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2KQG
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A G-RICH SEQUENCE WITHIN THE C-KIT ONCOGENE PROMOTER FORMS A PARALLEL G-QUADRUPLEX HAVING ASYMMETRIC G-TETRAD DYNAMICS
Descriptor:5'-D(*CP*GP*GP*GP*CP*GP*GP*GP*CP*AP*CP*GP*AP*GP*GP*GP*AP*GP*GP*GP*T)-3', POTASSIUM ION
Authors:Hsu, S.-T.D., Varnai, P., Bugaut, A., Reszka, A.P., Neidle, S., Balasubramanian, S.
Deposit date:2009-11-05
Release date:2009-11-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics
J.Am.Chem.Soc., 131, 2009
2KQH
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A G-RICH SEQUENCE WITHIN THE C-KIT ONCOGENE PROMOTER FORMS A PARALLEL G-QUADRUPLEX HAVING ASYMMETRIC G-TETRAD DYNAMICS
Descriptor:5'-D(*CP*GP*GP*GP*CP*GP*GP*GP*CP*GP*CP*GP*AP*GP*GP*GP*AP*GP*GP*GP*T)-3', POTASSIUM ION
Authors:Hsu, S.-T.D., Varnai, P., Bugaut, A., Reszka, A.P., Neidle, S., Balasubramanian, S.
Deposit date:2009-11-05
Release date:2009-11-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics
J.Am.Chem.Soc., 131, 2009
4QKK
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CRYSTAL STRUCTURE OF AN OLIGONUCLEOTIDE CONTAINING 5-FORMYLCYTOSINE
Descriptor:DNA (5'-D(*CP*TP*AP*(5FC)P*GP*(5FC)P*GP*(5FC)P*GP*TP*AP*G)-3')
Authors:Raiber, E.-A., Murat, P., Chirgadze, D.Y., Luisi, B.F., Balasubramanian, S.
Deposit date:2014-06-06
Release date:2014-12-10
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:5-Formylcytosine alters the structure of the DNA double helix.
Nat.Struct.Mol.Biol., 2014
4XK0
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CRYSTAL STRUCTURE OF A TETRAMOLECULAR RNA G-QUADRUPLEX IN POTASSIUM
Descriptor:RNA (5'-(*UP*GP*GP*GP*GP*U)-3'), POTASSIUM ION, BARIUM ION
Authors:Chen, M.C., Murat, P., Abecassis, K.A., Ferre-D'Amare, A.R., Balasubramanian, S.
Deposit date:2015-01-09
Release date:2015-02-11
Last modified:2015-08-19
Method:X-RAY DIFFRACTION (1.08 Å)
Cite:Insights into the mechanism of a G-quadruplex-unwinding DEAH-box helicase.
Nucleic Acids Res., 43, 2015
6AC7
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STRUCTURE OF A (3+1) HYBRID G-QUADRUPLEX IN THE PARP1 PROMOTER
Descriptor:5'-D(*TP*GP*GP*GP*GP*TP*CP*CP*GP*AP*GP*GP*CP*GP*GP*GP*GP*CP*TP*TP*GP*GP*G)-3'
Authors:Sengar, A., Vandana, J.J., Chambers, V.S., Di Antonio, M., Winnerdy, F.R., Balasubramanian, S., Phan, A.T.
Deposit date:2018-07-25
Release date:2019-02-27
Last modified:2019-07-10
Method:SOLUTION NMR
Cite:Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter.
Nucleic Acids Res., 47, 2019
5LS6
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STRUCTURE OF HUMAN POLYCOMB REPRESSIVE COMPLEX 2 (PRC2) WITH INHIBITOR
Descriptor:Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, Polycomb protein SUZ12, ...
Authors:Zhang, Y., Justin, N., Chen, S., Wilson, J., Gamblin, S.
Deposit date:2016-08-22
Release date:2017-02-22
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (3.47 Å)
Cite:Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas.
J. Med. Chem., 59, 2016
5VHA
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DHX36 WITH AN N-TERMINAL TRUNCATION
Descriptor:DEAH (Asp-Glu-Ala-His) box polypeptide 36
Authors:Chen, M., Ferre-D'Amare, A.
Deposit date:2017-04-12
Release date:2018-06-13
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.227 Å)
Cite:Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.
Nature, 558, 2018
5VHC
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DHX36 WITH AN N-TERMINAL TRUNCATION BOUND TO ADP-BEF3
Descriptor:DEAH (Asp-Glu-Ala-His) box polypeptide 36, MAGNESIUM ION, BERYLLIUM TRIFLUORIDE ION, ...
Authors:Chen, M., Ferre-D'Amare, A.
Deposit date:2017-04-12
Release date:2018-06-13
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.
Nature, 558, 2018
5VHD
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DHX36 WITH AN N-TERMINAL TRUNCATION BOUND TO ADP-ALF4
Descriptor:DEAH (Asp-Glu-Ala-His) box polypeptide 36, ADENOSINE-5'-DIPHOSPHATE, TETRAFLUOROALUMINATE ION
Authors:Chen, M., Ferre-D'Amare, A.
Deposit date:2017-04-13
Release date:2018-06-13
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.
Nature, 558, 2018
5VHE
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DHX36 IN COMPLEX WITH THE C-MYC G-QUADRUPLEX
Descriptor:DEAH (Asp-Glu-Ala-His) box polypeptide 36, DNA (5'-D(*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*TP*TP*TP*TP*TP*T)-3'), POTASSIUM ION
Authors:Chen, M., Ferre-D'Amare, A.
Deposit date:2017-04-13
Release date:2018-06-13
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (3.793 Å)
Cite:Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.
Nature, 558, 2018
3HRY
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CRYSTAL STRUCTURE OF PHD IN A TRIGONAL SPACE GROUP AND PARTIALLY DISORDERED
Descriptor:Prevent host death protein
Authors:Garcia-Pino, A., Loris, R.
Deposit date:2009-06-10
Release date:2010-06-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Allostery and intrinsic disorder mediate transcription regulation by conditional cooperativity.
Cell(Cambridge,Mass.), 142, 2010
3HS2
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CRYSTAL STRUCTURE OF PHD TRUNCATED TO RESIDUE 57 IN AN ORTHORHOMBIC SPACE GROUP
Descriptor:Prevent host death protein, SULFATE ION
Authors:Garcia-Pino, A., Loris, R.
Deposit date:2009-06-10
Release date:2010-06-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Allostery and intrinsic disorder mediate transcription regulation by conditional cooperativity.
Cell(Cambridge,Mass.), 142, 2010
3K33
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CRYSTAL STRUCTURE OF THE PHD-DOC COMPLEX
Descriptor:Death on curing protein, Prevent host death protein, Polypeptide of unknown amino acids and source, ...
Authors:Loris, R., Garcia-Pino, A.
Deposit date:2009-10-01
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Allostery and intrinsic disorder mediate transcription regulation by conditional cooperativity.
Cell(Cambridge,Mass.), 142, 2010