Author results

5H14
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EED IN COMPLEX WITH AN ALLOSTERIC PRC2 INHIBITOR EED666
Descriptor:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, GLYCEROL, ...
Authors:Zhao, K., Zhao, M., Luo, X., Zhang, H.
Deposit date:2016-10-08
Release date:2017-01-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
PLoS ONE, 12, 2017
5H15
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EED IN COMPLEX WITH PRC2 ALLOSTERIC INHIBITOR EED709
Descriptor:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, (3R,4S)-1-[(2-methoxyphenyl)methyl]-N,N-dimethyl-4-(1-methylindol-3-yl)pyrrolidin-3-amine
Authors:Zhao, K., Zhao, M., Luo, X., Zhang, H.
Deposit date:2016-10-08
Release date:2017-01-25
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
PLoS ONE, 12, 2017
5H17
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EED IN COMPLEX WITH PRC2 ALLOSTERIC INHIBITOR EED210
Descriptor:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, (3R,4aS,10aS)-6-methoxy-3-[(3-methoxyphenyl)methyl]-1-methyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinoline
Authors:Zhao, K., Zhao, M., Luo, X., Zhang, H.
Deposit date:2016-10-08
Release date:2017-01-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
PLoS ONE, 12, 2017
3WOH
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STRUCTURE OF KETOREDUCTASE SIAM FROM STREPTOMYCES SP. A7248
Descriptor:SiaM
Authors:Wang, H., Zhang, H.
Deposit date:2013-12-29
Release date:2014-08-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insight into the tetramerization of an iterative ketoreductase siam through aromatic residues in the interfaces
Plos One, 9, 2014
1RKU
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CRYSTAL STRUCTURE OF THRH GENE PRODUCT OF PSEUDOMONAS AERUGINOSA
Descriptor:homoserine kinase, MAGNESIUM ION, 1,2-ETHANEDIOL
Authors:Singh, S.K., Yang, K., Subramanian, K., Karthikeyan, S., Huynh, T., Zhang, X., Phillips, M.A., Zhang, H.
Deposit date:2003-11-23
Release date:2004-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:The thrH Gene Product of Pseudomonas aeruginosa Is a Dual Activity Enzyme with a Novel Phosphoserine:Homoserine Phosphotransferase Activity.
J.Biol.Chem., 279, 2004
1RKV
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STRUCTURE OF PHOSPHATE COMPLEX OF THRH FROM PSEUDOMONAS AERUGINOSA
Descriptor:homoserine kinase, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Singh, S.K., Yang, K., Subramanian, K., Karthikeyan, S., Huynh, T., Zhang, X., Phillips, M.A., Zhang, H.
Deposit date:2003-11-23
Release date:2004-03-30
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The thrH Gene Product of Pseudomonas aeruginosa Is a Dual Activity Enzyme with a Novel Phosphoserine:Homoserine Phosphotransferase Activity.
J.Biol.Chem., 279, 2004
1VYT
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BETA3 SUBUNIT COMPLEXED WITH AID
Descriptor:CALCIUM CHANNEL BETA-3 SUBUNIT, VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL ALPHA-1C SUBUNIT
Authors:Chen, Y.-H., Li, M.-H., Zhang, Y., He, L.-L., Yamada, Y., Fitzmaurice, A., Yang, S., Zhang, H., Tong, L., Yang, J.
Deposit date:2004-05-07
Release date:2004-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Basis of the Alpha(1)-Beta Subunit Interaction of Voltage-Gated Ca(2+) Channels
Nature, 429, 2004
1VYU
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BETA3 SUBUNIT OF VOLTAGE-GATED CA2+-CHANNEL
Descriptor:CALCIUM CHANNEL BETA-3 SUBUNIT
Authors:Chen, Y.-H., Li, M.-H., Zhang, Y., He, L.-L., Yamada, Y., Fitzmaurice, A., Yang, S., Zhang, H., Liang, T., Yang, J.
Deposit date:2004-05-07
Release date:2004-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis of the Alpha(1)-Beta Subunit Interaction of Voltage-Gated Ca(2+) Channels
Nature, 429, 2004
1VYV
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BETA4 SUBUNIT OF CA2+ CHANNEL
Descriptor:CALCIUM CHANNEL BETA-4SUBUNIT
Authors:Chen, Y.-H., Li, M.-H., Zhang, Y., He, L.-L., Yamada, Y., Fitzmaurice, A., Yang, S., Zhang, H., Liang, T., Yang, J.
