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6RIR
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BU of 6rir by Molmil
Crystal structure of phosphorylated Rab8a in complex with the Rab-binding domain of RILPL2
Descriptor: GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Waschbusch, D, Purlyte, E, Alessi, D.R, Khan, A.R.
Deposit date:2019-04-25
Release date:2020-01-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.767 Å)
Cite:Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2.
Structure, 28, 2020
4V11
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BU of 4v11 by Molmil
Structure of Synaptotagmin-1 with SV2A peptide phosphorylated at Thr84
Descriptor: CALCIUM ION, GLYCEROL, SYNAPTIC VESICLE GLYCOPROTEIN 2A, ...
Authors:Zhang, N, Gordon, S.L, Fritsch, M.J, Esoof, N, Campbell, D, Gourlay, R, Velupillai, S, Macartney, T, Peggie, M, vanAalten, D.M.F, Cousin, M.A, Alessi, D.R.
Deposit date:2014-09-22
Release date:2015-02-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Phosphorylation of Synaptic Vesicle Protein 2A at Thr84 by Casein Kinase 1 Family Kinases Controls the Specific Retrieval of Synaptotagmin-1.
J.Neurosci., 35, 2015
1EAZ
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BU of 1eaz by Molmil
Crystal structure of the phosphoinositol (3,4)-bisphosphate binding PH domain of TAPP1 from human.
Descriptor: CITRIC ACID, TANDEM PH DOMAIN CONTAINING PROTEIN-1
Authors:Thomas, C.C, Dowler, S, Deak, M, Alessi, D.R, Van Aalten, D.M.F.
Deposit date:2001-07-17
Release date:2002-07-11
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal Structure of the Phosphatidylinositol 3,4-Bisphosphate-Binding Pleckstrin Homology (Ph) Domain of Tandem Ph-Domain-Containing Protein 1 (Tapp1): Molecular Basis of Lipid Specificity
Biochem.J., 358, 2001
3GNI
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BU of 3gni by Molmil
Structure of STRAD and MO25
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CITRIC ACID, Protein Mo25, ...
Authors:Zeqiraj, E, Goldie, S, Alessi, D.R, van Aalten, D.M.F.
Deposit date:2009-03-17
Release date:2009-06-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor
Plos Biol., 7, 2009
4YZM
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BU of 4yzm by Molmil
Humanized Roco4 bound to LRRK2-In1
Descriptor: 2-[(2-methoxy-4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}phenyl)amino]-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, MAGNESIUM ION, Probable serine/threonine-protein kinase roco4
Authors:Gilsbach, B.K, Messias, A.C, Ito, G, Sattler, M, Alessi, D.R, Wittinghofer, A, Kortholt, A.
Deposit date:2015-03-25
Release date:2015-05-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Characterization of LRRK2 Inhibitors.
J.Med.Chem., 58, 2015
4YZN
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BU of 4yzn by Molmil
Humanized Roco4 bound to Compound 19
Descriptor: (4-{[4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-2-fluoro-5-methoxyphenyl)(morpholin-4-yl)methanone, Probable serine/threonine-protein kinase roco4
Authors:Gilsbach, B.K, Messias, A.C, Ito, G, Sattler, M, Alessi, D.R, Wittinghofer, A, Kortholt, A.
Deposit date:2015-03-25
Release date:2015-05-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural Characterization of LRRK2 Inhibitors.
J.Med.Chem., 58, 2015
3ZHP
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BU of 3zhp by Molmil
Human MST3 (STK24) in complex with MO25beta
Descriptor: CALCIUM-BINDING PROTEIN 39-LIKE, SERINE/THREONINE-PROTEIN KINASE 24, SULFATE ION
Authors:Elkins, J.M, Szklarz, M, Krojer, T, Mehellou, Y, Alessi, D.R, Chaikaud, A, von Delft, F, Bountra, C, Edwards, A, Knapp, S.
Deposit date:2012-12-24
Release date:2013-01-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Insights Into the Activation of Mst3 by Mo25.
Biochem.Biophys.Res.Commun., 431, 2013
4CHB
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BU of 4chb by Molmil
Crystal structure of the human KLHL2 Kelch domain in complex with a WNK4 peptide
Descriptor: 1,2-ETHANEDIOL, DODECAETHYLENE GLYCOL, KELCH-LIKE PROTEIN 2, ...
Authors:Sorrell, F.J, Schumacher, F.R, Kurz, T, Alessi, D.R, Newman, J, Cooper, C.D.O, Canning, P, Kopec, J, Williams, E, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.
