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1T8I
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BU of 1t8i by Molmil
Human DNA Topoisomerase I (70 Kda) In Complex With The Poison Camptothecin and Covalent Complex With A 22 Base Pair DNA Duplex
Descriptor: 4-ETHYL-4-HYDROXY-1,12-DIHYDRO-4H-2-OXA-6,12A-DIAZA-DIBENZO[B,H]FLUORENE-3,13-DIONE, 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', ...
Authors:Staker, B.L, Feese, M.D, Cushman, M, Pommier, Y, Zembower, D, Stewart, L, Burgin, A.B.
Deposit date:2004-05-12
Release date:2005-05-31
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex
J.Med.Chem., 48, 2005
1K4T
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BU of 1k4t by Molmil
HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE POISON TOPOTECAN AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
Descriptor: (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID, 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', ...
Authors:Staker, B.L, Hjerrild, K, Feese, M.D, Behnke, C.A, Burgin Jr, A.B, Stewart, L.J.
Deposit date:2001-10-08
Release date:2002-12-04
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The mechanism of topoisomerase I poisoning by a camptothecin analog
Proc.Natl.Acad.Sci.USA, 99, 2002
1K4S
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BU of 1k4s by Molmil
HUMAN DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
Descriptor: 5'-D(*(SPT)P*GP*AP*AP*AP*AP*AP*(5IU)P*(5IU)P*(5IU)P*(5IU)P*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*(5IU)P*(5IU))-3', 5'-D(*AP*AP*AP*AP*AP*TP*(IDO)UP*(IDO)UP*(IDO)UP*(IDO)UP*CP*AP*AP*AP*GP*(IDO)UP*CP*(IDO)UP*(IDO)UP*(IDO)UP*(IDO)UP*T)-3', ...
Authors:Staker, B.L, Hjerrild, K, Feese, M.D, Behnke, C.A, Burgin Jr, A.B, Stewart, L.J.
Deposit date:2001-10-08
Release date:2002-12-04
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The mechanism of topoisomerase I poisoning by a camptothecin analog
Proc.Natl.Acad.Sci.USA, 99, 2002
1DM9
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BU of 1dm9 by Molmil
HEAT SHOCK PROTEIN 15 KD
Descriptor: HYPOTHETICAL 15.5 KD PROTEIN IN MRCA-PCKA INTERGENIC REGION, SULFATE ION
Authors:Staker, B.L, Korber, P, Bardwell, J.C.A, Saper, M.A.
Deposit date:1999-12-14
Release date:2000-02-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Hsp15 reveals a novel RNA-binding motif.
EMBO J., 19, 2000
1SEU
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BU of 1seu by Molmil
Human DNA Topoisomerase I (70 Kda) In Complex With The Indolocarbazole SA315F and Covalent Complex With A 22 Base Pair DNA Duplex
Descriptor: 2,10-DIHYDROXY-12-(BETA-D-GLUCOPYRANOSYL)-6,7,12,13-TETRAHYDROINDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7-DIONE, 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', ...
Authors:Staker, B.L, Feese, M.D, Cushman, M, Pommier, Y, Zembower, D, Stewart, L, Burgin, A.B.
Deposit date:2004-02-18
Release date:2005-04-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex
J.Med.Chem., 48, 2005
1SC7
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BU of 1sc7 by Molmil
Human DNA Topoisomerase I (70 Kda) In Complex With The Indenoisoquinoline MJ-II-38 and Covalent Complex With A 22 Base Pair DNA Duplex
Descriptor: 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE, 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', ...
Authors:Staker, B.L, Feese, M.D, Cushman, M, Pommier, Y, Zembower, D, Stewart, L, Burgin, A.B.
Deposit date:2004-02-11
Release date:2005-04-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex
J.Med.Chem., 48, 2005
8FBM
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BU of 8fbm by Molmil
Crystal structure of Cryptosporidium parvum N-myristoyltransferase with bound myristoyl-CoA and inhibitor 1
Descriptor: 2-chloro-5-[ethyl(phenyl)sulfamoyl]-N-[2-(2-oxopyrrolidin-1-yl)phenyl]benzamide, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Staker, B.L, Fenwick, M, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2022-11-29
Release date:2023-05-31
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of Cryptosporidium parvum N-myristoyltransferase with bound myristoyl-CoA
To Be Published
8FBT
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BU of 8fbt by Molmil
Crystal structure of Cryptosporidium parvum N-myristoyltransferase with bound myristoyl-CoA
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Staker, B.L, Fenwick, M, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2022-11-30
Release date:2023-05-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of Cryptosporidium parvum N-myristoyltransferase with bound myristoyl-CoA
To Be Published
8FBU
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BU of 8fbu by Molmil
Crystal structure of Cryptosporidium parvum N-myristoyltransferase with bound myristoyl-CoA and Compound-2
Descriptor: (2M)-2-[2-(piperazin-1-yl)phenyl]-N-(1,3-thiazol-2-yl)-1H-benzimidazole-4-carboxamide, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Staker, B.L, Fenwick, M, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2022-11-30
Release date:2023-05-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of Cryptosporidium parvum N-myristoyltransferase with bound myristoyl-CoA
To Be Published
3I4E
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BU of 3i4e by Molmil
Crystal structure of Isocitrate Lyase from Burkholderia pseudomallei
Descriptor: Isocitrate lyase
Authors:Staker, B.L, Arakaki, T, Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-07-01
Release date:2009-07-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Crystal structure of Isocitrate Lyase from Burkholderia pseudomallei
To be Published
6NXG
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BU of 6nxg by Molmil
Crystal structure of glycylpeptide N-tetradecanoyltransferase from Plasmodium vivax in complex with inhibitor 303a
Descriptor: 1,2-ETHANEDIOL, 5-(4-chlorophenyl)-3-({[3-(morpholine-4-carbonyl)phenyl]amino}methyl)pyridin-2(1H)-one, BETA-MERCAPTOETHANOL, ...
