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5E3B
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STRUCTURE OF MACRODOMAIN PROTEIN FROM STREPTOMYCES COELICOLOR
Descriptor:Macrodomain protein, SODIUM ION, 1,2-ETHANEDIOL
Authors:Lalic, J., Posavec Marjanovic, M., Perina, D., Sabljic, I., Zaja, R., Plese, B., Imesek, M., Bucca, G., Ahel, M., Cetkovic, H., Luic, M., Mikoc, A., Ahel, I.
Deposit date:2015-10-02
Release date:2016-09-28
Last modified:2016-11-09
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Disruption of Macrodomain Protein SCO6735 Increases Antibiotic Production in Streptomyces coelicolor.
J.Biol.Chem., 291, 2016
5A35
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CRYSTAL STRUCTURE OF GLYCINE CLEAVAGE PROTEIN H-LIKE (GCVH-L) FROM STREPTOCOCCUS PYOGENES
Descriptor:GLYCINE CLEAVAGE SYSTEM H PROTEIN, PENTAETHYLENE GLYCOL
Authors:Rack, J.G.M., Morra, R., Barkauskaite, E., Kraehenbuehl, R., Ariza, A., Qu, Y., Ortmayer, M., Leidecker, O., Cameron, D.R., Matic, I., Peleg, A.Y., Leys, D., Traven, A., Ahel, I.
Deposit date:2015-05-27
Release date:2015-07-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Identification of a Class of Protein Adp-Ribosylating Sirtuins in Microbial Pathogens.
Mol.Cell, 59, 2015
5A3A
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CRYSTAL STRUCTURE OF THE ADP-RIBOSYLATING SIRTUIN (SIRTM) FROM STREPTOCOCCUS PYOGENES (APO FORM)
Descriptor:SIR2 FAMILY PROTEIN, GLYCINE, ZINC ION, ...
Authors:Rack, J.G.M., Morra, R., Barkauskaite, E., Kraehenbuehl, R., Ariza, A., Qu, Y., Ortmayer, M., Leidecker, O., Cameron, D.R., Matic, I., Peleg, A.Y., Leys, D., Traven, A., Ahel, I.
Deposit date:2015-05-28
Release date:2015-07-29
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Identification of a Class of Protein Adp-Ribosylating Sirtuins in Microbial Pathogens.
Mol.Cell, 59, 2015
5A3B
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CRYSTAL STRUCTURE OF THE ADP-RIBOSYLATING SIRTUIN (SIRTM) FROM STREPTOCOCCUS PYOGENES IN COMPLEX WITH ADP-RIBOSE
Descriptor:SIR2 FAMILY PROTEIN, GLYCINE, ALANINE, ...
Authors:Rack, J.G.M., Morra, R., Barkauskaite, E., Kraehenbuehl, R., Ariza, A., Qu, Y., Ortmayer, M., Leidecker, O., Cameron, D.R., Matic, I., Peleg, A.Y., Leys, D., Traven, A., Ahel, I.
Deposit date:2015-05-28
Release date:2015-07-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification of a Class of Protein Adp-Ribosylating Sirtuins in Microbial Pathogens.
Mol.Cell, 59, 2015
5A3C
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CRYSTAL STRUCTURE OF THE ADP-RIBOSYLATING SIRTUIN (SIRTM) FROM STREPTOCOCCUS PYOGENES IN COMPLEX WITH NAD
Descriptor:SIR2 FAMILY PROTEIN, GLYCINE, ZINC ION, ...
Authors:Rack, J.G.M., Morra, R., Barkauskaite, E., Kraehenbuehl, R., Ariza, A., Qu, Y., Ortmayer, M., Leidecker, O., Cameron, D.R., Matic, I., Peleg, A.Y., Leys, D., Traven, A., Ahel, I.
Deposit date:2015-05-28
Release date:2015-07-29
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Identification of a Class of Protein Adp-Ribosylating Sirtuins in Microbial Pathogens.
Mol.Cell, 59, 2015
2X47
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CRYSTAL STRUCTURE OF HUMAN MACROD1
Descriptor:MACRO DOMAIN-CONTAINING PROTEIN 1, SULFATE ION
Authors:Vollmar, M., Phillips, C., Mehrotra, P.V., Ahel, I., Krojer, T., Yue, W., Ugochukwu, E., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Gileadi, O.
Deposit date:2010-01-28
Release date:2010-03-02
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Identification of Macro Domain Proteins as Novel O-Acetyl-Adp-Ribose Deacetylases.
