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1EAQ
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BU of 1eaq by Molmil
The RUNX1 Runt domain at 1.25A resolution: A structural switch and specifically bound chloride ions modulate DNA binding
Descriptor: CHLORIDE ION, RUNT-RELATED TRANSCRIPTION FACTOR 1
Authors:Backstrom, S, Wolf-Watz, M, Grundstrom, C, Hard, T, Grundstrom, T, Sauer, U.H.
Deposit date:2001-07-14
Release date:2002-09-12
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:The Runx1 Runt Domain at 1.25 A Resolution: A Structural Switch and Specifically Bound Chloride Ions Modulate DNA Binding
J.Mol.Biol., 322, 2002
1EAO
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BU of 1eao by Molmil
THE RUNX1 Runt domain at 1.4A resolution: a structural switch and specifically bound chloride ions modulate DNA binding
Descriptor: BROMIDE ION, RUNT-RELATED TRANSCRIPTION FACTOR 1
Authors:Backstrom, S, Wolf-Watz, M, Grundstrom, C, Hard, T.H, Grundstrom, T, Sauer, U.H.
Deposit date:2001-07-14
Release date:2002-09-12
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Runx1 Runt Domain at 1.25A Resolution: A Structural Switch and Specifically Bound Chloride Ions Modulate DNA Binding
J.Mol.Biol., 322, 2002
1EAN
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BU of 1ean by Molmil
THE RUNX1 Runt domain at 1.70A resolution: A structural switch and specifically bound chloride ions modulate DNA binding
Descriptor: CHLORIDE ION, RUNT-RELATED TRANSCRIPTION FACTOR 1
Authors:Backstrom, S, Wolf-Watz, M, Grundstrom, C, Hard, T, Grundstrom, T, Sauer, U.H.
Deposit date:2001-07-13
Release date:2002-09-12
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Runx1 Runt Domain at 1.25 A Resolution: A Structural Switch and Specifically Bound Chloride Ions Modulate DNA Binding
J.Mol.Biol., 322, 2002
4CSJ
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BU of 4csj by Molmil
The discovery of potent selective glucocorticoid receptor modulators, suitable for inhalation
Descriptor: 1,2-ETHANEDIOL, GLUCOCORTICOID RECEPTOR, N-[(2S)-1-[[1-(4-fluorophenyl)indazol-4-yl]amino]propan-2-yl]-2,4,6-trimethyl-benzenesulfonamide, ...
Authors:Edman, K, Ahlgren, R, Bengtsson, M, Bladh, H, Backstrom, S, Dahmen, J, Henriksson, K, Hillertz, P, Hulikal, V, Jerre, A, Kinchin, L, Kase, C, Lepisto, M, Mile, I, Nilsson, S, Smailagic, A, Taylor, J, Tjornebo, A, Wissler, L, Hansson, T.
Deposit date:2014-03-07
Release date:2014-05-07
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Discovery of Potent and Selective Non-Steroidal Glucocorticoid Receptor Modulators, Suitable for Inhalation.
Bioorg.Med.Chem.Lett., 24, 2014
5FP0
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BU of 5fp0 by Molmil
ligand complex structure of soluble epoxide hydrolase
Descriptor: BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE, N-cyclopentyl-2-[4-(trifluoromethyl)phenyl]-3H-benzimidazole-4-sulfonamide
Authors:Xue, Y, Olsson, T, Johansson, C.A, Oster, L, Beisel, H.G, Rohman, M, Karis, D, Backstrom, S.
Deposit date:2015-11-26
Release date:2016-03-02
Last modified:2016-03-16
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Fragment Screening of Soluble Epoxide Hydrolase for Lead Generation-Structure-Based Hit Evaluation and Chemistry Exploration.
Chemmedchem, 11, 2016
4UDB
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BU of 4udb by Molmil
MR in complex with desisobutyrylciclesonide
Descriptor: DESISOBUYTYRYL CICLESONIDE, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Edman, K, Hogner, A, Hussein, A, Aagaard, A, Backstrom, S, Bodin, C, Wissler, L, JellesmarkJensen, T, Cavallin, A, Nilsson, E, Lepisto, M, Guallar, V.
Deposit date:2014-12-09
Release date:2015-11-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints.
Structure, 23, 2015
4UDD
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BU of 4udd by Molmil
GR in complex with desisobutyrylciclesonide
Descriptor: 1,2-ETHANEDIOL, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, DESISOBUYTYRYL CICLESONIDE, ...
Authors:Edman, K, Hogner, A, Hussein, A, Bjursell, M, Aagaard, A, Backstrom, S, Bodin, C, Wissler, L, Jellesmark-Jensen, T, Cavallin, A, Karlsson, U, Nilsson, E, Lecina, D, Takahashi, R, Grebner, C, Lepisto, M, Guallar, V.
Deposit date:2014-12-09
Release date:2015-11-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints.
Structure, 23, 2015
4UDA
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BU of 4uda by Molmil
MR in complex with dexamethasone
Descriptor: DEXAMETHASONE, GLYCEROL, MINERALOCORTICOID RECEPTOR, ...
Authors:Edman, K, Hogner, A, Hussein, A, Bjursell, M, Aagaard, A, Backstrom, S, Bodin, C, Wissler, L, Jellesmark-Jensen, T, Cavallin, A, Karlsson, U, Nilsson, E, Lecina, D, Takahashi, R, Grebner, C, Lepisto, M, Guallar, V.
