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8A3T
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BU of 8a3t by Molmil
S. cerevisiae APC/C-Cdh1 complex
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 11, Anaphase-promoting complex subunit 2, ...
Authors:Barford, D, Vazquez-Fernandez, E, Zhang, Z, Yang, J.
Deposit date:2022-06-09
Release date:2022-08-31
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structure of the S. cerevisiae APC/C-Cdh1 complex
To Be Published
8A61
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BU of 8a61 by Molmil
S. cerevisiae apo phosphorylated APC/C
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 11, Anaphase-promoting complex subunit 2, ...
Authors:Barford, D, Fernandez-Vazquez, E, Zhang, Z, Yang, J.
Deposit date:2022-06-16
Release date:2022-08-31
Method:ELECTRON MICROSCOPY (5.4 Å)
Cite:Cryo-EM structure of the S. cerevisiae apo phosphorylated APC/C
To Be Published
8GPB
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BU of 8gpb by Molmil
STRUCTURAL MECHANISM FOR GLYCOGEN PHOSPHORYLASE CONTROL BY PHOSPHORYLATION AND AMP
Descriptor: ADENOSINE MONOPHOSPHATE, GLYCOGEN PHOSPHORYLASE B, PYRIDOXAL-5'-PHOSPHATE
Authors:Barford, D, Hu, S.-H, Johnson, L.N.
Deposit date:1990-11-13
Release date:1992-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural mechanism for glycogen phosphorylase control by phosphorylation and AMP.
J.Mol.Biol., 218, 1991
8A5Y
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BU of 8a5y by Molmil
S. cerevisiae apo unphosphorylated APC/C.
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 11, Anaphase-promoting complex subunit 2, ...
Authors:Barford, D, Fernandez-Vazquez, E, Zhang, Z, Yang, J.
Deposit date:2022-06-16
Release date:2022-08-31
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Cryo-EM structure of the S. cerevisiae APC/C-Cdh1 complex and comparison to apo unphosphorylated and phosphorylated states
To Be Published
7GPB
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BU of 7gpb by Molmil
STRUCTURAL MECHANISM FOR GLYCOGEN PHOSPHORYLASE CONTROL BY PHOSPHORYLATION AND AMP
Descriptor: ADENOSINE MONOPHOSPHATE, GLYCOGEN PHOSPHORYLASE B, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Barford, D, Hu, S.-H, Johnson, L.N.
Deposit date:1990-11-13
Release date:1992-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural mechanism for glycogen phosphorylase control by phosphorylation and AMP.
J.Mol.Biol., 218, 1991
9GPB
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BU of 9gpb by Molmil
THE ALLOSTERIC TRANSITION OF GLYCOGEN PHOSPHORYLASE
Descriptor: GLYCOGEN PHOSPHORYLASE B, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION
Authors:Barford, D, Johnson, L.N.
Deposit date:1990-12-17
Release date:1992-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The allosteric transition of glycogen phosphorylase.
Nature, 340, 1989
1GPA
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BU of 1gpa by Molmil
STRUCTURAL MECHANISM FOR GLYCOGEN PHOSPHORYLASE CONTROL BY PHOSPHORYLATION AND AMP
Descriptor: GLYCOGEN PHOSPHORYLASE A, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION
Authors:Barford, D, Hu, S.-H, Johnson, L.N.
Deposit date:1990-11-13
Release date:1992-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural mechanism for glycogen phosphorylase control by phosphorylation and AMP.
J.Mol.Biol., 218, 1991
2HNQ
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BU of 2hnq by Molmil
CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE 1B
Descriptor: PROTEIN-TYROSINE PHOSPHATASE-1B, TUNGSTATE(VI)ION
Authors:Barford, D, Flint, A.J, Tonks, N.K.
Deposit date:1994-09-28
Release date:1994-12-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystal structure of human protein tyrosine phosphatase 1B.
Science, 263, 1994
2HNP
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BU of 2hnp by Molmil
CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE 1B
Descriptor: PROTEIN-TYROSINE PHOSPHATASE-1B
Authors:Barford, D, Flint, A.J, Tonks, N.K.
Deposit date:1994-09-19
Release date:1994-12-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystal structure of human protein tyrosine phosphatase 1B.
Science, 263, 1994
3KAE
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BU of 3kae by Molmil
Cdc27 N-terminus
Descriptor: CHLORIDE ION, GLYCEROL, Possible protein of nuclear scaffold, ...
Authors:Barford, D, Zhang, Z, Roe, S.M.
Deposit date:2009-10-19
Release date:2010-03-23
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.298 Å)
Cite:Molecular structure of the N-terminal domain of the APC/C subunit Cdc27 reveals a homo-dimeric tetratricopeptide repeat architecture
J.Mol.Biol., 397, 2010
1UWJ
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BU of 1uwj by Molmil
The complex of mutant V599E B-RAF and BAY439006.
Descriptor: 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
Authors:Barford, D, Roe, S.M, Wan, P.T.C, Cancer Genome Project
Deposit date:2004-02-05
Release date:2004-03-19
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Mechanism of Activation of the Raf-Erk Signaling Pathway by Oncogenic Mutations of B-Raf
Cell(Cambridge,Mass.), 116, 2004
1UWH
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BU of 1uwh by Molmil
The complex of wild type B-RAF and BAY439006.
