6TYD
 
 | | Structure of human LDB1 in complex with SSBP2 | | Descriptor: | LIM domain-binding protein 1, Single-stranded DNA-binding protein 2 | | Authors: | Wang, H, Wang, Z, Xu, W. | | Deposit date: | 2019-08-08 | | Release date: | 2020-01-01 | | Last modified: | 2020-01-29 | | Method: | X-RAY DIFFRACTION (2.803 Å) | | Cite: | Crystal structure of human LDB1 in complex with SSBP2.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6T9K
 | | SAGA Core module | | Descriptor: | Protein SPT3, SAGA-associated factor 73, Transcription factor SPT20, ... | | Authors: | Wang, H, Cheung, A, Cramer, P. | | Deposit date: | 2019-10-28 | | Release date: | 2020-01-29 | | Last modified: | 2020-02-19 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure of the transcription coactivator SAGA.
Nature, 577, 2020
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6T9J
 | | SAGA Tra1 module | | Descriptor: | Transcription factor SPT20, Transcription initiation factor TFIID subunit 12, Transcription-associated protein 1 | | Authors: | Wang, H, Cheung, A, Cramer, P. | | Deposit date: | 2019-10-28 | | Release date: | 2020-01-29 | | Last modified: | 2020-02-19 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structure of the transcription coactivator SAGA.
Nature, 577, 2020
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6T9I
 | | cryo-EM structure of transcription coactivator SAGA | | Descriptor: | Protein SPT3, SAGA-associated factor 73, Transcription factor SPT20, ... | | Authors: | Wang, H, Cheung, A, Cramer, P. | | Deposit date: | 2019-10-28 | | Release date: | 2020-01-29 | | Last modified: | 2020-02-19 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structure of the transcription coactivator SAGA.
Nature, 577, 2020
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6T9L
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8BZN
 | | SARS-CoV-2 non-structural protein 10 (nsp10) variant T102I | | Descriptor: | CHLORIDE ION, DIMETHYL SULFOXIDE, Replicase polyprotein 1ab, ... | | Authors: | Wang, H, Rizvi, S.R.A, Dong, D, Lou, J, Wang, Q, Sopipong, W, Najar, F, Agarwal, P.K, Kozielski, F, Haider, S. | | Deposit date: | 2022-12-15 | | Release date: | 2023-12-27 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16.
Elife, 12, 2023
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8EAT
 | | Yeast VO missing subunits a, e, and f in complex with Vma12-22p | | Descriptor: | V-type proton ATPase subunit F, V-type proton ATPase subunit c, V-type proton ATPase subunit c', ... | | Authors: | Wang, H, Bueler, S.A, Rubinstein, J.L. | | Deposit date: | 2022-08-29 | | Release date: | 2022-11-02 | | Last modified: | 2023-02-15 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis of V-ATPase V O region assembly by Vma12p, 21p, and 22p.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8EAU
 | | Yeast VO in complex with Vma21p | | Descriptor: | V-type proton ATPase subunit a, vacuolar isoform, V-type proton ATPase subunit c, ... | | Authors: | Wang, H, Bueler, S.A, Rubinstein, J.L. | | Deposit date: | 2022-08-29 | | Release date: | 2022-11-02 | | Last modified: | 2023-02-15 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis of V-ATPase V O region assembly by Vma12p, 21p, and 22p.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8EAS
 | | Yeast VO in complex with Vma12-22p | | Descriptor: | V-type proton ATPase assembly factor Vma12p, V-type proton ATPase subunit F, V-type proton ATPase subunit a, ... | | Authors: | Wang, H, Bueler, S.A, Rubinstein, J.L. | | Deposit date: | 2022-08-29 | | Release date: | 2022-11-02 | | Last modified: | 2023-02-15 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Structural basis of V-ATPase V O region assembly by Vma12p, 21p, and 22p.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8EAV
 | | YAR027W and YAR028W in complex with c subunits from yeast VO complex | | Descriptor: | YAR027W or YAR028W, subunit from the c ring of yeast VO complex | | Authors: | Wang, H, Bueler, S.A, Rubinstein, J.L. | | Deposit date: | 2022-08-29 | | Release date: | 2022-11-02 | | Last modified: | 2023-02-15 | | Method: | ELECTRON MICROSCOPY (5.7 Å) | | Cite: | Structural basis of V-ATPase V O region assembly by Vma12p, 21p, and 22p.
