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1Z2B
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BU of 1z2b by Molmil
Tubulin-colchicine-vinblastine: stathmin-like domain complex
Descriptor: (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE, 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Gigant, B, Wang, C, Ravelli, R.B.G, Roussi, F, Steinmetz, M.O, Curmi, P.A, Sobel, A, Knossow, M.
Deposit date:2005-03-08
Release date:2005-05-31
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Structural basis for the regulation of tubulin by vinblastine.
Nature, 435, 2005
3GJP
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BU of 3gjp by Molmil
Crystal structure of mutant coiled coil GCN4 leucine zipper
Descriptor: General control protein GCN4
Authors:Honnappa, S, Steinmetz, M.O.
Deposit date:2009-03-09
Release date:2010-03-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis of coiled-coil oligomerization-state specificity
Proc.Natl.Acad.Sci.USA, 107, 2010
3GJO
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BU of 3gjo by Molmil
Crystal structure of human EB1 in complex with microtubule Tip localization signal peptide of MACF
Descriptor: Dystonin, Microtubule-associated protein RP/EB family member 1
Authors:Honnappa, S, Steinmetz, M.O.
Deposit date:2009-03-09
Release date:2009-08-04
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:An EB1-binding motif acts as a microtubule tip localization signal
Cell(Cambridge,Mass.), 138, 2009
2AKF
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BU of 2akf by Molmil
Crystal structure of the coiled-coil domain of coronin 1
Descriptor: Coronin-1A, ZINC ION
Authors:Kammerer, R.A, Kostrewa, D, Progias, P, Honnappa, S, Avila, D, Lustig, A, Winkler, F.K, Pieters, J, Steinmetz, M.O.
Deposit date:2005-08-03
Release date:2005-09-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:A conserved trimerization motif controls the topology of short coiled coils
Proc.Natl.Acad.Sci.Usa, 102, 2005
8RIV
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BU of 8riv by Molmil
T2R-TTL-1-K08 complex
Descriptor: (4-fluoranyl-2-methyl-1~{H}-indol-5-yl) 3,4,5-trimethoxybenzenesulfonate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
Authors:Boiarska, Z, Homer, J.A, Steinmetz, M.O, Moses, J.E, Prota, A.E.P.
Deposit date:2023-12-19
Release date:2024-03-27
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Modular synthesis of functional libraries by accelerated SuFEx click chemistry.
Chem Sci, 15, 2024
8RIW
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BU of 8riw by Molmil
T2R-TTL-1-L01 complex
Descriptor: (2-methyl-1~{H}-indol-5-yl) 3,4,5-trimethoxybenzenesulfonate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
Authors:Prota, A.E.P, Boiarska, Z, Homer, J.A, Steinmetz, M.O, Moses, J.E.
Deposit date:2023-12-19
Release date:2024-03-27
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Modular synthesis of functional libraries by accelerated SuFEx click chemistry.
Chem Sci, 15, 2024
3CO1
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BU of 3co1 by Molmil
Crystal structure of microtubule binding domain of human EB3
Descriptor: Microtubule-associated protein RP/EB family member 3
Authors:De Groot, C.O, Honnappa, S, Steinmetz, M.O.
Deposit date:2008-03-27
Release date:2009-03-17
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Mammalian end binding proteins control persistent microtubule growth.
J.Cell Biol., 2009
3E2U
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BU of 3e2u by Molmil
Crystal structure of the zink-knuckle 2 domain of human CLIP-170 in complex with CAP-Gly domain of human dynactin-1 (p150-GLUED)
Descriptor: CAP-Gly domain-containing linker protein 1, Dynactin subunit 1, ZINC ION
Authors:Weisbrich, A, Honnappa, S, Capitani, G, Steinmetz, M.O.
Deposit date:2008-08-06
Release date:2008-08-19
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-function relationship of CAP-Gly domains
Nat.Struct.Mol.Biol., 14, 2007
7Z7D
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BU of 7z7d by Molmil
Tubulin-Todalam-Vinblastine-complex
Descriptor: (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
Authors:Muehlethaler, T, Milanos, L, Ortega, J.A, Blum, T.B, Gioia, D, Roy, B, Prota, A.E, Cavalli, A, Steinmetz, M.O.