J.Biol.Chem., 286, 2011
5A7R
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HUMAN POLY(ADP-RIBOSE) GLYCOHYDROLASE IN COMPLEX WITH SYNTHETIC DIMERIC ADP-RIBOSE
Descriptor:POLY(ADP-RIBOSE) GLYCOHYDROLASE, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, BETA-MERCAPTOETHANOL, ...
Authors:Lambrecht, M.J., Brichacek, M., Barkauskaite, E., Ariza, A., Ahel, I., Hergenrother, P.J.
Deposit date:2015-07-09
Release date:2015-07-22
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Synthesis of Dimeric Adp-Ribose and its Structure with Human Poly(Adp-Ribose) Glycohydrolase.
J.Am.Chem.Soc., 137, 2015
5LW6
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CRYSTAL STRUCTURE OF A SE-MET SUBSTITUTED DICTYOSTELIUM DISCOIDEUM ADP-RIBOSE BINDING MACRODOMAIN (RESIDUES 342-563) OF DDB_G0293866
Descriptor:DDB_G0293866
Authors:Leys, D., Barkauskaite, E., Pinero, B.B., Ahel, I.
Deposit date:2016-09-15
Release date:2016-09-28
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The role of ADP-ribosylation in regulating DNA interstrand crosslink repair.
J.Cell.Sci., 129, 2016
4J5Q
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TARG1 (C6ORF130), TERMINAL ADP-RIBOSE GLYCOHYDROLASE 1, APO STRUCTURE
Descriptor:O-acetyl-ADP-ribose deacetylase 1
Authors:Schellenberg, M.J., Appel, C.D., Krahn, J., Williams, R.S.
Deposit date:2013-02-09
Release date:2013-03-27
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease.
Embo J., 32, 2013
4J5R
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TARG1 (C6ORF130), TERMINAL ADP-RIBOSE GLYCOHYDROLASE 1 BOUND TO ADP-HPD
Descriptor:O-acetyl-ADP-ribose deacetylase 1, 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, CHLORIDE ION, ...
Authors:Schellenberg, M.J., Appel, C.D., Krahn, J., Williams, R.S.
Deposit date:2013-02-09
Release date:2013-03-27
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease.
Embo J., 32, 2013
4J5S
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TARG1 (C6ORF130), TERMINAL ADP-RIBOSE GLYCOHYDROLASE 1 ADP-RIBOSE COMPLEX
Descriptor:O-acetyl-ADP-ribose deacetylase 1, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [[(2R,3R)-2,3-DIHYDROXY-4-OXO-PENTOXY]-OXIDO-PHOSPHORYL] PHOSPHATE, BORATE ION, ...
Authors:Schellenberg, M.J., Appel, C.D., Krahn, J., Williams, R.S.
Deposit date:2013-02-09
Release date:2013-03-27
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease.
Embo J., 32, 2013
3SIG
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THE X-RAY CRYSTAL STRUCTURE OF POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) BOUND TO ADP-RIBOSE FROM THERMOMONOSPORA CURVATA
Descriptor:poly(ADP-ribose) glycohydrolase, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
Authors:Leys, D., Dunstan, M.S.
Deposit date:2011-06-18
Release date:2011-08-24
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase.
Nature, 477, 2011
3SIH
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THE X-RAY CRYSTAL STRUCTURE OF POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) FROM THERMOMONOSPORA CURVATA
Descriptor:poly(ADP-ribose) glycohydrolase
Authors:Dunstan, M.S., Leys, D.
Deposit date:2011-06-18
Release date:2011-08-24
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase.
Nature, 477, 2011
3SII
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THE X-RAY CRYSTAL STRUCTURE OF POLY(ADP-RIBOSE) GLYCOHYDROLASE BOUND TO THE INHIBITOR ADP-HPD FROM THERMOMONOSPORA CURVATA
Descriptor:poly(ADP-ribose) glycohydrolase, 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE
Authors:Dunstan, M.S., Leys, D.
Deposit date:2011-06-18
Release date:2011-08-24
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase.
Nature, 477, 2011
3SIJ
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THE X-RAY CRYSTAL STRUCTURE OF POLY(ADP-RIBOSE) GLYCOHYDROLASE E115A MUTANT FROM THERMOMONOSPORA CURVATA
Descriptor:poly(ADP-ribose) glycohydrolase
Authors:Dunstan, M.S., Leys, D.
Deposit date:2011-06-18
Release date:2011-08-24
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase.
Nature, 477, 2011
4EPP
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CANONICAL POLY(ADP-RIBOSE) GLYCOHYDROLASE FROM TETRAHYMENA THERMOPHILA.
