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5V2A
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CRYSTAL STRUCTURE OF FAB H7.167 IN COMPLEX WITH INFLUENZA VIRUS HEMAGGLUTININ FROM A/SHANGHAI/02/2013 (H7N9)
Descriptor:Hemagglutinin, Light chain (kappa) of H7.167 antibody, Heavy chain of H7.167 antibody, ...
Authors:Zhang, H., Zhu, X., Wilson, I.A.
Deposit date:2017-03-03
Release date:2017-04-05
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (4.656 Å)
Cite:H7N9 influenza virus neutralizing antibodies that possess few somatic mutations.
J. Clin. Invest., 126, 2016
5W42
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CRYSTAL STRUCTURE OF HUMAN MONOCLONAL ANTIBODY H3V-47 IN COMPLEX WITH INFLUENZA VIRUS HEMAGGLUTININ FROM A/MINNESOTA/11/2010 (H3N2)
Descriptor:Hemagglutinin, Fab H3v-47 heavy chain, Fab H3v-47 light chain, ...
Authors:Zhang, H., Wilson, I.A.
Deposit date:2017-06-08
Release date:2018-07-25
Method:X-RAY DIFFRACTION (3.569 Å)
Cite:A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA.
Nat Commun, 9, 2018
5XOM
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HYDRA FAM20
Descriptor:Glycosaminoglycan xylosylkinase, N-ACETYL-D-GLUCOSAMINE
Authors:Xiao, J., Zhang, H.
Deposit date:2017-05-29
Release date:2018-04-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and evolution of the Fam20 kinases
Nat Commun, 9, 2018
5XRQ
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CRYSTAL STRUCTURE OF HUMAN MONOCLONAL ANTIBODY H3V-47
Descriptor:Fab H3v-47 heavy chain, Fab H3v-47 light chain
Authors:Zhang, H., Willson, I.A.
Deposit date:2017-06-09
Release date:2018-07-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA.
Nat Commun, 9, 2018
5XRS
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CRYSTAL STRUCTURE OF A/MINNESOTA/11/2010 (H3N2) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH LSTC
Descriptor:Hemagglutinin, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Zhang, H., Wilson, I.A.
Deposit date:2017-06-09
Release date:2018-07-25
Method:X-RAY DIFFRACTION (2.907 Å)
Cite:A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA.
Nat Commun, 9, 2018
5XRT
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CRYSTAL STRUCTURE OF A/MINNESOTA/11/2010 (H3N2) INFLUENZA VIRUS HEMAGGLUTININ
Descriptor:Hemagglutinin, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Zhang, H., Wilson, I.A.
Deposit date:2017-06-09
Release date:2018-07-25
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA.
Nat Commun, 9, 2018
5GSA
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EED IN COMPLEX WITH AN ALLOSTERIC PRC2 INHIBITOR
Descriptor:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine
Authors:Zhao, K., Zhao, M., Luo, X., Zhang, H.
Deposit date:2016-08-15
Release date:2017-02-01
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of
Nat. Chem. Biol., 13, 2017
5H19
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EED IN COMPLEX WITH PRC2 ALLOSTERIC INHIBITOR EED162
Descriptor:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, 5-(furan-2-ylmethylamino)-9-(phenylmethyl)-8,10-dihydro-7H-[1,2,4]triazolo[3,4-a][2,7]naphthyridine-6-carbonitrile
Authors:Zhao, K., Zhao, M., Luo, X., Zhang, H.
Deposit date:2016-10-08
Release date:2017-01-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
PLoS ONE, 12, 2017
5H24
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EED IN COMPLEX WITH PRC2 ALLOSTERIC INHIBITOR COMPOUND 8
Descriptor:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, 5-(furan-2-ylmethylamino)-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile
Authors:Zhao, K., Zhao, M., Luo, X., Zhang, H.
Deposit date:2016-10-14
Release date:2017-01-25
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
J. Med. Chem., 60, 2017
5H25
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EED IN COMPLEX WITH PRC2 ALLOSTERIC INHIBITOR COMPOUND 11
Descriptor:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, 5-(2-fluorophenyl)-2,3-dihydroimidazo[2,1-a]isoquinoline
Authors:Zhao, K., Zhao, M., Luo, X., Zhang, H.
