Author results

2BB2
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X-RAY ANALYSIS OF BETA B2-CRYSTALLIN AND EVOLUTION OF OLIGOMERIC LENS PROTEINS
Descriptor:BETA B2-CRYSTALLIN, BETA-MERCAPTOETHANOL
Authors:Bax, B., Lapatto, R., Nalini, V., Driessen, H., Lindley, P.F., Mahadevan, D., Blundell, T.L., Slingsby, C.
Deposit date:1992-09-21
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-ray analysis of beta B2-crystallin and evolution of oligomeric lens proteins.
Nature, 347, 1990
1GNG
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GLYCOGEN SYNTHASE KINASE-3 BETA (GSK3) COMPLEX WITH FRATTIDE PEPTIDE
Descriptor:GLYCOGEN SYNTHASE KINASE-3 BETA, FRATTIDE, SULFATE ION, ...
Authors:Bax, B., Carter, P.S., Lewis, C., Guy, A.R., Bridges, A., Tanner, R., Pettman, G., Mannix, C., Culbert, A.A., Brown, M.J.B., Smith, D.G., Reith, A.D.
Deposit date:2001-10-04
Release date:2002-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Structure of Phosphorylated Gsk-3Beta Complexed with a Peptide, Frattide, that Inhibits Beta-Catenin Phosphorylation
Structure, 9, 2001
4BUL
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NOVEL HYDROXYL TRICYCLICS (E.G. GSK966587) AS POTENT INHIBITORS OF BACTERIAL TYPE IIA TOPOISOMERASES
Descriptor:DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A, 5'-D(*TP*GP*TP*GP*CP*GP*GP*TP*GP*TP*AP*CP*CP*TP *AP*CP*GP*GP*CP*T)-3', ...
Authors:Miles, T.J., Hennessy, A.J., Bax, B., Brooks, G., Brown, B.S., Brown, P., Cailleau, N., Chen, D., Dabbs, S., Davies, D.T., Esken, J.M., Giordano, I., Hoover, J.L., Huang, J., Jones, G.E., Sukmar, S.K.K., Spitzfaden, C., Markwell, R.E., Minthorn, E.A., Rittenhouse, S., Gwynn, M.N., Pearson, N.D.
Deposit date:2013-06-20
Release date:2013-08-07
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Novel Hydroxyl Tricyclics (E.G., Gsk966587) as Potent Inhibitors of Bacterial Type Iia Topoisomerases.
Bioorg.Med.Chem.Lett., 23, 2013
1BLB
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CLOSE PACKING OF AN OLIGOMERIC EYE LENS BETA-CRYSTALLIN INDUCES LOSS OF SYMMETRY AND ORDERING OF SEQUENCE EXTENSIONS
Descriptor:BETA B2-CRYSTALLIN
Authors:Nalini, V., Bax, B., Driessen, H., Moss, D.S., Lindley, P.F., Slingsby, C.
Deposit date:1993-12-22
Release date:1994-12-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Close packing of an oligomeric eye lens beta-crystallin induces loss of symmetry and ordering of sequence extensions.
J.Mol.Biol., 236, 1994
1RRF
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NON-MYRISTOYLATED RAT ADP-RIBOSYLATION FACTOR-1 COMPLEXED WITH GDP, MONOMERIC CRYSTAL FORM
Descriptor:RAT ADP-RIBOSYLATION FACTOR-1, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Greasley, S.E., Jhoti, H., Bax, B.
Deposit date:1995-12-16
Release date:1996-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms.
Nat.Struct.Biol., 2, 1995
1RRG
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NON-MYRISTOYLATED RAT ADP-RIBOSYLATION FACTOR-1 COMPLEXED WITH GDP, DIMERIC CRYSTAL FORM
Descriptor:RAT ADP-RIBOSYLATION FACTOR-1, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Greasley, S.E., Jhoti, H., Bax, B.
Deposit date:1995-12-16
Release date:1996-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms.
Nat.Struct.Biol., 2, 1995
1A0R
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HETEROTRIMERIC COMPLEX OF PHOSDUCIN/TRANSDUCIN BETA-GAMMA
Descriptor:TRANSDUCIN (BETA SUBUNIT), TRANSDUCIN (GAMMA SUBUNIT), PHOSDUCIN, ...
Authors:Loew, A., Ho, Y.-K., Blundell, T.L., Bax, B.
Deposit date:1997-12-05
Release date:1998-12-30
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Phosducin induces a structural change in transducin beta gamma.
Structure, 6, 1998
1G0W
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CRYSTAL STRUCTURE OF BOVINE RETINAL CREATINE KINASE
Descriptor:CREATINE KINASE, SULFATE ION
Authors:Tisi, D., Bax, B., Loew, A.
Deposit date:2000-10-09
Release date:2001-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The three-dimensional structure of cytosolic bovine retinal creatine kinase.