Deposit date:2004-05-07
Release date:2004-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Basis of the Alpha(1)-Beta Subunit Interaction of Voltage-Gated Ca(2+) Channels
Nature, 429, 2004
2NYD
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS HYPOTHETICAL PROTEIN SA1388
Descriptor:UPF0135 protein SA1388, ZINC ION
Authors:Singh, K.S., Zhang, X., Zhang, H.
Deposit date:2006-11-20
Release date:2007-01-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a conserved hypothetical protein SA1388 from S. aureus reveals a capped hexameric toroid with two PII domain lids and a dinuclear metal center.
Bmc Struct.Biol., 6, 2006
2QJO
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CRYSTAL STRUCTURE OF A BIFUNCTIONAL NMN ADENYLYLTRANSFERASE/ADP RIBOSE PYROPHOSPHATASE (NADM) COMPLEXED WITH ADPRP AND NAD FROM SYNECHOCYSTIS SP.
Descriptor:Bifunctional NMN adenylyltransferase/Nudix hydrolase, SULFATE ION, ADENOSINE-5-DIPHOSPHORIBOSE, ...
Authors:Huang, N., Sorci, L., Zhang, X., Brautigan, C., Raffaelli, N., Magni, G., Grishin, N.V., Osterman, A., Zhang, H.
Deposit date:2007-07-08
Release date:2008-03-11
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Bifunctional NMN Adenylyltransferase/ADP-Ribose Pyrophosphatase: Structure and Function in Bacterial NAD Metabolism.
Structure, 16, 2008
2QJT
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CRYSTAL STRUCTURE OF A BIFUNCTIONAL NMN ADENYLYLTRANSFERASE/ADP RIBOSE PYROPHOSPHATASE COMPLEXED WITH AMP AND MN ION FROM FRANCISELLA TULARENSIS
Descriptor:Nicotinamide-nucleotide adenylyltransferase, MANGANESE (II) ION, ADENOSINE MONOPHOSPHATE
Authors:Huang, N., Sorci, L., Zhang, X., Brautigan, C., Raffaelli, N., Magni, G., Grishin, N.V., Osterman, A., Zhang, H.
Deposit date:2007-07-09
Release date:2008-03-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Bifunctional NMN Adenylyltransferase/ADP-Ribose Pyrophosphatase: Structure and Function in Bacterial NAD Metabolism.
Structure, 16, 2008
2R5W
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CRYSTAL STRUCTURE OF A BIFUNCTIONAL NMN ADENYLYLTRANSFERASE/ADP RIBOSE PYROPHOSPHATASE FROM FRANCISELLA TULARENSIS
Descriptor:Nicotinamide-nucleotide adenylyltransferase, MAGNESIUM ION, CHLORIDE ION
Authors:Huang, N., Sorci, L., Zhang, X., Brautigan, C., Li, X., Raffaelli, N., Grishin, N., Osterman, A., Zhang, H.
Deposit date:2007-09-04
Release date:2008-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Bifunctional NMN Adenylyltransferase/ADP-Ribose Pyrophosphatase: Structure and Function in Bacterial NAD Metabolism.
Structure, 16, 2008
3L8I
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CRYSTAL STRUCTURE OF CCM3, A CEREBRAL CAVERNOUS MALFORMATION PROTEIN CRITICAL FOR VASCULAR INTEGRITY
Descriptor:Programmed cell death protein 10
Authors:Li, X., Zhang, R., Zhang, H., He, Y., Ji, W., Min, W., Boggon, T.J.
Deposit date:2009-12-31
Release date:2010-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity.
J.Biol.Chem., 285, 2010
3L8J
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CRYSTAL STRUCTURE OF CCM3, A CEREBRAL CAVERNOUS MALFORMATION PROTEIN CRITICAL FOR VASCULAR INTEGRITY
Descriptor:Programmed cell death protein 10
Authors:Li, X., Zhang, R., Zhang, H., He, Y., Ji, W., Min, W., Boggon, T.J.
Deposit date:2009-12-31
Release date:2010-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity.
J.Biol.Chem., 285, 2010
3LNL
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS PROTEIN SA1388
Descriptor:UPF0135 protein SA1388, ZINC ION, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Singh, K.S., Chruszcz, M., Zhang, X., Minor, W., Zhang, H.
Deposit date:2010-02-02
Release date:2010-03-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a Conserved Hypothetical Protein Sa1388 from S. aureus Reveals a Capped Hexameric Toroid with Two Pii Domain Lids and a Dinuclear Metal Center.
