Author results

5Z1T
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CRYSTAL STRUCTURE ANALYSIS OF THE BRD4(1)
Descriptor:Bromodomain-containing protein 4, 5-bromo-N-(6-hydroxy-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)-2-methoxybenzene-1-sulfonamide, NITRATE ION, ...
Authors:Xu, Y., Zhang, Y., Xiang, Q., Song, M., Wang, C.
Deposit date:2017-12-28
Release date:2019-01-02
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Crystal Structure Analysis of the BRD4(1)
To Be Published
5Z6Q
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CRYSTAL STRUCTURE OF AAA OF SPASTIN
Descriptor:Spastin, CHLORIDE ION
Authors:Lin, Z., Wang, C., Shen, Y.
Deposit date:2018-01-25
Release date:2018-12-05
Method:X-RAY DIFFRACTION (3 Å)
Cite:The AAA protein spastin possesses two levels of basal ATPase activity
FEBS Lett., 592, 2018
5Z6R
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SPASTIN AAA WITH ATP
Descriptor:Spastin, ADENOSINE-5'-TRIPHOSPHATE
Authors:Lin, Z., Wang, C., Shen, Y.
Deposit date:2018-01-25
Release date:2019-01-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:The Aaa Family Protein Spastin Severs A Microtubule
To Be Published
6AJK
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CRYSTAL STRUCTURE OF TFB1M AND H45 IN HOMO SAPIENS
Descriptor:Dimethyladenosine transferase 1, mitochondrial, RNA (28-MER)
Authors:Liu, X., Shen, S., Wu, P., Li, F., Wang, C., Gong, Q., Wu, J., Zhang, H., Shi, Y.
Deposit date:2018-08-28
Release date:2019-06-05
Method:X-RAY DIFFRACTION (3.001 Å)
Cite:Crystal structure of TFB1M and h45 in homo sapiens
To Be Published
6AO3
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CRYSTAL STRUCTURE OF THE MURINE GASDERMIN D C-TERMINAL DOMAIN
Descriptor:Gasdermin-D
Authors:Liu, Z., Wang, C., Yang, J., Xiao, T.S.
Deposit date:2017-08-15
Release date:2018-04-11
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition.
Structure, 26, 2018
6AO4
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CRYSTAL STRUCTURE OF THE HUMAN GASDERMIN D C-TERMINAL DOMAIN
Descriptor:Gasdermin-D
Authors:Liu, Z., Wang, C., Yang, J., Xiao, T.S.
Deposit date:2017-08-15
Release date:2018-04-11
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (2.901 Å)
Cite:Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition.
Structure, 26, 2018
6BZ9
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CRYSTAL STRUCTURE OF HUMAN CASPASE-1 IN COMPLEX WITH AC-FLTD-CMK
Descriptor:Caspase-1, Ac-FLTD-CMK, DI(HYDROXYETHYL)ETHER
Authors:Xiao, T.S., Yang, J., Liu, Z., Wang, C., Yang, R.
Deposit date:2017-12-22
Release date:2018-06-13
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.796 Å)
Cite:Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DNF
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CRYO-EM STRUCTURE OF THE MITOCHONDRIAL CALCIUM UNIPORTER MCU FROM THE FUNGUS CYPHELLOPHORA EUROPAEA
Descriptor:Mitochondrial calcium uniporter MCU, 1-[GLYCEROLYLPHOSPHONYL]-2-[8-(2-HEXYL-CYCLOPROPYL)-OCTANAL-1-YL]-3-[HEXADECANAL-1-YL]-GLYCEROL, CALCIUM ION
Authors:Long, S.B., Baradaran, R., Wang, C.
Deposit date:2018-06-06
Release date:2018-07-11
Last modified:2018-08-08
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters.
Nature, 559, 2018
6MRO
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CRYSTAL STRUCTURE OF METHYL TRANSFERASE FROM METHANOSARCINA ACETIVORANS AT 1.6 ANGSTROMS RESOLUTION, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET MVR53.
Descriptor:methyl transferase from Methanosarcina acetivorans, S-ADENOSYL-L-HOMOCYSTEINE, CALCIUM ION, ...
