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3G4A
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BU of 3g4a by Molmil
Crystal structure of flavine dependant thymidylate synthase S88A mutant from Thermotoga maritima at 1.95 angstrom resolution
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, Thymidylate synthase thyX
Authors:Mathews, I.I, Lesley, S.A, Kohen, A.
Deposit date:2009-02-03
Release date:2009-04-07
Last modified:2023-02-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene.
Nature, 458, 2009
3G4C
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BU of 3g4c by Molmil
Flavine dependant thymidylate syntahse S88C mutant
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, Thymidylate synthase thyX
Authors:Mathews, I.I, Lesley, S.A, Kohen, A.
Deposit date:2009-02-03
Release date:2009-04-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene.
Nature, 458, 2009
2AQX
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BU of 2aqx by Molmil
Crystal Structure of the Catalytic and CaM-Binding domains of Inositol 1,4,5-Trisphosphate 3-Kinase B
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PREDICTED: inositol 1,4,5-trisphosphate 3-kinase B
Authors:Chamberlain, P.P, Sandberg, M.L, Sauer, K, Cooke, M.P, Lesley, S.A, Spraggon, G.
Deposit date:2005-08-18
Release date:2005-12-06
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B
Biochemistry, 44, 2005
1LM4
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BU of 1lm4 by Molmil
Structure of Peptide Deformylase from Staphylococcus aureus at 1.45 A
Descriptor: FE (III) ION, GLYCEROL, peptide deformylase PDF1
Authors:Kreusch, A, Spraggon, G, Lee, C.C, Klock, H, McMullan, D, Ng, K, Shin, T, Vincent, J, Warner, I, Ericson, C, Lesley, S.A.
Deposit date:2002-04-30
Release date:2003-06-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure analysis of peptide deformylases from streptococcus pneumoniae,staphylococcus aureus, thermotoga maritima, and pseudomonas aeruginosa: snapshots of the oxygen sensitivity of peptide deformylase
J.MOL.BIOL., 330, 2003
1LME
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BU of 1lme by Molmil
Crystal Structure of Peptide Deformylase from Thermotoga maritima
Descriptor: peptide deformylase
Authors:Kreusch, A, Spraggon, G, Lee, C.C, Klock, H, McMullan, D, Ng, K, Shin, T, Vincent, J, Warner, I, Ericson, C, Lesley, S.A, Joint Center for Structural Genomics (JCSG)
Deposit date:2002-05-01
Release date:2003-06-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure analysis of peptide deformylases from streptococcus pneumoniae,staphylococcus aureus, thermotoga maritima, and pseudomonas aeruginosa: snapshots of the oxygen sensitivity of peptide deformylase
J.MOL.BIOL., 330, 2003
1LM6
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BU of 1lm6 by Molmil
Crystal Structure of Peptide Deformylase from Streptococcus pneumoniae
Descriptor: FE (III) ION, GLYCEROL, peptide deformylase DEFB
Authors:Kreusch, A, Spraggon, G, Lee, C.C, Klock, H, McMullan, D, Ng, K, Shin, T, Vincent, J, Warner, I, Ericson, C, Lesley, S.A.
Deposit date:2002-04-30
Release date:2003-06-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure analysis of peptide deformylases from streptococcus pneumoniae,staphylococcus aureus, thermotoga maritima, and pseudomonas aeruginosa: snapshots of the oxygen sensitivity of peptide deformylase
J.MOL.BIOL., 330, 2003
2VKJ
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BU of 2vkj by Molmil
Structure of the soluble domain of the membrane protein TM1634 from Thermotoga maritima
Descriptor: SULFATE ION, TM1634
Authors:McCleverty, C.J, Columbus, L, Kreusch, A, Lesley, S.A, Joint Center for Structural Genomics (JCSG)
Deposit date:2007-12-19
Release date:2008-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure and Ligand Binding of the Soluble Domain of a Thermotoga Maritima Membrane Protein of Unknown Function Tm1634.
