptor: Beta-2-microglobulin, TRIETHYLENE GLYCOL
Authors:Ricagno, S, Bellotti, V, Bolognesi, M.
Deposit date:2011-01-18
Release date:2011-06-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:The two tryptophans of beta2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure.
BMC Evol Biol, 11, 2011
2VB5
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BU of 2vb5 by Molmil
Solution structure of W60G mutant of human beta2-microglobulin
Descriptor: BETA-2-MICROGLOBULIN
Authors:Esposito, G, Corazza, A, Rennella, E, Gumral, D, Mimmi, M.C, Fogolari, F, Viglino, P, Raimondi, S, Giorgetti, S, Bolognesi, B, Merlini, G, Stoppini, M, Bellotti, V.
Deposit date:2007-09-06
Release date:2007-09-25
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The Controlling Roles of Trp60 and Trp95 in Beta2-Microglobulin Function, Folding and Amyloid Aggregation Properties.
J.Mol.Biol., 378, 2008
4L3C
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BU of 4l3c by Molmil
Structure of HLA-A2 in complex with D76N b2m mutant and NY-ESO1 double mutant
Descriptor: Beta-2-microglobulin, CHLORIDE ION, GLYCEROL, ...
Authors:Halabelian, L, Giorgetti, S, Bellotti, V, Bolognesi, M, Ricagno, S.
Deposit date:2013-06-05
Release date:2013-12-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic beta 2-Microglobulin.
J.Biol.Chem., 289, 2014
4L29
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BU of 4l29 by Molmil
Structure of wtMHC class I with NY-ESO1 double mutant
Descriptor: Beta-2-microglobulin, CHLORIDE ION, GLYCEROL, ...
Authors:Halabelian, L, Giorgetti, S, Bellotti, V, Bolognesi, M, Ricagno, S.
Deposit date:2013-06-04
Release date:2013-12-25
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic beta 2-Microglobulin.
J.Biol.Chem., 289, 2014
2Z9T
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BU of 2z9t by Molmil
Crystal structure of the human beta-2 microglobulin mutant W60G
Descriptor: Beta-2-microglobulin
Authors:Ricagno, S, Bolognesi, M, Bellotti, V, Corazza, A, Rennella, E, Gural, D, Mimmi, M.C, Betto, E, Pucillo, C, Fogolari, F, Viglino, P, Raimondi, S, Giorgetti, S, Bolognesi, B, Merlini, G, Stoppini, M.
Deposit date:2007-09-26
Release date:2008-04-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties
J.Mol.Biol., 378, 2008
3TM6
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BU of 3tm6 by Molmil
Crystal structure of the beta-2 microglobulin DIMC50 disulphide-linked homodimer mutant
Descriptor: Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, PHOSPHATE ION
Authors:Colombo, M, Ricagno, S, Bolognesi, M.
Deposit date:2011-08-31
Release date:2012-09-05
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A recurrent D-strand association interface is observed in beta-2 microglobulin oligomers.
Febs J., 279, 2012
3IPB
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BU of 3ipb by Molmil
Human Transthyretin (TTR) complexed with a palindromic bivalent amyloid inhibitor (11 carbon linker).
Descriptor: 2,2'-{undecane-1,11-diylbis[oxy(3,5-dichlorobenzene-4,1-diyl)imino]}dibenzoic acid, Transthyretin
Authors:Kolstoe, S.E, Wood, S.P, Pepys, M.B.
Deposit date:2009-08-17
Release date:2010-11-17
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Trapping of palindromic ligands within native transthyretin prevents amyloid formation.
Proc.Natl.Acad.Sci.USA, 107, 2010
3IPE
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BU of 3ipe by Molmil
Human Transthyretin (TTR) complexed with a palindromic bivalent amyloid inhibitor (7 carbon linker).
Descriptor: 2,2'-{heptane-1,7-diylbis[oxy(3,5-dichlorobenzene-4,1-diyl)imino]}dibenzoic acid, Transthyretin
Authors:Kolstoe, S.E, Wood, S.P, Pepys, M.B.
Deposit date:2009-08-17
Release date:2010-11-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Trapping of palindromic ligands within native transthyretin prevents amyloid formation.