Proc.Natl.Acad.Sci.USA, 120, 2023
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2R8Q
 | | Structure of LmjPDEB1 in complex with IBMX | | Descriptor: | 3-ISOBUTYL-1-METHYLXANTHINE, Class I phosphodiesterase PDEB1, MAGNESIUM ION, ... | | Authors: | Wang, H, Yan, Z, Geng, J, Kunz, S, Seebeck, T, Ke, H. | | Deposit date: | 2007-09-11 | | Release date: | 2007-12-18 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors.
Mol.Microbiol., 66, 2007
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2YW8
 | | Crystal structure of human RUN and FYVE domain-containing protein | | Descriptor: | RUN and FYVE domain-containing protein 1, SULFATE ION, ZINC ION | | Authors: | Wang, H, Kishishita, S, Murayama, K, Takemoto, C, Terada, T, Shirouzu, M, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-04-20 | | Release date: | 2008-04-22 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of human RUN and FYVE domain-containing protein
To be Published
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2YV6
 | | Crystal structure of human Bcl-2 family protein Bak | | Descriptor: | Bcl-2 homologous antagonist/killer, SULFATE ION | | Authors: | Wang, H, Kishishita, S, Murayama, K, Takemoto, C, Terada, T, Shirouzu, M, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-04-09 | | Release date: | 2008-04-15 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Novel dimerization mode of the human Bcl-2 family protein Bak, a mitochondrial apoptosis regulator.
J.Struct.Biol., 166, 2009
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1ZKL
 | | Multiple Determinants for Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases | | Descriptor: | 3-ISOBUTYL-1-METHYLXANTHINE, High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A, MAGNESIUM ION, ... | | Authors: | Wang, H, Liu, Y, Chen, Y, Robinson, H, Ke, H. | | Deposit date: | 2005-05-03 | | Release date: | 2005-07-05 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7
J.Biol.Chem., 280, 2005
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2RID
 | | Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with Allyl 7-O-carbamoyl-L-glycero-D-manno-heptopyranoside | | Descriptor: | CALCIUM ION, Pulmonary surfactant-associated protein D, prop-2-en-1-yl 7-O-carbamoyl-L-glycero-alpha-D-manno-heptopyranoside | | Authors: | Wang, H, Head, J, Kosma, P, Sheikh, S, McDonald, B, Smith, K, Cafarella, T, Seaton, B, Crouch, E. | | Deposit date: | 2007-10-10 | | Release date: | 2008-01-15 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Recognition of heptoses and the inner core of bacterial lipopolysaccharides by surfactant protein d.
Biochemistry, 47, 2008
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2RIB
 | | Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with L-glycero-D-manno-heptose | | Descriptor: | CALCIUM ION, L-glycero-alpha-D-manno-heptopyranose, Pulmonary surfactant-associated protein D | | Authors: | Wang, H, Head, J, Kosma, P, Sheikh, S, McDonald, B, Smith, K, Cafarella, T, Seaton, B, Crouch, E. | | Deposit date: | 2007-10-10 | | Release date: | 2008-01-15 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Recognition of heptoses and the inner core of bacterial lipopolysaccharides by surfactant protein d.
Biochemistry, 47, 2008
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2RIA
 | | Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with D-glycero-D-manno-heptose | | Descriptor: | CALCIUM ION, D-glycero-alpha-D-manno-heptopyranose, Pulmonary surfactant-associated protein D | | Authors: | Wang, H, Head, J, Kosma, P, Sheikh, S, McDonald, B, Smith, K, Cafarella, T, Seaton, B, Crouch, E. | | Deposit date: | 2007-10-10 | | Release date: | 2008-01-15 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Recognition of heptoses and the inner core of bacterial lipopolysaccharides by surfactant protein d.