Authors:Singh, S., Forouhar, F., Wang, C., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
Deposit date:2018-10-15
Release date:2018-10-24
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of a methyl transferase from Methanosarcina acetivorans at 1.6 Angstroms resolution.
To Be Published
6MUR
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CRYO-EM STRUCTURE OF CSM-CRRNA-TARGET RNA TERNARY COMPLEX IN TYPE III-A CRISPR-CAS SYSTEM
Descriptor:Uncharacterized protein, Uncharacterized protein Csm3, RNA (27-MER), ...
Authors:Jia, N., Wang, C., Eng, E.T., Patel, D.J.
Deposit date:2018-10-23
Release date:2018-12-12
Last modified:2019-01-30
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.
Mol. Cell, 73, 2019
6MUS
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CRYO-EM STRUCTURE OF LARGER CSM-CRRNA-TARGET RNA TERNARY COMPLEX IN TYPE III-A CRISPR-CAS SYSTEM
Descriptor:Uncharacterized protein Csm1, Uncharacterized protein Csm2, Uncharacterized protein Csm3, ...
Authors:Jia, N., Wang, C., Eng, E.T.
Deposit date:2018-10-23
Release date:2018-12-12
Last modified:2019-01-30
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.
Mol. Cell, 73, 2019
6MUT
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CRYO-EM STRUCTURE OF TERNARY CSM-CRRNA-TARGET RNA WITH ANTI-TAG SEQUENCE COMPLEX IN TYPE III-A CRISPR-CAS SYSTEM
Descriptor:Uncharacterized protein Csm1, Uncharacterized protein Csm2, Uncharacterized protein Csm3, ...
Authors:Jia, N., Wang, C., Eng, E.T., Patel, D.J.
Deposit date:2018-10-23
Release date:2018-12-12
Last modified:2019-01-30
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.
Mol. Cell, 73, 2019
6MUU
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CRYO-EM STRUCTURE OF CSM-CRRNA BINARY COMPLEX IN TYPE III-A CRISPR-CAS SYSTEM
Descriptor:Uncharacterized protein Csm1, Uncharacterized protein Csm2, Uncharacterized protein Csm3, ...
Authors:Jia, N., Wang, C., Eng, E.T., Patel, D.J.
Deposit date:2018-10-23
Release date:2018-12-19
Last modified:2019-01-30
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.
Mol. Cell, 73, 2019
6N9N
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CRYSTAL STRUCTURE OF MURINE GSDMD
Descriptor:Gasdermin-D
Authors:Liu, Z., Wang, C., Yang, J., Xiao, T.S.
Deposit date:2018-12-03
Release date:2019-06-05
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization.
Immunity, 2019
6N9O
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CRYSTAL STRUCTURE OF HUMAN GSDMD
Descriptor:Gasdermin-D
Authors:Liu, Z., Wang, C., Yang, J., Xiao, T.S.
Deposit date:2018-12-03
Release date:2019-06-05
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization.
Immunity, 2019
6NIV
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RACEMIC PHENOL-SOLUBLE MODULIN ALPHA 3 PEPTIDE
Descriptor:Phenol-soluble modulin PSM-alpha-3
Authors:Yao, Z., Cary, B.P., Bingman, C.A., Wang, C., Kreitler, D.F., Satyshur, K.A., Forest, K.T., Gellman, S.H.
Deposit date:2018-12-31
Release date:2019-05-15
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Use of a Stereochemical Strategy To Probe the Mechanism of Phenol-Soluble Modulin alpha 3 Toxicity.
J.Am.Chem.Soc., 141, 2019
6NZK
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STRUCTURAL BASIS FOR HUMAN CORONAVIRUS ATTACHMENT TO SIALIC ACID RECEPTORS
Descriptor:Spike surface glycoprotein, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Tortorici, M.A., Walls, A.C., Lang, Y., Wang, C., Li, Z., Koerhuis, D., Boons, G.J., Bosch, B.J., Rey, F.A., de Groot, R., Veesler, D.
Deposit date:2019-02-13
Release date:2019-06-05
Last modified:2019-06-19
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for human coronavirus attachment to sialic acid receptors.