Deposit date:2022-03-15
Release date:2022-04-27
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action.
Angew.Chem.Int.Ed.Engl., 61, 2022
7Z2P
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BU of 7z2p by Molmil
Tubulin-nocodazole complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Prota, A.E, Muehlethaler, T, Cavalli, A, Steinmetz, M.O.
Deposit date:2022-02-28
Release date:2022-08-31
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents.
Eur.J.Med.Chem., 241, 2022
2L56
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BU of 2l56 by Molmil
NMR structure of the GCN4 trigger peptide refined using biased molecular dynamics simulations
Descriptor: General control protein GCN4
Authors:Missimer, J.H, Dolenc, J, Steinmetz, M.O, van Gunsteren, W.F.
Deposit date:2010-10-26
Release date:2010-12-01
Last modified:2011-10-26
Method:SOLUTION NMR
Cite:Exploring the trigger sequence of the GCN4 coiled-coil: Biased molecular dynamics resolves apparent inconsistencies in NMR measurements
Protein Sci., 19, 2010
1D7M
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BU of 1d7m by Molmil
COILED-COIL DIMERIZATION DOMAIN FROM CORTEXILLIN I
Descriptor: CORTEXILLIN I
Authors:Burkhard, P, Kammerer, R.A, Steinmetz, M.O, Bourenkov, G.P, Aebi, U.
Deposit date:1999-10-19
Release date:2000-03-27
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The coiled-coil trigger site of the rod domain of cortexillin I unveils a distinct network of interhelical and intrahelical salt bridges.
Structure Fold.Des., 8, 2000
6SES
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BU of 6ses by Molmil
Tubulin-B2 complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Guo, B, Rodriguez-Gabin, A, Prota, A.E, Muehlethaler, T, Zhang, N, Ye, K, Steinmetz, M.O, Band Horwitz, S, Smith III, A.B, McDaid, H.M.
Deposit date:2019-07-30
Release date:2020-07-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Refinement of the Tubulin Ligand (+)-Discodermolide to Attenuate Chemotherapy-Mediated Senescence.
Mol.Pharmacol., 98, 2020
6S9E
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BU of 6s9e by Molmil
Tubulin-GDP.AlF complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ALUMINUM FLUORIDE, CALCIUM ION, ...
Authors:Oliva, M.A, Estevez-Gallego, J, Diaz, J.F, Prota, A.E, Steinmetz, M.O, Balaguer, F.A, Lucena-Agell, D.
Deposit date:2019-07-12
Release date:2020-02-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural model for differential cap maturation at growing microtubule ends.
Elife, 9, 2020
1WU9
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BU of 1wu9 by Molmil
Crystal structure of the C-terminal domain of the end-binding protein 1 (EB1)
Descriptor: Microtubule-associated protein RP/EB family member 1
Authors:Honnappa, S, John, C.M, Kostrewa, D, Winkler, F.K, Steinmetz, M.O.
Deposit date:2004-12-02
Release date:2005-02-01
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Structural insights into the EB1-APC interaction
Embo J., 24, 2005
6Y6D
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BU of 6y6d by Molmil
Tubulin-7-Aminonoscapine complex
Descriptor: (3~{S})-7-azanyl-6-methoxy-3-[(5~{R})-4-methoxy-6-methyl-7,8-dihydro-5~{H}-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3~{H}-2-benzofuran-1-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
Authors:Oliva, M.A, Prota, A.E, Rodriguez-Salarichs, J, Gu, W, Bennani, Y.L, Jimenez-Barbero, J, Canales, A, Steinmetz, M.O, Diaz, J.F.
Deposit date:2020-02-26
Release date:2020-07-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis of Noscapine Activation for Tubulin Binding.
J.Med.Chem., 63, 2020
1S9Z
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BU of 1s9z by Molmil
SYNTHETIC 17 AMINO ACID LONG PEPTIDE THAT FORMS A NATIVE-LIKE COILED-COIL AT AMBIENT TEMPERATURE AND AGGREGATES INTO AMYLOID-LIKE FIBRILS AT HIGHER TEMPERATURES.