Deposit date:2016-10-14
Release date:2017-01-25
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
J. Med. Chem., 60, 2017
5Z2S
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CRYSTAL STRUCTURE OF DUX4-HD2 DOMAIN
Descriptor:Double homeobox protein 4
Authors:Dong, X., Zhang, W., Wu, H., Huang, J., Zhang, M., Wang, P., Zhang, H., Chen, Z., Chen, S., Meng, G.
Deposit date:2018-01-03
Release date:2018-04-04
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis of DUX4/IGH-driven transactivation.
Leukemia, 32, 2018
5Z2T
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CRYSTAL STRUCTURE OF DNA-BOUND DUX4-HD2
Descriptor:Double homeobox protein 4, 5'-D(*TP*TP*CP*TP*AP*AP*TP*CP*TP*AP*AP*TP*CP*TP*T)-3', 5'-D(P*AP*AP*GP*AP*TP*TP*AP*GP*AP*TP*TP*AP*GP*T)-3'
Authors:Dong, X., Zhang, W., Wu, H., Huang, J., Zhang, M., Wang, P., Zhang, H., Chen, Z., Chen, S., Meng, G.
Deposit date:2018-01-04
Release date:2018-04-04
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.623 Å)
Cite:Structural basis of DUX4/IGH-driven transactivation.
Leukemia, 32, 2018
3ED0
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CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH EMODIN
Descriptor:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, BENZAMIDINE, CHLORIDE ION, ...
Authors:Zhang, L., Zhang, H., Liu, W., Guo, Y., Shen, X., Jiang, H.
Deposit date:2008-09-02
Release date:2009-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Emodin targets the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: enzymatic inhibition assay with crystal structural and thermodynamic characterization
BMC MICROBIOL., 9, 2009
3C0F
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CRYSTAL STRUCTURE OF A NOVEL NON-PFAM PROTEIN AF1514 FROM ARCHEOGLOBUS FULGIDUS DSM 4304 SOLVED BY S-SAD USING A CR X-RAY SOURCE
Descriptor:Uncharacterized protein AF_1514
Authors:Li, Y., Bahti, P., Shaw, N., Song, G., Yin, J., Zhu, J.-Y., Zhang, H., Xu, H., Wang, B.-C., Liu, Z.-J.
Deposit date:2008-01-20
Release date:2008-02-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a novel non-Pfam protein AF1514 from Archeoglobus fulgidus DSM 4304 solved by S-SAD using a Cr X-ray source.
Proteins, 71, 2008
5YIP
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CRYSTAL STRUCTURE OF ANKG LIR/GABARAPL1 COMPLEX
Descriptor:Gamma-aminobutyric acid receptor-associated protein-like 1, Ankyrin-3, GLYCEROL
Authors:Li, J., Zhu, R., Chen, K., Zheng, H., Yuan, C., Zhang, H., Wang, C., Zhang, M.
Deposit date:2017-10-06
Release date:2018-05-23
Last modified:2018-08-01
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins.
Nat. Chem. Biol., 14, 2018
5YIQ
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CRYSTAL STRUCTURE OF ANKG LIR/LC3B COMPLEX
Descriptor:Microtubule-associated proteins 1A/1B light chain 3B, Ankyrin-3, ZINC ION
Authors:Li, J., Zhu, R., Chen, K., Zheng, H., Yuan, C., Zhang, H., Wang, C., Zhang, M.
Deposit date:2017-10-06
Release date:2018-05-23
Last modified:2018-08-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins.
Nat. Chem. Biol., 14, 2018
5YIR
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CRYSTAL STRUCTURE OF ANKB LIR/GABARAP COMPLEX
Descriptor:Gamma-aminobutyric acid receptor-associated protein, Ankyrin-2, NICKEL (II) ION
Authors:Li, J., Zhu, R., Chen, K., Zheng, H., Yuan, C., Zhang, H., Wang, C., Zhang, M.
Deposit date:2017-10-06
Release date:2018-05-23
Last modified:2018-08-01
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins.
Nat. Chem. Biol., 14, 2018
5YIS
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CRYSTAL STRUCTURE OF ANKB LIR/LC3B COMPLEX
Descriptor:Microtubule-associated proteins 1A/1B light chain 3B, Ankyrin-2, GLYCEROL, ...
Authors:Li, J., Zhu, R., Chen, K., Zheng, H., Yuan, C., Zhang, H., Wang, C., Zhang, M.
Deposit date:2017-10-06
Release date:2018-05-23
Last modified:2018-08-01
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins.