Authors:Staker, B.L, Mayclin, S, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2019-02-08
Release date:2020-01-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Identification of Selective Inhibitors ofPlasmodiumN-Myristoyltransferase by High-Throughput Screening.
J.Med.Chem., 63, 2020
3BLA
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BU of 3bla by Molmil
Synthetic Gene Encoded DcpS bound to inhibitor DG153249
Descriptor: 5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine, Scavenger mRNA-decapping enzyme DcpS
Authors:Staker, B.L, Christensen, J, Stewart, L, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-12-10
Release date:2008-10-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
3BL9
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BU of 3bl9 by Molmil
Synthetic Gene Encoded DcpS bound to inhibitor DG157493
Descriptor: 5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine, Scavenger mRNA-decapping enzyme DcpS
Authors:Staker, B.L, Christensen, J, Stewart, L, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-12-10
Release date:2008-10-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
3BL7
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BU of 3bl7 by Molmil
Synthetic Gene Encoded DcpS bound to inhibitor DG156844
Descriptor: 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine, Scavenger mRNA-decapping enzyme DcpS
Authors:Staker, B.L, Christensen, J, Stewart, L, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-12-10
Release date:2008-10-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
3IEW
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BU of 3iew by Molmil
Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Burkholderia pseudomallei with bound CTP and CDP
Descriptor: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, CYTIDINE-5'-DIPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, ...
Authors:Staker, B.L, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-07-23
Release date:2009-08-18
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei.
J Struct Funct Genomics, 12, 2011
3G45
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BU of 3g45 by Molmil
Crystal structure of human phosphodiesterase 4b with regulatory domain and d155988
Descriptor: 8-(3-nitrophenyl)-6-(pyridin-4-ylmethyl)quinoline, MAGNESIUM ION, ZINC ION, ...
Authors:Staker, B.L.
Deposit date:2009-02-03
Release date:2010-01-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Nat.Biotechnol., 28, 2010
3G4G
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BU of 3g4g by Molmil
Crystal structure of human phosphodiesterase 4d with regulatory domain and d155871
Descriptor: 1-(3-nitrophenyl)-3-(pyridin-4-ylmethyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione, CALCIUM ION, MAGNESIUM ION, ...
Authors:Staker, B.L.
Deposit date:2009-02-03
Release date:2010-01-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Nat.Biotechnol., 28, 2010
3G4I
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BU of 3g4i by Molmil
Crystal structure of human phosphodiesterase 4d with d155871
Descriptor: 1-(3-nitrophenyl)-3-(pyridin-4-ylmethyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione, ETHANOL, MAGNESIUM ION, ...
Authors:Staker, B.L.
Deposit date:2009-02-03
Release date:2010-01-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Nat.Biotechnol., 28, 2010
3G4L
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BU of 3g4l by Molmil
Crystal structure of human phosphodiesterase 4d with roflumilast
Descriptor: 1,2-ETHANEDIOL, 3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)BENZAMIDE, MAGNESIUM ION, ...
Authors:Staker, B.L.
Deposit date:2009-02-03
Release date:2010-01-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Nat.Biotechnol., 28, 2010
3G58
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BU of 3g58 by Molmil
Crystal structure of human phosphodiesterase 4d with d155988/pmnpq
Descriptor: 1,2-ETHANEDIOL, 8-(3-nitrophenyl)-6-(pyridin-4-ylmethyl)quinoline, MAGNESIUM ION, ...
Authors:Staker, B.L.
Deposit date:2009-02-04
Release date:2010-01-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Nat.Biotechnol., 28, 2010
3G4K
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BU of 3g4k by Molmil
Crystal structure of human phosphodiesterase 4d with rolipram
Descriptor: 1,2-ETHANEDIOL, MAGNESIUM ION, ROLIPRAM, ...
Authors:Staker, B.L.
Deposit date:2009-02-03
Release date:2010-01-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Nat.Biotechnol., 28, 2010
3HZG
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BU of 3hzg by Molmil
Crystal structure of mycobacterium tuberculosis thymidylate synthase X bound with FAD
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, PHOSPHATE ION, ...
Authors:Staker, B.L, Rathod, P, Hunter, J, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-06-23
Release date:2009-07-07
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
3IML
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BU of 3iml by Molmil
Crystal Structure Of S-Adenosylmethionine Synthetase From Burkholderia Pseudomallei
Descriptor: S-adenosylmethionine synthetase
Authors:Staker, B.L, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-08-10
Release date:2009-09-22
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Combining functional and structural genomics to sample the essential Burkholderia structome.
Plos One, 8, 2013
3IAD
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BU of 3iad by Molmil
Crystal structure of human phosphodiesterase 4D with bound allosteric modulator
Descriptor: 1-{4-[(2-fluoro-6-methoxy-3'-nitrobiphenyl-3-yl)methyl]phenyl}urea, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, MAGNESIUM ION, ...
Authors:Staker, B.L, Burgin Jr, A.B.
Deposit date:2009-07-13
Release date:2010-01-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Nat.Biotechnol., 28, 2010
3L56
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BU of 3l56 by Molmil
Crystal structure of the large c-terminal domain of polymerase basic protein 2 from influenza virus a/viet nam/1203/2004 (h5n1)
Descriptor: Polymerase PB2
Authors:Staker, B.L, Edwards, T, Eric, S, Raymond, A, Stewart, L, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-12-21
Release date:2010-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Biological and structural characterization of a host-adapting amino acid in influenza virus.
Plos Pathog., 6, 2010

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