Acta Crystallogr.,Sect.D, 57, 2001
1VZO
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THE STRUCTURE OF THE N-TERMINAL KINASE DOMAIN OF MSK1 REVEALS A NOVEL AUTOINHIBITORY CONFORMATION FOR A DUAL KINASE PROTEIN
Descriptor:RIBOSOMAL PROTEIN S6 KINASE ALPHA 5, BETA-MERCAPTOETHANOL, SULFATE ION
Authors:Smith, K.J., Carter, P.S., Bridges, A., Horrocks, P., Lewis, C., Pettman, G., Clarke, A., Brown, M., Hughes, J., Wilkinson, M., Bax, B., Reith, A.
Deposit date:2004-05-21
Release date:2004-06-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Structure of Msk1 Reveals a Novel Autoinhibitory Conformation for a Dual Kinase Protein
Structure, 12, 2004
3ZKB
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CRYSTAL STRUCTURE OF THE ATPASE REGION OF MYCOBACTERIUM TUBERCULOSIS GYRB WITH AMPPNP
Descriptor:DNA GYRASE SUBUNIT B, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION
Authors:Agrawal, A., Roue, M., Spitzfaden, C., Petrella, S., Aubry, A., Volker, C., Mossakowska, D., Hann, M., Bax, B., Mayer, C.
Deposit date:2013-01-22
Release date:2013-09-18
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Mycobacterium Tuberculosis DNA Gyrase ATPase Domain Structures Suggest a Dissociative Mechanism that Explains How ATP Hydrolysis is Coupled to Domain Motion.
Biochem.J., 456, 2013
3ZKD
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CRYSTAL STRUCTURE OF THE ATPASE REGION OF MYCOBACTERIUM TUBERCULOSIS GYRB WITH AMPPNP
Descriptor:DNA GYRASE SUBUNIT B, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION
Authors:Agrawal, A., Roue, M., Spitzfaden, C., Petrella, S., Aubry, A., Volker, C., Mossakowska, D., Hann, M., Bax, B., Mayer, C.
Deposit date:2013-01-22
Release date:2013-09-18
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Mycobacterium Tuberculosis DNA Gyrase ATPase Domain Structures Suggest a Dissociative Mechanism that Explains How ATP Hydrolysis is Coupled to Domain Motion.
Biochem.J., 456, 2013
3ZM7
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CRYSTAL STRUCTURE OF THE ATPASE REGION OF MYCOBACTERIUM TUBERCULOSIS GYRB WITH AMPPCP
Descriptor:DNA GYRASE SUBUNIT B, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, MAGNESIUM ION
Authors:Agrawal, A., Roue, M., Spitzfaden, C., Petrella, S., Aubry, A., Volker, C., Mossakowska, D., Hann, M., Bax, B., Mayer, C.
Deposit date:2013-02-05
Release date:2013-09-18
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Mycobacterium Tuberculosis DNA Gyrase ATPase Domain Structures Suggest a Dissociative Mechanism that Explains How ATP Hydrolysis is Coupled to Domain Motion.
Biochem.J., 456, 2013
3ZRK
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IDENTIFICATION OF 2-(4-PYRIDYL)THIENOPYRIDINONES AS GSK-3BETA INHIBITORS
Descriptor:GLYCOGEN SYNTHASE KINASE-3 BETA, PROTO-ONCOGENE FRAT1, SULFATE ION, ...
Authors:Gentile, G., Bernasconi, G., Pozzan, A., Merlo, G., Marzorati, P., Bamborough, P., Bax, B., Bridges, A., Brough, C., Carter, P., Cutler, G., Neu, M., Takada, M.
Deposit date:2011-06-16
Release date:2011-06-29
Last modified:2012-04-25
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Identification of 2-(4-Pyridyl)Thienopyridinones as Gsk-3Beta Inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
3ZRL
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IDENTIFICATION OF 2-(4-PYRIDYL)THIENOPYRIDINONES AS GSK-3BETA INHIBITORS
Descriptor:GLYCOGEN SYNTHASE KINASE-3 BETA, PROTO-ONCOGENE FRAT1, SULFATE ION, ...
Authors:Gentile, G., Bernasconi, G., Pozzan, A., Merlo, G., Marzorati, P., Bamborough, P., Bax, B., Bridges, A., Brough, C., Carter, P., Cutler, G., Neu, M., Takada, M.
Deposit date:2011-06-17
Release date:2011-06-29
Last modified:2012-04-25
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Identification of 2-(4-Pyridyl)Thienopyridinones as Gsk-3Beta Inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
3ZRM
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IDENTIFICATION OF 2-(4-PYRIDYL)THIENOPYRIDINONES AS GSK-3BETA INHIBITORS
Descriptor:GLYCOGEN SYNTHASE KINASE-3 BETA, PROTO-ONCOGENE FRAT1, SULFATE ION, ...
Authors:Gentile, G., Bernasconi, G., Pozzan, A., Merlo, G., Marzorati, P., Bamborough, P., Bax, B., Bridges, A., Brough, C., Carter, P., Cutler, G., Neu, M., Takada, M.
Deposit date:2011-06-17
Release date:2011-06-29
Last modified:2012-04-25
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Identification of 2-(4-Pyridyl)Thienopyridinones as Gsk-3Beta Inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
4AFJ
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5-ARYL-4-CARBOXAMIDE-1,3-OXAZOLES: POTENT AND SELECTIVE GSK-3 INHIBITORS
Descriptor:GLYCOGEN SYNTHASE KINASE-3 BETA, PROTO-ONCOGENE FRAT1, SULFATE ION, ...
