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478D
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CRYSTAL STRUCTURE OF THE B-DNA DODECAMER 5'-D(CGCGAA(TAF)TCGCG), WHERE TAF IS 2'-DEOXY-2'-FLUORO-ARABINO-FURANOSYL THYMINE
Descriptor:5'-D(*CP*GP*CP*GP*AP*AP*(TAF)P*TP*CP*GP*CP*G)-3', CALCIUM ION
Authors:Minasov, G., Tereshko, V., Egli, M.
Deposit date:1999-06-26
Release date:1999-07-19
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Atomic-resolution crystal structures of B-DNA reveal specific influences of divalent metal ions on conformation and packing.
J.Mol.Biol., 291, 1999
4F2X
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STRUCTURE OF 3'-FLUORO CYCLOHEXENYL NUCLEIC ACID HEPTAMER
Descriptor:5'-D(*GP*CP*GP*(XTF)P*GP*CP*G)-3', 5'-D(*CP*GP*CP*AP*CP*GP*C)-3', COBALT HEXAMMINE(III), ...
Authors:Pallan, P.S., Egli, M.
Deposit date:2012-05-08
Release date:2012-05-30
Last modified:2012-06-13
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Synthesis and Antisense Properties of Fluoro Cyclohexenyl Nucleic Acid (F-CeNA), a Nuclease Stable Mimic of 2'-Fluoro RNA.
J.Org.Chem., 77, 2012
4F2Y
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STRUCTURE OF 3'-FLUORO CYCLOHEXENYL NUCLEIC ACID DECAMER
Descriptor:5'-D(*GP*CP*GP*TP*AP*(XTF)P*AP*CP*GP*C)-3', MAGNESIUM ION
Authors:Pallan, P.S., Egli, M.
Deposit date:2012-05-08
Release date:2012-05-30
Last modified:2012-06-13
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Synthesis and Antisense Properties of Fluoro Cyclohexenyl Nucleic Acid (F-CeNA), a Nuclease Stable Mimic of 2'-Fluoro RNA.
J.Org.Chem., 77, 2012
4G86
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CRYSTAL STRUCTURE OF THE REDOX-ACTIVE COFACTOR DBMIB BOUND TO THE FULL LENGTH CIRCADIAN CLOCK PROTEIN KAIA FROM SYNECHOCOCCUS ELONGATUS
Descriptor:Circadian clock protein kaiA, 2,5-DIBROMO-3-ISOPROPYL-6-METHYLBENZO-1,4-QUINONE, PENTAETHYLENE GLYCOL, ...
Authors:Pattanayek, R., Egli, M.
Deposit date:2012-07-21
Release date:2012-10-24
Last modified:2013-03-06
Method:X-RAY DIFFRACTION (2.387 Å)
Cite:Crystal Structure of the Redox-Active Cofactor Dibromothymoquinone Bound to Circadian Clock Protein KaiA and Structural Basis for Dibromothymoquinone's Ability to Prevent Stimulation of KaiC Phosphorylation by KaiA.
Biochemistry, 51, 2012
4HQH
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DECAMER FLUORO CARBOCYCLIC LNA (R-F-CLNA) CRYSTAL STRUCTURE
Descriptor:DNA (5'-D(*GP*CP*GP*TP*AP*(ULF)P*AP*CP*GP*C)-3')
Authors:Seth, P.P., Pallan, P.S., Swayze, E.E., Egli, M.
Deposit date:2012-10-25
Release date:2013-11-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Properties of a Fluorinated Carbocyclic LNA Analog
To be Published
4HQI
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STRUCTURE OF O6-BENZYL-2'-DEOXYGUANOSINE OPPOSITE PERIMIDINONE-DERIVED SYNTHETIC NUCLEOSIDE IN DNA DUPLEX
Descriptor:Short modified nucleic acids, SPERMINE, STRONTIUM ION
Authors:Kowal, E.A., Lad, R., Pallan, P.S., Muffly, E., Wawrzak, Z., Egli, M., Sturla, S.J., Stone, M.P.
Deposit date:2012-10-25
Release date:2013-07-10
Last modified:2013-09-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Recognition of O6-benzyl-2'-deoxyguanosine by a perimidinone-derived synthetic nucleoside: a DNA interstrand stacking interaction.
Nucleic Acids Res., 41, 2013
4HTU
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STRUCTURE OF 5-CHLOROURACIL MODIFIED A:U BASE PAIR
Descriptor:Ribonuclease H, DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*(UCL)P*CP*GP*CP*G)-3'), MAGNESIUM ION, ...
Authors:Patra, A., Egli, M.