Deposit date:2014-12-09
Release date:2015-11-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints.
Structure, 23, 2015
4UDC
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BU of 4udc by Molmil
GR in complex with dexamethasone
Descriptor: 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, DEXAMETHASONE, GLUCOCORTICOID RECEPTOR, ...
Authors:Edman, K, Hogner, A, Hussein, A, Bjursell, M, Aagaard, A, Backstrom, S, Bodin, C, Wissler, L, Jellesmark-Jensen, T, Cavallin, A, Karlsson, U, Nilsson, E, Lecina, D, Takahashi, R, Grebner, C, Lepisto, M, Guallar, V.
Deposit date:2014-12-09
Release date:2015-11-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints.
Structure, 23, 2015
2G2P
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BU of 2g2p by Molmil
Crystal Structure of E.coli transthyretin-related protein with bound Zn and Br
Descriptor: BROMIDE ION, SULFATE ION, Transthyretin-like protein, ...
Authors:Lundberg, E, Backstrom, S, Sauer, U.H, Sauer-Eriksson, A.E.
Deposit date:2006-02-16
Release date:2006-12-12
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The transthyretin-related protein: structural investigation of a novel protein family
J.Struct.Biol., 155, 2006
2G2N
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BU of 2g2n by Molmil
Crystal Structure of E.coli transthyretin-related protein with bound Zn
Descriptor: SULFATE ION, Transthyretin-like protein, ZINC ION
Authors:Lundberg, E, Backstrom, S, Sauer, U.H, Sauer-Eriksson, A.E.
Deposit date:2006-02-16
Release date:2006-12-12
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The transthyretin-related protein: structural investigation of a novel protein family
J.Struct.Biol., 155, 2006
2YOP
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BU of 2yop by Molmil
Long wavelength S-SAD structure of FAM3B PANDER
Descriptor: GLYCEROL, PROTEIN FAM3B
Authors:Johansson, P, Bernstrom, J, Gorman, T, Oster, L, Backstrom, S, Schweikart, F, Xu, B, Xue, Y, Holmberg Schiavone, L.
Deposit date:2012-10-26
Release date:2013-01-30
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Fam3B Pander and Fam3C Ilei Represent a Distinct Class of Signaling Molecules with a Non-Cytokine-Like Fold.
Structure, 21, 2013
2YOQ
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BU of 2yoq by Molmil
Structure of FAM3B PANDER E30 construct
Descriptor: GLYCEROL, PROTEIN FAM3B
Authors:Johansson, P, Bernstrom, J, Gorman, T, Oster, L, Backstrom, S, Schweikart, F, Xu, B, Xue, Y, Holmberg Schiavone, L.
Deposit date:2012-10-26
Release date:2013-01-30
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Fam3B Pander and Fam3C Ilei Represent a Distinct Class of Signaling Molecules with a Non-Cytokine-Like Fold.
Structure, 21, 2013
5L7H
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BU of 5l7h by Molmil
MCR IN COMPLEX WITH ligand
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 3-methyl-5,8-dioxa-17lambda-thia-4,18-diazatetracyclo[18.2.2.1,.0]pentacosa-1(22),2(6),3,9,11,13(25),20,23-octaene-17,17-dione, Mineralocorticoid receptor, ...
Authors:Xue, Y, Aagaard, A, Backstrom, S, Edman, K.
Deposit date:2016-06-03
Release date:2016-12-07
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structure-Based Drug Design of Mineralocorticoid Receptor Antagonists to Explore Oxosteroid Receptor Selectivity.
ChemMedChem, 12, 2017
5L7E
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BU of 5l7e by Molmil
MCR IN COMPLEX WITH ligand
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ...
Authors:Edman, K, Aagaard, A, Backstrom, S, Xue, Y.
Deposit date:2016-06-03
Release date:2016-12-07
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structure-Based Drug Design of Mineralocorticoid Receptor Antagonists to Explore Oxosteroid Receptor Selectivity.
ChemMedChem, 12, 2017
5L7G
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BU of 5l7g by Molmil
MCR IN COMPLEX WITH ligand
Descriptor: 1,2-ETHANEDIOL, Mineralocorticoid receptor, NCOA1 peptide, ...
Authors:Edman, K, Aagaard, A, Backstrom, S, Xue, Y.
Deposit date:2016-06-03
Release date:2016-12-07
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structure-Based Drug Design of Mineralocorticoid Receptor Antagonists to Explore Oxosteroid Receptor Selectivity.
ChemMedChem, 12, 2017
5MWP
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BU of 5mwp by Molmil
The structure of MR in complex with AZD9977.
Descriptor: 2-[(3~{S})-7-fluoranyl-4-[(3-oxidanylidene-4~{H}-1,4-benzoxazin-6-yl)carbonyl]-2,3-dihydro-1,4-benzoxazin-3-yl]-~{N}-methyl-ethanamide, Mineralocorticoid receptor, NCOA1 peptide
Authors:Edman, K, Aagaard, A, Backstrom, S.
Deposit date:2017-01-19
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion.
PLoS ONE, 13, 2018
5MWY
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BU of 5mwy by Molmil
The structure of MR in complex with eplerenone.
Descriptor: Mineralocorticoid receptor, NCOA1, eplerenone
Authors:Edman, K, Aagaard, A, Backstrom, S.
Deposit date:2017-01-20
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion.
PLoS ONE, 13, 2018

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