Authors:Gentile, G., Merlo, G., Pozzan, A., Bernasconi, G., Bax, B., Bamborough, P., Bridges, A., Carter, P., Neu, M., Yao, G., Brough, C., Cutler, G., Coffin, A., Belyanskaya, S.
Deposit date:2012-01-19
Release date:2012-02-29
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:5-Aryl-4-Carboxamide-1,3-Oxazoles: Potent and Selective Gsk-3 Inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
6HPQ
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CRYSTAL STRUCTURE OF HUMAN PIF1 HELICASE IN COMPLEX WITH AMP-PNP, BROMINATED CRYSTAL FORM.
Descriptor:ATP-dependent DNA helicase PIF1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:Ledikov, V.M., Dehghani-Tafti, S., Bax, B., Sanders, C.M., Antson, A.A.
Deposit date:2018-09-21
Release date:2019-01-23
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase.
Nucleic Acids Res., 2019
1SGF
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CRYSTAL STRUCTURE OF 7S NGF: A COMPLEX OF NERVE GROWTH FACTOR WITH FOUR BINDING PROTEINS (SERINE PROTEINASES)
Descriptor:NERVE GROWTH FACTOR, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
Authors:Bax, B.D.V., Blundell, T.L., Murray-Rust, J., Mcdonald, N.Q.
Deposit date:1997-08-08
Release date:1998-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins.
Structure, 5, 1997
5IWI
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1.98A STRUCTURE OF GSK945237 WITH S.AUREUS DNA GYRASE AND SINGLY NICKED DNA
Descriptor:DNA gyrase subunit B,DNA gyrase subunit B, DNA gyrase subunit A, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*TP*AP*CP*AP*CP*CP*GP*CP*AP*CP*A)-3'), ...
Authors:Bax, B.D., Miles, T.J.
Deposit date:2016-03-22
Release date:2016-05-25
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases.
Bioorg.Med.Chem.Lett., 26, 2016
5IWM
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2.5A STRUCTURE OF GSK945237 WITH S.AUREUS DNA GYRASE AND DNA.
Descriptor:DNA gyrase subunit B,DNA gyrase subunit B, DNA gyrase subunit A, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*TP*TP*CP*AP*CP*CP*GP*CP*AP*CP*A)-3'), ...
Authors:Bax, B.D., Miles, T.J.
Deposit date:2016-03-22
Release date:2016-05-25
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases.
Bioorg.Med.Chem.Lett., 26, 2016
6HPH
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CRYSTAL STRUCTURE OF HUMAN PIF1 HELICASE IN COMPLEX WITH AMP-PNP
Descriptor:ATP-dependent DNA helicase PIF1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION
Authors:Levdikov, V.M., Dehghani-Tafti, S., Bax, B.D., Sanders, C.M., Antson, A.A.
Deposit date:2018-09-20
Release date:2019-01-23
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase.
Nucleic Acids Res., 2019
6HPT
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CRYSTAL STRUCTURE OF HUMAN PIF1 HELICASE, APOFORM.
Descriptor:ATP-dependent DNA helicase PIF1, SULFATE ION
Authors:Levdikov, V.M., Dehghani-Tafti, S., Bax, B.D., Sanders, C.M., Antson, A.A.
Deposit date:2018-09-21
Release date:2019-01-23
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase.
Nucleic Acids Res., 2019
6HPU
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CRYSTAL STRUCTURE OF HUMAN PIF1 HELICASE IN COMPLEX WITH ADP-ALF4
Descriptor:ATP-dependent DNA helicase PIF1, ADENOSINE-5'-DIPHOSPHATE, TETRAFLUOROALUMINATE ION, ...
Authors:Levdikov, V.M., Dehghani-Tafti, S., Bax, B.D., Sanders, C.M., Antson, A.A.
Deposit date:2018-09-21
Release date:2019-01-23
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (3.96 Å)
Cite:Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase.
Nucleic Acids Res., 2019
6QTK
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2.31A STRUCTURE OF GEPOTIDACIN WITH S.AUREUS DNA GYRASE AND DOUBLY NICKED DNA
Descriptor:DNA gyrase subunit B, DNA gyrase subunit A, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*G*GP*GP*TP*AP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), ...
Authors:Bax, B.D.
Deposit date:2019-02-25
Release date:2019-03-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.
ACS Infect Dis, 2019
6QTP
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2.37A STRUCTURE OF GEPOTIDACIN WITH S.AUREUS DNA GYRASE AND UNCLEAVED DNA
Descriptor:DNA gyrase subunit B,DNA gyrase subunit B, DNA gyrase subunit A, DNA (5'-D(*GP*AP*GP*CP*GP*TP*AP*CP*AP*GP*CP*TP*GP*TP*AP*CP*GP*CP*TP*T)-3'), ...
Authors:Bax, B.D.
Deposit date:2019-02-25
Release date:2019-03-13
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.
ACS Infect Dis, 2019
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