Proc.Natl.Acad.Sci.USA, 107, 2010
3TLR
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BU of 3tlr by Molmil
Crystal Structure of the tetrameric Beta-2 microglobulin DIMC20 mutant
Descriptor: Beta-2-microglobulin, CADMIUM ION, SODIUM ION
Authors:Colombo, M, Ricagno, S, Bolognesi, M.
Deposit date:2011-08-30
Release date:2012-09-05
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:A recurrent D-strand association interface is observed in beta-2 microglobulin oligomers.
Febs J., 279, 2012
4RMW
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BU of 4rmw by Molmil
Crystal structure of the D76A Beta-2 Microglobulin mutant
Descriptor: ACETATE ION, Beta-2-microglobulin, TRIETHYLENE GLYCOL
Authors:de Rosa, M, Bolognesi, M, Ricagno, S.
Deposit date:2014-10-22
Release date:2015-11-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity.
Nat Commun, 9, 2018
4RMU
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BU of 4rmu by Molmil
Crystal structure of the D76E Beta-2 Microglobulin mutant
Descriptor: Beta-2-microglobulin, TRIETHYLENE GLYCOL
Authors:de Rosa, M, Bolognesi, M, Ricagno, S.
Deposit date:2014-10-22
Release date:2015-11-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity.
Nat Commun, 9, 2018
4RMV
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BU of 4rmv by Molmil
Crystal structure of the D76H Beta-2 Microglobulin mutant
Descriptor: ACETATE ION, Beta-2-microglobulin, TRIETHYLENE GLYCOL
Authors:de Rosa, M, Bolognesi, M, Ricagno, S.
Deposit date:2014-10-22
Release date:2015-11-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.463 Å)
Cite:Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity.
Nat Commun, 9, 2018
3M1O
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BU of 3m1o by Molmil
Human Transthyretin (TTR) complexed with 2-((3,5-dichloro-4-hydroxyphenyl)amino)benzoic acid
Descriptor: 2-[(3,5-dichloro-4-hydroxyphenyl)amino]benzoic acid, Transthyretin
Authors:Kolstoe, S.E, Wood, S.P.
Deposit date:2010-03-05
Release date:2010-11-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Trapping of palindromic ligands within native transthyretin prevents amyloid formation.
Proc.Natl.Acad.Sci.USA, 107, 2010
3NA4
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BU of 3na4 by Molmil
D53P beta-2 microglobulin mutant
Descriptor: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Beta-2-microglobulin
Authors:Azinas, S, Ricagno, S, Bolognesi, M.
Deposit date:2010-06-01
Release date:2011-06-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:D-strand perturbation and amyloid propensity in beta-2 microglobulin
Febs J., 278, 2011
1LOZ
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BU of 1loz by Molmil
AMYLOIDOGENIC VARIANT (I56T) VARIANT OF HUMAN LYSOZYME
Descriptor: LYSOZYME
Authors:Sunde, M, Blake, C.C.F.
Deposit date:1997-01-16
Release date:1997-04-01
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis.
Nature, 385, 1997
1LYY
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BU of 1lyy by Molmil
AMYLOIDOGENIC VARIANT (ASP67HIS) OF HUMAN LYSOZYME
Descriptor: LYSOZYME
Authors:Sunde, M, Blake, C.C.F.
Deposit date:1997-01-16
Release date:1997-04-01
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis.
Nature, 385, 1997
4KDT
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BU of 4kdt by Molmil
Structure of an early native-like intermediate of beta2-microglobulin amyloidosis
Descriptor: Beta-2-microglobulin, GLYCEROL, Nanobody24, ...
Authors:Vanderhaegen, S, Fislage, M, Pardon, E, Versees, W, Steyaert, J.
Deposit date:2013-04-25
Release date:2013-08-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of an early native-like intermediate of beta 2-microglobulin amyloidogenesis.
Protein Sci., 22, 2013
2W08
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BU of 2w08 by Molmil
The structure of serum amyloid P component bound to 0-phospho- threonine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, PHOSPHOTHREONINE, ...
Authors:Kolstoe, S.E, Pepys, M.B, Wood, S.P.
Deposit date:2008-08-12
Release date:2009-04-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular Dissection of Alzheimer'S Disease Neuropathology by Depletion of Serum Amyloid P Component.
Proc.Natl.Acad.Sci.USA, 106, 2009

 

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