Deposit date:2013-11-29
Release date:2014-01-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Structural and Biochemical Characterisation of the Klhl3-Wnk Kinase Interaction Important in Blood Pressure Regulation.
Biochem.J., 460, 2014
4CH9
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BU of 4ch9 by Molmil
Crystal structure of the human KLHL3 Kelch domain in complex with a WNK4 peptide
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, KELCH-LIKE PROTEIN 3, ...
Authors:Sorrell, F.J, Schumacher, F.R, Kurz, T, Alessi, D.R, Newman, J, Goubin, S, Chalk, R, Kopec, J, Tallant, C, Williams, E, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.
Deposit date:2013-11-29
Release date:2014-01-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structural and Biochemical Characterisation of the Klhl3-Wnk Kinase Interaction Important in Blood Pressure Regulation.
Biochem.J., 460, 2014
2BIY
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BU of 2biy by Molmil
Structure of PDK1-S241A mutant kinase domain
Descriptor: 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ...
Authors:Komander, D, Kular, G.S, Deak, M, Alessi, D.R, van Aalten, D.M.F.
Deposit date:2005-01-26
Release date:2005-02-23
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding.
J. Biol. Chem., 280, 2005
2V3S
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BU of 2v3s by Molmil
Structural insights into the recognition of substrates and activators by the OSR1 kinase
Descriptor: ACETATE ION, SERINE/THREONINE-PROTEIN KINASE OSR1, SERINE/THREONINE-PROTEIN KINASE WNK4
Authors:Villa, F, Goebel, J, Rafiqi, F.H, Deak, M, Thastrup, J, Alessi, D.R, van Aalten, D.M.F.
Deposit date:2007-06-21
Release date:2007-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Insights Into the Recognition of Substrates and Activators by the Osr1 Kinase
Embo Rep., 8, 2007
2VKI
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BU of 2vki by Molmil
Structure of the PDK1 PH domain K465E mutant
Descriptor: 3-PHOPSHOINOSITIDE DEPENDENT PROTEIN KINASE 1, GLYCEROL, SULFATE ION
Authors:Komander, D, Bayascas, J.R, Deak, M, Alessi, D.R, van Aalten, D.M.F.
Deposit date:2007-12-19
Release date:2008-05-13
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mutation of the Pdk1 Ph Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance.
Mol.Cell.Biol., 28, 2008
2VWI
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BU of 2vwi by Molmil
Structure of the OSR1 kinase, a hypertension drug target
Descriptor: GOLD ION, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Villa, F, Deak, M, Alessi, D.R, vanAalten, D.M.F.
Deposit date:2008-06-25
Release date:2008-07-08
Last modified:2013-04-17
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of the Osr1 Kinase, a Hypertension Drug Target.
Proteins, 73, 2008
1OKY
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BU of 1oky by Molmil
Structure of human PDK1 kinase domain in complex with staurosporine
Descriptor: 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1, GLYCEROL, STAUROSPORINE, ...
Authors:Komander, D, Kular, G.S, Alessi, D.R, Van Aalten, D.M.F.
Deposit date:2003-08-01
Release date:2004-07-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for Ucn-01 (7-Hydroxystaurosporine) Specificity and Pdk1 (3-Phosphoinositide-Dependent Protein Kinase-1) Inhibition
Biochem.J., 375, 2003
1OKZ
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BU of 1okz by Molmil
Structure of human PDK1 kinase domain in complex with UCN-01
Descriptor: 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1, 7-HYDROXYSTAUROSPORINE, GLYCEROL, ...
Authors:Komander, D, Kular, G.S, Alessi, D.R, Van Aalten, D.M.F.
Deposit date:2003-08-01
Release date:2004-07-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structural Basis for Ucn-01 (7-Hydroxystaurosporine) Specificity and Pdk1 (3-Phosphoinositide-Dependent Protein Kinase-1) Inhibition
Biochem.J., 375, 2003
1H10
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BU of 1h10 by Molmil
HIGH RESOLUTION STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN OF PROTEIN KINASE B/AKT BOUND TO INS(1,3,4,5)-TETRAKISPHOPHATE
Descriptor: INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, RAC-ALPHA SERINE/THREONINE KINASE
Authors:Thomas, C.C, Deak, M, Alessi, D.R, Van Aalten, D.M.F.
Deposit date:2002-07-01
Release date:2003-06-27
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:High Resolution Structure of the Pleckstrin Homology Domain of Protein Kinase B/Akt Bound to Phosphatidylinositol (3,4,5)-Trisphosphate
Curr.Biol., 12, 2002
1H1W
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BU of 1h1w by Molmil
High resolution crystal structure of the human PDK1 catalytic domain
Descriptor: 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ...