Protein Sci., 17, 2008
2VKO
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BU of 2vko by Molmil
Structure of the soluble domain of the membrane protein TM1634 from Thermotoga maritima
Descriptor: HEXAETHYLENE GLYCOL, TETRAETHYLENE GLYCOL, TM1634
Authors:McCleverty, C.J, Columbus, L, Kreusch, A, Lesley, S.A, Joint Center for Structural Genomics (JCSG)
Deposit date:2007-12-20
Release date:2008-04-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structure and Ligand Binding of the Soluble Domain of a Thermotoga Maritima Membrane Protein of Unknown Function Tm1634.
Protein Sci., 17, 2008
4GTC
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BU of 4gtc by Molmil
T. Maritima FDTS (E144R mutant) plus FAD
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Thymidylate synthase thyX
Authors:Mathews, I.I, Lesley, S.A, Kohen, A, Prabhakar, A.
Deposit date:2012-08-28
Release date:2012-10-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Folate binding site of flavin-dependent thymidylate synthase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GT9
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BU of 4gt9 by Molmil
T. Maritima FDTS with FAD, dUMP and Folate.
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Mathews, I.I, Lesley, S.A, Kohen, A.
Deposit date:2012-08-28
Release date:2012-10-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Folate binding site of flavin-dependent thymidylate synthase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GTD
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BU of 4gtd by Molmil
T. Maritima FDTS (E144R mutant) with FAD and dUMP
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, Thymidylate synthase thyX
Authors:Mathews, I.I, Lesley, S.A, Kohen, A, Prabhakar, A.
Deposit date:2012-08-28
Release date:2012-10-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Folate binding site of flavin-dependent thymidylate synthase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GTE
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BU of 4gte by Molmil
T. Maritima FDTS (E144R mutant) with FAD and Folate
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, N-({4-[(6aR)-3-amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]phenyl}carbonyl)-L-glutamic acid, Thymidylate synthase thyX
Authors:Mathews, I.I, Lesley, S.A, Kohen, A, Prabhakar, A.
Deposit date:2012-08-28
Release date:2012-10-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Folate binding site of flavin-dependent thymidylate synthase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GTF
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BU of 4gtf by Molmil
T. Maritima FDTS (H53A mutant) with FAD, dUMP and Folate
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Mathews, I.I, Lesley, S.A, Kohen, A.
Deposit date:2012-08-28
Release date:2012-10-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Folate binding site of flavin-dependent thymidylate synthase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GTA
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BU of 4gta by Molmil
T. Maritima FDTS with FAD, dUMP, and Folinic Acid
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Mathews, I.I, Lesley, S.A, Kohen, A.
Deposit date:2012-08-28
Release date:2012-10-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Folate binding site of flavin-dependent thymidylate synthase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GTB
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BU of 4gtb by Molmil
T. Maritima FDTS with FAD, dUMP, and Raltitrexed.
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Mathews, I.I, Lesley, S.A, Kohen, A.
Deposit date:2012-08-28
Release date:2012-10-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Folate binding site of flavin-dependent thymidylate synthase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GTL
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BU of 4gtl by Molmil
T. Maritima FDTS (R174K mutant) with FAD
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Thymidylate synthase thyX
Authors:Mathews, I.I, Lesley, S.A, Kohen, A.
Deposit date:2012-08-28
Release date:2012-10-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Folate binding site of flavin-dependent thymidylate synthase.
Proc.Natl.Acad.Sci.USA, 109, 2012
2OP3
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BU of 2op3 by Molmil
The structure of cathepsin S with a novel 2-arylphenoxyacetaldehyde inhibitor derived by the Substrate Activity Screening (SAS) method
Descriptor: 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL, 2-[(2',3',4'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOL, Cathepsin S, ...
Authors:Spraggon, G, Inagaki, H, Tsuruoka, H, Hornsby, M, Lesley, S.A, Ellman, J.A.
Deposit date:2007-01-26
Release date:2007-05-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode.
