Author results

3IEF
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CRYSTAL STRUCTURE OF TRNA GUANINE-N1-METHYLTRANSFERASE FROM BARTONELLA HENSELAE USING MPCS.
Descriptor:tRNA (guanine-N(1)-)-methyltransferase
Authors:Edwards, T.E., Stahl, G., Gerdts, C.J., Staker, B.L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-07-22
Release date:2009-08-11
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of tRNA guanine-n1-methyltransferase from Bartonella henselae using MPCS.
To be Published
2RHH
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SYNTHETIC GENE ENCODED BACILLUS SUBTILIS FTSZ WITH BOUND SULFATE ION
Descriptor:Cell Division Protein ftsZ, SULFATE ION
Authors:Lovell, S., Halloran, Z., Hjerrild, K., Sheridan, D., Burgin, A., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-10-09
Release date:2008-10-21
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Combined protein construct and synthetic gene engineering for heterologous protein expression and crystallization using Gene Composer.
BMC Biotechnol., 9, 2009
2RHJ
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SYNTHETIC GENE ENCODED BACILLUS SUBTILIS FTSZ WITH TWO SULFATE IONS AND SODIUM ION IN THE NUCLEOTIDE POCKET
Descriptor:Cell Division Protein ftsZ, ACETATE ION, SULFATE ION, ...
Authors:Lovell, S., Halloran, Z., Hjerrild, K., Sheridan, D., Burgin, A., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-10-09
Release date:2008-10-21
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.761 Å)
Cite:Combined protein construct and synthetic gene engineering for heterologous protein expression and crystallization using Gene Composer.
BMC Biotechnol., 9, 2009
2RHL
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SYNTHETIC GENE ENCODED BACILLUS SUBTILIS FTSZ NCS DIMER WITH BOUND GDP
Descriptor:Cell Division Protein ftsZ, GUANOSINE-5'-DIPHOSPHATE
Authors:Lovell, S., Halloran, Z., Hjerrild, K., Sheridan, D., Burgin, A., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-10-09
Release date:2008-10-21
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Combined protein construct and synthetic gene engineering for heterologous protein expression and crystallization using Gene Composer.
BMC Biotechnol., 9, 2009
2RHO
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SYNTHETIC GENE ENCODED BACILLUS SUBTILIS FTSZ NCS DIMER WITH BOUND GDP AND GTP-GAMMA-S
Descriptor:Cell Division Protein ftsZ, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE
Authors:Lovell, S., Halloran, Z., Hjerrild, K., Sheridan, D., Burgin, A., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-10-09
Release date:2008-10-21
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Combined protein construct and synthetic gene engineering for heterologous protein expression and crystallization using Gene Composer.
BMC Biotechnol., 9, 2009
3CXK
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1.7 A CRYSTAL STRUCTURE OF METHIONINE-R-SULFOXIDE REDUCTASE FROM BURKHOLDERIA PSEUDOMALLEI: CRYSTALLIZATION IN A MICROFLUIDIC CRYSTAL CARD.
Descriptor:Methionine-R-sulfoxide reductase, ZINC ION, ACETATE ION
Authors:Lovell, S., Gerdts, C., Staker, B., Craigen, D., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2008-04-24
Release date:2008-05-27
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The plug-based nanovolume Microcapillary Protein Crystallization System (MPCS).
Acta Crystallogr.,Sect.D, 64, 2008
3D4S
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CHOLESTEROL BOUND FORM OF HUMAN BETA2 ADRENERGIC RECEPTOR.
Descriptor:Beta-2 adrenergic receptor/T4-lysozyme chimera, (2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol, CHOLESTEROL, ...
Authors:Hanson, M.A., Cherezov, V., Roth, C.B., Griffith, M.T., Jaakola, V.-P., Chien, E.Y.T., Velasquez, J., Kuhn, P., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2008-05-14
Release date:2008-06-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor.
Structure, 16, 2008
3ODU
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THE 2.5 A STRUCTURE OF THE CXCR4 CHEMOKINE RECEPTOR IN COMPLEX WITH SMALL MOLECULE ANTAGONIST IT1T
Descriptor:C-X-C chemokine receptor type 4, Lysozyme Chimera, (6,6-dimethyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-3-yl)methyl N,N'-dicyclohexylimidothiocarbamate, ...
Authors:Wu, B., Mol, C.D., Han, G.W., Katritch, V., Chien, E.Y.T., Liu, W., Cherezov, V., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2010-08-11
Release date:2010-10-27
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.