Deposit date:2012-11-01
Release date:2012-12-19
Last modified:2013-03-27
Method:X-RAY DIFFRACTION (1.489 Å)
Cite:Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs.
Nucleic Acids Res., 41, 2013
4HUE
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STRUCTURE OF 5-CHLOROURACIL MODIFIED G:U BASE PAIR
Descriptor:Ribonuclease H, DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*(UCL)P*GP*CP*G)-3'), GLYCEROL, ...
Authors:Patra, A., Egli, M.
Deposit date:2012-11-02
Release date:2012-12-19
Last modified:2013-03-27
Method:X-RAY DIFFRACTION (1.561 Å)
Cite:Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs.
Nucleic Acids Res., 41, 2013
4HUF
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STRUCTURE OF 5-CHLOROURACIL MODIFIED A:U BASE PAIR
Descriptor:Ribonuclease H, DNA (5'-D(*CP*GP*CP*GP*AP*AP*(UCL)P*TP*CP*GP*CP*G)-3'), GLYCEROL, ...
Authors:Patra, A., Egli, M.
Deposit date:2012-11-02
Release date:2012-12-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs.
Nucleic Acids Res., 41, 2013
4HUG
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STRUCTURE OF 5-CHLOROURACIL MODIFIED A:U BASE PAIRS
Descriptor:Ribonuclease H, DNA (5'-D(*CP*GP*CP*GP*AP*AP*(UCL)P*(UCL)P*CP*GP*CP*G)-3'), MAGNESIUM ION, ...
Authors:Patra, A., Egli, M.
Deposit date:2012-11-02
Release date:2012-12-19
Last modified:2013-03-27
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs.
Nucleic Acids Res., 41, 2013
4KSO
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CRYSTAL STRUCTURE OF CIRCADIAN CLOCK PROTEIN KAIB FROM S.ELONGATUS
Descriptor:Circadian clock protein KaiB
Authors:Pattanayek, R., Egli, M.
Deposit date:2013-05-17
Release date:2013-07-10
Last modified:2013-09-18
Method:X-RAY DIFFRACTION (2.622 Å)
Cite:CryoEM and Molecular Dynamics of the Circadian KaiB-KaiC Complex Indicates KaiB Monomers Interact with KaiC and Block ATP Binding Clefts.
J.Mol.Biol., 425, 2013
4O0M
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CRYSTAL STRUCTURE OF T. ELONGATUS BP-1 CLOCK PROTEIN KAIC
Descriptor:Circadian clock protein kinase KaiC, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Pattanayek, R., Egli, M.
Deposit date:2013-12-13
Release date:2014-05-14
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:An arginine tetrad as mediator of input-dependent and input-independent ATPases in the clock protein KaiC
Acta Crystallogr.,Sect.D, D70, 2014
4O3N
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CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA IN TERNARY COMPLEX WITH NATIVE DNA AND INCOMING NUCLEOTIDE (DCP)
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*GP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Patra, A., Egli, M.
Deposit date:2013-12-18
Release date:2014-04-30
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (1.579 Å)
Cite:Kinetics, Structure, and Mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Bypass by Human DNA Polymerase eta
J.Biol.Chem., 289, 2014
4O3O
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CRYSTAL STRUCTURE OF HUMAN POLYMERASE ETA INSERTING DATP OPPOSITE AN 8-OXOG CONTAINING DNA TEMPLATE
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Patra, A., Egli, M.
Deposit date:2013-12-18
Release date:2014-04-30
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (1.698 Å)
Cite:Kinetics, Structure, and Mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Bypass by Human DNA Polymerase eta
J.Biol.Chem., 289, 2014
4O3P
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CRYSTAL STRUCTURE OF HUMAN POLYMERASE ETA INSERTING DCTP OPPOSITE AN 8-OXOG CONTAINING DNA TEMPLATE
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Patra, A., Egli, M.
Deposit date:2013-12-18
Release date:2014-04-30
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Kinetics, Structure, and Mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Bypass by Human DNA Polymerase eta
J.Biol.Chem., 289, 2014
4O3Q
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CRYSTAL STRUCTURE OF HUMAN POLYMERASE ETA INSERTING DGTP OPPOSITE AN 8-OXOG CONTAINING DNA TEMPLATE
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Patra, A., Egli, M.
Deposit date:2013-12-18
Release date:2014-04-30
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Kinetics, Structure, and Mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Bypass by Human DNA Polymerase eta
J.Biol.Chem., 289, 2014
4O3R
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CRYSTAL STRUCTURE OF HUMAN POLYMERASE ETA EXTENDING AN 8-OXOG DNA LESION: POST INSERTION OF 8-OXOG-DA PAIR
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*GP*(8OG)P*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*A)-3'), ...
Authors:Patra, A., Egli, M.