J.Med.Chem., 50, 2007
2Q7D
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BU of 2q7d by Molmil
Crystal Structure of Human Inositol 1,3,4-Trisphosphate 5/6-kinase (ITPK1) in complex with AMPPNP and Mn2+
Descriptor: Inositol-tetrakisphosphate 1-kinase, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Chamberlain, P.P, Lesley, S.A, Spraggon, G.
Deposit date:2007-06-06
Release date:2007-07-03
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Integration of inositol phosphate signaling pathways via human ITPK1.
J.Biol.Chem., 282, 2007
2QB5
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BU of 2qb5 by Molmil
Crystal Structure of Human Inositol 1,3,4-Trisphosphate 5/6-Kinase (ITPK1) in Complex with ADP and Mn2+
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Inositol-tetrakisphosphate 1-kinase, MANGANESE (II) ION, ...
Authors:Chamberlain, P.P, Lesley, S.A, Spraggon, G.
Deposit date:2007-06-15
Release date:2007-07-03
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Integration of inositol phosphate signaling pathways via human ITPK1.
J.Biol.Chem., 282, 2007
2QTW
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BU of 2qtw by Molmil
The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals structural homology to Resistin within the C-terminal domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Proprotein convertase subtilisin/kexin type 9, ...
Authors:Hampton, E.N, Knuth, M.W, Li, J, Harris, J.L, Lesley, S.A, Spraggon, G.
Deposit date:2007-08-02
Release date:2007-09-18
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain.
Proc.Natl.Acad.Sci.Usa, 104, 2007
1SJ5
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BU of 1sj5 by Molmil
Crystal structure of a duf151 family protein (tm0160) from thermotoga maritima at 2.8 A resolution
Descriptor: conserved hypothetical protein TM0160
Authors:Spraggon, G, Panatazatos, D, Klock, H.E, Wilson, I.A, Woods Jr, V.L, Lesley, S.A, Joint Center for Structural Genomics (JCSG)
Deposit date:2004-03-02
Release date:2005-03-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:On the use of DXMS to produce more crystallizable proteins: structures of the T. maritima proteins TM0160 and TM1171.
Protein Sci., 13, 2004
3GYM
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BU of 3gym by Molmil
Structure of Prostasin in Complex with Aprotinin
Descriptor: Pancreatic trypsin inhibitor, Prostasin
Authors:Spraggon, G, Hornsby, M, Shipway, A, Harris, J.L, Lesley, S.A.
Deposit date:2009-04-03
Release date:2009-05-05
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.
Protein Sci., 18, 2009
3GYL
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BU of 3gyl by Molmil
Structure of Prostasin at 1.3 Angstroms resolution in complex with a Calcium Ion.
Descriptor: CALCIUM ION, GLYCEROL, Prostasin
Authors:Spraggon, G, Hornsby, M, Shipway, A, Harris, J.L, Lesley, S.A.
Deposit date:2009-04-03
Release date:2009-04-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.
Protein Sci., 18, 2009
3JXO
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BU of 3jxo by Molmil
Crystal Structure of an Octomeric Two-Subunit TrkA K+ Channel Ring Gating Assembly, TM1088A:TM1088B, from Thermotoga maritima
Descriptor: TrkA-N domain protein
Authors:Deller, M.C, Johnson, H.A, Miller, M, Spraggon, G, Wilson, I.A, Lesley, S.A, Joint Center for Structural Genomics (JCSG)
Deposit date:2009-09-20
Release date:2009-10-06
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal Structure of an Octomeric Two-Subunit TrkA K+ Channel Ring Gating Assembly, TM1088A:TM1088B, from Thermotoga maritima
To be Published
2IUB
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BU of 2iub by Molmil
Crystal structure of a divalent metal ion transporter CorA at 2.9 A resolution.
Descriptor: CHLORIDE ION, DIVALENT CATION TRANSPORT-RELATED PROTEIN, MAGNESIUM ION
Authors:Eshaghi, S, Niegowski, D, Kohl, A, Martinez Molina, D, Lesley, S.A, Nordlund, P.
Deposit date:2006-06-01
Release date:2006-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of a Divalent Metal Ion Transporter Cora at 2.9 Angstrom Resolution.
Science, 313, 2006

217705

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