Nat.Struct.Mol.Biol., 26, 2019
6OHW
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STRUCTURAL BASIS FOR HUMAN CORONAVIRUS ATTACHMENT TO SIALIC ACID RECEPTORS. APO-HCOV-OC43 S
Descriptor:Spike surface glycoprotein, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Tortorici, M.A., Walls, A.C., Lang, Y., Wang, C., Li, Z., Koerhuis, D., Boons, G.J., Bosch, B.J., Rey, F.A., de Groot, R., Veesler, D.
Deposit date:2019-04-07
Release date:2019-06-05
Last modified:2019-06-19
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for human coronavirus attachment to sialic acid receptors.
Nat.Struct.Mol.Biol., 26, 2019
5WB6
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FACTOR XIA IN COMPLEX WITH THE INHIBITOR METHYL [(11S)-11-({(2E)-3-[5-CHLORO-2-(1H-TETRAZOL-1-YL)PHENYL]PROP-2-ENOYL}AMINO)-6-FLUORO-2-OXO-1,3,4,10,11,13-HEXAHYDRO-2H-5,9:15,12-DI(AZENO)-1,13-BENZODIAZACYCLOHEPTADECIN-18-YL]CARBAMATE
Descriptor:Coagulation factor XI, methyl [(11S)-11-({(2E)-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-6-fluoro-2-oxo-1,3,4,10,11,13-hexahydro-2H-5,9:15,12-di(azeno)-1,13-benzodiazacycloheptadecin-18-yl]carbamate, SULFATE ION, ...
Authors:Sheriff, S.
Deposit date:2017-06-28
Release date:2017-08-02
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Macrocyclic factor XIa inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
4I5S
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STRUCTURE AND FUNCTION OF SENSOR HISTIDINE KINASE
Descriptor:Putative histidine kinase CovS; VicK-like protein
Authors:Cai, Y.
Deposit date:2012-11-28
Release date:2013-03-27
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Mechanistic insights revealed by the crystal structure of a histidine kinase with signal transducer and sensor domains
Plos Biol., 11, 2013
4RBW
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 5, HD5 (THR7ARG GLU21ARG MUTANT)
Descriptor:Defensin-5, SULFATE ION, CHLORIDE ION
Authors:Pazgier, M., Gohain, N., Tolbert, W.D.
Deposit date:2014-09-13
Release date:2015-07-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Design of a potent antibiotic peptide based on the active region of human defensin 5.
J.Med.Chem., 58, 2015
4RBX
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 5, HD5 (GLU21ARG MUTANT)
Descriptor:Defensin-5, SULFATE ION
Authors:Pazgier, M., Gohain, N., Tolbert, W.D.
Deposit date:2014-09-13
Release date:2015-07-29
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Design of a potent antibiotic peptide based on the active region of human defensin 5.
J.Med.Chem., 58, 2015
5XN5
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HOMO-DIMER CRYSTAL STRUCTURE OF GERANYLGERANYL DIPHOSPHATE SYNTHASES 1 FROM ORYZA SATIVA
Descriptor:Os07g0580900 protein
Authors:Wang, C., Zhou, F., Lu, S., Zhang, P.
Deposit date:2017-05-18
Release date:2017-06-21
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:A recruiting protein of geranylgeranyl diphosphate synthase controls metabolic flux toward chlorophyll biosynthesis in rice
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5XN6
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HETERODIMER CRYSTAL STRUCTURE OF GERANYLGERANYL DIPHOSPHATE SYNTHASES 1 WITH GGPPS RECRUITING PROTEIN(OSGRP) FROM ORYZA SATIVA
Descriptor:Os07g0580900 protein, Os02g0668100 protein
Authors:Wang, C., Zhou, F., Lu, S., Zhang, P.
Deposit date:2017-05-18
Release date:2017-06-28
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (3.598 Å)
Cite:A recruiting protein of geranylgeranyl diphosphate synthase controls metabolic flux toward chlorophyll biosynthesis in rice
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5VBU
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CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 21A2 HYDROXYPROGESTERONE COMPLEX
Descriptor:Cytochrome P450 21-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, (9beta)-17-hydroxypregn-4-ene-3,20-dione
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-03-30
Release date:2017-05-31
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Functional analysis of human cytochrome P450 21A2 variants involved in congenital adrenal hyperplasia.
J. Biol. Chem., 292, 2017