Author results

1GPA
  • Download 1gpa
  • View 1gpa
Molmil generated image of 1gpa
STRUCTURAL MECHANISM FOR GLYCOGEN PHOSPHORYLASE CONTROL BY PHOSPHORYLATION AND AMP
Descriptor:GLYCOGEN PHOSPHORYLASE A, SULFATE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Barford, D., Hu, S.-H., Johnson, L.N.
Deposit date:1990-11-13
Release date:1992-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural mechanism for glycogen phosphorylase control by phosphorylation and AMP.
J.Mol.Biol., 218, 1991
7GPB
  • Download 7gpb
  • View 7gpb
Molmil generated image of 7gpb
STRUCTURAL MECHANISM FOR GLYCOGEN PHOSPHORYLASE CONTROL BY PHOSPHORYLATION AND AMP
Descriptor:GLYCOGEN PHOSPHORYLASE B, SULFATE ION, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Barford, D., Hu, S.-H., Johnson, L.N.
Deposit date:1990-11-13
Release date:1992-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural mechanism for glycogen phosphorylase control by phosphorylation and AMP.
J.Mol.Biol., 218, 1991
8GPB
  • Download 8gpb
  • View 8gpb
Molmil generated image of 8gpb
STRUCTURAL MECHANISM FOR GLYCOGEN PHOSPHORYLASE CONTROL BY PHOSPHORYLATION AND AMP
Descriptor:GLYCOGEN PHOSPHORYLASE B, PYRIDOXAL-5'-PHOSPHATE, ADENOSINE MONOPHOSPHATE
Authors:Barford, D., Hu, S.-H., Johnson, L.N.
Deposit date:1990-11-13
Release date:1992-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural mechanism for glycogen phosphorylase control by phosphorylation and AMP.
J.Mol.Biol., 218, 1991
9GPB
  • Download 9gpb
  • View 9gpb
Molmil generated image of 9gpb
THE ALLOSTERIC TRANSITION OF GLYCOGEN PHOSPHORYLASE
Descriptor:GLYCOGEN PHOSPHORYLASE B, SULFATE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Barford, D., Johnson, L.N.
Deposit date:1990-12-17
Release date:1992-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The allosteric transition of glycogen phosphorylase.
Nature, 340, 1989
2HNP
  • Download 2hnp
  • View 2hnp
Molmil generated image of 2hnp
CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE 1B
Descriptor:PROTEIN-TYROSINE PHOSPHATASE-1B
Authors:Barford, D., Flint, A.J., Tonks, N.K.
Deposit date:1994-09-19
Release date:1994-12-20
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystal structure of human protein tyrosine phosphatase 1B.
Science, 263, 1994
2HNQ
  • Download 2hnq
  • View 2hnq
Molmil generated image of 2hnq
CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE 1B
Descriptor:PROTEIN-TYROSINE PHOSPHATASE-1B, TUNGSTATE(VI)ION
Authors:Barford, D., Flint, A.J., Tonks, N.K.
Deposit date:1994-09-28
Release date:1994-12-20
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystal structure of human protein tyrosine phosphatase 1B.
Science, 263, 1994
1PTT
  • Download 1ptt
  • View 1ptt
Molmil generated image of 1ptt
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH PHOSPHOTYROSINE-CONTAINING TETRA-PEPTIDE (AC-DEPYL-NH2)
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B, PHOSPHOTYROSINE-CONTAINING TETRA-PEPTIDE
Authors:Barford, D., Jia, Z.
Deposit date:1995-04-21
Release date:1996-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B.
Science, 268, 1995
1PTU
  • Download 1ptu
  • View 1ptu
Molmil generated image of 1ptu
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH PHOSPHOTYROSINE-CONTAINING HEXA-PEPTIDE (DADEPYL-NH2)
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B, PHOSPHOTYROSINE-CONTAINING HEXA-PEPTIDE
Authors:Barford, D., Jia, Z.
Deposit date:1995-04-21
Release date:1996-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B.
Science, 268, 1995
1PTV
  • Download 1ptv
  • View 1ptv
Molmil generated image of 1ptv
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH PHOSPHOTYROSINE
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B, O-PHOSPHOTYROSINE
Authors:Barford, D., Jia, Z.
Deposit date:1995-04-21
Release date:1996-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B.