Descriptor: 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE, CHLORIDE ION
Authors:Barford, D, Roe, S.M, Wan, P.T.C, Cancer Genome Project
Deposit date:2004-02-05
Release date:2004-03-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Mechanism of Activation of the Raf-Erk Signaling Pathway by Oncogenic Mutations of B-Raf
Cell(Cambridge,Mass.), 116, 2004
3ZV2
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BU of 3zv2 by Molmil
Human protein-tyrosine phosphatase 1b C215A, S216A mutant
Descriptor: Tyrosine-protein phosphatase non-receptor type 1
Authors:Barford, D, Salmeen, A, Tonks, N.K.
Deposit date:2011-07-22
Release date:2011-08-31
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Conformation-sensing antibodies stabilize the oxidized form of PTP1B and inhibit its phosphatase activity.
Cell, 147, 2011
6TKZ
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BU of 6tkz by Molmil
Crystal structure of the DHR2 domain of DOCK10 in complex with CDC42
Descriptor: Cell division control protein 42 homolog, Dedicator of cytokinesis protein 10, GLYCEROL, ...
Authors:Barford, D.
Deposit date:2019-11-29
Release date:2020-01-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Structural basis for CDC42 and RAC activation by the dual specificity GEF DOCK10
Biorxiv, 2022
1GZO
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BU of 1gzo by Molmil
Structure of protein kinase B unphosphorylated
Descriptor: RAC-BETA SERINE/THREONINE PROTEIN KINASE
Authors:Barford, D, Yang, J, Hemmings, B.A.
Deposit date:2002-05-24
Release date:2003-05-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Molecular Mechanism for the Regulation of Protein Kinase B/Akt by Hydrophobic Motif Phosphorylation
Mol.Cell, 9, 2002
1GZK
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BU of 1gzk by Molmil
Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation
Descriptor: RAC-BETA SERINE/THREONINE PROTEIN KINASE
Authors:Barford, D, Yang, J, Hemmings, B.A.
Deposit date:2002-05-23
Release date:2003-05-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular Mechanism for the Regulation of Protein Kinase B/Akt by Hydrophobic Motif Phosphorylation
Mol.Cell, 9, 2002
1GZN
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BU of 1gzn by Molmil
Structure of PKB kinase domain
Descriptor: RAC-BETA SERINE/THREONINE PROTEIN KINASE
Authors:Barford, D, Yang, J, Hemmings, B.A.
Deposit date:2002-05-24
Release date:2003-05-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular Mechanism for the Regulation of Protein Kinase B/Akt by Hydrophobic Motif Phosphorylation
Mol.Cell, 9, 2002
1WAO
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BU of 1wao by Molmil
PP5 structure
Descriptor: MANGANESE (II) ION, SERINE/THREONINE PROTEIN PHOSPHATASE 5
Authors:Barford, D.
Deposit date:2004-10-27
Release date:2005-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Molecular Basis for Tpr Domain-Mediated Regulation of Protein Phosphatase 5
Embo J., 24, 2005
6TKY
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BU of 6tky by Molmil
Crystal structure of the DHR2 domain of DOCK10 in complex with CDC42
Descriptor: Cell division control protein 42 homolog, Dedicator of cytokinesis protein 10, GLYCEROL
Authors:Barford, D, Fan, D, Cronin, N, Yang, J.
Deposit date:2019-11-29
Release date:2020-01-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural basis for CDC42 and RAC activation by the dual specificity GEF DOCK10
Biorxiv, 2022
6TM1
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BU of 6tm1 by Molmil
Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3
Descriptor: Dedicator of cytokinesis protein 10, Ras-related C3 botulinum toxin substrate 3
Authors:Barford, D, Fan, D, Cronin, N, Yang, J.
Deposit date:2019-12-03
Release date:2020-01-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.71 Å)
Cite:Structural basis for CDC42 and RAC activation by the dual specificity GEF DOCK10
Biorxiv, 2022
1PTV
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BU of 1ptv by Molmil
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH PHOSPHOTYROSINE
Descriptor: O-PHOSPHOTYROSINE, PROTEIN TYROSINE PHOSPHATASE 1B
Authors:Barford, D, Jia, Z.
Deposit date:1995-04-21
Release date:1996-08-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B.
Science, 268, 1995
1PTT
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BU of 1ptt by Molmil
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH PHOSPHOTYROSINE-CONTAINING TETRA-PEPTIDE (AC-DEPYL-NH2)
Descriptor: PHOSPHOTYROSINE-CONTAINING TETRA-PEPTIDE, PROTEIN TYROSINE PHOSPHATASE 1B
Authors:Barford, D, Jia, Z.
Deposit date:1995-04-21
Release date:1996-08-01
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B.
Science, 268, 1995
1PTU
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BU of 1ptu by Molmil
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH PHOSPHOTYROSINE-CONTAINING HEXA-PEPTIDE (DADEPYL-NH2)
Descriptor: PHOSPHOTYROSINE-CONTAINING HEXA-PEPTIDE, PROTEIN TYROSINE PHOSPHATASE 1B
Authors:Barford, D, Jia, Z.
Deposit date:1995-04-21
Release date:1996-08-01
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B.
Science, 268, 1995
6TNT
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BU of 6tnt by Molmil
SUMOylated apoAPC/C with repositioned APC2 WHB domain
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Barford, D, Yatskevich, S.
Deposit date:2019-12-10
Release date:2021-01-13
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylation.
Cell Rep, 34, 2021
1BZC
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BU of 1bzc by Molmil
HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI
Descriptor: 4-CARBAMOYL-4-{[6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBONYL]-AMINO}-BUTYRIC ACID, PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE)
Authors:Groves, M.R, Yao, Z.J, Jr Burke, T.R, Barford, D.
Deposit date:1998-10-27
Release date:1999-02-16
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998

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