Nat. Chem. Biol., 14, 2018
1NUP
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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC NMN/NAMN ADENYLYLTRANSFERASE COMPLEX WITH NMN
Descriptor:FKSG76, SULFATE ION, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE
Authors:Zhang, X., Kurnasov, O.V., Karthikeyan, S., Grishin, N.V., Osterman, A.L., Zhang, H.
Deposit date:2003-02-01
Release date:2003-06-03
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:STRUCTURAL CHARACTERIZATION OF A HUMAN CYTOSOLIC NMN/NaMN ADENYLYLTRANSFERASE AND IMPLICATION IN HUMAN NAD BIOSYNTHESIS
J.Biol.Chem., 278, 2003
1NUQ
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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC NMN/NAMN ADENYLYLTRANSFERASE COMPLEXED WITH NAAD
Descriptor:FKSG76, SULFATE ION, 1-[(2R,3R,4S,5R)-5-({[(R)-{[(R)-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-3,4-dihydroxytetrahydrofuran-2-yl]-3-carboxypyridinium
Authors:Zhang, X., Kurnasov, O.V., Karthikeyan, S., Grishin, N.V., Osterman, A.L., Zhang, H.
Deposit date:2003-02-01
Release date:2003-06-03
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:STRUCTURAL CHARACTERIZATION OF A HUMAN CYTOSOLIC NMN/NaMN ADENYLYLTRANSFERASE AND IMPLICATION IN HUMAN NAD BIOSYNTHESIS
J.Biol.Chem., 278, 2003
1NUR
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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC NMN/NAMN ADENYLYLTRANSFERASE
Descriptor:FKSG76, SULFATE ION
Authors:Zhang, X., Kurnasov, O.V., Karthikeyan, S., Grishin, N.V., Osterman, A.L., Zhang, H.
Deposit date:2003-02-01
Release date:2003-06-03
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:STRUCTURAL CHARACTERIZATION OF A HUMAN CYTOSOLIC NMN/NaMN ADENYLYLTRANSFERASE AND IMPLICATION IN HUMAN NAD BIOSYNTHESIS
J.Biol.Chem., 278, 2003
1NUS
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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC NMN/NAMN ADENYLYLTRANSFERASE COMPLEXED WITH ATP ANALOG AND NMN
Descriptor:FKSG76, SULFATE ION, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, ...
Authors:Zhang, X., Kurnasov, O.V., Karthikeyan, S., Grishin, N.V., Osterman, A.L., Zhang, H.
Deposit date:2003-02-01
Release date:2003-06-03
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:STRUCTURAL CHARACTERIZATION OF A HUMAN CYTOSOLIC NMN/NaMN ADENYLYLTRANSFERASE AND IMPLICATION IN HUMAN NAD BIOSYNTHESIS
J.Biol.Chem., 278, 2003
1NUT
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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC NMN/NAMN ADENYLYLTRANSFERASE COMPLEXED WITH ATP ANALOG
Descriptor:FKSG76, SULFATE ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER
Authors:Zhang, X., Kurnasov, O.V., Karthikeyan, S., Grishin, N.V., Osterman, A.L., Zhang, H.
Deposit date:2003-02-01
Release date:2003-06-03
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:STRUCTURAL CHARACTERIZATION OF A HUMAN CYTOSOLIC NMN/NaMN ADENYLYLTRANSFERASE AND IMPLICATION IN HUMAN NAD BIOSYNTHESIS
J.Biol.Chem., 278, 2003
1NUU
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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC NMN/NAMN ADENYLYLTRANSFERASE COMPLEXED WITH NAD
Descriptor:FKSG76, SULFATE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Zhang, X., Kurnasov, O.V., Karthikeyan, S., Grishin, N.V., Osterman, A.L., Zhang, H.
Deposit date:2003-02-01
Release date:2003-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:STRUCTURAL CHARACTERIZATION OF A HUMAN CYTOSOLIC NMN/NaMN ADENYLYLTRANSFERASE AND IMPLICATION IN HUMAN NAD BIOSYNTHESIS
J.Biol.Chem., 278, 2003
5H13
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EED IN COMPLEX WITH PRC2 ALLOSTERIC INHIBITOR EED396
Descriptor:Polycomb protein EED, GLYCEROL, PRASEODYMIUM ION, ...
Authors:Zhao, K., Zhao, M., Luo, X., Zhang, H.
Deposit date:2016-10-08
Release date:2017-01-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
PLoS ONE, 12, 2017