Science, 268, 1995
1GZK
  • Download 1gzk
  • View 1gzk
Molmil generated image of 1gzk
MOLECULAR MECHANISM FOR THE REGULATION OF PROTEIN KINASE B/AKT BY HYDROPHOBIC MOTIF PHOSPHORYLATION
Descriptor:RAC-BETA SERINE/THREONINE PROTEIN KINASE
Authors:Barford, D., Yang, J., Hemmings, B.A.
Deposit date:2002-05-23
Release date:2003-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular Mechanism for the Regulation of Protein Kinase B/Akt by Hydrophobic Motif Phosphorylation
Mol.Cell, 9, 2002
1GZN
  • Download 1gzn
  • View 1gzn
Molmil generated image of 1gzn
STRUCTURE OF PKB KINASE DOMAIN
Descriptor:RAC-BETA SERINE/THREONINE PROTEIN KINASE
Authors:Barford, D., Yang, J., Hemmings, B.A.
Deposit date:2002-05-24
Release date:2003-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular Mechanism for the Regulation of Protein Kinase B/Akt by Hydrophobic Motif Phosphorylation
Mol.Cell, 9, 2002
1GZO
  • Download 1gzo
  • View 1gzo
Molmil generated image of 1gzo
STRUCTURE OF PROTEIN KINASE B UNPHOSPHORYLATED
Descriptor:RAC-BETA SERINE/THREONINE PROTEIN KINASE
Authors:Barford, D., Yang, J., Hemmings, B.A.
Deposit date:2002-05-24
Release date:2003-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Molecular Mechanism for the Regulation of Protein Kinase B/Akt by Hydrophobic Motif Phosphorylation
Mol.Cell, 9, 2002
1UWH
  • Download 1uwh
  • View 1uwh
Molmil generated image of 1uwh
THE COMPLEX OF WILD TYPE B-RAF AND BAY439006.
Descriptor:B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, CHLORIDE ION
Authors:Barford, D., Roe, S.M., Wan, P.T.C., Cancer Genome Project
Deposit date:2004-02-05
Release date:2004-03-19
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Mechanism of Activation of the Raf-Erk Signaling Pathway by Oncogenic Mutations of B-Raf
Cell(Cambridge,Mass.), 116, 2004
1UWJ
  • Download 1uwj
  • View 1uwj
Molmil generated image of 1uwj
THE COMPLEX OF MUTANT V599E B-RAF AND BAY439006.
Descriptor:B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE
Authors:Barford, D., Roe, S.M., Wan, P.T.C., Cancer Genome Project
Deposit date:2004-02-05
Release date:2004-03-19
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Mechanism of Activation of the Raf-Erk Signaling Pathway by Oncogenic Mutations of B-Raf
Cell(Cambridge,Mass.), 116, 2004
1WAO
  • Download 1wao
  • View 1wao
Molmil generated image of 1wao
PP5 STRUCTURE
Descriptor:SERINE/THREONINE PROTEIN PHOSPHATASE 5, MANGANESE (II) ION
Authors:Barford, D.
Deposit date:2004-10-27
Release date:2005-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Molecular Basis for Tpr Domain-Mediated Regulation of Protein Phosphatase 5
Embo J., 24, 2005
3KAE
  • Download 3kae
  • View 3kae
Molmil generated image of 3kae
CDC27 N-TERMINUS
Descriptor:Possible protein of nuclear scaffold, GLYCEROL, CHLORIDE ION, ...
Authors:Barford, D., Zhang, Z., Roe, S.M.
Deposit date:2009-10-19
Release date:2010-03-23
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (2.298 Å)
Cite:Molecular structure of the N-terminal domain of the APC/C subunit Cdc27 reveals a homo-dimeric tetratricopeptide repeat architecture
J.Mol.Biol., 397, 2010
3ZV2
  • Download 3zv2
  • View 3zv2
Molmil generated image of 3zv2
HUMAN PROTEIN-TYROSINE PHOSPHATASE 1B C215A, S216A MUTANT
Descriptor:Tyrosine-protein phosphatase non-receptor type 1
Authors:Barford, D., Salmeen, A., Tonks, N.K.
Deposit date:2011-07-22
Release date:2011-08-31
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Conformation-sensing antibodies stabilize the oxidized form of PTP1B and inhibit its phosphatase activity.
Cell, 147, 2011
1ABB
  • Download 1abb
  • View 1abb
Molmil generated image of 1abb
CONTROL OF PHOSPHORYLASE B CONFORMATION BY A MODIFIED COFACTOR: CRYSTALLOGRAPHIC STUDIES ON R-STATE GLYCOGEN PHOSPHORYLASE RECONSTITUTED WITH PYRIDOXAL 5'-DIPHOSPHATE
Descriptor:GLYCOGEN PHOSPHORYLASE B, SULFATE ION, PYRIDOXAL-5'-DIPHOSPHATE, ...