Science, 330, 2010
3OE0
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CRYSTAL STRUCTURE OF THE CXCR4 CHEMOKINE RECEPTOR IN COMPLEX WITH A CYCLIC PEPTIDE ANTAGONIST CVX15
Descriptor:C-X-C chemokine receptor type 4, Lysozyme Chimera, Polyphemusin analog, ...
Authors:Wu, B., Mol, C.D., Han, G.W., Katritch, V., Chien, E.Y.T., Liu, W., Cherezov, V., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2010-08-12
Release date:2010-10-27
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.
Science, 330, 2010
3OE6
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CRYSTAL STRUCTURE OF THE CXCR4 CHEMOKINE RECEPTOR IN COMPLEX WITH A SMALL MOLECULE ANTAGONIST IT1T IN I222 SPACEGROUP
Descriptor:C-X-C chemokine receptor type 4, Lysozyme Chimera, (6,6-dimethyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-3-yl)methyl N,N'-dicyclohexylimidothiocarbamate, ...
Authors:Wu, B., Mol, C.D., Han, G.W., Katritch, V., Chien, E.Y.T., Liu, W., Cherezov, V., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2010-08-12
Release date:2010-10-27
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.
Science, 330, 2010
3OE8
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CRYSTAL STRUCTURE OF THE CXCR4 CHEMOKINE RECEPTOR IN COMPLEX WITH A SMALL MOLECULE ANTAGONIST IT1T IN P1 SPACEGROUP
Descriptor:C-X-C chemokine receptor type 4, Lysozyme Chimera, (6,6-dimethyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-3-yl)methyl N,N'-dicyclohexylimidothiocarbamate
Authors:Wu, B., Mol, C.D., Han, G.W., Katritch, V., Chien, E.Y.T., Liu, W., Cherezov, V., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2010-08-12
Release date:2010-10-27
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.
Science, 330, 2010
3OE9
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CRYSTAL STRUCTURE OF THE CHEMOKINE CXCR4 RECEPTOR IN COMPLEX WITH A SMALL MOLECULE ANTAGONIST IT1T IN P1 SPACEGROUP
Descriptor:C-X-C chemokine receptor type 4, Lysozyme Chimera, (6,6-dimethyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-3-yl)methyl N,N'-dicyclohexylimidothiocarbamate
Authors:Wu, B., Mol, C.D., Han, G.W., Katritch, V., Chien, E.Y.T., Liu, W., Cherezov, V., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2010-08-12
Release date:2010-10-27
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.
Science, 330, 2010
3PBL
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STRUCTURE OF THE HUMAN DOPAMINE D3 RECEPTOR IN COMPLEX WITH ETICLOPRIDE
Descriptor:D(3) dopamine receptor, Lysozyme chimera, 3-chloro-5-ethyl-N-{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-6-hydroxy-2-methoxybenzamide, ...
Authors:Chien, E.Y.T., Liu, W., Han, G.W., Katritch, V., Zhao, Q., Cherezov, V., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2010-10-20
Release date:2010-11-03
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Structure of the human dopamine d3 receptor in complex with a d2/d3 selective antagonist.
Science, 330, 2010
2BBA
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CRYSTAL STRUCTURE AND THERMODYNAMIC CHARACTERIZATION OF THE EPHB4 RECEPTOR IN COMPLEX WITH AN EPHRIN-B2 ANTAGONIST PEPTIDE REVEALS THE DETERMINANTS FOR RECEPTOR SPECIFICITY.
Descriptor:Ephrin type-B receptor 4, Agonist peptide, SULFATE ION
Authors:Chrencik, J.E., Kuhn, P., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2005-10-17
Release date:2006-07-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity.
Structure, 14, 2006
2HLE
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STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OF THE EPHB4-EPHRINB2 PROTEIN PROTEIN INTERACTION AND RECEPTOR SPECIFICITY.
Descriptor:Ephrin type-B receptor 4, Ephrin-B2
Authors:Chrencik, J.E., Brooun, A., Kuhn, P., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2006-07-06
Release date:2006-08-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural and Biophysical Characterization of the EphB4-EphrinB2 Protein-Protein Interaction and Receptor Specificity.
J.Biol.Chem., 281, 2006
3BJI
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STRUCTURAL BASIS OF PROMISCUOUS GUANINE NUCLEOTIDE EXCHANGE BY THE T-CELL ESSENTIAL VAV1
Descriptor:Proto-oncogene vav, Ras-related C3 botulinum toxin substrate 1 precursor, ZINC ION
Authors:Chrencik, J.E., Brooun, A., Kuhn, P., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-12-04
Release date:2008-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1.