Biochemistry, 47, 2008
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2RIC
 | | Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with L-glycero-D-manno-heptopyranosyl-(1-3)-L-glycero-D-manno-heptopyranose | | Descriptor: | CALCIUM ION, L-glycero-alpha-D-manno-heptopyranose, L-glycero-alpha-D-manno-heptopyranose-(1-3)-L-glycero-alpha-D-manno-heptopyranose, ... | | Authors: | Wang, H, Head, J, Kosma, P, Sheikh, S, McDonald, B, Smith, K, Cafarella, T, Seaton, B, Crouch, E. | | Deposit date: | 2007-10-10 | | Release date: | 2008-01-15 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Recognition of heptoses and the inner core of bacterial lipopolysaccharides by surfactant protein d.
Biochemistry, 47, 2008
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2RIE
 | | Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with 2-deoxy-L-glycero-D-manno-heptose | | Descriptor: | 2-deoxy-beta-L-galacto-heptopyranose, CALCIUM ION, Pulmonary surfactant-associated protein D | | Authors: | Wang, H, Head, J, Kosma, P, Sheikh, S, McDonald, B, Smith, K, Cafarella, T, Seaton, B, Crouch, E. | | Deposit date: | 2007-10-10 | | Release date: | 2008-01-15 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Recognition of heptoses and the inner core of bacterial lipopolysaccharides by surfactant protein d.
Biochemistry, 47, 2008
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6S01
 | | Structure of LEDGF PWWP domain bound H3K36 methylated nucleosome | | Descriptor: | Histone H2A, Histone H2B 1.1, Histone H3, ... | | Authors: | Wang, H, Farnung, L, Dienemann, C, Cramer, P. | | Deposit date: | 2019-06-13 | | Release date: | 2019-12-18 | | Last modified: | 2020-01-22 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of H3K36-methylated nucleosome-PWWP complex reveals multivalent cross-gyre binding.
Nat.Struct.Mol.Biol., 27, 2020
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2CSL
 | | Crystal structure of TTHA0137 from Thermus Thermophilus HB8 | | Descriptor: | protein translation initiation inhibitor | | Authors: | Wang, H, Murayama, K, Terada, T, Chen, L, Jin, Z, Chrzas, J, Liu, Z.J, Wang, B.C, Shirouzu, M, Kuramitsu, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-05-22 | | Release date: | 2005-11-22 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of TTHA0137 from Thermus Thermophilus HB8
To be Published
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6VCD
 | | Cryo-EM structure of IRP2-FBXL5-SKP1 complex | | Descriptor: | F-box/LRR-repeat protein 5, FE2/S2 (INORGANIC) CLUSTER, Iron-responsive element binding protein 2, ... | | Authors: | Wang, H, Shi, H, Zheng, N. | | Deposit date: | 2019-12-20 | | Release date: | 2020-08-05 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster.
Mol.Cell, 78, 2020
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3K3E
 | | Crystal structure of the PDE9A catalytic domain in complex with (R)-BAY73-6691 | | Descriptor: | 1-(2-chlorophenyl)-6-[(2R)-3,3,3-trifluoro-2-methylpropyl]-1,7-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... | | Authors: | Wang, H, Luo, X, Ye, M, Hou, J, Robinson, H, Ke, H. | | Deposit date: | 2009-10-02 | | Release date: | 2010-02-16 | | Last modified: | 2013-11-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis
J.Med.Chem., 53, 2010
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3K3H
 | | Crystal structure of the PDE9A catalytic domain in complex with (S)-BAY73-6691 | | Descriptor: | 1-(2-chlorophenyl)-6-[(2S)-3,3,3-trifluoro-2-methylpropyl]-1,7-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... | | Authors: | Wang, H, Luo, X, Ye, M, Hou, J, Robinson, H, Ke, H. | | Deposit date: | 2009-10-02 | | Release date: | 2010-02-16 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis
J.Med.Chem., 53, 2010
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3WOH
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