Descriptor:Poly(ADP-ribose) glycohydrolase, ADENOSINE-5-DIPHOSPHORIBOSE
Authors:Dunstan, M.S., Leys, D.
Deposit date:2012-04-17
Release date:2012-06-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure and mechanism of a canonical poly(ADP-ribose) glycohydrolase.
Nat Commun, 3, 2012
4EPQ
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CANONICAL POLY(ADP-RIBOSE) GLYCOHYDROLASE RBPI INHIBITOR COMPLEX FROM TETRAHYMENA THERMOPHILA
Descriptor:Poly(ADP-ribose) glycohydrolase, 3-{(5Z)-5-[5-chloro-1-(2,6-dichlorobenzyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}propanoic acid
Authors:Dunstan, M.S., Leys, D.
Deposit date:2012-04-17
Release date:2012-06-13
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.399 Å)
Cite:Structure and mechanism of a canonical poly(ADP-ribose) glycohydrolase.
Nat Commun, 3, 2012
4L2H
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STRUCTURE OF A CATALYTICALLY INACTIVE PARG IN COMPLEX WITH A POLY-ADP-RIBOSE FRAGMENT
Descriptor:Poly(ADP-ribose) glycohydrolase, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
Authors:Brassington, A., Dunstan, M.S., Leys, D.
Deposit date:2013-06-04
Release date:2013-07-24
Last modified:2013-08-21
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities.
Nat Commun, 4, 2013
5M31
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MACRODOMAIN OF THERMUS AQUATICUS DARG
Descriptor:Appr-1-p processing domain protein, GLYCEROL, CHLORIDE ION
Authors:Ariza, A.
Deposit date:2016-10-13
Release date:2016-12-21
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:The Toxin-Antitoxin System DarTG Catalyzes Reversible ADP-Ribosylation of DNA.
Mol. Cell, 64, 2016
5M3E
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MACRODOMAIN OF THERMUS AQUATICUS DARG IN COMPLEX WITH ADP-RIBOSE
Descriptor:Appr-1-p processing domain protein, ADENOSINE-5-DIPHOSPHORIBOSE, CHLORIDE ION
Authors:Ariza, A.
Deposit date:2016-10-14
Release date:2016-12-21
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Toxin-Antitoxin System DarTG Catalyzes Reversible ADP-Ribosylation of DNA.
Mol. Cell, 64, 2016
5M3I
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MACRODOMAIN OF MYCOBACTERIUM TUBERCULOSIS DARG
Descriptor:RNase III inhibitor, CHLORIDE ION
Authors:Ariza, A.
Deposit date:2016-10-14
Release date:2016-12-21
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:The Toxin-Antitoxin System DarTG Catalyzes Reversible ADP-Ribosylation of DNA.
Mol. Cell, 64, 2016
5O2D
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PARP14 MACRODOMAIN 2 WITH INHIBITOR
Descriptor:Poly [ADP-ribose] polymerase 14, ~{N}-[2-(9~{H}-carbazol-1-yl)phenyl]methanesulfonamide
Authors:Uth, K., Schuller, M., Sieg, C., Wang, J., Krojer, T., Knapp, S., Riedels, K., Bracher, F., Edwards, A.M., Arrowsmith, C., Bountra, C., Elkins, J.M., Structural Genomics Consortium (SGC)
Deposit date:2017-05-20
Release date:2017-11-08
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14.
ACS Chem. Biol., 12, 2017
6FGE
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CRYSTAL STRUCTURE OF HUMAN ZUFSP/ZUP1 IN COMPLEX WITH UBIQUITIN
Descriptor:Zinc finger with UFM1-specific peptidase domain protein, Polyubiquitin-B, MALONATE ION, ...
Authors:Kwasna, D., Abdul Rehman, S.A., Kulathu, Y.
Deposit date:2018-01-10
Release date:2018-04-04
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.
Mol. Cell, 70, 2018
2KQB
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FIRST PBZ DOMAIN OF HUMAN APLF PROTEIN
Descriptor:Aprataxin and PNK-like factor, ZINC ION
Authors:Neuhaus, D., Eustermann, S., Brockmann, C., Yang, J.
Deposit date:2009-11-04
Release date:2010-01-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).
Nat.Struct.Mol.Biol., 17, 2010
2KQC
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SECOND PBZ DOMAIN OF HUMAN APLF PROTEIN
Descriptor:Aprataxin and PNK-like factor, ZINC ION
Authors:Neuhaus, D., Eustermann, S., Brockmann, C., Yang, J.
Deposit date:2009-11-04
Release date:2010-01-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).
Nat.Struct.Mol.Biol., 17, 2010
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