Deposit date:2013-12-18
Release date:2014-04-30
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Kinetics, Structure, and Mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Bypass by Human DNA Polymerase eta
J.Biol.Chem., 289, 2014
4O3S
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CRYSTAL STRUCTURE OF HUMAN POLYMERASE ETA EXTENDING AN 8-OXOG DNA LESION: POST INSERTION OF 8-OXOG-DC PAIR
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*GP*(8OG)P*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*C)-3'), ...
Authors:Patra, A., Egli, M.
Deposit date:2013-12-18
Release date:2014-04-30
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (1.717 Å)
Cite:Kinetics, Structure, and Mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Bypass by Human DNA Polymerase eta
J.Biol.Chem., 289, 2014
4O41
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AMIDE LINKED RNA
Descriptor:AMIDE LINKED RNA, STRONTIUM ION
Authors:Pallan, P.S., Egli, M.
Deposit date:2013-12-18
Release date:2014-07-09
Last modified:2014-09-03
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs.
Nucleic Acids Res., 42, 2014
4QC7
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DODECAMER STRUCTURE OF 5-FORMYLCYTOSINE CONTAINING DNA
Descriptor:short DNA strands
Authors:Szulik, M.W., Pallan, P., Egli, M., Stone, M.P.
Deposit date:2014-05-09
Release date:2015-02-11
Last modified:2015-02-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Differential stabilities and sequence-dependent base pair opening dynamics of watson-crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine.
Biochemistry, 54, 2015
4R1Z
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ZEBRA FISH CYTOCHROME P450 17A1 WITH ABIRATERONE
Descriptor:Cyp17a1 protein, PROTOPORPHYRIN IX CONTAINING FE, Abiraterone
Authors:Pallan, P.S., Egli, M.
Deposit date:2014-08-08
Release date:2014-12-31
Last modified:2015-03-04
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural and Kinetic Basis of Steroid 17 alpha, 20-Lyase Activity in Teleost Fish Cytochrome P450 17A1 and Its Absence in Cytochrome P450 17A2.
J.Biol.Chem., 290, 2015
4R20
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ZEBRA FISH CYTOCHROME P450 17A2 WITH ABIRATERONE
Descriptor:Cytochrome P450 family 17 polypeptide 2, PROTOPORPHYRIN IX CONTAINING FE, Abiraterone, ...
Authors:Pallan, P.S., Egli, M.
Deposit date:2014-08-08
Release date:2014-12-31
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Structural and Kinetic Basis of Steroid 17 alpha, 20-Lyase Activity in Teleost Fish Cytochrome P450 17A1 and Its Absence in Cytochrome P450 17A2.
J.Biol.Chem., 290, 2015
4R21
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ZEBRA FISH CYTOCHROME P450 17A2 WITH PROGESTERONE
Descriptor:Cytochrome P450 family 17 polypeptide 2, PROTOPORPHYRIN IX CONTAINING FE, PROGESTERONE
Authors:Pallan, P.S., Egli, M.
Deposit date:2014-08-08
Release date:2014-12-31
Last modified:2015-03-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Kinetic Basis of Steroid 17 alpha, 20-Lyase Activity in Teleost Fish Cytochrome P450 17A1 and Its Absence in Cytochrome P450 17A2.
J.Biol.Chem., 290, 2015
4RNM
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CRYSTAL STRUCTURE OF HUMAN POLYMERASE ETA INSERTING DAMPNPP OPPOSITE DNA TEMPLATE CONTAINING AN ABASIC SITE
Descriptor:DNA polymerase eta, DNA Template: CAT(3DR)ATGACGCT, DNA Primar: AGCGTCAT, ...
Authors:Patra, A., Egli, M.
Deposit date:2014-10-24
Release date:2015-02-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.144 Å)
Cite:Structural and Kinetic Analysis of Nucleoside Triphosphate Incorporation Opposite an Abasic Site by Human Translesion DNA Polymerase eta.
J.Biol.Chem., 290, 2015
4RNN
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CRYSTAL STRUCTURE OF HUMAN POLYMERASE ETA INSERTING DGMPNPP OPPOSITE DNA TEMPLATE CONTAINING AN ABASIC SITE
Descriptor:DNA polymerase eta, Nucleic acids Template: CAT(3DR)ATGACGCT, Nucleic acids Primar: AGCGTCAT, ...
Authors:Patra, A., Egli, M.
Deposit date:2014-10-24
Release date:2015-02-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.808 Å)
Cite:Structural and Kinetic Analysis of Nucleoside Triphosphate Incorporation Opposite an Abasic Site by Human Translesion DNA Polymerase eta.
J.Biol.Chem., 290, 2015