Authors:Biondi, R.M, Komander, D, Thomas, C.C, Lizcano, J.M, Deak, M, Alessi, D.R, Van Aalten, D.M.F.
Deposit date:2002-07-23
Release date:2003-07-17
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:High Resolution Crystal Structure of the Human Pdk1 Catalytic Domain Defines the Regulatory Phosphopeptide Docking Site
Embo J., 21, 2003
1UNQ
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BU of 1unq by Molmil
High resolution crystal structure of the Pleckstrin Homology Domain Of Protein Kinase B/Akt Bound To Ins(1,3,4,5)-Tetrakisphophate
Descriptor: INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, RAC-ALPHA SERINE/THREONINE KINASE
Authors:Milburn, C.C, Deak, M, Kelly, S.M, Price, N.C, Alessi, D.R, van Aalten, D.M.F.
Deposit date:2003-09-12
Release date:2004-09-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (0.98 Å)
Cite:Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change.
Biochem. J., 375, 2003
1UNP
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BU of 1unp by Molmil
Crystal structure of the pleckstrin homology domain of PKB alpha
Descriptor: RAC-ALPHA SERINE/THREONINE KINASE
Authors:Milburn, C.C, Deak, M, Kelly, S.M, Price, N.C, Alessi, D.R, van Aalten, D.M.F.
Deposit date:2003-09-12
Release date:2004-09-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change.
Biochem. J., 375, 2003
1UNR
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BU of 1unr by Molmil
Crystal structure of the PH domain of PKB alpha in complex with a sulfate molecule
Descriptor: RAC-ALPHA SERINE/THREONINE KINASE, SULFATE ION
Authors:Milburn, C.C, Deak, M, Kelly, S.M, Price, N.C, Alessi, D.R, van Aalten, D.M.F.
Deposit date:2003-09-15
Release date:2004-09-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change.
Biochem. J., 375, 2003
1UU8
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BU of 1uu8 by Molmil
Structure of human PDK1 kinase domain in complex with BIM-1
Descriptor: 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, GLYCEROL, ...
Authors:Komander, D, Kular, G.S, Schuttelkopf, A.W, Deak, M, Prakash, K.R, Bain, J, Elliot, M, Garrido-Franco, M, Kozikowski, A.P, Alessi, D.R, Van Aalten, D.M.F.
Deposit date:2003-12-16
Release date:2004-03-04
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004
1UPL
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BU of 1upl by Molmil
Crystal structure of MO25 alpha
Descriptor: MO25 PROTEIN
Authors:Milburn, C.C, Boudeau, J, Deak, M, Alessi, D.R, Van Aalten, D.M.F.
Deposit date:2003-10-07
Release date:2004-01-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of Mo25 Alpha in Complex with the C-Terminus of the Pseudo Kinase Ste-20 Related Adaptor (Strad)
Nat.Struct.Mol.Biol., 11, 2004
1UPK
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BU of 1upk by Molmil
Crystal structure of MO25 in complex with a C-terminal peptide of STRAD
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MO25 PROTEIN, STE-20 RELATED ADAPTOR
Authors:Milburn, C.C, Boudeau, J, Deak, M, Alessi, D.R, Van Aalten, D.M.F.
Deposit date:2003-10-07
Release date:2004-01-22
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of Mo25 Alpha in Complex with the C-Terminus of the Pseudo Kinase Ste-20 Related Adaptor (Strad)
Nat.Struct.Mol.Biol., 11, 2004
1UPR
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BU of 1upr by Molmil
Crystal structure of the PEPP1 pleckstrin homology domain in complex with Inositol 1,3,4,5-tetrakisphosphate
Descriptor: INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 4
Authors:Milburn, C.C, Komander, D, Deak, M, Alessi, D.R, Van Aalten, D.M.F.
Deposit date:2003-10-10
Release date:2004-10-20
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Crystal Structure of the Pleckstrin Homology Domain of Pepp1
To be Published
1UVR
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BU of 1uvr by Molmil
Structure of human PDK1 kinase domain in complex with BIM-8
Descriptor: 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, GLYCEROL, ...
Authors:Komander, D, Garrido-Franco, M, Kular, G.S, Schuttelkopf, A.W, Deak, M, Prakash, K.R, Bain, J, Elliot, M, Kozikowski, A.P, Alessi, D.R, Van Aalten, D.M.F.
Deposit date:2004-01-22
Release date:2004-03-04
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004

 

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