Bmc Struct.Biol., 6, 2006
3R1A
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CLOSED CRYSTAL STRUCTURE OF CYTOCHROME P450 2B4 COVALENTLY BOUND TO THE MECHANISM-BASED INACTIVATOR TERT-BUTYLPHENYLACETYLENE
Descriptor:Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, (4-tert-butylphenyl)acetaldehyde
Authors:Gay, S.C., Zhang, H., Stout, C.D., Hollenberg, P.F., Halpert, J.R.
Deposit date:2011-03-09
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert-Butylphenylacetylene: Insight into Partial Enzymatic Activity.
Biochemistry, 50, 2011
3R1B
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OPEN CRYSTAL STRUCTURE OF CYTOCHROME P450 2B4 COVALENTLY BOUND TO THE MECHANISM-BASED INACTIVATOR TERT-BUTYLPHENYLACETYLENE
Descriptor:Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, (4-tert-butylphenyl)acetaldehyde, ...
Authors:Gay, S.C., Zhang, H., Stout, C.D., Hollenberg, P.F., Halpert, J.R.
Deposit date:2011-03-09
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert-Butylphenylacetylene: Insight into Partial Enzymatic Activity.
Biochemistry, 50, 2011
4I5X
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CRYSTAL STRUCTURE OF AKR1B10 COMPLEXED WITH NADP+ AND FLUFENAMIC ACID
Descriptor:Aldo-keto reductase family 1 member B10, 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zhang, L., Zheng, X., Chen, S., Zhai, J., Zhang, H., Zhao, Y.
Deposit date:2012-11-29
Release date:2013-10-23
Last modified:2013-12-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111)
Febs Lett., 587, 2013
4JIH
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CRYSTAL STRUCTURE OF AKR1B10 COMPLEXED WITH NADP+ AND EPALRESTAT
Descriptor:Aldo-keto reductase family 1 member B10, {5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zhang, L., Zheng, X., Zhang, H., Zhao, Y., Chen, K., Zhai, J., Hu, X., Structural Genomics Consortium (SGC)
Deposit date:2013-03-06
Release date:2013-10-23
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111).
Febs Lett., 587, 2013
4JII
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CRYSTAL STRUCTURE OF AKR1B10 COMPLEXED WITH NADP+ AND ZOPOLRESTAT
Descriptor:Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, ...
Authors:Zhang, L., Zheng, X., Zhang, H., Zhao, Y., Chen, K., Zhai, J., Hu, X., Structural Genomics Consortium (SGC)
Deposit date:2013-03-06
Release date:2013-10-23
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111).
Febs Lett., 587, 2013
4JIR
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CRYSTAL STRUCTURE OF ALDOSE REDUCTASE (AKR1B1) COMPLEXED WITH NADP+ AND EPALRESTAT
Descriptor:Aldose reductase, {5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid, SULFATE ION, ...
Authors:Zhang, L., Zheng, X., Zhang, H., Zhao, Y., Chen, K., Zhai, J., Hu, X.
Deposit date:2013-03-06
Release date:2013-10-23
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111).
Febs Lett., 587, 2013
4KYH
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CRYSTAL STRUCTURE OF MOUSE GLYOXALASE I COMPLEXED WITH ZOPOLRESTAT
Descriptor:Lactoylglutathione lyase, ZINC ION, 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID
Authors:Zhai, J., Yuan, M., Zhang, L., Chen, Y., Zhang, H., Chen, S., Zhao, Y.
Deposit date:2013-05-29
Release date:2013-08-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis
Chemmedchem, 2013
4KYK
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CRYSTAL STRUCTURE OF MOUSE GLYOXALASE I COMPLEXED WITH INDOMETHACIN
Descriptor:Lactoylglutathione lyase, ZINC ION, INDOMETHACIN
Authors:Zhai, J., Yuan, M., Zhang, L., Chen, Y., Zhang, H., Chen, S., Zhao, Y.
Deposit date:2013-05-29
Release date:2013-08-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis
Chemmedchem, 2013
1VQB
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GENE V PROTEIN (SINGLE-STRANDED DNA BINDING PROTEIN)
Descriptor:GENE V PROTEIN
Authors:Skinner, M.M., Zhang, H., Leschnitzer, D.H., Guan, Y., Bellamy, H., Sweet, R.M., Gray, C.W., Konings, R.N.H., Wang, A.H.-J., Terwilliger, T.C.
Deposit date:1996-08-14
Release date:1997-02-12
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the gene V protein of bacteriophage f1 determined by multiwavelength x-ray diffraction on the selenomethionyl protein.
Proc.Natl.Acad.Sci.USA, 91, 1994