Authors:Leonidas, D.D., Oikonomakos, N.G., Papageorgiou, A.C., Acharya, K.R., Barford, D., Johnson, L.N.
Deposit date:1992-04-09
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Control of phosphorylase b conformation by a modified cofactor: crystallographic studies on R-state glycogen phosphorylase reconstituted with pyridoxal 5'-diphosphate.
Protein Sci., 1, 1992
1BZC
  • Download 1bzc
  • View 1bzc
Molmil generated image of 1bzc
HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI
Descriptor:PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE), 4-CARBAMOYL-4-{[6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBONYL]-AMINO}-BUTYRIC ACID
Authors:Groves, M.R., Yao, Z.J., Jr Burke, T.R., Barford, D.
Deposit date:1998-10-27
Release date:1999-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
1BZH
  • Download 1bzh
  • View 1bzh
Molmil generated image of 1bzh
CYCLIC PEPTIDE INHIBITOR OF HUMAN PTP1B
Descriptor:PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B), PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B INHIBITOR)
Authors:Groves, M.R., Yao, Z.J., Burke Jr., T.R., Barford, D.
Deposit date:1998-10-28
Release date:1999-02-16
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
2BGG
  • Download 2bgg
  • View 2bgg
Molmil generated image of 2bgg
THE STRUCTURE OF A PIWI PROTEIN FROM ARCHAEOGLOBUS FULGIDUS COMPLEXED WITH A 16NT SIRNA DUPLEX.
Descriptor:PROTEIN AF1318, 5'-R(*UP*UP*CP*GP*AP*CP*GP*CP)-3', 5'-R(*GP*UP*CP*GP*AP*AP*UP*UP)-3', ...
Authors:Parker, J.S., Roe, S.M., Barford, D.
Deposit date:2004-12-22
Release date:2005-03-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Insights Into Mrna Recognition from a Piwi Domain-Sirna Guide Complex
Nature, 434, 2005
2JF5
  • Download 2jf5
  • View 2jf5
Molmil generated image of 2jf5
CRYSTAL STRUCTURE OF LYS63-LINKED DI-UBIQUITIN
Descriptor:UBIQUITIN, CADMIUM ION, MAGNESIUM ION, ...
Authors:Komander, D., Odenwaelder, P., Barford, D.
Deposit date:2007-01-26
Release date:2008-02-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Molecular Discrimination of Structurally Equivalent Lys 63-Linked and Linear Polyubiquitin Chains.
Embo Rep., 10, 2009
2V55
  • Download 2v55
  • View 2v55
Molmil generated image of 2v55
MECHANISM OF MULTI-SITE PHOSPHORYLATION FROM A ROCK-I:RHOE COMPLEX STRUCTURE
Descriptor:RHO-ASSOCIATED PROTEIN KINASE 1, RHO-RELATED GTP-BINDING PROTEIN RHOE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Komander, D., Garg, R., Wan, P.T.C., Ridley, A.J., Barford, D.
Deposit date:2008-10-01
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.705 Å)
Cite:Mechanism of Multi-Site Phosphorylation from a Rock-I:Rhoe Complex Structure.
Embo J., 27, 2008
2VFJ
  • Download 2vfj
  • View 2vfj
Molmil generated image of 2vfj
STRUCTURE OF THE A20 OVARIAN TUMOUR (OTU) DOMAIN
Descriptor:TUMOR NECROSIS FACTOR, SULFATE ION, MAGNESIUM ION
Authors:Komander, D., Barford, D.
Deposit date:2007-11-04
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of the A20 Otu Domain and Mechanistic Insights Into Deubiquitination
Biochem.J., 409, 2008
2VHF
  • Download 2vhf
  • View 2vhf
Molmil generated image of 2vhf
STRUCTURE OF THE CYLD USP DOMAIN
Descriptor:UBIQUITIN CARBOXYL-TERMINAL HYDROLASE CYLD, ZINC ION
Authors:Komander, D., Lord, C.J., Scheel, H., Swift, S., Hofmann, K., Ashworth, A., Barford, D.
Deposit date:2007-11-21
Release date:2008-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Structure of the Cyld Usp Domain Explains its Specificity for Lys63-Linked Polyubiquitin and Reveals a B-Box Module
Mol.Cell.Biol., 29, 2008