J.Mol.Biol., 380, 2008
3D38
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CRYSTAL STRUCTURE OF NEW TRIGONAL FORM OF PHOTOSYNTHETIC REACTION CENTER FROM BLASTOCHLORIS VIRIDIS. CRYSTALS GROWN IN MICROFLUIDICS BY DETERGENT CAPTURE.
Descriptor:Photosynthetic reaction center cytochrome c subunit, Reaction center protein H chain, Reaction center protein L chain, ...
Authors:Li, L., Nachtergaele, S.H.M., Seddon, A.M., Tereshko, V., Ponomarenko, N., Ismagilov, R.F., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2008-05-09
Release date:2008-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Simple host-guest chemistry to modulate the process of concentration and crystallization of membrane proteins by detergent capture in a microfluidic device.
J.Am.Chem.Soc., 130, 2008
3II9
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CRYSTAL STRUCTURE OF GLUTARYL-COA DEHYDROGENASE FROM BURKHOLDERIA PSEUDOMALLEI AT 1.73 ANGSTROM
Descriptor:Glutaryl-CoA dehydrogenase, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ...
Authors:Ismagilov, R.F., Li, L., Du, W.B., Staker, B., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-07-31
Release date:2009-12-15
Last modified:2012-10-10
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:User-loaded SlipChip for equipment-free multiplexed nanoliter-scale experiments.
J.Am.Chem.Soc., 132, 2010
3KJR
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CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE/THYMIDYLATE SYNTHASE FROM BABESIA BOVIS DETERMINED USING SLIPCHIP BASED MICROFLUIDICS
Descriptor:Dihydrofolate reductase/thymidylate synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ...
Authors:Li, L., Du, W., Edwards, T.E., Staker, B.L., Phan, I., Stacy, R., Ismagilov, R.F., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-11-03
Release date:2009-11-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Multiparameter screening on SlipChip used for nanoliter protein crystallization combining free interface diffusion and microbatch methods.
J.Am.Chem.Soc., 132, 2010
2RH1
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HIGH RESOLUTION CRYSTAL STRUCTURE OF HUMAN B2-ADRENERGIC G PROTEIN-COUPLED RECEPTOR.
Descriptor:beta-2-adrenergic receptor/T4-lysozyme chimera, MALTOSE, SULFATE ION, ...
Authors:Cherezov, V., Rosenbaum, D.M., Hanson, M.A., Rasmussen, S.G.F., Thian, F.S., Kobilka, T.S., Choi, H.J., Kuhn, P., Weis, W.I., Kobilka, B.K., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2007-10-05
Release date:2007-10-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.
Science, 318, 2007
3BL7
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SYNTHETIC GENE ENCODED DCPS BOUND TO INHIBITOR DG156844
Descriptor:Scavenger mRNA-decapping enzyme DcpS, 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine
Authors:Staker, B.L., Christensen, J., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-12-10
Release date:2008-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
3BL9
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SYNTHETIC GENE ENCODED DCPS BOUND TO INHIBITOR DG157493
Descriptor:Scavenger mRNA-decapping enzyme DcpS, 5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine
Authors:Staker, B.L., Christensen, J., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-12-10
Release date:2008-10-21
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
3BLA
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SYNTHETIC GENE ENCODED DCPS BOUND TO INHIBITOR DG153249
Descriptor:Scavenger mRNA-decapping enzyme DcpS, 5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine
Authors:Staker, B.L., Christensen, J., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-12-10
Release date:2008-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
3NY8
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CRYSTAL STRUCTURE OF THE HUMAN BETA2 ADRENERGIC RECEPTOR IN COMPLEX WITH THE INVERSE AGONIST ICI 118,551
Descriptor:Beta-2 adrenergic receptor, Lysozyme, CHOLESTEROL, ...
Authors:Wacker, D., Fenalti, G., Brown, M.A., Katritch, V., Abagyan, R., Cherezov, V., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2010-07-14
Release date:2010-08-11
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Conserved Binding Mode of Human beta(2) Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography
J.Am.Chem.Soc., 132, 2010
3NY9
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CRYSTAL STRUCTURE OF THE HUMAN BETA2 ADRENERGIC RECEPTOR IN COMPLEX WITH A NOVEL INVERSE AGONIST
Descriptor:Beta-2 adrenergic receptor, Lysozyme, CHOLESTEROL, ...
Authors:Fenalti, G., Wacker, D., Brown, M.A., Katritch, V., Abagyan, R., Cherezov, V., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2010-07-14
Release date:2010-08-11
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Conserved Binding Mode of Human beta(2) Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography
J.Am.Chem.Soc., 132, 2010
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