Descriptor: SODIUM ION, SYNTHETIC COILED-COIL PEPTIDE, ZINC ION
Authors:Kammerer, R.A, Kostrewa, D, Zurdo, J, Detken, A, Garcia-Echeverria, C, Green, J.D, Muller, S.A, Meier, B.H, Winkler, F.K, Dobson, C.M, Steinmetz, M.O.
Deposit date:2004-02-06
Release date:2004-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Exploring amyloid formation by a de novo design
Proc.Natl.Acad.Sci.USA, 101, 2004
5SB7
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BU of 5sb7 by Molmil
Tubulin-todalam-18-complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Muehlethaler, T, Milanos, L, Ortega, J.A, Blum, T.B, Gioia, D, Prota, A.E, Cavalli, A, Steinmetz, M.O.
Deposit date:2021-07-08
Release date:2022-04-27
Last modified:2022-06-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action.
Angew.Chem.Int.Ed.Engl., 61, 2022
5SB4
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BU of 5sb4 by Molmil
Tubulin-todalam-8-complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Muehlethaler, T, Milanos, L, Ortega, J.A, Blum, T.B, Gioia, D, Prota, A.E, Cavalli, A, Steinmetz, M.O.
Deposit date:2021-07-08
Release date:2022-04-27
Last modified:2022-06-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action.
Angew.Chem.Int.Ed.Engl., 61, 2022
5SB6
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BU of 5sb6 by Molmil
Tubulin-todalam-10-complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Muehlethaler, T, Milanos, L, Ortega, J.A, Blum, T.B, Gioia, D, Prota, A.E, Cavalli, A, Steinmetz, M.O.
Deposit date:2021-07-08
Release date:2022-04-27
Last modified:2022-06-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action.
Angew.Chem.Int.Ed.Engl., 61, 2022
5SB5
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BU of 5sb5 by Molmil
Tubulin-todalam-9-complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Muehlethaler, T, Milanos, L, Ortega, J.A, Blum, T.B, Gioia, D, Prota, A.E, Cavalli, A, Steinmetz, M.O.
Deposit date:2021-07-08
Release date:2022-04-27
Last modified:2022-06-22
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action.
Angew.Chem.Int.Ed.Engl., 61, 2022
5SB3
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BU of 5sb3 by Molmil
Tubulin-todalam-4-complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Muehlethaler, T, Milanos, L, Ortega, J.A, Blum, T.B, Gioia, D, Prota, A.E, Cavalli, A, Steinmetz, M.O.
Deposit date:2021-07-08
Release date:2022-04-27
Last modified:2022-06-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action.
Angew.Chem.Int.Ed.Engl., 61, 2022
5D3A
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BU of 5d3a by Molmil
KIF21A regulatory coiled coil
Descriptor: GLYCEROL, Kinesin-like protein KIF21A
Authors:Bianchi, S, Kraatz, S, Steinmetz, M.O, Kammerer, A.R.
Deposit date:2015-08-06
Release date:2016-09-14
Method:X-RAY DIFFRACTION (2.495 Å)
Cite:Structure of KIF21A regulatory coiled coil
To Be Published
3TQ7
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BU of 3tq7 by Molmil
EB1c/EB3c heterodimer in complex with the CAP-Gly domain of P150glued
Descriptor: Dynactin subunit 1, Microtubule-associated protein RP/EB family member 1, Microtubule-associated protein RP/EB family member 3
Authors:De Groot, C.O, Scharer, M.A, Capitani, G, Steinmetz, M.O.
Deposit date:2011-09-09
Release date:2012-01-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Interaction of mammalian end binding proteins with CAP-Gly domains of CLIP-170 and p150(glued).
J.Struct.Biol., 177, 2012
5FCM
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BU of 5fcm by Molmil
CrBld10-N 1-70
Descriptor: Basal body protein, ISOPROPYL ALCOHOL, SULFATE ION
Authors:Kraatz, S.H.W, Steinmetz, M.O.
Deposit date:2015-12-15
Release date:2016-07-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.229 Å)
Cite:The Human Centriolar Protein CEP135 Contains a Two-Stranded Coiled-Coil Domain Critical for Microtubule Binding.
Structure, 24, 2016

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